| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lymphedema | D008209 | 4 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Geng XF et al. | [The progress of research on ginlcgobiobal flavone]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015321 |
| Zhang YJ et al. | [Identification and evaluation of TCM shayuanzi]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015323 |
| Betti L et al. | Design, synthesis, and alpha(1)-adrenoceptor binding properties of new arylpiperazine derivatives bearing a flavone nucleus as the terminal heterocyclic molecular portion. | 2004 | Bioorg. Med. Chem. | pmid:15018926 |
| Blonska M et al. | Effects of ethanol extract of propolis (EEP) and its flavones on inducible gene expression in J774A.1 macrophages. | 2004 | J Ethnopharmacol | pmid:15036463 |
| van Zanden JJ et al. | Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells. | 2004 | Biochem. Pharmacol. | pmid:15041478 |
| Yang L et al. | Purification and characterization of an isoflavone-conjugates-hydrolyzing beta-glucosidase from endophytic bacterium. | 2004 | J. Agric. Food Chem. | pmid:15053533 |
| Wang SP and Huang KJ | Determination of flavonoids by high-performance liquid chromatography and capillary electrophoresis. | 2004 | J Chromatogr A | pmid:15065805 |
| Onyilagha JC et al. | Effect of flavonoids on feeding preference and development of the crucifer pest Mamestra configurata Walker. | 2004 | J. Chem. Ecol. | pmid:15074660 |
| Choi JS et al. | Enhanced bioavailability of paclitaxel after oral coadministration with flavone in rats. | 2004 | Int J Pharm | pmid:15081147 |
| Wang HB et al. | Flavone glucosides with immunomodulatory activity from the leaves of Pleioblastus amarus. | 2004 | Phytochemistry | pmid:15081303 |
| Atkinson C et al. | Red-clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial [ISRCTN42940165]. | 2004 | Breast Cancer Res. | pmid:15084240 |
| Ohno S et al. | Flavonoid inhibition of overexpressed human 3beta-hydroxysteroid dehydrogenase type II. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15084349 |
| Hall BJ et al. | Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors. | 2004 | Eur. J. Pharmacol. | pmid:15102527 |
| Kong C et al. | Two compounds from allelopathic rice accession and their inhibitory activity on weeds and fungal pathogens. | 2004 | Phytochemistry | pmid:15110693 |
| Tammela P et al. | Permeability characteristics and membrane affinity of flavonoids and alkyl gallates in Caco-2 cells and in phospholipid vesicles. | 2004 | Arch. Biochem. Biophys. | pmid:15111127 |
| Goppel M and Franz G | Stability control of senna leaves and senna extracts. | 2004 | Planta Med. | pmid:15124088 |
| Morimitsu Y et al. | Inhibitory effect of flavonoids on sulfo- and glucurono-conjugation of acetaminophen in rat cultured hepatocytes and liver subcellular preparations. | 2004 | Biol. Pharm. Bull. | pmid:15133252 |
| Souza J et al. | A study on the antipicornavirus activity of flavonoid compounds (flavones) by using quantum chemical and chemometric methods. | J Chem Inf Comput Sci | pmid:15154785 | |
| Scheidt HA et al. | Investigation of the membrane localization and distribution of flavonoids by high-resolution magic angle spinning NMR spectroscopy. | 2004 | Biochim. Biophys. Acta | pmid:15157612 |
| Gouédard C et al. | Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism. | 2004 | Mol. Cell. Biol. | pmid:15169886 |