| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lymphedema | D008209 | 4 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim DH et al. | Molecular characterization of flavonoid malonyltransferase from Oryza sativa. | 2009 Nov-Dec | Plant Physiol. Biochem. | pmid:19733090 |
| Rostom SA et al. | Synthesis and biological evaluation of some polymethoxylated fused pyridine ring systems as antitumor agents. | 2009 | Arch. Pharm. (Weinheim) | pmid:19714673 |
| Cao H et al. | Arsenic accumulation in Scutellaria baicalensis Georgi and its effects on plant growth and pharmaceutical components. | 2009 | J. Hazard. Mater. | pmid:19577841 |
| Kwak HS et al. | Marked individual variation in isoflavone metabolism after a soy challenge can modulate the skeletal effect of isoflavones in premenopausal women. | 2009 | J. Korean Med. Sci. | pmid:19794985 |
| Xia C et al. | Differential effect of Shenmai injection, a herbal preparation, on the cytochrome P450 3A-mediated 1'-hydroxylation and 4-hydroxylation of midazolam. | 2009 | Chem. Biol. Interact. | pmid:19557931 |
| Fiorentino A et al. | Identification and assessment of antioxidant capacity of phytochemicals from kiwi fruits. | 2009 | J. Agric. Food Chem. | pmid:19358604 |
| Yenjai C et al. | Structural modification of 5,7-dimethoxyflavone from Kaempferia parviflora and biological activities. | 2009 | Arch. Pharm. Res. | pmid:19784571 |
| Cesla P et al. | Optimization of two-dimensional gradient liquid chromatography separations. | 2009 | J Chromatogr A | pmid:18804770 |
| Li Z et al. | Up-regulation of Toll-like receptor 4 was suppressed by emodin and baicalin in the setting of acute pancreatitis. | 2009 | Biomed. Pharmacother. | pmid:18343629 |
| Furuta T et al. | Concise synthesis of chafurosides A and B. | 2009 | Org. Lett. | pmid:19473042 |
| Zhu JT et al. | Estrogenic and neuroprotective properties of scutellarin from Erigeron breviscapus: a drug against postmenopausal symptoms and Alzheimer's disease. | 2009 | Planta Med. | pmid:19533578 |
| Jin M et al. | Suppressive effects of T-412, a flavone on interleukin-4 production in T cells. | 2009 | Biol. Pharm. Bull. | pmid:19881301 |
| Walle T | Methylation of dietary flavones increases their metabolic stability and chemopreventive effects. | 2009 | Int J Mol Sci | pmid:20087474 |
| Ryu YB et al. | Structural characteristics of flavanones and flavones from Cudrania tricuspidata for neuraminidase inhibition. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19660948 |
| Chokchaisiri R et al. | Bioactive flavonoids of the flowers of Butea monosperma. | 2009 | Chem. Pharm. Bull. | pmid:19336944 |
| Appeldoorn MM et al. | Some phenolic compounds increase the nitric oxide level in endothelial cells in vitro. | 2009 | J. Agric. Food Chem. | pmid:19722703 |
| Androutsopoulos VP et al. | Anticancer effects of the flavonoid diosmetin on cell cycle progression and proliferation of MDA-MB 468 breast cancer cells due to CYP1 activation. | 2009 | Oncol. Rep. | pmid:19424633 |
| Zhang ZF et al. | Separation and purification of two flavone glucuronides from Erigeron multiradiatus (Lindl.) Benth with macroporous resins. | 2009 | J. Biomed. Biotechnol. | pmid:19918373 |
| Liu Q et al. | Metabolism profile of scutellarin in urine following oral administration to rats by ultra performance liquid chromatography coupled to time-of-flight mass spectrometry. | 2009 | Talanta | pmid:19782195 |
| Najmus-Saqib Q et al. | Antimicrobial and cytotoxicity activities of the medicinal plant Primula macrophylla. | 2009 | J Enzyme Inhib Med Chem | pmid:18686139 |
| Tanaka Y et al. | Recent progress of flower colour modification by biotechnology. | 2009 | Int J Mol Sci | pmid:20054474 |
| Mohammed MM et al. | New acylated flavone and cyanogenic glycosides from Linum grandiflorum. | 2009 | Nat. Prod. Res. | pmid:19296395 |
| Li ZF et al. | Emodin and baicalein inhibit pancreatic stromal derived factor-1 expression in rats with acute pancreatitis. | 2009 | HBPD INT | pmid:19357036 |
| Lee E et al. | Inhibition of P-glycoprotein by wogonin is involved with the potentiation of etoposide-induced apoptosis in cancer cells. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723047 |
| Tan M et al. | Synthesis, cytotoxic activity, and DNA binding properties of copper (II) complexes with hesperetin, naringenin, and apigenin. | 2009 | Bioinorg Chem Appl | pmid:19830248 |
| Bregestovski P et al. | Genetically encoded optical sensors for monitoring of intracellular chloride and chloride-selective channel activity. | 2009 | Front Mol Neurosci | pmid:20057911 |
| Baek I et al. | Flavone Attenuates Vascular Contractions by Inhibiting RhoA/Rho Kinase Pathway. | 2009 | Korean J. Physiol. Pharmacol. | pmid:19885038 |
| Galla G et al. | Computational annotation of genes differentially expressed along olive fruit development. | 2009 | BMC Plant Biol. | pmid:19852839 |
| Li N et al. | Proteomic analysis of differentially expressed proteins in hepatitis B virus-related hepatocellular carcinoma tissues. | 2009 | J. Exp. Clin. Cancer Res. | pmid:19715608 |
| Masada S et al. | Functional and structural characterization of a flavonoid glucoside 1,6-glucosyltransferase from Catharanthus roseus. | 2009 | Plant Cell Physiol. | pmid:19561332 |
| Yokohira M et al. | Lack of Modifying Effects of Intratracheal Instillation of Quartz or Dextran Sulfate Sodium (DSS) in Drinking Water on Lung Tumor Development Initiated with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Female A/J Mice. | 2009 | J Toxicol Pathol | pmid:22271992 |
| Li HQ et al. | Synthesis of C(7) modified chrysin derivatives designing to inhibit beta-ketoacyl-acyl carrier protein synthase III (FabH) as antibiotics. | 2009 | Bioorg. Med. Chem. | pmid:19664929 |
| Studholme DJ et al. | A draft genome sequence and functional screen reveals the repertoire of type III secreted proteins of Pseudomonas syringae pathovar tabaci 11528. | 2009 | BMC Genomics | pmid:19703286 |
| Kim KS et al. | Inhibition of overexpressed CDC-25.1 phosphatase activity by flavone in Caenorhabditis elegans. | 2009 | Mol. Cells | pmid:19326082 |
| Wang Y et al. | Inactivation of GSK-3beta by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling. | 2009 | Diabetes | pmid:19324938 |
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| Xiong HP et al. | 5,7-Dihydr-oxy-3,6,8-trimethoxy-flavone. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578970 |
| Aree T and Sawasdee P | 3,5,7-Trimeth-oxy-2-(4-methoxy-phen-yl)-4H-1-benzopyran-4-one. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578306 |
| Si D et al. | Mechanism of CYP2C9 inhibition by flavones and flavonols. | 2009 | Drug Metab. Dispos. | pmid:19074529 |
| Aree T et al. | 5,7-Dimeth-oxy-2-(4-methoxy-phen-yl)-4H-1-benzopyran-4-one methanol solvate monohydrate. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578297 |
| van Tonder JH et al. | Tricarbon-yl(η-flavone)chromium(0). | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578102 |
| Geraets L et al. | Inhibition of LPS-induced pulmonary inflammation by specific flavonoids. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19292976 |
| Herath W et al. | Microbial metabolism. Part 10: Metabolites of 7,8-dimethoxyflavone and 5-methoxyflavone. | 2009 | Nat. Prod. Res. | pmid:19731142 |
| Gong T et al. | Novel benzil and isoflavone derivatives from Millettia dielsiana. | 2009 | Planta Med. | pmid:19140097 |
| Shimada T et al. | Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study. | 2009 | Chem. Res. Toxicol. | pmid:19563207 |
| Karvela E et al. | Deployment of response surface methodology to optimise recovery of grape (Vitis vinifera) stem polyphenols. | 2009 | Talanta | pmid:19635365 |
| Liu G et al. | On-line strategies for the identification of unknown flavone glycosides in Dracocephalum tanguticum Maxim. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19615954 |
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| Petroianu G et al. | Monitoring by HPLC of chamomile flavonoids exposed to rat liver microsomal metabolism. | 2009 | Open Med Chem J | pmid:19707521 |
| Ibanez S et al. | Plant chemical defence: a partner control mechanism stabilising plant--seed-eating pollinator mutualisms. | 2009 | BMC Evol. Biol. | pmid:19887006 |