Xia C et al. |
Differential effect of Shenmai injection, a herbal preparation, on the cytochrome P450 3A-mediated 1'-hydroxylation and 4-hydroxylation of midazolam. |
2009 |
Chem. Biol. Interact. |
pmid:19557931
|
Tsuji PA and Walle T |
Benzo[a]pyrene-induced cytochrome P450 1A and DNA binding in cultured trout hepatocytes - inhibition by plant polyphenols. |
2007 |
Chem. Biol. Interact. |
pmid:17583686
|
Khan MS et al. |
Methylated chrysin induces co-ordinated attenuation of the canonical Wnt and NF-kB signaling pathway and upregulates apoptotic gene expression in the early hepatocarcinogenesis rat model. |
2011 |
Chem. Biol. Interact. |
pmid:21554863
|
Lanoë PH et al. |
Cyclometallated platinum(II) complexes incorporating ethynyl-flavone ligands: switching between triplet and singlet emission induced by selective binding of Pb2+ ions. |
2008 |
Chem. Commun. (Camb.) |
pmid:18802561
|
Liu B et al. |
A step toward simplified detection of serum albumin on SDS-PAGE using an environment-sensitive flavone sensor. |
2015 |
Chem. Commun. (Camb.) |
pmid:26068596
|
Asakawa T et al. |
PET imaging of nobiletin based on a practical total synthesis. |
2011 |
Chem. Commun. (Camb.) |
pmid:21243163
|
Khoobi M et al. |
A facile route to flavone and neoflavone backbones via a regioselective palladium catalyzed oxidative Heck reaction. |
2012 |
Chem. Commun. (Camb.) |
pmid:22318701
|
Kanho H et al. |
Biotransformation of benzaldehyde-type and acetophenone-type derivatives by Pharbitis nil hairy roots. |
2005 |
Chem. Pharm. Bull. |
pmid:15802832
|
Kesava Reddy M et al. |
A new chalcone and a flavone from Andrographis neesiana. |
2003 |
Chem. Pharm. Bull. |
pmid:12843595
|
Wu LZ et al. |
Two new flavone C-glycosides from Trollius ledebourii. |
2011 |
Chem. Pharm. Bull. |
pmid:22041076
|
Phrutivorapongkul A et al. |
Studies on the chemical constituents of stem bark of Millettia leucantha: isolation of new chalcones with cytotoxic, anti-herpes simplex virus and anti-inflammatory activities. |
2003 |
Chem. Pharm. Bull. |
pmid:12576653
|
Herath W et al. |
Microbial metabolism. Part 6. Metabolites of 3- and 7-hydroxyflavones. |
2006 |
Chem. Pharm. Bull. |
pmid:16508185
|
Maheswara M et al. |
Two new 5-deoxyflavonoids from Calliandra inermis. |
2004 |
Chem. Pharm. Bull. |
pmid:15304993
|
Waki T et al. |
Key role of chemical hardness to compare 2,2-diphenyl-1-picrylhydrazyl radical scavenging power of flavone and flavonol O-glycoside and C-glycoside derivatives. |
2012 |
Chem. Pharm. Bull. |
pmid:22223373
|
Chokchaisiri R et al. |
Bioactive flavonoids of the flowers of Butea monosperma. |
2009 |
Chem. Pharm. Bull. |
pmid:19336944
|
Murata T et al. |
Hyaluronidase inhibitors from Keiskea japonica. |
2012 |
Chem. Pharm. Bull. |
pmid:22223383
|
Ragab FA et al. |
Synthesis and anticonvulsant activity of certain substituted furochromone, benzofuran and flavone derivatives. |
2010 |
Chem. Pharm. Bull. |
pmid:20823592
|
Herath W et al. |
Microbial metabolism part 9. Structure and antioxidant significance of the metabolites of 5,7-dihydroxyflavone (chrysin), and 5- and 6-hydroxyflavones. |
2008 |
Chem. Pharm. Bull. |
pmid:18379084
|
Alam MS and Lee DU |
Facile synthesis and antibacterial activity of naturally occurring 5-methoxyfuroflavone. |
2010 |
Chem. Pharm. Bull. |
pmid:21139271
|
Fernandes DC et al. |
Myeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitens. |
2008 |
Chem. Pharm. Bull. |
pmid:18451567
|
Hayashi T et al. |
A cytotoxic flavone from Scoparia dulcis L. |
1988 |
Chem. Pharm. Bull. |
pmid:3246045
|
Wang XL et al. |
Effects of eleven flavonoids from the osteoprotective fraction of Drynaria fortunei (KUNZE) J. SM. on osteoblastic proliferation using an osteoblast-like cell line. |
2008 |
Chem. Pharm. Bull. |
pmid:18175973
|
Moorthy NS et al. |
Synthesis, biological evaluation and in silico metabolic and toxicity prediction of some flavanone derivatives. |
2006 |
Chem. Pharm. Bull. |
pmid:17015974
|
Goyal N et al. |
Ethynylflavones, highly potent, and selective inhibitors of cytochrome P450 1A1. |
2014 |
Chem. Res. Toxicol. |
pmid:25033111
|
Fang H et al. |
Structure-activity relationships for a large diverse set of natural, synthetic, and environmental estrogens. |
2001 |
Chem. Res. Toxicol. |
pmid:11258977
|
Fang H et al. |
Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. |
2003 |
Chem. Res. Toxicol. |
pmid:14565775
|
Shimada T et al. |
Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. |
2010 |
Chem. Res. Toxicol. |
pmid:21053930
|
Shimada T et al. |
Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study. |
2009 |
Chem. Res. Toxicol. |
pmid:19563207
|
Tarling CA et al. |
The search for novel human pancreatic alpha-amylase inhibitors: high-throughput screening of terrestrial and marine natural product extracts. |
2008 |
Chembiochem |
pmid:18214874
|
Goettert M et al. |
Biological evaluation and structural determinants of p38α mitogen-activated-protein kinase and c-Jun-N-terminal kinase 3 inhibition by flavonoids. |
2010 |
Chembiochem |
pmid:21108268
|
Wang DJ et al. |
Effect of Total Flavone of Haw Leaves on Nuclear Factor Erythroid-2 Related Factor and Other Related Factors in Nonalcoholic Steatohepatitis Rats. |
2018 |
Chin J Integr Med |
pmid:26919834
|
Guo AJ et al. |
Kaempferol as a flavonoid induces osteoblastic differentiation via estrogen receptor signaling. |
2012 |
Chin Med |
pmid:22546174
|
Xu F et al. |
Quasi-MSn identification of flavanone 7-glycoside isomers in Da Chengqi Tang by high performance liquid chromatography-tandem mass spectrometry. |
2009 |
Chin Med |
pmid:19630957
|
Tan W et al. |
Anti-cancer natural products isolated from chinese medicinal herbs. |
2011 |
Chin Med |
pmid:21777476
|
Tang W et al. |
Simultaneous determination of eight major bioactive compounds in Dachengqi Tang (DT) by high-performance liquid chromatography. |
2008 |
Chin Med |
pmid:18445276
|
Liu Z et al. |
Protective effect of chrysoeriol against doxorubicin-induced cardiotoxicity in vitro. |
2009 |
Chin. Med. J. |
pmid:19951587
|
Cappelli C et al. |
Computational study of conformational and chiroptical properties of (2R,3S,4R)-(+)-3,3',4,4',7-flavanpentol. |
2005 |
Chirality |
pmid:16196026
|
Goto S and Handa S |
Antithrombotic effects of flavonoid. |
2001 |
Circulation |
pmid:11157735
|
Li GR et al. |
Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs. |
2008 |
Circulation |
pmid:18458165
|
Mruk JS et al. |
Flavone-8-acetic acid (Flavonoid) profoundly reduces platelet-dependent thrombosis and vasoconstriction after deep arterial injury In vivo. |
2000 |
Circulation |
pmid:10645930
|
Yan H et al. |
Treating senile dementia with traditional Chinese medicine. |
2007 |
Clin Interv Aging |
pmid:18044136
|
Baguley BC |
Preclinical efficacy of vascular disrupting agents in non-small-cell lung cancer. |
2011 |
Clin Lung Cancer |
pmid:21550553
|
Wurglics M and Schubert-Zsilavecz M |
Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. |
2006 |
Clin Pharmacokinet |
pmid:16640452
|
Li Y et al. |
Induction of apoptosis and inhibition of c-erbB-2 in breast cancer cells by flavopiridol. |
2000 |
Clin. Cancer Res. |
pmid:10656453
|
Motwani M et al. |
Flavopiridol, a cyclin-dependent kinase inhibitor, prevents spindle inhibitor-induced endoreduplication in human cancer cells. |
2000 |
Clin. Cancer Res. |
pmid:10741717
|
Manna SK et al. |
Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis. |
2007 |
Clin. Cancer Res. |
pmid:17404114
|
Kestell P et al. |
Measurement of plasma 5-hydroxyindoleacetic acid as a possible clinical surrogate marker for the action of antivascular agents. |
2001 |
Clin. Chim. Acta |
pmid:11718691
|
Lefort EC and Blay J |
The dietary flavonoid apigenin enhances the activities of the anti-metastatic protein CD26 on human colon carcinoma cells. |
2011 |
Clin. Exp. Metastasis |
pmid:21298326
|
Jeon SB et al. |
Flavone inhibits vascular contraction by decreasing phosphorylation of the myosin phosphatase target subunit. |
2007 |
Clin. Exp. Pharmacol. Physiol. |
pmid:17880363
|
Buchanan CM et al. |
DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular. |
2012 |
Clin. Sci. |
pmid:22142330
|
Samarghandian S et al. |
Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. |
2011 |
Clinics (Sao Paulo) |
pmid:21808878
|
Gasiorowski K et al. |
Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? |
2011 |
CNS Neurol Disord Drug Targets |
pmid:21222632
|
Silvério CA and Okano LT |
Laser flash photolysis and time-resolved fluorescence measurements of the aggregation number of SDS-biopolymer complexes. |
2004 |
Colloids Surf B Biointerfaces |
pmid:15465303
|
Das S et al. |
Antioxidant flavone analog functionalized fluorescent silica nanoparticles: Synthesis and exploration of their possible use as biomolecule sensor. |
2017 |
Colloids Surf B Biointerfaces |
pmid:28601757
|
Agosin M |
The aerobic metabolism of metronidazole by Trypanosoma cruzi epimastigotes. |
1983 |
Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. |
pmid:6138198
|
Kanth BK et al. |
Homology modeling, binding site identification and docking in flavone hydroxylase CYP105P2 in Streptomyces peucetius ATCC 27952. |
2010 |
Comput Biol Chem |
pmid:20889382
|
Kim DO and Lee CY |
Comprehensive study on vitamin C equivalent antioxidant capacity (VCEAC) of various polyphenolics in scavenging a free radical and its structural relationship. |
2004 |
Crit Rev Food Sci Nutr |
pmid:15462129
|
Wang F et al. |
Neuroactive flavonoids interacting with GABAA receptor complex. |
2005 |
Curr Drug Targets CNS Neurol Disord |
pmid:16266290
|
Kovacic P |
Fundamental, electron transfer mechanism by pyrylium-type ions for the anticancer drugs 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA). |
2005 |
Curr Med Chem Anticancer Agents |
pmid:16178775
|
López-Lázaro M |
Flavonoids as anticancer agents: structure-activity relationship study. |
2002 |
Curr Med Chem Anticancer Agents |
pmid:12678721
|
Sagar SM et al. |
Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 1. |
2006 |
Curr Oncol |
pmid:17576437
|
Marder M and Paladini AC |
GABA(A)-receptor ligands of flavonoid structure. |
2002 |
Curr Top Med Chem |
pmid:12171576
|
Manthey JA et al. |
Biological properties of citrus flavonoids pertaining to cancer and inflammation. |
2001 |
Curr. Med. Chem. |
pmid:11172671
|
Voskresensky ON and Levitsky AP |
QSAR aspects of flavonoids as a plentiful source of new drugs. |
2002 |
Curr. Med. Chem. |
pmid:12132993
|
Lee JH et al. |
Flavone reduces the production of virulence factors, staphyloxanthin and α-hemolysin, in Staphylococcus aureus. |
2012 |
Curr. Microbiol. |
pmid:22965624
|
Guo M et al. |
Iron-binding properties of plant phenolics and cranberry's bio-effects. |
2007 |
Dalton Trans |
pmid:17992280
|
Xue L et al. |
Pd-carbene catalyzed carbonylation reactions of aryl iodides. |
2011 |
Dalton Trans |
pmid:21677940
|
Saeidnia S et al. |
A review on phytochemistry and medicinal properties of the genus Achillea. |
2011 |
Daru |
pmid:22615655
|
Neveu V et al. |
Phenol-Explorer: an online comprehensive database on polyphenol contents in foods. |
2010 |
Database (Oxford) |
pmid:20428313
|
Ouyang P et al. |
[Effects of flavone from leaves of Diospyros kaki on adventitial fibroblast proliferation induced by advanced glycation end-products in vitro]. |
2003 |
Di Yi Jun Yi Da Xue Xue Bao |
pmid:14678884
|
Wang Y et al. |
Inactivation of GSK-3beta by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling. |
2009 |
Diabetes |
pmid:19324938
|
Sato S et al. |
Flavopiridol as a radio-sensitizer for esophageal cancer cell lines. |
2004 |
Dis. Esophagus |
pmid:15569374
|
Tsai IT et al. |
Flavone is efficient to protect zebrafish fins from UV-induced damage. |
2012 |
Drug Chem Toxicol |
pmid:22289409
|
Jian J et al. |
Bauhinia championii flavone inhibits apoptosis and autophagy via the PI3K/Akt pathway in myocardial ischemia/reperfusion injury in rats. |
2015 |
Drug Des Devel Ther |
pmid:26604691
|
Tahanian E et al. |
Flavonoids targeting of IκB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells. |
2011 |
Drug Des Devel Ther |
pmid:21625419
|
Pham MH et al. |
Identification and induction of cytochrome P450s involved in the metabolism of flavone-8-acetic acid in mice. |
2011 |
Drug Metab Lett |
pmid:21457135
|
Walle UK and Walle T |
Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones. |
2007 |
Drug Metab. Dispos. |
pmid:17709371
|
Kim SK et al. |
The mitogen-activated protein kinase kinase (mek) inhibitor PD98059 elevates primary cultured rat hepatocyte glutathione levels independent of inhibiting mek. |
2006 |
Drug Metab. Dispos. |
pmid:16443668
|
Khan KK et al. |
Homotropic versus heterotopic cooperativity of cytochrome P450eryF: a substrate oxidation and spectral titration study. |
2003 |
Drug Metab. Dispos. |
pmid:12642459
|
Chen EP et al. |
A mechanism-based mathematical model of aryl hydrocarbon receptor-mediated CYP1A induction in rats using beta-naphthoflavone as a tool compound. |
2010 |
Drug Metab. Dispos. |
pmid:20843940
|
Si D et al. |
Mechanism of CYP2C9 inhibition by flavones and flavonols. |
2009 |
Drug Metab. Dispos. |
pmid:19074529
|
Hosoda K et al. |
Plasma profiling of intact isoflavone metabolites by high-performance liquid chromatography and mass spectrometric identification of flavone glycosides daidzin and genistin in human plasma after administration of kinako. |
2008 |
Drug Metab. Dispos. |
pmid:18443032
|
Pham MH et al. |
Identification of new flavone-8-acetic acid metabolites using mouse microsomes and comparison with human microsomes. |
2007 |
Drug Metab. Dispos. |
pmid:17664249
|
Otake Y and Walle T |
Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9. |
2002 |
Drug Metab. Dispos. |
pmid:11792676
|
Ruffmann R and Sartani A |
Flavoxate, a drug with smooth muscle relaxing activity. |
1987 |
Drugs Exp Clin Res |
pmid:3595445
|
Cesla P et al. |
Separation of phenolic acids and flavone natural antioxidants by two-dimensional method combining liquid chromatography and micellar electrokinetic capillary chromatography. |
2010 |
Electrophoresis |
pmid:20593394
|
Gassmann K et al. |
Species-specific differential AhR expression protects human neural progenitor cells against developmental neurotoxicity of PAHs. |
2010 |
Environ. Health Perspect. |
pmid:20570779
|
Mackenzie CA et al. |
Gonadal differentiation in frogs exposed to estrogenic and antiestrogenic compounds. |
2003 |
Environ. Toxicol. Chem. |
pmid:14552012
|
Vermelho AB et al. |
Microbial enzyme: applications in industry and in bioremediation. |
2012 |
Enzyme Res |
pmid:22496966
|
Vila-Real H et al. |
Enzymatic Synthesis of the Flavone Glucosides, Prunin and Isoquercetin, and the Aglycones, Naringenin and Quercetin, with Selective α-L-Rhamnosidase and β-D-Glucosidase Activities of Naringinase. |
2011 |
Enzyme Res |
pmid:21941631
|
Marinova MD and Tchorbanov BP |
Preparation of antioxidant enzymatic hydrolysates from honeybee-collected pollen using plant enzymes. |
2011 |
Enzyme Res |
pmid:21318132
|
Hirvonen T et al. |
Intake of flavonols and flavones and risk of coronary heart disease in male smokers. |
2001 |
Epidemiology |
pmid:11138821
|
Kerr DJ and Kaye SB |
Flavone acetic acid--preclinical and clinical activity. |
1989 |
Eur J Cancer Clin Oncol |
pmid:2680512
|
Baguley BC et al. |
Comparison of the effects of flavone acetic acid, fostriecin, homoharringtonine and tumour necrosis factor alpha on colon 38 tumours in mice. |
1989 |
Eur J Cancer Clin Oncol |
pmid:2702981
|
Lewis CR et al. |
Autonomic neuropathy following treatment with flavone acetic acid. |
1989 |
Eur J Cancer Clin Oncol |
pmid:2703010
|
Ching LM and Baguley BC |
Effect of flavone acetic acid (NSC 347,512) on splenic cytotoxic effector cells and their role in tumour necrosis. |
1989 |
Eur J Cancer Clin Oncol |
pmid:2737219
|
Ching LM and Baguley BC |
Enhancement of in vitro cytotoxicity of mouse peritoneal exudate cells by flavone acetic acid (NSC 347512). |
1988 |
Eur J Cancer Clin Oncol |
pmid:3181272
|
Dodion P et al. |
Sensitivity of normal human bone marrow myeloid progenitor cells to anthracycline, cisplatin, anthracene and flavone acetic acid derivatives, and its relevance for the prediction of human plasma concentrations of anticancer drugs. |
1987 |
Eur J Cancer Clin Oncol |
pmid:3436354
|
Ching LM and Baguley BC |
Induction of natural killer cell activity by the antitumour compound flavone acetic acid (NSC 347 512). |
1987 |
Eur J Cancer Clin Oncol |
pmid:3665989
|
Capolongo LS et al. |
Antiproliferative properties of flavone acetic acid (NSC 347512) (LM 975), a new anticancer agent. |
1987 |
Eur J Cancer Clin Oncol |
pmid:3678316
|