FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Cell Transformation, Neoplastic D002471 126 associated lipids
Leukemia P388 D007941 43 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypertension D006973 115 associated lipids
Hyperlipidemias D006949 73 associated lipids
Adenoma D000236 40 associated lipids
Cystitis D003556 23 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Encephalitis D004660 15 associated lipids
Weight Loss D015431 56 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Lymphedema D008209 4 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

Download all related citations
Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Cassidy J et al. Could interspecies differences in the protein binding of flavone acetic acid contribute to the failure to predict lack of efficacy in patients? 1989 Cancer Chemother. Pharmacol. pmid:2713962
Ertan R et al. Synthesis of new annellated flavonoid derivatives possessing spasmolytic activity--VII. 1989 Arch. Pharm. (Weinheim) pmid:2751412
Chabot GG et al. Flavone acetic acid (LM-975; NSC-347512) activation to cytotoxic species in vivo and in vitro. 1989 Cancer Chemother. Pharmacol. pmid:2758556
Cummings J et al. Characterization of the major metabolites of flavone acetic acid and comparison of their disposition in humans and mice. 1989 Cancer Res. pmid:2731178
Bibby MC et al. Influence of site on the chemosensitivity of transplantable murine colon tumours to flavone acetic acid (LM975, NSC 347512). 1989 Cancer Chemother. Pharmacol. pmid:2731316
Rabinovitz M Flavone-8-acetic acid and the natural flavonoids. 1989 J. Natl. Cancer Inst. pmid:2733041
Zwi LJ et al. Blood flow failure as a major determinant in the antitumor action of flavone acetic acid. 1989 J. Natl. Cancer Inst. pmid:2733044
Roy D and Liehr JG Metabolic oxidation of diethylstilbestrol to diethylstilbestrol-4',4"-quinone in Syrian hamsters. 1989 Carcinogenesis pmid:2736717
Ching LM and Baguley BC Effect of flavone acetic acid (NSC 347,512) on splenic cytotoxic effector cells and their role in tumour necrosis. 1989 Eur J Cancer Clin Oncol pmid:2737219
Atwell GJ et al. Synthesis and anti-tumour activity of topologically-related analogues of flavoneacetic acid. 1989 Anticancer Drug Des. pmid:2803464