| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cui XQ et al. | A new Diels-Alder type adduct and two new flavones from the stem bark of Morus yunanensis Koidz. | J Asian Nat Prod Res | pmid:18348061 | |
| Jin L et al. | Chemical constituents from Belamcanda chinensis. | J Asian Nat Prod Res | pmid:18058385 | |
| Kumar R et al. | A new chromone from Cassia nodosa. | J Asian Nat Prod Res | pmid:17135042 | |
| Cong Y et al. | A new flavonoside from Leonurus heterophyllus. | 2005 | J Asian Nat Prod Res | pmid:15621638 |
| Tao SH and Wu FE | A new flavone from Hypericum wightianum. | 2004 | J Asian Nat Prod Res | pmid:15621592 |
| Kumar GS et al. | Synthesis and biological evaluation of novel benzyl-substituted flavones as free radical (DPPH) scavengers and α-glucosidase inhibitors. | 2010 | J Asian Nat Prod Res | pmid:21061220 |
| Li YP et al. | Three new C-alkylated flavonoids from Desmodium oblongum. | 2017 | J Asian Nat Prod Res | pmid:28145124 |
| Wei H et al. | Neuropective constituents from the rhizomes of Abacopteris penangiana. | 2011 | J Asian Nat Prod Res | pmid:21751838 |
| Li LJ et al. | Flavans from the leaf of Ilex centrochinensis. | 2011 | J Asian Nat Prod Res | pmid:21462042 |
| Zhang JW et al. | Structural elucidation of a new flavone from Sarcopyramis nepalensis. | 2011 | J Asian Nat Prod Res | pmid:21409688 |
| Most MM | Estimated phytochemical content of the dietary approaches to stop hypertension (DASH) diet is higher than in the Control Study Diet. | 2004 | J Am Diet Assoc | pmid:15499362 |
| Sampson L et al. | Flavonol and flavone intakes in US health professionals. | 2002 | J Am Diet Assoc | pmid:12396158 |
| da Silva EL et al. | Inhibitory effect of flavonoids on low-density lipoprotein peroxidation catalyzed by mammalian 15-lipoxygenase. | 2000 | IUBMB Life | pmid:10995031 |
| Patel CA et al. | Remedial Prospective of Hippophae rhamnoides Linn. (Sea Buckthorn). | 2012 | ISRN Pharmacol | pmid:22530142 |
| Drewinko B and Yang LY | The activity of flavone acetic acid (NSC 347512) on human colon cancer cells in vitro. | 1986 | Invest New Drugs | pmid:3583640 |
| Corbett TH et al. | Activity of flavone acetic acid (NSC-347512) against solid tumors of mice. | 1986 | Invest New Drugs | pmid:3546183 |
| Kyselova Z | Toxicological aspects of the use of phenolic compounds in disease prevention. | 2011 | Interdiscip Toxicol | pmid:22319251 |
| Ismail NA and Jusoh SA | Molecular Docking and Molecular Dynamics Simulation Studies to Predict Flavonoid Binding on the Surface of DENV2 E Protein. | 2017 | Interdiscip Sci | pmid:26969331 |
| Xiao J et al. | Non-covalent interaction of dietary polyphenols with total plasma proteins of type II diabetes: molecular structure/property-affinity relationships. | 2011 | Integr Biol (Camb) | pmid:21947088 |
| Hara T et al. | Flavopiridol potentiates the cytotoxic effects of radiation in radioresistant tumor cells in which p53 is mutated or Bcl-2 is overexpressed. | 2008 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:18640498 |
| Horsman MR and Murata R | Combination of vascular targeting agents with thermal or radiation therapy. | 2002 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:12459380 |
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| Pichichero E et al. | Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression. | 2010 | Int. J. Oncol. | pmid:20811719 |
| Lin CC et al. | Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. | 2011 | Int. J. Oncol. | pmid:21573491 |
| Chen YC et al. | Flavone inhibition of tumor growth via apoptosis in vitro and in vivo. | 2004 | Int. J. Oncol. | pmid:15289867 |
| Feng XT et al. | Protective role of Pollen Typhae total flavone against the palmitic acid-induced impairment of glucose-stimulated insulin secretion involving GPR40 signaling in INS-1 cells. | 2017 | Int. J. Mol. Med. | pmid:28731171 |
| Böcker D and Verspohl EJ | Role of protein kinase C, PI3-kinase and tyrosine kinase in activation of MAP kinase by glucose and agonists of G-protein coupled receptors in INS-1 cells. | 2001 | Int. J. Exp. Diabetes Res. | pmid:12369712 |
| Wenzel U et al. | Nitric oxide suppresses apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions. | 2003 | Int. J. Cancer | pmid:12866025 |
| Winkelmann I et al. | Proteome response in HT-29 human colorectal cancer cells to two apoptosis-inducing compounds with different mode of action. | 2008 | Int. J. Cancer | pmid:18214853 |
| Wenzel U et al. | Melatonin potentiates flavone-induced apoptosis in human colon cancer cells by increasing the level of glycolytic end products. | 2005 | Int. J. Cancer | pmid:15800915 |
| Simons CC et al. | Dietary flavonol, flavone and catechin intake and risk of colorectal cancer in the Netherlands Cohort Study. | 2009 | Int. J. Cancer | pmid:19530252 |
| Gates MA et al. | A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer. | 2007 | Int. J. Cancer | pmid:17471564 |
| Herzog A et al. | Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. | 2004 | Int. J. Cancer | pmid:14750173 |
| Tsui KH et al. | Upregulation of prostate-derived Ets factor by luteolin causes inhibition of cell proliferation and cell invasion in prostate carcinoma cells. | 2012 | Int. J. Cancer | pmid:21780100 |
| Jayaraman P et al. | Activity and interactions of antibiotic and phytochemical combinations against Pseudomonas aeruginosa in vitro. | 2010 | Int. J. Biol. Sci. | pmid:20941374 |
| Yuqing Z et al. | Flavone ingredients can synergistically inhibit NDV infecting cell and improve ND vaccine's protective rate. | 2012 | Int. J. Biol. Macromol. | pmid:22575392 |
| Fan Y et al. | Liposome and epimedium polysaccharide-propolis flavone can synergistically enhance immune effect of vaccine. | 2012 | Int. J. Biol. Macromol. | pmid:22020157 |
| Chen X et al. | Effects of epimedium polysaccharide-propolis flavone oral liquid on mucosal immunity in chickens. | 2014 | Int. J. Biol. Macromol. | pmid:24296407 |
| Oh JM et al. | Characterization of two extracellular β-glucosidases produced from the cellulolytic fungus Aspergillus sp. YDJ216 and their potential applications for the hydrolysis of flavone glycosides. | 2018 | Int. J. Biol. Macromol. | pmid:29339289 |
| Rawel HM et al. | Interactions of different phenolic acids and flavonoids with soy proteins. | 2002 | Int. J. Biol. Macromol. | pmid:12063116 |
| Shi G et al. | Molecular characteristics and antitumor capacity of Glycan extracted from Cynomorium songaricum. | 2011 | Int. J. Biol. Macromol. | pmid:21396396 |
| Fan Y et al. | The design of propolis flavone microemulsion and its effect on enhancing the immunity and antioxidant activity in mice. | 2014 | Int. J. Biol. Macromol. | pmid:24463267 |
| Fan Y et al. | Epimedium polysaccharide and propolis flavone can synergistically inhibit the cellular infectivity of NDV and improve the curative effect of ND in chicken. | 2011 | Int. J. Biol. Macromol. | pmid:21238483 |
| Fan Y et al. | Epimedium polysaccharide and propolis flavone can synergistically stimulate lymphocyte proliferation in vitro and enhance the immune responses to ND vaccine in chickens. | 2010 | Int. J. Biol. Macromol. | pmid:20562020 |
| Tudella VG et al. | In situ evidence of an alternative oxidase and an uncoupling protein in the respiratory chain of Aspergillus fumigatus. | 2004 | Int. J. Biochem. Cell Biol. | pmid:14592541 |
| Bontempo P et al. | Feijoa sellowiana derived natural Flavone exerts anti-cancer action displaying HDAC inhibitory activities. | 2007 | Int. J. Biochem. Cell Biol. | pmid:17604209 |
| Lee DW and Park KH | Testosterone metabolism by microsomal cytochrome P-450 in liver of rats treated with some inducers. | 1989 | Int. J. Biochem. | pmid:2502444 |
| Wu D et al. | D-Alanine:D-alanine ligase as a new target for the flavonoids quercetin and apigenin. | 2008 | Int. J. Antimicrob. Agents | pmid:18774266 |
| Sato Y et al. | Variation in synergistic activity by flavone and its related compounds on the increased susceptibility of various strains of methicillin-resistant Staphylococcus aureus to beta-lactam antibiotics. | 2004 | Int. J. Antimicrob. Agents | pmid:15325425 |
| Ci X et al. | Regulation of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 cells by 2''-hydroxy-3''-en-anhydroicaritin involves down-regulation of NF-kappaB and MAPK expression. | 2010 | Int. Immunopharmacol. | pmid:20462523 |