| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kassem ME et al. | A sulphated flavone glycoside from Livistona australis and its antioxidant and cytotoxic activity. | 2012 | Nat. Prod. Res. | pmid:21793764 |
| Tan WJ et al. | Bioactive compounds of inhibiting xanthine oxidase from Selaginella labordei. | 2009 | Nat. Prod. Res. | pmid:19296380 |
| Liu S et al. | Anticancer activity and quantitative analysis of flavone of Cirsium japonicum DC. | 2007 | Nat. Prod. Res. | pmid:17680503 |
| Li LZ et al. | Flavonoids and other constituents from Aletris spicata and their chemotaxonomic significance. | 2014 | Nat. Prod. Res. | pmid:24896299 |
| D'Abrosca B et al. | A new acylated flavone glycoside with antioxidant and radical scavenging activities from Teucrium polium leaves. | 2013 | Nat. Prod. Res. | pmid:22708583 |
| Chen LX et al. | A new flavonoid from the aerial parts of Andrographis paniculata. | 2014 | Nat. Prod. Res. | pmid:24236635 |
| Hammoud L et al. | A new flavonoid and other constituents from Centaurea nicaeensis All. var. walliana M. | 2012 | Nat. Prod. Res. | pmid:21815723 |
| Mohammed MM et al. | New acylated flavone and cyanogenic glycosides from Linum grandiflorum. | 2009 | Nat. Prod. Res. | pmid:19296395 |
| Likhitwitayawuid K et al. | Phenolics with antiviral activity from Millettia erythrocalyx and Artocarpus lakoocha. | 2005 | Nat. Prod. Res. | pmid:15715263 |
| Said SA | Two new special flavones from Uvaria accuminata. | 2011 | Nat. Prod. Res. | pmid:21644179 |
| Wang MH et al. | A new antioxidant flavone glycoside from Scutellaria baicalensis Georgi. | 2014 | Nat. Prod. Res. | pmid:24995563 |
| Wang KW et al. | A new lignan with anti-tumour activity from Polygonum perfoliatum L. | 2013 | Nat. Prod. Res. | pmid:22533633 |
| Herath W et al. | Microbial metabolism. Part 10: Metabolites of 7,8-dimethoxyflavone and 5-methoxyflavone. | 2009 | Nat. Prod. Res. | pmid:19731142 |
| Fang W et al. | Flavonoids from the aerial parts of Macrothelypteris torresiana. | 2011 | Nat. Prod. Res. | pmid:21240759 |
| Ulanovskaya OA et al. | Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide. | 2008 | Nat. Chem. Biol. | pmid:18516048 |
| Clark BR et al. | Flavone C-glycosides from Anthurium andraeanum. | 2012 | Nat Prod Commun | pmid:22816298 |
| Hapuarachchi SD et al. | Andrographidine G, a new flavone glucoside from Andrographis paniculata. | 2013 | Nat Prod Commun | pmid:23678804 |
| Kikuchi K et al. | Flavonoids induce germination of basidiospores of the ectomycorrhizal fungus Suillus bovinus. | 2007 | Mycorrhiza | pmid:17516095 |
| Elliger CA et al. | Mutagenicity of flavones, chromones and acetophenones in Salmonella typhimurium. New structure-activity relationships. | 1984 | Mutat. Res. | pmid:6363915 |
| Seo HJ and Surh YJ | Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human promyelocytic leukemia cells. | 2001 | Mutat. Res. | pmid:11551495 |
| O'Leary KA et al. | Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. | 2004 | Mutat. Res. | pmid:15225597 |
| Snijman PW et al. | The antimutagenic activity of the major flavonoids of rooibos (Aspalathus linearis): some dose-response effects on mutagen activation-flavonoid interactions. | 2007 | Mutat. Res. | pmid:17537670 |
| Begum N et al. | Apigenin ameliorates gamma radiation-induced cytogenetic alterations in cultured human blood lymphocytes. | 2012 | Mutat. Res. | pmid:22516036 |
| Liu L et al. | Rational Design for Multicolor Flavone-Based Fluorophores with Aggregation-Induced Emission Enhancement Characteristics and Applications in Mitochondria-Imaging. | 2018 | Molecules | pmid:30205485 |
| Nakabo D et al. | Convenient Synthesis and Physiological Activities of Flavonoids in Coreopsis lanceolata L. Petals and Their Related Compounds. | 2018 | Molecules | pmid:29987259 |
| Montenegro CA et al. | In Silico Study and Bioprospection of the Antibacterial and Antioxidant Effects of Flavone and Its Hydroxylated Derivatives. | 2017 | Molecules | pmid:28538688 |
| Xin HL et al. | Anti-inflammatory and analgesic activity of total flavone of Cunninghamia lanceolata. | 2012 | Molecules | pmid:22832885 |
| Shih TL et al. | An alternative synthesis of 3',4'-diaminoflavones to evaluate their antioxidant ability and cell apoptosis of zebrafish larvae. | 2012 | Molecules | pmid:22777189 |
| Resende FA et al. | Mutagenicity of flavonoids assayed by bacterial reverse mutation (Ames) test. | 2012 | Molecules | pmid:22565478 |
| Zandi K et al. | Flavone enhances dengue virus type-2 (NGC strain) infectivity and replication in vero cells. | 2012 | Molecules | pmid:22374315 |
| Chen WC et al. | Baicalin induces apoptosis in SW620 human colorectal carcinoma cells in vitro and suppresses tumor growth in vivo. | 2012 | Molecules | pmid:22456615 |
| Zhang M et al. | Comparison of flavonoid compounds in the flavedo and juice of two pummelo cultivars (Citrus grandis L. Osbeck) from different cultivation regions in China. | 2014 | Molecules | pmid:25353383 |
| Zielińska D et al. | Evaluation of flavonoid contents and antioxidant capacity of the aerial parts of common and tartary buckwheat plants. | 2012 | Molecules | pmid:22890171 |
| Rahmouni N et al. | L. Phenolic Content Clarifies Its Antioxidant Activity. | 2018 | Molecules | pmid:29861483 |
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| Chung YC et al. | Pratol, an O-Methylated Flavone, Induces Melanogenesis in B16F10 Melanoma Cells via p-p38 and p-JNK Upregulation. | 2017 | Molecules | pmid:29019920 |
| Zou GA et al. | Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook. | 2010 | Molecules | pmid:20335965 |
| Wenzel U et al. | Nitric oxide levels in human preneoplastic colonocytes determine their susceptibility toward antineoplastic agents. | 2003 | Mol. Pharmacol. | pmid:14645680 |
| Zhou JG et al. | Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements. | 2003 | Mol. Pharmacol. | pmid:12644593 |
| Kuffel MJ et al. | Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2. | 2002 | Mol. Pharmacol. | pmid:12065765 |
| Chen CC et al. | Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships. | 2004 | Mol. Pharmacol. | pmid:15322261 |
| Phromnoi K et al. | A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents. | 2011 | Mol. Pharmacol. | pmid:20930110 |
| Phromnoi K et al. | Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1. | 2011 | Mol. Pharmacol. | pmid:21816954 |
| Takada Y et al. | Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells. | 2008 | Mol. Pharmacol. | pmid:18287248 |
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| Armitage JP et al. | Comparison of the chemotactic behaviour of Rhizobium leguminosarum with and without the nodulation plasmid. | 1988 | Mol. Microbiol. | pmid:3210967 |
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| Nagar S et al. | Pharmacophore mapping of flavone derivatives for aromatase inhibition. | 2008 | Mol. Divers. | pmid:18506592 |
| Joe EJ et al. | Engineering of flavonoid O-methyltransferase for a novel regioselectivity. | 2010 | Mol. Cells | pmid:20680484 |
| Kim KS et al. | Inhibition of overexpressed CDC-25.1 phosphatase activity by flavone in Caenorhabditis elegans. | 2009 | Mol. Cells | pmid:19326082 |