FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lymphedema D008209 4 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Melanoma D008545 69 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Pain D010146 64 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Osteosarcoma D012516 50 associated lipids
Per page 10 20 50 | Total 32

PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

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Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Berim A et al. Unexpected roles for ancient proteins: flavone 8-hydroxylase in sweet basil trichomes is a Rieske-type, PAO-family oxygenase. 2014 Plant J. pmid:25139498
Goyal N et al. Ethynylflavones, highly potent, and selective inhibitors of cytochrome P450 1A1. 2014 Chem. Res. Toxicol. pmid:25033111
Prasad VG et al. Iminoflavones combat 1,2-dimethyl hydrazine-induced aberrant crypt foci development in colon cancer. 2014 Biomed Res Int pmid:24995310
Li LZ et al. Flavonoids and other constituents from Aletris spicata and their chemotaxonomic significance. 2014 Nat. Prod. Res. pmid:24896299
Yan J et al. GmFNSII-controlled soybean flavone metabolism responds to abiotic stresses and regulates plant salt tolerance. 2014 Plant Cell Physiol. pmid:24192294
Wang MH et al. A new antioxidant flavone glycoside from Scutellaria baicalensis Georgi. 2014 Nat. Prod. Res. pmid:24995563
Ahmed N et al. Design, synthesis and antiproliferative activity of functionalized flavone-triazole-tetrahydropyran conjugates against human cancer cell lines. 2014 Eur J Med Chem pmid:24941129
Raghav N and Garg S SAR studies of o-hydroxychalcones and their cyclized analogs and study them as novel inhibitors of cathepsin B and cathepsin H. 2014 Eur J Pharm Sci pmid:24780403
Berczyński P et al. Studies on the antioxidant activity of some thiazolidinedione, imidazolidinedione and rhodanine derivatives having a flavone core. 2014 Luminescence pmid:24733694
Venditti A et al. A C-methylated resacetophenone from Cistus monspeliensis L. 2014 Fitoterapia pmid:24685506
Lin SH and Shih YW Antitumor effects of the flavone chalcone: inhibition of invasion and migration through the FAK/JNK signaling pathway in human gastric adenocarcinoma AGS cells. 2014 Mol. Cell. Biochem. pmid:24510324
Fan Y et al. The design of propolis flavone microemulsion and its effect on enhancing the immunity and antioxidant activity in mice. 2014 Int. J. Biol. Macromol. pmid:24463267
Modelli A and Pshenichnyuk SA Gas-phase dissociative electron attachment to flavonoids and possible similarities to their metabolic pathways. 2013 Phys Chem Chem Phys pmid:23243660
Golub AG et al. Discovery and characterization of synthetic 4'-hydroxyflavones-New CK2 inhibitors from flavone family. 2013 Bioorg. Med. Chem. pmid:24011954
Wiejak J et al. Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells. 2013 Biochem. J. pmid:23782265
D'Abrosca B et al. A new acylated flavone glycoside with antioxidant and radical scavenging activities from Teucrium polium leaves. 2013 Nat. Prod. Res. pmid:22708583
Choe H et al. Structure-based design of flavone-based inhibitors of wild-type and T315I mutant of ABL. 2013 Bioorg. Med. Chem. Lett. pmid:23790540
Richter D et al. Effects of phytoestrogen extracts isolated from pumpkin seeds on estradiol production and ER/PR expression in breast cancer and trophoblast tumor cells. 2013 Nutr Cancer pmid:23859042
Hapuarachchi SD et al. Andrographidine G, a new flavone glucoside from Andrographis paniculata. 2013 Nat Prod Commun pmid:23678804
Yin FZ et al. [Optimization of preparation of salt-processed psoraleae fructus medicines with multi-index orthogonal method]. 2013 Zhongguo Zhong Yao Za Zhi pmid:23668006
Zhang JY et al. [Rapid recognition and identification of chemical constituents in Qinghuo Zhimai tablets by SPE-HPLC-ESI-MS(n)]. 2013 Zhongguo Zhong Yao Za Zhi pmid:23672039
Kalisz S et al. Stabilization of anthocyanin and skullcap flavone complexes--investigations with computer simulation and experimental methods. 2013 Food Chem pmid:23265516
Rane RA et al. Synthesis and evaluation of novel marine bromopyrrole alkaloid-based hybrids as anticancer agents. 2013 Eur J Med Chem pmid:23584542
Sun Y et al. Enrichment and antioxidant properties of flavone C-glycosides from trollflowers using macroporous resin. 2013 Food Chem pmid:23768390
Zhong LR et al. Radix tetrastigma hemsleyani flavone induces apoptosis in human lung carcinoma a549 cells by modulating the MAPK pathway. 2013 Asian Pac. J. Cancer Prev. pmid:24289612
Dong JJ et al. Synthesis, biological evaluation and molecular docking studies of flavone and isoflavone derivatives as a novel class of KSP (kinesin spindle protein) inhibitors. 2013 Eur J Med Chem pmid:24184776
Cai X et al. Digitoflavone inhibits IκBα kinase and enhances apoptosis induced by TNFα through downregulation of expression of nuclear factor κB-regulated gene products in human pancreatic cancer cells. 2013 PLoS ONE pmid:24146961
Wang KW et al. A new lignan with anti-tumour activity from Polygonum perfoliatum L. 2013 Nat. Prod. Res. pmid:22533633
Kassem ME et al. A sulphated flavone glycoside from Livistona australis and its antioxidant and cytotoxic activity. 2012 Nat. Prod. Res. pmid:21793764
Fong YK et al. In vitro and in situ evaluation of herb-drug interactions during intestinal metabolism and absorption of baicalein. 2012 J Ethnopharmacol pmid:21906668
Wei Z et al. Cardamonin protects septic mice from acute lung injury by preventing endothelial barrier dysfunction. 2012 J. Biochem. Mol. Toxicol. pmid:22696397
Lee JM et al. Acute Toxicity and General Pharmacological Action of QGC EXT. 2012 Korean J. Physiol. Pharmacol. pmid:22416220
Duraipandiyan V et al. Antimicrobial activity of sesquiterpene lactones isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm. 2012 BMC Complement Altern Med pmid:22397713
Adejumo OE et al. Moringa oleifera Lam. (Moringaceae) grown in Nigeria: In vitro antisickling activity on deoxygenated erythrocyte cells. 2012 J Pharm Bioallied Sci pmid:22557922
Guo AJ et al. Kaempferol as a flavonoid induces osteoblastic differentiation via estrogen receptor signaling. 2012 Chin Med pmid:22546174
Galindo P et al. Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation. 2012 PLoS ONE pmid:22427863
Asadi S and Theoharides TC Corticotropin-releasing hormone and extracellular mitochondria augment IgE-stimulated human mast-cell vascular endothelial growth factor release, which is inhibited by luteolin. 2012 J Neuroinflammation pmid:22559745
Yang Y et al. Bioactivity-guided fractionation of the triglyceride-lowering component and in vivo and in vitro evaluation of hypolipidemic effects of Calyx seu Fructus Physalis. 2012 Lipids Health Dis pmid:22413998
Collins-Burow BM et al. Antiestrogenic activity of flavonoid phytochemicals mediated via the c-Jun N-terminal protein kinase pathway. Cell-type specific regulation of estrogen receptor alpha. 2012 J. Steroid Biochem. Mol. Biol. pmid:22634477
Yuqing Z et al. Flavone ingredients can synergistically inhibit NDV infecting cell and improve ND vaccine's protective rate. 2012 Int. J. Biol. Macromol. pmid:22575392
Fan Y et al. Liposome and epimedium polysaccharide-propolis flavone can synergistically enhance immune effect of vaccine. 2012 Int. J. Biol. Macromol. pmid:22020157
Chang CW et al. Daphne Genkwa sieb. Et zucc. Water-soluble extracts act on enterovirus 71 by inhibiting viral entry. 2012 Viruses pmid:22590685
Zhou G and Lv G [Comparative studies on scavenging DPPH free radicals activity of flavone C-glycosides from different parts of Dendrobium officinale]. 2012 Zhongguo Zhong Yao Za Zhi pmid:22993976
Resende FA et al. Mutagenicity of flavonoids assayed by bacterial reverse mutation (Ames) test. 2012 Molecules pmid:22565478
Lies B et al. Flavone potently stimulates an apical transporter for flavonoids in human intestinal Caco-2 cells. 2012 Mol Nutr Food Res pmid:22965487
Lee JH et al. Flavone reduces the production of virulence factors, staphyloxanthin and α-hemolysin, in Staphylococcus aureus. 2012 Curr. Microbiol. pmid:22965624
Bairwa R et al. Trachyspermum ammi. 2012 Pharmacogn Rev pmid:22654405
Hostetler GL et al. Endogenous enzymes, heat, and pH affect flavone profiles in parsley (Petroselinum crispum var. neapolitanum) and celery (Apium graveolens) during juice processing. 2012 J. Agric. Food Chem. pmid:22224550
Huang Y et al. Down-regulation of the PI3K/Akt signaling pathway and induction of apoptosis in CA46 Burkitt lymphoma cells by baicalin. 2012 J. Exp. Clin. Cancer Res. pmid:22607709
Greeff J et al. Antioxidant properties of 4-quinolones and structurally related flavones. 2012 Bioorg. Med. Chem. pmid:22197671
Welch A et al. Habitual flavonoid intakes are positively associated with bone mineral density in women. 2012 J. Bone Miner. Res. pmid:22549983
Yarmolinsky L et al. Potent antiviral flavone glycosides from Ficus benjamina leaves. 2012 Fitoterapia pmid:22155188
Clark BR et al. Flavone C-glycosides from Anthurium andraeanum. 2012 Nat Prod Commun pmid:22816298
Niraula NP et al. Biotransformation of flavone by CYP105P2 from Streptomyces peucetius. 2012 J. Microbiol. Biotechnol. pmid:22713981
Yong-Chun J et al. A novel high-performance liquid chromatography fingerprint approach to discriminate Phyllostachys pubescens from China. 2012 Pharmacogn Mag pmid:22438662
Zamboni A et al. Genome-wide microarray analysis of tomato roots showed defined responses to iron deficiency. 2012 BMC Genomics pmid:22433273
Furukawa Y et al. Isolation and characterization of activators of ERK/MAPK from citrus plants. 2012 Int J Mol Sci pmid:22408427
Li H et al. De novo transcriptome of safflower and the identification of putative genes for oleosin and the biosynthesis of flavonoids. 2012 PLoS ONE pmid:22363528
Hostetler G et al. Flavone deglycosylation increases their anti-inflammatory activity and absorption. 2012 Mol Nutr Food Res pmid:22351119
Zhang H and Zhang C Vasoprotection by dietary supplements and exercise: role of TNFα signaling. 2012 Exp Diabetes Res pmid:22110483
Shi L et al. Gossypin induces G2/M arrest in human malignant glioma U251 cells by the activation of Chk1/Cdc25C pathway. 2012 Cell. Mol. Neurobiol. pmid:21984341
Yang WS et al. Nanostructured, self-assembling peptide K5 blocks TNF-α and PGE₂ production by suppression of the AP-1/p38 pathway. 2012 Mediators Inflamm. pmid:22315508
Toton E et al. The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease. 2012 Eur. J. Pharmacol. pmid:22381066
Christensen KY et al. The risk of lung cancer related to dietary intake of flavonoids. 2012 Nutr Cancer pmid:23061904
Skizim NJ et al. Metabolic pathways for photobiological hydrogen production by nitrogenase- and hydrogenase-containing unicellular cyanobacteria Cyanothece. 2012 J. Biol. Chem. pmid:22128188
Fasinu PS et al. An overview of the evidence and mechanisms of herb-drug interactions. 2012 Front Pharmacol pmid:22557968
Ni Q et al. Seasonal variations of the antioxidant composition in ground bamboo Sasa argenteastriatus leaves. 2012 Int J Mol Sci pmid:22408451
Chan LP et al. Apigenin induces apoptosis via tumor necrosis factor receptor- and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fluorouracil and cisplatin. 2012 Biochim. Biophys. Acta pmid:22554915
Cai M et al. The neuroprotective effect of eupatilin against ischemia/reperfusion-induced delayed neuronal damage in mice. 2012 Eur. J. Pharmacol. pmid:22683875
Wang Y et al. Flavone C-glycosides from the leaves of Lophatherum gracile and their in vitro antiviral activity. 2012 Planta Med. pmid:21870321
Chung MJ et al. Suppressive effects of Schizandra chinensis Baillon water extract on allergy-related cytokine generation and degranulation in IgE-antigen complex-stimulated RBL-2H3 cells. 2012 Nutr Res Pract pmid:22586497
Hatnapure GD et al. Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent. 2012 Bioorg. Med. Chem. Lett. pmid:22981334
Hamilton ML et al. Elucidation of the biosynthesis of the di-C-glycosylflavone isoschaftoside, an allelopathic component from Desmodium spp. that inhibits Striga spp. development. 2012 Phytochemistry pmid:22959223
Klier L et al. Lewis acid-triggered selective zincation of chromones, quinolones, and thiochromones: application to the preparation of natural flavones and isoflavones. 2012 J. Am. Chem. Soc. pmid:22860983
Kim D et al. Synthetic approach to flavanones and flavones via ligand-free palladium(II)-catalyzed conjugate addition of arylboronic acids to chromones. 2012 Org. Biomol. Chem. pmid:22850763
Jansakul C et al. Relaxant mechanisms of 3, 5, 7, 3', 4'-pentamethoxyflavone on isolated human cavernosum. 2012 Eur. J. Pharmacol. pmid:22800934
Ulrich-Merzenich G et al. Novel neurological and immunological targets for salicylate-based phytopharmaceuticals and for the anti-depressant imipramine. 2012 Phytomedicine pmid:22743246
Wilczańska-Barska A et al. Enhanced accumulation of secondary metabolites in hairy root cultures of Scutellaria lateriflora following elicitation. 2012 Biotechnol. Lett. pmid:22639092
Surichan S et al. Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells. 2012 Food Chem. Toxicol. pmid:22743247
Guo F et al. Effect of the citrus lycopene β-cyclase transgene on carotenoid metabolism in transgenic tomato fruits. 2012 PLoS ONE pmid:22384184
de-Faria FM et al. Antioxidant action of mangrove polyphenols against gastric damage induced by absolute ethanol and ischemia-reperfusion in the rat. 2012 ScientificWorldJournal pmid:22654592
Li G et al. Pharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC-MS method. 2012 Fitoterapia pmid:22056665
Kongkum N et al. DNA topoisomerase IIα inhibitory and anti-HIV-1 flavones from leaves and twigs of Gardenia carinata. 2012 Fitoterapia pmid:22155186
Buchanan CM et al. DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular. 2012 Clin. Sci. pmid:22142330
Park NI et al. Enhancement of rutin in Fagopyrum esculentum hairy root cultures by the Arabidopsis transcription factor AtMYB12. 2012 Biotechnol. Lett. pmid:22113884
Fatima T et al. Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. 2012 PLoS ONE pmid:22558083
Lolli G et al. Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight. 2012 Biochemistry pmid:22794353
Zhang T et al. Inhibitory effects and underlying mechanism of 7-hydroxyflavone phosphate ester in HeLa cells. 2012 PLoS ONE pmid:22574207
Lin TY et al. Hispidulin inhibits the release of glutamate in rat cerebrocortical nerve terminals. 2012 Toxicol. Appl. Pharmacol. pmid:22759588
Pohanka M Antioxidants countermeasures against sulfur mustard. 2012 Mini Rev Med Chem pmid:22512566
Xiao L et al. Transcriptome of protoplasts reprogrammed into stem cells in Physcomitrella patens. 2012 PLoS ONE pmid:22545152
Begum N et al. Apigenin ameliorates gamma radiation-induced cytogenetic alterations in cultured human blood lymphocytes. 2012 Mutat. Res. pmid:22516036
Kostrzewa-Susłow E and Janeczko T Microbial transformations of 7-hydroxyflavanone. 2012 ScientificWorldJournal pmid:22654578
Zbidah M et al. Apigenin-induced suicidal erythrocyte death. 2012 J. Agric. Food Chem. pmid:22132906
Xie C et al. The açaí flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-α and IL-6 production through inhibiting NF-κB activation and MAPK pathway. 2012 J. Nutr. Biochem. pmid:22137267
Shukla S et al. Apigenin attenuates insulin-like growth factor-I signaling in an autochthonous mouse prostate cancer model. 2012 Pharm. Res. pmid:22139534
Hirohata M et al. Anti-amyloidogenic effects of soybean isoflavones in vitro: Fluorescence spectroscopy demonstrating direct binding to Aβ monomers, oligomers and fibrils. 2012 Biochim. Biophys. Acta pmid:22587837
Duchnowicz P et al. Hypolipidemic and antioxidant effects of hydroxycinnamic acids, quercetin, and cyanidin 3-glucoside in hypercholesterolemic erythrocytes (in vitro study). 2012 Eur J Nutr pmid:21755326
Tsui KH et al. Upregulation of prostate-derived Ets factor by luteolin causes inhibition of cell proliferation and cell invasion in prostate carcinoma cells. 2012 Int. J. Cancer pmid:21780100
Palmieri D et al. Apigenin inhibits the TNFα-induced expression of eNOS and MMP-9 via modulating Akt signalling through oestrogen receptor engagement. 2012 Mol. Cell. Biochem. pmid:22899172