| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kurian GA and Paddikkala J | Role of Mitochondrial Enzymes and Sarcoplasmic ATPase in Cardioprotection Mediated by Aqueous Extract of Desmodium gangeticum (L) DC Root on Ischemic Reperfusion Injury. | 2010 | Indian J Pharm Sci | pmid:21969747 |
| Yamada K et al. | A lipase inhibitor monoterpene and monoterpene glycosides from Monarda punctata. | 2010 | Phytochemistry | pmid:20832830 |
| Han Y et al. | Ectopic expression of apple F3'H genes contributes to anthocyanin accumulation in the Arabidopsis tt7 mutant grown under nitrogen stress. | 2010 | Plant Physiol. | pmid:20357139 |
| Meydani M and Hasan ST | Dietary polyphenols and obesity. | 2010 | Nutrients | pmid:22254051 |
| Torres-Piedra M et al. | A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition. | 2010 | Eur J Med Chem | pmid:20346546 |
| Jeong HJ et al. | Chungsim-Yeunja-Tang decreases the inflammatory response in peripheral blood mononuclear cells from patients with cerebral infarction through an NF-κB dependent mechanism. | 2010 | J Neuroinflammation | pmid:21108840 |
| Ghasemzadeh A et al. | Effect of different light intensities on total phenolics and flavonoids synthesis and anti-oxidant activities in young ginger varieties (Zingiber officinale Roscoe). | 2010 | Int J Mol Sci | pmid:21152306 |
| Medjakovic S et al. | Potential health-modulating effects of isoflavones and metabolites via activation of PPAR and AhR. | 2010 | Nutrients | pmid:22254019 |
| Xiang H et al. | Synthesis and biological evaluation of isoflavone fatty acid esters with potential weight loss and hypolipidemic activities. | 2010 | Bioorg. Med. Chem. | pmid:20392645 |
| Wang P et al. | Structural basis for certain naturally occurring bioflavonoids to function as reducing co-substrates of cyclooxygenase I and II. | 2010 | PLoS ONE | pmid:20808785 |
| Liao Z et al. | Antidiabetic effect of flavones from Cirsium japonicum DC in diabetic rats. | 2010 | Arch. Pharm. Res. | pmid:20361298 |
| Ono E et al. | Co-pigmentation and flavonoid glycosyltransferases in blue Veronica persica flowers. | 2010 | Phytochemistry | pmid:20223486 |
| Villaflores OB et al. | Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis. | 2010 | Pharmacogn Mag | pmid:21120040 |
| Prajapati RP et al. | Phytochemical and pharmacological review of Lagenaria sicereria. | 2010 | J Ayurveda Integr Med | pmid:21731373 |
| Kim MJ et al. | TNF-α induces expression of urokinase-type plasminogen activator and β-catenin activation through generation of ROS in human breast epithelial cells. | 2010 | Biochem. Pharmacol. | pmid:20804741 |
| Vidyalakshmi K et al. | Antinociceptive effect of certain dihydroxy flavones in mice. | 2010 | Pharmacol. Biochem. Behav. | pmid:20346369 |
| Joe EJ et al. | Engineering of flavonoid O-methyltransferase for a novel regioselectivity. | 2010 | Mol. Cells | pmid:20680484 |
| Sharma RD et al. | Possible implication of oxidative stress in anti filarial effect of certain traditionally used medicinal plants in vitro against Brugia malayi microfilariae. | 2010 | Pharmacognosy Res | pmid:21713137 |
| Pichichero E et al. | Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression. | 2010 | Int. J. Oncol. | pmid:20811719 |
| Shukla S and Gupta S | Apigenin: a promising molecule for cancer prevention. | 2010 | Pharm. Res. | pmid:20306120 |
| Zhou JM et al. | Structure-function relationships of wheat flavone O-methyltransferase: Homology modeling and site-directed mutagenesis. | 2010 | BMC Plant Biol. | pmid:20670441 |
| Kurian G et al. | A Novel Approach for Oral Delivery of Insulin via Desmodium gangeticum Aqueous Root Extract. | 2010 | J Young Pharm | pmid:21264119 |
| Ghasemzadeh A et al. | Synthesis of phenolics and flavonoids in ginger (Zingiber officinale Roscoe) and their effects on photosynthesis rate. | 2010 | Int J Mol Sci | pmid:21151455 |
| Goettel W and Messing J | Divergence of gene regulation through chromosomal rearrangements. | 2010 | BMC Genomics | pmid:21118519 |
| Zou GA et al. | Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook. | 2010 | Molecules | pmid:20335965 |
| Schubert M et al. | Two novel disaccharides, rutinose and methylrutinose, are involved in carbon metabolism in Datisca glomerata. | 2010 | Planta | pmid:19915863 |
| Goodger JQ et al. | Isolation of intact sub-dermal secretory cavities from Eucalyptus. | 2010 | Plant Methods | pmid:20807444 |
| Zhang A et al. | Augmented inhibition of angiogenesis by combination of HER2 antibody chA21 and trastuzumab in human ovarian carcinoma xenograft. | 2010 | J Ovarian Res | pmid:20723224 |
| Du Y et al. | CYP93G2 is a flavanone 2-hydroxylase required for C-glycosylflavone biosynthesis in rice. | 2010 | Plant Physiol. | pmid:20647377 |
| Filak LK et al. | Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy. | 2010 | J. Biol. Inorg. Chem. | pmid:20369265 |
| Lei W et al. | Molecular cloning and expression profiling of a chalcone synthase gene from hairy root cultures of Scutellaria viscidula Bunge. | 2010 | Genet. Mol. Biol. | pmid:21637484 |
| Parravicini C et al. | Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach. | 2010 | BMC Struct. Biol. | pmid:20233425 |
| Zhang A et al. | Anti-HER-2 engineering antibody ChA21 inhibits growth and induces apoptosis of SK-OV-3 cells. | 2010 | J. Exp. Clin. Cancer Res. | pmid:20214830 |
| Akhtar TA et al. | Photosynthetic redox imbalance influences flavonoid biosynthesis in Lemna gibba. | 2010 | Plant Cell Environ. | pmid:20199616 |
| Perez-Vizcaino F and Duarte J | Flavonols and cardiovascular disease. | 2010 | Mol. Aspects Med. | pmid:20837053 |
| Yang JM et al. | Hispidulin sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by AMPK activation leading to Mcl-1 block in translation. | 2010 | J. Agric. Food Chem. | pmid:20734985 |
| Büchner FL et al. | Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). | 2010 | Cancer Causes Control | pmid:19924549 |
| Song WY et al. | Effect of ethanol extracts from red pepper seeds on antioxidative defense system and oxidative stress in rats fed high-fat . high-cholesterol diet. | 2010 | Nutr Res Pract | pmid:20198203 |
| Mays JR et al. | The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derrubone. | 2010 | Bioorg. Med. Chem. | pmid:19932969 |
| Choi CW et al. | Yeast α-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose. | 2010 | J. Agric. Food Chem. | pmid:20734984 |
| Lewin G et al. | Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin. | 2010 | J. Nat. Prod. | pmid:20356063 |
| Schrader KK | Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus). | 2010 | Toxins (Basel) | pmid:22069655 |
| Mitra I et al. | Chemometric modeling of free radical scavenging activity of flavone derivatives. | 2010 | Eur J Med Chem | pmid:20800321 |
| Kanth BK et al. | Homology modeling, binding site identification and docking in flavone hydroxylase CYP105P2 in Streptomyces peucetius ATCC 27952. | 2010 | Comput Biol Chem | pmid:20889382 |
| Xiao J et al. | Structure-affinity relationship of flavones on binding to serum albumins: effect of hydroxyl groups on ring A. | 2010 | Mol Nutr Food Res | pmid:20306480 |
| Zeng YW et al. | [The zonal characteristics and cultivated types difference of functional components in brown rice for core collection of Yunnan rice]. | 2010 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:21322246 |
| Wang J et al. | Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation. | 2010 | PLoS ONE | pmid:20221395 |
| Nessa F et al. | Xanthine oxidase inhibitory activities of extracts and flavonoids of the leaves of Blumea balsamifera. | 2010 | Pharm Biol | pmid:20738223 |
| Valant-Vetschera KM et al. | Chemodiversity of exudate flavonoids in Dionysia (Primulaceae): a comparative study. | 2010 | Phytochemistry | pmid:20378133 |
| Chen Q et al. | Measurement of total flavone content in snow lotus (Saussurea involucrate) using near infrared spectroscopy combined with interval PLS and genetic algorithm. | 2010 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:20338806 |