| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kanho H et al. | Glucosylation of phenolic compounds by Pharbitis nil hairy roots: I. Glucosylation of coumarin and flavone derivatives. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15502347 |
| Wu W et al. | Structural analysis of selected characteristic flavones by electrospray tandem mass spectrometry. | 2004 | Anal Sci | pmid:15293412 |
| Ching LM et al. | Relationship between tumour endothelial cell apoptosis and tumour blood flow shutdown following treatment with the antivascular agent DMXAA in mice. | 2004 | Br. J. Cancer | pmid:14970872 |
| Mizoyama Y et al. | Inhibitory effect of flavonoids on N-acetylation of 5-aminosalicylic acid in cultured rat hepatocytes. | 2004 | Biol. Pharm. Bull. | pmid:15340238 |
| Takada Y and Aggarwal BB | Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. | 2004 | J. Biol. Chem. | pmid:14630924 |
| Ueda H et al. | A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-alpha production. | 2004 | Biosci. Biotechnol. Biochem. | pmid:14745173 |
| Uyemura SA et al. | Oxidative phosphorylation and rotenone-insensitive malate- and NADH-quinone oxidoreductases in Plasmodium yoelii yoelii mitochondria in situ. | 2004 | J. Biol. Chem. | pmid:14561763 |
| Gouédard C et al. | Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism. | 2004 | Mol. Cell. Biol. | pmid:15169886 |
| Tudella VG et al. | In situ evidence of an alternative oxidase and an uncoupling protein in the respiratory chain of Aspergillus fumigatus. | 2004 | Int. J. Biochem. Cell Biol. | pmid:14592541 |
| Sanderson JT et al. | Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. | 2004 | Toxicol. Sci. | pmid:15319488 |
| Betti L et al. | Design, synthesis, and alpha(1)-adrenoceptor binding properties of new arylpiperazine derivatives bearing a flavone nucleus as the terminal heterocyclic molecular portion. | 2004 | Bioorg. Med. Chem. | pmid:15018926 |
| Ruberto G and Tringali C | Secondary metabolites from the leaves of Feijoa sellowiana Berg. | 2004 | Phytochemistry | pmid:15501265 |
| Arakaki N et al. | Induction of G1 cell cycle arrest in human umbilical vein endothelial cells by flavone's inhibition of the extracellular signal regulated kinase cascade. | 2004 | Biochem. Cell Biol. | pmid:15499387 |
| Atkinson C et al. | Red-clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial [ISRCTN42940165]. | 2004 | Breast Cancer Res. | pmid:15084240 |
| Wu W et al. | Studies on the flavones using liquid chromatography-electrospray ionization tandem mass spectrometry. | 2004 | J Chromatogr A | pmid:15460251 |
| Jones DJ et al. | Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity. | 2004 | Br. J. Cancer | pmid:15292928 |
| Quiney C et al. | Flavones and polyphenols inhibit the NO pathway during apoptosis of leukemia B-cells. | 2004 | Leuk. Res. | pmid:15203283 |
| Maheswara M et al. | Two new 5-deoxyflavonoids from Calliandra inermis. | 2004 | Chem. Pharm. Bull. | pmid:15304993 |
| Kanaze FI et al. | A validated HPLC determination of the flavone aglycone diosmetin in human plasma. | 2004 | Biomed. Chromatogr. | pmid:15386576 |
| Morimitsu Y et al. | Inhibitory effect of flavonoids on sulfo- and glucurono-conjugation of acetaminophen in rat cultured hepatocytes and liver subcellular preparations. | 2004 | Biol. Pharm. Bull. | pmid:15133252 |
| Leung LK et al. | Effect of dietary flavonols on oestrogen receptor transactivation and cell death induction. | 2004 | Br. J. Nutr. | pmid:15182386 |
| Gao H et al. | Structure-activity relationships for alpha-glucosidase inhibition of baicalein, 5,6,7-trihydroxyflavone: the effect of A-ring substitution. | 2004 | Biosci. Biotechnol. Biochem. | pmid:14981300 |
| Chen CC et al. | Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships. | 2004 | Mol. Pharmacol. | pmid:15322261 |
| Kagawa H et al. | Oxidation and rearrangements of flavanones by mammalian cytochrome P450. | 2004 | Xenobiotica | pmid:15742975 |
| Kim YW et al. | Synthesis and aromatase inhibitory activity of novel pyridine-containing isoflavones. | 2004 | J. Med. Chem. | pmid:15267241 |
| Most MM | Estimated phytochemical content of the dietary approaches to stop hypertension (DASH) diet is higher than in the Control Study Diet. | 2004 | J Am Diet Assoc | pmid:15499362 |
| Verbeek R et al. | The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells. | 2004 | Biochem. Pharmacol. | pmid:15276069 |
| Burns SA et al. | Direct liquid chromatography-mass spectrometry method for the detection of glutathione S-transferase isozymes and investigation of their expression in response to dietary flavone. | 2004 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:15315784 |
| Kong X et al. | Effects of Chinese herbal medicinal ingredients on peripheral lymphocyte proliferation and serum antibody titer after vaccination in chicken. | 2004 | Int. Immunopharmacol. | pmid:15233143 |
| O'Leary KA et al. | Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. | 2004 | Mutat. Res. | pmid:15225597 |
| Hirvonen T et al. | Flavonol and flavone intake and the risk of intermittent claudication in male smokers. | 2004 | Eur. J. Epidemiol. | pmid:15180100 |
| Goppel M and Franz G | Stability control of senna leaves and senna extracts. | 2004 | Planta Med. | pmid:15124088 |
| Kavvadias D et al. | The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects. | 2004 | Br. J. Pharmacol. | pmid:15231642 |
| Cho H et al. | Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin derivatives. | 2004 | Pharmacol. Res. | pmid:14597150 |
| Silvério CA and Okano LT | Laser flash photolysis and time-resolved fluorescence measurements of the aggregation number of SDS-biopolymer complexes. | 2004 | Colloids Surf B Biointerfaces | pmid:15465303 |
| Scheidt HA et al. | Investigation of the membrane localization and distribution of flavonoids by high-resolution magic angle spinning NMR spectroscopy. | 2004 | Biochim. Biophys. Acta | pmid:15157612 |
| Kim DO and Lee CY | Comprehensive study on vitamin C equivalent antioxidant capacity (VCEAC) of various polyphenolics in scavenging a free radical and its structural relationship. | 2004 | Crit Rev Food Sci Nutr | pmid:15462129 |
| Son D et al. | Neuroprotective effect of wogonin in hippocampal slice culture exposed to oxygen and glucose deprivation. | 2004 | Eur. J. Pharmacol. | pmid:15189769 |
| van Duursen MB et al. | Phytochemicals inhibit catechol-O-methyltransferase activity in cytosolic fractions from healthy human mammary tissues: implications for catechol estrogen-induced DNA damage. | 2004 | Toxicol. Sci. | pmid:15254334 |
| Cai H et al. | Growth-inhibitory and cell cycle-arresting properties of the rice bran constituent tricin in human-derived breast cancer cells in vitro and in nude mice in vivo. | 2004 | Br. J. Cancer | pmid:15316567 |
| Wenzel U and Daniel H | Early and late apoptosis events in human transformed and non-transformed colonocytes are independent on intracellular acidification. | 2004 | Cell. Physiol. Biochem. | pmid:14976408 |
| Wang QE et al. | Isolation and purification of inflacoumarin A and licochalcone A from licorice by high-speed counter-current chromatography. | 2004 | J Chromatogr A | pmid:15453418 |
| Herzog A et al. | Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. | 2004 | Int. J. Cancer | pmid:14750173 |
| Hall BJ et al. | Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors. | 2004 | Eur. J. Pharmacol. | pmid:15102527 |
| Wenzel U et al. | Ascorbic acid suppresses drug-induced apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions. | 2004 | Carcinogenesis | pmid:14754875 |
| Kim SJ et al. | Inhibition of nitric oxide production from lipopolysaccharide-treated RAW 264.7 cells by synthetic flavones: structure-activity relationship and action mechanism. | 2004 | Arch. Pharm. Res. | pmid:15473664 |
| Saracoglu I et al. | Acylated flavonoids and phenol glycosides from Veronica thymoides subsp. pseudocinerea. | 2004 | Phytochemistry | pmid:15381011 |
| del Baño MJ et al. | Flavonoid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. postulation of a biosynthetic pathway. | 2004 | J. Agric. Food Chem. | pmid:15291464 |
| Soriano IR et al. | Inducible Flavone in Oats (Avena sativa) Is a Novel Defense Against Plant-Parasitic Nematodes. | 2004 | Phytopathology | pmid:18944456 |
| Wang SP and Huang KJ | Determination of flavonoids by high-performance liquid chromatography and capillary electrophoresis. | 2004 | J Chromatogr A | pmid:15065805 |