Xia C et al. |
Differential effect of Shenmai injection, a herbal preparation, on the cytochrome P450 3A-mediated 1'-hydroxylation and 4-hydroxylation of midazolam. |
2009 |
Chem. Biol. Interact. |
pmid:19557931
|
Brunskole M et al. |
Trihydroxynaphthalene reductase of Curvularia lunata--a target for flavonoid action? |
2009 |
Chem. Biol. Interact. |
pmid:19010313
|
Khan MS et al. |
Methylated chrysin induces co-ordinated attenuation of the canonical Wnt and NF-kB signaling pathway and upregulates apoptotic gene expression in the early hepatocarcinogenesis rat model. |
2011 |
Chem. Biol. Interact. |
pmid:21554863
|
Lanoë PH et al. |
Cyclometallated platinum(II) complexes incorporating ethynyl-flavone ligands: switching between triplet and singlet emission induced by selective binding of Pb2+ ions. |
2008 |
Chem. Commun. (Camb.) |
pmid:18802561
|
Liu B et al. |
A step toward simplified detection of serum albumin on SDS-PAGE using an environment-sensitive flavone sensor. |
2015 |
Chem. Commun. (Camb.) |
pmid:26068596
|
Asakawa T et al. |
PET imaging of nobiletin based on a practical total synthesis. |
2011 |
Chem. Commun. (Camb.) |
pmid:21243163
|
Khoobi M et al. |
A facile route to flavone and neoflavone backbones via a regioselective palladium catalyzed oxidative Heck reaction. |
2012 |
Chem. Commun. (Camb.) |
pmid:22318701
|
Kanho H et al. |
Biotransformation of benzaldehyde-type and acetophenone-type derivatives by Pharbitis nil hairy roots. |
2005 |
Chem. Pharm. Bull. |
pmid:15802832
|
Kesava Reddy M et al. |
A new chalcone and a flavone from Andrographis neesiana. |
2003 |
Chem. Pharm. Bull. |
pmid:12843595
|
Wu LZ et al. |
Two new flavone C-glycosides from Trollius ledebourii. |
2011 |
Chem. Pharm. Bull. |
pmid:22041076
|
Phrutivorapongkul A et al. |
Studies on the chemical constituents of stem bark of Millettia leucantha: isolation of new chalcones with cytotoxic, anti-herpes simplex virus and anti-inflammatory activities. |
2003 |
Chem. Pharm. Bull. |
pmid:12576653
|
Herath W et al. |
Microbial metabolism. Part 6. Metabolites of 3- and 7-hydroxyflavones. |
2006 |
Chem. Pharm. Bull. |
pmid:16508185
|
Maheswara M et al. |
Two new 5-deoxyflavonoids from Calliandra inermis. |
2004 |
Chem. Pharm. Bull. |
pmid:15304993
|
Waki T et al. |
Key role of chemical hardness to compare 2,2-diphenyl-1-picrylhydrazyl radical scavenging power of flavone and flavonol O-glycoside and C-glycoside derivatives. |
2012 |
Chem. Pharm. Bull. |
pmid:22223373
|
Chokchaisiri R et al. |
Bioactive flavonoids of the flowers of Butea monosperma. |
2009 |
Chem. Pharm. Bull. |
pmid:19336944
|
Murata T et al. |
Hyaluronidase inhibitors from Keiskea japonica. |
2012 |
Chem. Pharm. Bull. |
pmid:22223383
|
Ragab FA et al. |
Synthesis and anticonvulsant activity of certain substituted furochromone, benzofuran and flavone derivatives. |
2010 |
Chem. Pharm. Bull. |
pmid:20823592
|
Herath W et al. |
Microbial metabolism part 9. Structure and antioxidant significance of the metabolites of 5,7-dihydroxyflavone (chrysin), and 5- and 6-hydroxyflavones. |
2008 |
Chem. Pharm. Bull. |
pmid:18379084
|
Alam MS and Lee DU |
Facile synthesis and antibacterial activity of naturally occurring 5-methoxyfuroflavone. |
2010 |
Chem. Pharm. Bull. |
pmid:21139271
|
Fernandes DC et al. |
Myeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitens. |
2008 |
Chem. Pharm. Bull. |
pmid:18451567
|
Hayashi T et al. |
A cytotoxic flavone from Scoparia dulcis L. |
1988 |
Chem. Pharm. Bull. |
pmid:3246045
|
Wang XL et al. |
Effects of eleven flavonoids from the osteoprotective fraction of Drynaria fortunei (KUNZE) J. SM. on osteoblastic proliferation using an osteoblast-like cell line. |
2008 |
Chem. Pharm. Bull. |
pmid:18175973
|
Moorthy NS et al. |
Synthesis, biological evaluation and in silico metabolic and toxicity prediction of some flavanone derivatives. |
2006 |
Chem. Pharm. Bull. |
pmid:17015974
|
Goyal N et al. |
Ethynylflavones, highly potent, and selective inhibitors of cytochrome P450 1A1. |
2014 |
Chem. Res. Toxicol. |
pmid:25033111
|
Fang H et al. |
Structure-activity relationships for a large diverse set of natural, synthetic, and environmental estrogens. |
2001 |
Chem. Res. Toxicol. |
pmid:11258977
|
Fang H et al. |
Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. |
2003 |
Chem. Res. Toxicol. |
pmid:14565775
|
Shimada T et al. |
Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. |
2010 |
Chem. Res. Toxicol. |
pmid:21053930
|
Shimada T et al. |
Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study. |
2009 |
Chem. Res. Toxicol. |
pmid:19563207
|
Tarling CA et al. |
The search for novel human pancreatic alpha-amylase inhibitors: high-throughput screening of terrestrial and marine natural product extracts. |
2008 |
Chembiochem |
pmid:18214874
|
Goettert M et al. |
Biological evaluation and structural determinants of p38α mitogen-activated-protein kinase and c-Jun-N-terminal kinase 3 inhibition by flavonoids. |
2010 |
Chembiochem |
pmid:21108268
|
Wang DJ et al. |
Effect of Total Flavone of Haw Leaves on Nuclear Factor Erythroid-2 Related Factor and Other Related Factors in Nonalcoholic Steatohepatitis Rats. |
2018 |
Chin J Integr Med |
pmid:26919834
|
Guo AJ et al. |
Kaempferol as a flavonoid induces osteoblastic differentiation via estrogen receptor signaling. |
2012 |
Chin Med |
pmid:22546174
|
Xu F et al. |
Quasi-MSn identification of flavanone 7-glycoside isomers in Da Chengqi Tang by high performance liquid chromatography-tandem mass spectrometry. |
2009 |
Chin Med |
pmid:19630957
|
Tan W et al. |
Anti-cancer natural products isolated from chinese medicinal herbs. |
2011 |
Chin Med |
pmid:21777476
|
Tang W et al. |
Simultaneous determination of eight major bioactive compounds in Dachengqi Tang (DT) by high-performance liquid chromatography. |
2008 |
Chin Med |
pmid:18445276
|
Liu Z et al. |
Protective effect of chrysoeriol against doxorubicin-induced cardiotoxicity in vitro. |
2009 |
Chin. Med. J. |
pmid:19951587
|
Cappelli C et al. |
Computational study of conformational and chiroptical properties of (2R,3S,4R)-(+)-3,3',4,4',7-flavanpentol. |
2005 |
Chirality |
pmid:16196026
|
Goto S and Handa S |
Antithrombotic effects of flavonoid. |
2001 |
Circulation |
pmid:11157735
|
Li GR et al. |
Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs. |
2008 |
Circulation |
pmid:18458165
|
Mruk JS et al. |
Flavone-8-acetic acid (Flavonoid) profoundly reduces platelet-dependent thrombosis and vasoconstriction after deep arterial injury In vivo. |
2000 |
Circulation |
pmid:10645930
|
Yan H et al. |
Treating senile dementia with traditional Chinese medicine. |
2007 |
Clin Interv Aging |
pmid:18044136
|
Baguley BC |
Preclinical efficacy of vascular disrupting agents in non-small-cell lung cancer. |
2011 |
Clin Lung Cancer |
pmid:21550553
|
Wurglics M and Schubert-Zsilavecz M |
Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. |
2006 |
Clin Pharmacokinet |
pmid:16640452
|
Li Y et al. |
Induction of apoptosis and inhibition of c-erbB-2 in breast cancer cells by flavopiridol. |
2000 |
Clin. Cancer Res. |
pmid:10656453
|
Motwani M et al. |
Flavopiridol, a cyclin-dependent kinase inhibitor, prevents spindle inhibitor-induced endoreduplication in human cancer cells. |
2000 |
Clin. Cancer Res. |
pmid:10741717
|
Manna SK et al. |
Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis. |
2007 |
Clin. Cancer Res. |
pmid:17404114
|
Kestell P et al. |
Measurement of plasma 5-hydroxyindoleacetic acid as a possible clinical surrogate marker for the action of antivascular agents. |
2001 |
Clin. Chim. Acta |
pmid:11718691
|
Lefort EC and Blay J |
The dietary flavonoid apigenin enhances the activities of the anti-metastatic protein CD26 on human colon carcinoma cells. |
2011 |
Clin. Exp. Metastasis |
pmid:21298326
|
Jeon SB et al. |
Flavone inhibits vascular contraction by decreasing phosphorylation of the myosin phosphatase target subunit. |
2007 |
Clin. Exp. Pharmacol. Physiol. |
pmid:17880363
|
Buchanan CM et al. |
DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular. |
2012 |
Clin. Sci. |
pmid:22142330
|
Samarghandian S et al. |
Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. |
2011 |
Clinics (Sao Paulo) |
pmid:21808878
|
Gasiorowski K et al. |
Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? |
2011 |
CNS Neurol Disord Drug Targets |
pmid:21222632
|
Silvério CA and Okano LT |
Laser flash photolysis and time-resolved fluorescence measurements of the aggregation number of SDS-biopolymer complexes. |
2004 |
Colloids Surf B Biointerfaces |
pmid:15465303
|
Das S et al. |
Antioxidant flavone analog functionalized fluorescent silica nanoparticles: Synthesis and exploration of their possible use as biomolecule sensor. |
2017 |
Colloids Surf B Biointerfaces |
pmid:28601757
|
Agosin M |
The aerobic metabolism of metronidazole by Trypanosoma cruzi epimastigotes. |
1983 |
Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. |
pmid:6138198
|
Kanth BK et al. |
Homology modeling, binding site identification and docking in flavone hydroxylase CYP105P2 in Streptomyces peucetius ATCC 27952. |
2010 |
Comput Biol Chem |
pmid:20889382
|
Kim DO and Lee CY |
Comprehensive study on vitamin C equivalent antioxidant capacity (VCEAC) of various polyphenolics in scavenging a free radical and its structural relationship. |
2004 |
Crit Rev Food Sci Nutr |
pmid:15462129
|
Wang F et al. |
Neuroactive flavonoids interacting with GABAA receptor complex. |
2005 |
Curr Drug Targets CNS Neurol Disord |
pmid:16266290
|
Kovacic P |
Fundamental, electron transfer mechanism by pyrylium-type ions for the anticancer drugs 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA). |
2005 |
Curr Med Chem Anticancer Agents |
pmid:16178775
|
López-Lázaro M |
Flavonoids as anticancer agents: structure-activity relationship study. |
2002 |
Curr Med Chem Anticancer Agents |
pmid:12678721
|
Sagar SM et al. |
Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 1. |
2006 |
Curr Oncol |
pmid:17576437
|
Marder M and Paladini AC |
GABA(A)-receptor ligands of flavonoid structure. |
2002 |
Curr Top Med Chem |
pmid:12171576
|
Manthey JA et al. |
Biological properties of citrus flavonoids pertaining to cancer and inflammation. |
2001 |
Curr. Med. Chem. |
pmid:11172671
|
Voskresensky ON and Levitsky AP |
QSAR aspects of flavonoids as a plentiful source of new drugs. |
2002 |
Curr. Med. Chem. |
pmid:12132993
|
Lee JH et al. |
Flavone reduces the production of virulence factors, staphyloxanthin and α-hemolysin, in Staphylococcus aureus. |
2012 |
Curr. Microbiol. |
pmid:22965624
|
Guo M et al. |
Iron-binding properties of plant phenolics and cranberry's bio-effects. |
2007 |
Dalton Trans |
pmid:17992280
|
Xue L et al. |
Pd-carbene catalyzed carbonylation reactions of aryl iodides. |
2011 |
Dalton Trans |
pmid:21677940
|
Saeidnia S et al. |
A review on phytochemistry and medicinal properties of the genus Achillea. |
2011 |
Daru |
pmid:22615655
|
Neveu V et al. |
Phenol-Explorer: an online comprehensive database on polyphenol contents in foods. |
2010 |
Database (Oxford) |
pmid:20428313
|
Ouyang P et al. |
[Effects of flavone from leaves of Diospyros kaki on adventitial fibroblast proliferation induced by advanced glycation end-products in vitro]. |
2003 |
Di Yi Jun Yi Da Xue Xue Bao |
pmid:14678884
|
Wang Y et al. |
Inactivation of GSK-3beta by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling. |
2009 |
Diabetes |
pmid:19324938
|
Sato S et al. |
Flavopiridol as a radio-sensitizer for esophageal cancer cell lines. |
2004 |
Dis. Esophagus |
pmid:15569374
|
Tsai IT et al. |
Flavone is efficient to protect zebrafish fins from UV-induced damage. |
2012 |
Drug Chem Toxicol |
pmid:22289409
|
Jian J et al. |
Bauhinia championii flavone inhibits apoptosis and autophagy via the PI3K/Akt pathway in myocardial ischemia/reperfusion injury in rats. |
2015 |
Drug Des Devel Ther |
pmid:26604691
|
Tahanian E et al. |
Flavonoids targeting of IκB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells. |
2011 |
Drug Des Devel Ther |
pmid:21625419
|
Pham MH et al. |
Identification and induction of cytochrome P450s involved in the metabolism of flavone-8-acetic acid in mice. |
2011 |
Drug Metab Lett |
pmid:21457135
|
Walle UK and Walle T |
Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones. |
2007 |
Drug Metab. Dispos. |
pmid:17709371
|
Kim SK et al. |
The mitogen-activated protein kinase kinase (mek) inhibitor PD98059 elevates primary cultured rat hepatocyte glutathione levels independent of inhibiting mek. |
2006 |
Drug Metab. Dispos. |
pmid:16443668
|
Khan KK et al. |
Homotropic versus heterotopic cooperativity of cytochrome P450eryF: a substrate oxidation and spectral titration study. |
2003 |
Drug Metab. Dispos. |
pmid:12642459
|
Chen EP et al. |
A mechanism-based mathematical model of aryl hydrocarbon receptor-mediated CYP1A induction in rats using beta-naphthoflavone as a tool compound. |
2010 |
Drug Metab. Dispos. |
pmid:20843940
|
Si D et al. |
Mechanism of CYP2C9 inhibition by flavones and flavonols. |
2009 |
Drug Metab. Dispos. |
pmid:19074529
|
Hosoda K et al. |
Plasma profiling of intact isoflavone metabolites by high-performance liquid chromatography and mass spectrometric identification of flavone glycosides daidzin and genistin in human plasma after administration of kinako. |
2008 |
Drug Metab. Dispos. |
pmid:18443032
|
Pham MH et al. |
Identification of new flavone-8-acetic acid metabolites using mouse microsomes and comparison with human microsomes. |
2007 |
Drug Metab. Dispos. |
pmid:17664249
|
Otake Y and Walle T |
Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9. |
2002 |
Drug Metab. Dispos. |
pmid:11792676
|
Ruffmann R and Sartani A |
Flavoxate, a drug with smooth muscle relaxing activity. |
1987 |
Drugs Exp Clin Res |
pmid:3595445
|
Cesla P et al. |
Separation of phenolic acids and flavone natural antioxidants by two-dimensional method combining liquid chromatography and micellar electrokinetic capillary chromatography. |
2010 |
Electrophoresis |
pmid:20593394
|
Gassmann K et al. |
Species-specific differential AhR expression protects human neural progenitor cells against developmental neurotoxicity of PAHs. |
2010 |
Environ. Health Perspect. |
pmid:20570779
|
Mackenzie CA et al. |
Gonadal differentiation in frogs exposed to estrogenic and antiestrogenic compounds. |
2003 |
Environ. Toxicol. Chem. |
pmid:14552012
|
Vermelho AB et al. |
Microbial enzyme: applications in industry and in bioremediation. |
2012 |
Enzyme Res |
pmid:22496966
|
Vila-Real H et al. |
Enzymatic Synthesis of the Flavone Glucosides, Prunin and Isoquercetin, and the Aglycones, Naringenin and Quercetin, with Selective α-L-Rhamnosidase and β-D-Glucosidase Activities of Naringinase. |
2011 |
Enzyme Res |
pmid:21941631
|
Marinova MD and Tchorbanov BP |
Preparation of antioxidant enzymatic hydrolysates from honeybee-collected pollen using plant enzymes. |
2011 |
Enzyme Res |
pmid:21318132
|
Hirvonen T et al. |
Intake of flavonols and flavones and risk of coronary heart disease in male smokers. |
2001 |
Epidemiology |
pmid:11138821
|
Hill S et al. |
Vascular collapse after flavone acetic acid: a possible mechanism of its anti-tumour action. |
1989 |
Eur J Cancer Clin Oncol |
pmid:2591434
|
Ching LM and Baguley BC |
Hyporesponsiveness of macrophages from C3H/HeJ (endotoxin-resistant) mice to the antitumour agent flavone acetic acid (NSC 347512). |
1989 |
Eur J Cancer Clin Oncol |
pmid:2591444
|
Ching LM and Baguley BC |
Reduction of cytotoxic effector cell activity in colon 38 tumours following treatment with flavone acetic acid. |
1989 |
Eur J Cancer Clin Oncol |
pmid:2597283
|
Baguley BC et al. |
Comparison of the effects of flavone acetic acid, fostriecin, homoharringtonine and tumour necrosis factor alpha on colon 38 tumours in mice. |
1989 |
Eur J Cancer Clin Oncol |
pmid:2702981
|
Ching LM and Baguley BC |
Enhancement of in vitro cytotoxicity of mouse peritoneal exudate cells by flavone acetic acid (NSC 347512). |
1988 |
Eur J Cancer Clin Oncol |
pmid:3181272
|
Dodion PF et al. |
Clinical and pharmacokinetic phase I trial with the diethylaminoester of flavone acetic acid (LM985, NSC 293015). |
1987 |
Eur J Cancer Clin Oncol |
pmid:3653200
|
Schroyens WA et al. |
In vitro chemosensitivity testing of flavone acetic acid (LM975; NSC 347512) and its diethylaminoethyl ester derivative (LM985; NSC 293015). |
1987 |
Eur J Cancer Clin Oncol |
pmid:3653209
|
Smith GP et al. |
Flavone acetic acid (NSC 347512) induces haemorrhagic necrosis of mouse colon 26 and 38 tumours. |
1987 |
Eur J Cancer Clin Oncol |
pmid:3653213
|