| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ahlemeyer B and Krieglstein J | Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. | 2003 | Pharmacopsychiatry | pmid:13130383 |
| ANREP GV et al. | The spasmolytic action of flavone. | 1953 | J. Pharm. Pharmacol. | pmid:13035698 |
| Xiao Z et al. | [The inhibitory effect of total flavonoids of hippophae on the activation of NF-kappa B by stretching cultured cardiac myocytes]. | 2003 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:12947714 |
| Bauvois B et al. | Synthesis and biological evaluation of novel flavone-8-acetic acid derivatives as reversible inhibitors of aminopeptidase N/CD13. | 2003 | J. Med. Chem. | pmid:12930151 |
| Springsteel MF et al. | Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. | 2003 | Bioorg. Med. Chem. | pmid:12927873 |
| Bozdağ-Dündar O et al. | Synthesis and antimicrobial activity of flavone-3'-carboxaldehyde oxime ether derivatives. | 2003 | Arzneimittelforschung | pmid:12918219 |
| Gobbi S et al. | Synthesis and biological evaluation of 3-alkoxy analogues of flavone-8-acetic acid. | 2003 | J. Med. Chem. | pmid:12904070 |
| Newell DR et al. | Professor Tom Connors and the development of novel cancer therapies by the Phase I/II Clinical Trials Committee of Cancer Research UK. | 2003 | Br. J. Cancer | pmid:12888809 |
| Aklilu M et al. | Phase II study of flavopiridol in patients with advanced colorectal cancer. | 2003 | Ann. Oncol. | pmid:12881391 |
| van der Logt EM et al. | Induction of rat hepatic and intestinal UDP-glucuronosyltransferases by naturally occurring dietary anticarcinogens. | 2003 | Carcinogenesis | pmid:12869420 |
| Wenzel U et al. | Nitric oxide suppresses apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions. | 2003 | Int. J. Cancer | pmid:12866025 |
| Chen JJ et al. | Furoquinoline alkaloids and cytotoxic constituents from the leaves of Melicope semecarpifolia. | 2003 | Planta Med. | pmid:12865974 |
| Ray H et al. | Expression of anthocyanins and proanthocyanidins after transformation of alfalfa with maize Lc. | 2003 | Plant Physiol. | pmid:12857826 |
| Gabrieli C and Kokkalou E | A new acetylated glucoside of luteolin and two flavone glucosides from Lavandula stoechas ssp. stoechas. | 2003 | Pharmazie | pmid:12857010 |
| Maçanita AL et al. | Photochemistry of flavothione and hydroxyflavothiones: mechanisms and kinetics. | 2003 | Photochem. Photobiol. | pmid:12856878 |
| Kesava Reddy M et al. | A new chalcone and a flavone from Andrographis neesiana. | 2003 | Chem. Pharm. Bull. | pmid:12843595 |
| DÃaz F et al. | Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo. | 2003 | J. Nat. Prod. | pmid:12828478 |
| Zhang P et al. | A maize QTL for silk maysin levels contains duplicated Myb-homologous genes which jointly regulate flavone biosynthesis. | 2003 | Plant Mol. Biol. | pmid:12825685 |
| Vieira RF et al. | Chemical profiling of Ocimum americanum using external flavonoids. | 2003 | Phytochemistry | pmid:12809716 |
| Topcu G et al. | Studies on di- and triterpenoids from Salvia staminea with cytotoxic activity. | 2003 | Planta Med. | pmid:12802732 |