MeSH term | MeSH ID | Detail |
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Lung Neoplasms | D008175 | 171 associated lipids |
Body Weight | D001835 | 333 associated lipids |
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kuo SM | Transepithelial transport and accumulation of flavone in human intestinal Caco-2 cells. | 1998 | Life Sci. | pmid:9877222 |
Matusuura S et al. | [Synthesis studies of the flavone derivates. III. Photochemical reaction of chalcone derivative (author's transl)]. | 1976 | Yakugaku Zasshi | pmid:986458 |
Bai F et al. | Promoter activation and following induction of the p21/WAF1 gene by flavone is involved in G1 phase arrest in A549 lung adenocarcinoma cells. | 1998 | FEBS Lett. | pmid:9804172 |
Zhai S et al. | Inhibition of methoxyresorufin demethylase activity by flavonoids in human liver microsomes. | 1998 | Life Sci. | pmid:9718089 |
Belinky PA et al. | The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its oxidation. | 1998 | Atherosclerosis | pmid:9568736 |
Kitajima-Ihara T and Yagi T | Rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria: the enzyme expressed in Escherichia coli acts as a member of the respiratory chain in the host cells. | 1998 | FEBS Lett. | pmid:9462835 |
Hollman PC and Katan MB | Absorption, metabolism and health effects of dietary flavonoids in man. | 1997 | Biomed. Pharmacother. | pmid:9436520 |
Collins BM et al. | The estrogenic and antiestrogenic activities of phytochemicals with the human estrogen receptor expressed in yeast. | 1997 | Steroids | pmid:9090797 |
Konno C et al. | Morusinol, isoprenoid flavone from Morus root barks. | 1977 | Planta Med. | pmid:905426 |
Harlow GR and Halpert JR | Alanine-scanning mutagenesis of a putative substrate recognition site in human cytochrome P450 3A4. Role of residues 210 and 211 in flavonoid activation and substrate specificity. | 1997 | J. Biol. Chem. | pmid:9038138 |
Siess MH et al. | Time course of induction of rat hepatic drug-metabolizing enzyme activities following dietary administration of flavonoids. | 1996 | J Toxicol Environ Health | pmid:8968409 |
Canivenc-Lavier MC et al. | Comparative effects of flavonoids and model inducers on drug-metabolizing enzymes in rat liver. | 1996 | Toxicology | pmid:8931757 |
Chaumontet C et al. | Lack of tumor-promoting effects of flavonoids: studies on rat liver preneoplastic foci and on in vivo and in vitro gap junctional intercellular communication. | 1996 | Nutr Cancer | pmid:8910908 |
Critchfield JW et al. | Inhibition of HIV activation in latently infected cells by flavonoid compounds. | 1996 | AIDS Res. Hum. Retroviruses | pmid:8825617 |
Karton Y et al. | Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. | 1996 | J. Med. Chem. | pmid:8691424 |
Ebel J and Hahlbrock K | Enzymes of flavone and flavonol-glycoside biosynthesis. Coordinated and selective induction in cell-suspension cultures of Petroselinum hortense. | 1977 | Eur. J. Biochem. | pmid:862617 |
Ji XD et al. | Interactions of flavonoids and other phytochemicals with adenosine receptors. | 1996 | J. Med. Chem. | pmid:8576921 |
Ching LM et al. | Induction of tumor necrosis factor-alpha messenger RNA in human and murine cells by the flavone acetic acid analogue 5,6-dimethylxanthenone-4-acetic acid (NSC 640488). | 1994 | Cancer Res. | pmid:8313372 |
Monici M et al. | Flavone photoreactivity. UV-induced reactions in organic solvents and micellar systems. | 1993 | J. Photochem. Photobiol. B, Biol. | pmid:8271117 |
Valenti P et al. | Benzo-gamma-pyrone analogues of geiparvarin: synthesis and biological evaluation against B16 melanoma cells. | 1993 | Anticancer Drug Des. | pmid:8251042 |
Tamura M et al. | Effects of flavonoid compounds on the activity of NADPH diaphorase prepared from the mouse brain. | 1994 | Jpn. J. Pharmacol. | pmid:7990275 |
Liu H and Wehmeyer KR | Supercritical fluid extraction as a sample preparation technique for the direct isolation of drugs from plasma prior to analysis. | 1994 | J. Chromatogr. B, Biomed. Appl. | pmid:7952070 |
Nijhoff WA et al. | Enhancement of rat hepatic and gastrointestinal glutathione and glutathione S-transferases by alpha-angelicalactone and flavone. | 1995 | Carcinogenesis | pmid:7697820 |
Shin W et al. | Structure-taste correlations in sweet dihydrochalcone, sweet dihydroisocoumarin, and bitter flavone compounds. | 1995 | J. Med. Chem. | pmid:7473560 |
Iinuma M and Matsuura S | [Synthetic studies of the flavone derivatives. VII. Synthesis of 6,8-dimethoxyflavone derivatives and their 13C-NMR (author's transl)]. | 1980 | Yakugaku Zasshi | pmid:7463312 |
Alworth WL et al. | Stimulation of mammalian epoxide hydrase activity by flavones. | 1980 | Xenobiotica | pmid:7415221 |
Rossi M et al. | Molecular structures of 5,6- and 7,8-benzoflavones, inhibitors of aryl hydrocarbon hydroxylase. | 1980 | Cancer Res. | pmid:7388828 |
Udupa SR and Chadha MS | Microbiological transformations of flavonoids: Part V--Transformation of flavone. | 1978 | Indian J. Biochem. Biophys. | pmid:738753 |
Viswanathan T and Alworth WL | Effects of 1-arylpyrroles and naphthoflavones upon cytochrome P-450 dependent monooxygenase activities. | 1981 | J. Med. Chem. | pmid:7277387 |
Lasker JM et al. | In vivo activation of zoxazolamine metabolism by flavone. | 1982 | Science | pmid:7089530 |
Okuda J et al. | Inhibition of aldose reductases from rat and bovine lenses by flavonoids. | 1982 | Biochem. Pharmacol. | pmid:6818971 |
Keller G and Leuenberger PM | [Aldose-reductase inhibitors and cataract formation (author's transl)]. | 1980 | Klin Monbl Augenheilkd | pmid:6775130 |
Tóth L et al. | [Analysis of flavone derivatives by polyamide layer chromatography]. | 1984 | Acta Pharm Hung | pmid:6711313 |
Hausen BM et al. | 5,8-dihydroxyflavone (primetin) the contact sensitizer of Primula mistassinica Michaux. | 1983 | Arch. Dermatol. Res. | pmid:6660907 |
Matern U et al. | Further characterization and regulation of malonyl-coenzyme A: flavonoid glucoside malonyltransferases from parsley cell suspension cultures. | 1983 | Arch. Biochem. Biophys. | pmid:6639051 |
Dutta D et al. | Induction of benzo(a)pyrene hydroxylase in Aspergillus ochraceus TS: evidences of multiple forms of cytochrome P-450. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6626210 |
Ficarra P et al. | Analysis of 2-phenyl-chromon derivatives and chlorogenic acid. II. High-performance thin layer chromatography and high-performance liquid chromatography in flowers, leaves and buds extractives of Crataegus oxyacantha L. | 1984 | Farmaco Prat | pmid:6542533 |
Nose K | Inhibition by flavonoids of RNA synthesis in permeable WI-38 cells and of transcription by RNA polymerase II. | 1984 | Biochem. Pharmacol. | pmid:6508836 |
Ghosh DK et al. | Microsomal benzo(a)pyrene hydroxylase in Aspergillus ochraceus TS: assay and characterization of the enzyme system. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6409103 |
Elliger CA et al. | Mutagenicity of flavones, chromones and acetophenones in Salmonella typhimurium. New structure-activity relationships. | 1984 | Mutat. Res. | pmid:6363915 |
Paulin JJ et al. | Ultrastructural modifications during the metabolism of metronidazole by Trypanosoma cruzi. | 1983 | J. Submicrosc. Cytol. | pmid:6361276 |
Hildebrandt AG et al. | Studies on the mechanism of stimulation of microsomal H2O2 formation and benzo(a)pyrene hydroxylation by substrates and flavone. | 1981 | Adv. Exp. Med. Biol. | pmid:6283811 |
Huang MT et al. | Specificity in the activation and inhibition by flavonoids of benzo[a]pyrene hydroxylation by cytochrome P-450 isozymes from rabbit liver microsomes. | 1981 | J. Biol. Chem. | pmid:6270135 |
He ZY | [Preliminary study on the treatment of coronary heart disease with total flavone of Caulis piperis Futokadsurae]. | 1983 | Zhong Xi Yi Jie He Za Zhi | pmid:6227404 |
Agosin M | The aerobic metabolism of metronidazole by Trypanosoma cruzi epimastigotes. | 1983 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:6138198 |
Teubert H et al. | [Flavonols and flavones of vegetables. VIII. Flavones of carrot leaves (author's transl)]. | 1977 | Z Lebensm Unters Forsch | pmid:595898 |
Narain NK | Flavonoids from Vernonia fasciculata Michx. Isolation of genkwanin and a new flavone disaccharide, fasciculatin. | 1977 | J. Chem. Soc. Perkin Trans. I | pmid:559004 |
Iinuma M and Matsuura S | [Synthetic studies of the flavone derivatives. VI. The synthesis of skullcapflavone I, II and related flavones (author's transl)]. | 1979 | Yakugaku Zasshi | pmid:536899 |
Zhang BH et al. | [The effects of the total flavone of Ku-shen on cardiac arrhythmias (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:532643 |
Hänsel R and Ohlendorf D | [A new flavone from Achyrocline satureoides unsubstituted in ring B]. | 1971 | Arch Pharm Ber Dtsch Pharm Ges | pmid:5290613 |