MeSH term | MeSH ID | Detail |
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Lung Neoplasms | D008175 | 171 associated lipids |
Body Weight | D001835 | 333 associated lipids |
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Lai MY et al. | Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats. | 2003 | J. Pharm. Pharmacol. | pmid:12631413 |
Campos DA et al. | Gastroprotective effect of a flavone from Lonchocarpus araripensis Benth. (Leguminosae) and the possible mechanism. | 2008 | J. Pharm. Pharmacol. | pmid:18284821 |
Lim SS et al. | Synthesis of flavonoids and their effects on aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues. | 2001 | J. Pharm. Pharmacol. | pmid:11370705 |
Akao T et al. | Efflux of baicalin, a flavone glucuronide of Scutellariae Radix, on Caco-2 cells through multidrug resistance-associated protein 2. | 2007 | J. Pharm. Pharmacol. | pmid:17227625 |
Park H et al. | Anti-inflammatory activity of the synthetic C-C biflavonoids. | 2006 | J. Pharm. Pharmacol. | pmid:17331331 |
Zhao W et al. | Ammonium Iodide Induced Nonradical Regioselective Sulfenylation of Flavones via a C-H Functionalization Process. | 2015 | J. Org. Chem. | pmid:26291122 |
Ohchi H et al. | Effects of dietary xenobiotics on the metabolism of copper, alpha-tocopherol and cholesterol in rats. | 1987 | J. Nutr. Sci. Vitaminol. | pmid:3125311 |
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Urba WJ et al. | Enhancement of natural killer activity in human peripheral blood by flavone acetic acid. | 1988 | J. Natl. Cancer Inst. | pmid:2452890 |
Rabinovitz M | Flavone-8-acetic acid and the natural flavonoids. | 1989 | J. Natl. Cancer Inst. | pmid:2733041 |
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Bibby MC et al. | Reduction of tumor blood flow by flavone acetic acid: a possible component of therapy. | 1989 | J. Natl. Cancer Inst. | pmid:2911084 |
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Gleye C et al. | Acaricidal activity of tonka bean extracts. Synthesis and structure-activity relationships of bioactive derivatives. | 2003 | J. Nat. Prod. | pmid:12762809 |
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Lewin G et al. | Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin. | 2010 | J. Nat. Prod. | pmid:20356063 |
Gao F et al. | Sesquiterpene lactones and flavonoids from Helianthus species. | 1987 Jan-Feb | J. Nat. Prod. | pmid:3598595 |
Carcache-Blanco EJ et al. | Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase. | 2003 | J. Nat. Prod. | pmid:14510596 |
Rossi M et al. | Molecular structure and activity toward DNA of baicalein, a flavone constituent of the Asian herbal medicine "Sho-saiko-to". | 2001 | J. Nat. Prod. | pmid:11170661 |
Li H et al. | Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 | J. Mol. Graph. Model. | pmid:16497524 |
Yang Y et al. | Binding research on flavones as ligands of β-amyloid aggregates by fluorescence and their 3D-QSAR, docking studies. | 2010 | J. Mol. Graph. Model. | pmid:21094069 |
Park SR et al. | Enhanced flavonoid production in Streptomyces venezuelae via metabolic engineering. | 2011 | J. Microbiol. Biotechnol. | pmid:22127124 |
Jeon YM et al. | Biological synthesis of 7-O-methyl Apigenin from naringenin using escherichia coli expressing two genes. | 2009 | J. Microbiol. Biotechnol. | pmid:19494697 |
Niraula NP et al. | Biotransformation of flavone by CYP105P2 from Streptomyces peucetius. | 2012 | J. Microbiol. Biotechnol. | pmid:22713981 |
Young J et al. | Antimicrobial effects of flavone analogues and their structure-activity relationships. | 2007 | J. Microbiol. Biotechnol. | pmid:18050960 |
Guz NR et al. | Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump: structure-activity relationships. | 2001 | J. Med. Chem. | pmid:11170636 |
Karton Y et al. | Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. | 1996 | J. Med. Chem. | pmid:8691424 |
Griffin RJ et al. | Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro. | 2005 | J. Med. Chem. | pmid:15658870 |
Viswanathan T and Alworth WL | Effects of 1-arylpyrroles and naphthoflavones upon cytochrome P-450 dependent monooxygenase activities. | 1981 | J. Med. Chem. | pmid:7277387 |
Shin W et al. | Structure-taste correlations in sweet dihydrochalcone, sweet dihydroisocoumarin, and bitter flavone compounds. | 1995 | J. Med. Chem. | pmid:7473560 |
Gobbi S et al. | Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme. | 2006 | J. Med. Chem. | pmid:16854084 |
Toulmin A et al. | Toward prediction of alkane/water partition coefficients. | 2008 | J. Med. Chem. | pmid:18558667 |
Ono M et al. | Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain. | 2005 | J. Med. Chem. | pmid:16279784 |
Houghten RA et al. | Mixture-based synthetic combinatorial libraries. | 1999 | J. Med. Chem. | pmid:10508425 |
Kahnberg P et al. | Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. | 2002 | J. Med. Chem. | pmid:12213060 |
Kim YW et al. | Synthesis and aromatase inhibitory activity of novel pyridine-containing isoflavones. | 2004 | J. Med. Chem. | pmid:15267241 |
Ji XD et al. | Interactions of flavonoids and other phytochemicals with adenosine receptors. | 1996 | J. Med. Chem. | pmid:8576921 |
Gobbi S et al. | Synthesis and biological evaluation of 3-alkoxy analogues of flavone-8-acetic acid. | 2003 | J. Med. Chem. | pmid:12904070 |
Yao N et al. | Novel flavonoids with antiproliferative activities against breast cancer cells. | 2011 | J. Med. Chem. | pmid:21599001 |
El-Subbagh HI et al. | Synthesis and biological evaluation of certain alpha,beta-unsaturated ketones and their corresponding fused pyridines as antiviral and cytotoxic agents. | 2000 | J. Med. Chem. | pmid:10956199 |
Recanatini M et al. | A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase. | 2001 | J. Med. Chem. | pmid:11262078 |
Wu ES et al. | Flavones. 2. Synthesis and structure-activity relationship of flavodilol and its analogues, a novel class of antihypertensive agents with catecholamine depleting properties. | 1989 | J. Med. Chem. | pmid:2909730 |
Huang X et al. | 3D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors. | 2001 | J. Med. Chem. | pmid:11384234 |
Lu H et al. | Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. | 2005 | J. Med. Chem. | pmid:15689157 |