MeSH term | MeSH ID | Detail |
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Lung Neoplasms | D008175 | 171 associated lipids |
Body Weight | D001835 | 333 associated lipids |
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Cao H et al. | Binding Citrus flavanones to human serum albumin: effect of structure on affinity. | 2011 | Mol. Biol. Rep. | pmid:20878474 |
Schmidt A et al. | Polymethylated myricetin in trichomes of the wild tomato species Solanum habrochaites and characterization of trichome-specific 3'/5'- and 7/4'-myricetin O-methyltransferases. | 2011 | Plant Physiol. | pmid:21343428 |
Bredebach M et al. | Three 2-oxoglutarate-dependent dioxygenase activities of Equisetum arvense L. forming flavone and flavonol from (2S)-naringenin. | 2011 | Phytochemistry | pmid:21353683 |
Wu LZ et al. | Two new flavone C-glycosides from Trollius ledebourii. | 2011 | Chem. Pharm. Bull. | pmid:22041076 |
Park SR et al. | Enhanced flavonoid production in Streptomyces venezuelae via metabolic engineering. | 2011 | J. Microbiol. Biotechnol. | pmid:22127124 |
Luo H et al. | Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers. | 2011 | BMC Genomics | pmid:22369100 |
Zhao J et al. | MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula. | 2011 | Plant Cell | pmid:21467581 |
Mladěnka P et al. | In vitro analysis of iron chelating activity of flavonoids. | 2011 | J. Inorg. Biochem. | pmid:21450273 |
Nagib DA and MacMillan DW | Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis. | 2011 | Nature | pmid:22158245 |
Lima de Medeiros BJ et al. | Liver protective activity of a hydroethanolic extract of Arrabidaea chica (Humb. and Bonpl.) B. Verl. (pariri). | 2011 | Pharmacognosy Res | pmid:21772750 |
Nigam A | Senescence (ageing) @ 2011. | 2011 | Indian J Dermatol | pmid:22345758 |
Kyselova Z | Toxicological aspects of the use of phenolic compounds in disease prevention. | 2011 | Interdiscip Toxicol | pmid:22319251 |
Mazzio EA et al. | The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. | 2011 | Int J Mol Sci | pmid:21340000 |
Neves MP et al. | Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis. | 2011 | Eur J Med Chem | pmid:21496973 |
Yang C et al. | Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. | 2011 | PLoS ONE | pmid:21779360 |
Han S et al. | Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet. | 2011 | Nutr Res Pract | pmid:21779522 |
Tan W et al. | Anti-cancer natural products isolated from chinese medicinal herbs. | 2011 | Chin Med | pmid:21777476 |
Gohain M et al. | Racemic tricarbon-yl[7-meth-oxy-2-(η-phen-yl)chromane]-chromium(0). | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:21753961 |
Villela A et al. | Fast chromatographic separation for the quantitation of the main flavone dyes in Reseda luteola (weld). | 2011 | J Chromatogr A | pmid:21999916 |
Zhang J et al. | Studies on the active components and antioxidant activities of the extracts of Mimosa pudica Linn. from southern China. | 2011 | Pharmacogn Mag | pmid:21472077 |
Pham MH et al. | Identification and induction of cytochrome P450s involved in the metabolism of flavone-8-acetic acid in mice. | 2011 | Drug Metab Lett | pmid:21457135 |
Rasoanaivo P et al. | Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. | 2011 | Malar. J. | pmid:21411015 |
Gauci AJ et al. | Identification of polyphenolic compounds and black tea extract as potent inhibitors of lipid membrane destabilization by Aβ₄₂ aggregates. | 2011 | J. Alzheimers Dis. | pmid:21891862 |
Theoharides TC and Zhang B | Neuro-inflammation, blood-brain barrier, seizures and autism. | 2011 | J Neuroinflammation | pmid:22129087 |
Novy P et al. | In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus. | 2011 | J. Antimicrob. Chemother. | pmid:21421582 |
Seo YJ et al. | Apoptotic effects of genistein, biochanin-A and apigenin on LNCaP and PC-3 cells by p21 through transcriptional inhibition of polo-like kinase-1. | 2011 | J. Korean Med. Sci. | pmid:22065906 |
Ren L et al. | Effects of flavone 6-substitutions on GABAA receptors efficacy. | 2011 | Eur. J. Pharmacol. | pmid:21914441 |
Tayarani-Najaran Z et al. | Analyzing Cytotoxic and Apoptogenic Properties of Scutellaria litwinowii Root Extract on Cancer Cell Lines. | 2011 | Evid Based Complement Alternat Med | pmid:20028719 |
An L et al. | Total flavonoids extracted from xiaobuxin-tang on the hyperactivity of hypothalamic-pituitary-adrenal axis in chronically stressed rats. | 2011 | Evid Based Complement Alternat Med | pmid:20028718 |
Shin SY et al. | Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21907578 |
Kochevenko A and Fernie AR | The genetic architecture of branched-chain amino acid accumulation in tomato fruits. | 2011 | J. Exp. Bot. | pmid:21436187 |
Fletcher JN et al. | In vitro evaluation of flavonoids from Eriodictyon californicum for antagonist activity against the bitterness receptor hTAS2R31. | 2011 | J. Agric. Food Chem. | pmid:22059530 |
Phromnoi K et al. | A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents. | 2011 | Mol. Pharmacol. | pmid:20930110 |
Ortet R et al. | Furfuran lignans and a flavone from Artemisia gorgonum Webb and their in vitro activity against Plasmodium falciparum. | 2011 | J Ethnopharmacol | pmid:21982788 |
Yamagata K et al. | Apigenin inhibits tumor necrosis factor alpha plus high glucose-induced LOX-1 expression in human endothelial cells. | 2011 | Microvasc. Res. | pmid:21040737 |
Shi G et al. | Molecular characteristics and antitumor capacity of Glycan extracted from Cynomorium songaricum. | 2011 | Int. J. Biol. Macromol. | pmid:21396396 |
Jin J et al. | Design, synthesis and biological evaluation of new arylpiperazine derivatives bearing a flavone moiety as α1-adrenoceptor antagonists. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21236664 |
Polier G et al. | Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. | 2011 | Cell Death Dis | pmid:21776020 |
Li LJ et al. | Flavans from the leaf of Ilex centrochinensis. | 2011 | J Asian Nat Prod Res | pmid:21462042 |
Kim JY et al. | Isolation of cholinesterase-inhibiting flavonoids from Morus lhou. | 2011 | J. Agric. Food Chem. | pmid:21434689 |
Baxter A et al. | Non-covalent inhibitors of rhinovirus 3C protease. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21183345 |
Manhita A et al. | Extracting natural dyes from wool--an evaluation of extraction methods. | 2011 | Anal Bioanal Chem | pmid:21416400 |
Zhang JW et al. | Structural elucidation of a new flavone from Sarcopyramis nepalensis. | 2011 | J Asian Nat Prod Res | pmid:21409688 |
Kumagai A et al. | A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells. | 2011 | PLoS ONE | pmid:22022544 |
Cai RL et al. | Antihypertensive effect of total flavone extracts from Puerariae Radix. | 2011 | J Ethnopharmacol | pmid:20933075 |
Wang YJ et al. | Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment of menopausal symptoms. | 2011 | Regul. Toxicol. Pharmacol. | pmid:20920542 |
Chahar MK et al. | Flavonoids: A versatile source of anticancer drugs. | 2011 | Pharmacogn Rev | pmid:22096313 |
Kozics K et al. | Structure of flavonoids influences the degree inhibition of Benzo(a)pyrene - induced DNA damage and micronuclei in HepG2 cells. | 2011 | Neoplasma | pmid:21895405 |
Ohno S et al. | A bHLH transcription factor, DvIVS, is involved in regulation of anthocyanin synthesis in dahlia (Dahlia variabilis). | 2011 | J. Exp. Bot. | pmid:21765172 |
Xiao J et al. | Non-covalent interaction of dietary polyphenols with total plasma proteins of type II diabetes: molecular structure/property-affinity relationships. | 2011 | Integr Biol (Camb) | pmid:21947088 |