| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bibby MC et al. | Unique chemosensitivity of MAC 16 tumours to flavone acetic acid (LM975, NSC 347512). | 1988 | Br. J. Cancer | pmid:3179187 |
| Bibby MC et al. | Experimental anti-tumor effects of flavone acetic acid (LM975). | 1988 | Prog. Clin. Biol. Res. | pmid:3174695 |
| Weiss RB et al. | Phase I and clinical pharmacology study of intravenous flavone acetic acid (NSC 347512). | 1988 | Cancer Res. | pmid:3167843 |
| Pratesi G et al. | Response of chemically induced primary colon tumours of the mouse to flavone acetic acid (NSC 347 512). | 1988 | Br. J. Cancer | pmid:3166904 |
| Yamazoe Y et al. | Metabolic activation of pyrolysate arylamines by human liver microsomes; possible involvement of a P-488-H type cytochrome P-450. | 1988 | Jpn. J. Cancer Res. | pmid:3147272 |
| Ohchi H et al. | Effects of dietary xenobiotics on the metabolism of copper, alpha-tocopherol and cholesterol in rats. | 1987 | J. Nutr. Sci. Vitaminol. | pmid:3125311 |
| Yamazoe Y et al. | Metabolic activation of a protein pyrolysate promutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by rat liver microsomes and purified cytochrome P-450. | 1988 | Carcinogenesis | pmid:3121205 |
| Armand J et al. | Flavonoids: a new class of anticancer agents? Preclinical and clinical data of flavone acetic acid. | 1988 | Prog. Clin. Biol. Res. | pmid:3051027 |
| Liu L et al. | Rational Design for Multicolor Flavone-Based Fluorophores with Aggregation-Induced Emission Enhancement Characteristics and Applications in Mitochondria-Imaging. | 2018 | Molecules | pmid:30205485 |
| Ngabaza T et al. | Anti-acidogenic and anti-biofilm activity of 5,6,8-trihydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one. | 2018 | Microb. Pathog. | pmid:30008421 |
| Nakabo D et al. | Convenient Synthesis and Physiological Activities of Flavonoids in Coreopsis lanceolata L. Petals and Their Related Compounds. | 2018 | Molecules | pmid:29987259 |
| Lim H et al. | Flavonoids interfere with NLRP3 inflammasome activation. | 2018 | Toxicol. Appl. Pharmacol. | pmid:29960001 |
| Mitra A et al. | Studies on the interaction of a synthetic nitro-flavone derivative with DNA: A multi-spectroscopic and molecular docking approach. | 2018 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:29885634 |
| Rahmouni N et al. | L. Phenolic Content Clarifies Its Antioxidant Activity. | 2018 | Molecules | pmid:29861483 |
| Bevara GB et al. | C-glycosyl flavone from inhibits proliferation & angiogenesis & induces apoptosis via cyclin-dependent kinase 6 in human breast, hepatic & colon cancer cell lines. | 2018 | Indian J. Med. Res. | pmid:29806604 |
| Brauch D et al. | Changes in isovitexin-O-glycosylation during the development of young barley plants. | 2018 | Phytochemistry | pmid:29421507 |
| Li XF | [Effects of flavone II of Piper wallichii on the isolated rabbit heart]. | 1985 | Zhong Yao Tong Bao | pmid:2934172 |
| Oh JM et al. | Characterization of two extracellular β-glucosidases produced from the cellulolytic fungus Aspergillus sp. YDJ216 and their potential applications for the hydrolysis of flavone glycosides. | 2018 | Int. J. Biol. Macromol. | pmid:29339289 |
| Huang L et al. | Autophagy induction by hispidulin provides protection against sevoflurane-induced neuronal apoptosis in aged rats. | 2018 | Biomed. Pharmacother. | pmid:29287193 |
| Thangaraj K and Vaiyapuri M | Orientin, a C-glycosyl dietary flavone, suppresses colonic cell proliferation and mitigates NF-κB mediated inflammatory response in 1,2-dimethylhydrazine induced colorectal carcinogenesis. | 2017 | Biomed. Pharmacother. | pmid:29198745 |