MeSH term | MeSH ID | Detail |
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Lung Neoplasms | D008175 | 171 associated lipids |
Body Weight | D001835 | 333 associated lipids |
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Almada-Ruiz E et al. | Fungicidal potential of methoxylated flavones from citrus for in vitro control of Colletotrichum gloeosporioides, causal agent of anthracnose disease in tropical fruits. | 2003 | Pest Manag. Sci. | pmid:14620052 |
Zhao JH et al. | Chemical chaperone and inhibitor discovery: potential treatments for protein conformational diseases. | 2007 | Perspect Medicin Chem | pmid:19812735 |
Meng X et al. | Effects of Various Flavonoids on the α-Synuclein Fibrillation Process. | 2010 | Parkinsons Dis | pmid:20976092 |
Acharya A et al. | Redox regulation in cancer: a double-edged sword with therapeutic potential. | 2010 Jan-Feb | Oxid Med Cell Longev | pmid:20716925 |
Flora SJ | Structural, chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure. | 2009 Sep-Oct | Oxid Med Cell Longev | pmid:20716905 |
Boesten DM et al. | Protective Pleiotropic Effect of Flavonoids on NAD⺠Levels in Endothelial Cells Exposed to High Glucose. | 2015 | Oxid Med Cell Longev | pmid:26180598 |
Wang D et al. | Study of the effects of total flavonoids of Astragalus on atherosclerosis formation and potential mechanisms. | 2012 | Oxid Med Cell Longev | pmid:22496932 |
Vauzour D | Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. | 2012 | Oxid Med Cell Longev | pmid:22701758 |
Furuta T et al. | Concise synthesis of chafurosides A and B. | 2009 | Org. Lett. | pmid:19473042 |
Kim K et al. | Ru(II)-Catalyzed Site-Selective Hydroxylation of Flavone and Chromone Derivatives: The Importance of the 5-Hydroxyl Motif for the Inhibition of Aurora Kinases. | 2015 | Org. Lett. | pmid:25946086 |
Yang X et al. | Synthesis and immunosuppressive activity of L-rhamnopyranosyl flavonoids. | 2006 | Org. Biomol. Chem. | pmid:16763696 |
Hao B et al. | The biosynthesis of allelopathic di-C-glycosylflavones from the roots of Desmodium incanum (G. Mey.) DC. | 2015 | Org. Biomol. Chem. | pmid:26478440 |
Kim D et al. | Synthetic approach to flavanones and flavones via ligand-free palladium(II)-catalyzed conjugate addition of arylboronic acids to chromones. | 2012 | Org. Biomol. Chem. | pmid:22850763 |
Mijangos MV et al. | Microwave-assisted C-3 selective oxidative radical alkylation of flavones. | 2012 | Org. Biomol. Chem. | pmid:22395456 |
Bao K et al. | Selective demethylation and debenzylation of aryl ethers by magnesium iodide under solvent-free conditions and its application to the total synthesis of natural products. | 2009 | Org. Biomol. Chem. | pmid:20024102 |
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Petroianu G et al. | Monitoring by HPLC of chamomile flavonoids exposed to rat liver microsomal metabolism. | 2009 | Open Med Chem J | pmid:19707521 |
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Medjakovic S et al. | Potential health-modulating effects of isoflavones and metabolites via activation of PPAR and AhR. | 2010 | Nutrients | pmid:22254019 |
Peterson JJ et al. | Associations between flavonoids and cardiovascular disease incidence or mortality in European and US populations. | 2012 | Nutr. Rev. | pmid:22946850 |
Lee SJ et al. | Hypolipidemic and hypoglycemic effects of Orostachys japonicus A. Berger extracts in streptozotocin-induced diabetic rats. | 2011 | Nutr Res Pract | pmid:21994524 |
Han S et al. | Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet. | 2011 | Nutr Res Pract | pmid:21779522 |
Chung MJ et al. | Suppressive effects of Schizandra chinensis Baillon water extract on allergy-related cytokine generation and degranulation in IgE-antigen complex-stimulated RBL-2H3 cells. | 2012 | Nutr Res Pract | pmid:22586497 |
Song WY et al. | Effect of ethanol extracts from red pepper seeds on antioxidative defense system and oxidative stress in rats fed high-fat . high-cholesterol diet. | 2010 | Nutr Res Pract | pmid:20198203 |
Yin J et al. | Antioxidant and antidiabetic activities of extracts from Cirsium japonicum roots. | 2008 | Nutr Res Pract | pmid:20016726 |
Zhang Y et al. | Reproducibility and relative validity of a food frequency questionnaire to assess intake of dietary flavonol and flavone in Chinese university campus population. | 2010 | Nutr Res | pmid:20851305 |
Jeng YJ et al. | Subchronic exposure to phytoestrogens alone and in combination with diethylstilbestrol - pituitary tumor induction in Fischer 344 rats. | 2010 | Nutr Metab (Lond) | pmid:20459739 |
Bojić M et al. | Evaluation of antiaggregatory activity of flavonoid aglycone series. | 2011 | Nutr J | pmid:21745360 |
Boyer J et al. | In vitro digestion and lactase treatment influence uptake of quercetin and quercetin glucoside by the Caco-2 cell monolayer. | 2005 | Nutr J | pmid:15644141 |
Medić-Sarić M et al. | From functional food to medicinal product: systematic approach in analysis of polyphenolics from propolis and wine. | 2009 | Nutr J | pmid:19624827 |
Lakhan SE and Vieira KF | Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. | 2010 | Nutr J | pmid:20929532 |
Chaumontet C et al. | Lack of tumor-promoting effects of flavonoids: studies on rat liver preneoplastic foci and on in vivo and in vitro gap junctional intercellular communication. | 1996 | Nutr Cancer | pmid:8910908 |
Collins-Burow BM et al. | Estrogenic and antiestrogenic activities of flavonoid phytochemicals through estrogen receptor binding-dependent and -independent mechanisms. | 2000 | Nutr Cancer | pmid:11525602 |
Richter D et al. | Effects of phytoestrogen extracts isolated from pumpkin seeds on estradiol production and ER/PR expression in breast cancer and trophoblast tumor cells. | 2013 | Nutr Cancer | pmid:23859042 |
Christensen KY et al. | The risk of lung cancer related to dietary intake of flavonoids. | 2012 | Nutr Cancer | pmid:23061904 |
Zhang Y et al. | Dietary flavonol and flavone intakes and their major food sources in Chinese adults. | 2010 | Nutr Cancer | pmid:21058200 |
Somerset SM and Johannot L | Dietary flavonoid sources in Australian adults. | 2008 | Nutr Cancer | pmid:18584477 |
Tremblay AM and Giguère V | The NR3B subgroup: an ovERRview. | 2007 | Nucl Recept Signal | pmid:18174917 |
Rahigude A et al. | Participation of antioxidant and cholinergic system in protective effect of naringenin against type-2 diabetes-induced memory dysfunction in rats. | 2012 | Neuroscience | pmid:22999973 |
Cheng XP et al. | Inhibitory effect of total flavone of Abelmoschus manihot L. Medic on NMDA receptor-mediated current in cultured rat hippocampal neurons. | 2006 | Neurosci. Res. | pmid:16616791 |
Chen HQ et al. | Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation. | 2008 | Neurosci. Lett. | pmid:18952146 |
Kang KP et al. | Luteolin ameliorates cisplatin-induced acute kidney injury in mice by regulation of p53-dependent renal tubular apoptosis. | 2011 | Nephrol. Dial. Transplant. | pmid:20817674 |
Kozics K et al. | Structure of flavonoids influences the degree inhibition of Benzo(a)pyrene - induced DNA damage and micronuclei in HepG2 cells. | 2011 | Neoplasma | pmid:21895405 |
Kragh M et al. | Acute effects of vascular modifying agents in solid tumors assessed by noninvasive laser Doppler flowmetry and near infrared spectroscopy. | 2002 May-Jun | Neoplasia | pmid:11988846 |
Zhang H et al. | Stimulatory effect of nobiletin, a citrus polymethoxy flavone, on catecholamine synthesis through Ser19 and Ser40 phosphorylation of tyrosine hydroxylase in cultured bovine adrenal medullary cells. | 2014 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:24043291 |
Nagib DA and MacMillan DW | Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis. | 2011 | Nature | pmid:22158245 |
Shiono M et al. | Phytochemistry: structure of the blue cornflower pigment. | 2005 | Nature | pmid:16094358 |