| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Lymphedema | D008209 | 4 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sato Y et al. | Variation in synergistic activity by flavone and its related compounds on the increased susceptibility of various strains of methicillin-resistant Staphylococcus aureus to beta-lactam antibiotics. | 2004 | Int. J. Antimicrob. Agents | pmid:15325425 |
| DÃaz F et al. | Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo. | 2003 | J. Nat. Prod. | pmid:12828478 |
| Vaher M and Koel M | Separation of polyphenolic compounds extracted from plant matrices using capillary electrophoresis. | 2003 | J Chromatogr A | pmid:12685601 |
| Caci E et al. | CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12651632 |
| Kesava Reddy M et al. | A new chalcone and a flavone from Andrographis neesiana. | 2003 | Chem. Pharm. Bull. | pmid:12843595 |
| Jameson MB et al. | Clinical aspects of a phase I trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent. | 2003 | Br. J. Cancer | pmid:12799625 |
| Tombola F et al. | Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogen Helicobacter pylori. | 2003 | FEBS Lett. | pmid:12753930 |
| Rustin GJ et al. | 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: phase I clinical and pharmacokinetic study. | 2003 | Br. J. Cancer | pmid:12698178 |
| Zhou JG et al. | Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements. | 2003 | Mol. Pharmacol. | pmid:12644593 |
| Phrutivorapongkul A et al. | Studies on the chemical constituents of stem bark of Millettia leucantha: isolation of new chalcones with cytotoxic, anti-herpes simplex virus and anti-inflammatory activities. | 2003 | Chem. Pharm. Bull. | pmid:12576653 |
| Boué SM et al. | Identification of flavone aglycones and glycosides in soybean pods by liquid chromatography-tandem mass spectrometry. | 2003 | J Chromatogr A | pmid:12703901 |
| Lai MY et al. | Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats. | 2003 | J. Pharm. Pharmacol. | pmid:12631413 |
| MartÃnez-Richa A and Joseph-Nathan P | Carbon-13 CP-MAS nuclear magnetic resonance studies of teas. | 2003 | Solid State Nucl Magn Reson | pmid:12763559 |
| Cai H et al. | Determination of the flavone tricin in human plasma by high-performance liquid chromatography. | 2003 | Biomed. Chromatogr. | pmid:14598326 |
| Geng XF et al. | [The progress of research on ginlcgobiobal flavone]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015321 |
| Zhang YJ et al. | [Identification and evaluation of TCM shayuanzi]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015323 |
| Beyer G and Melzig MF | Effects of selected flavonoids and caffeic acid derivatives on hypoxanthine-xanthine oxidase-induced toxicity in cultivated human cells. | 2003 | Planta Med. | pmid:14750029 |
| Dias C et al. | Structural elucidation of natural 2-hydroxy di- and tricarboxylic acids and esters, phenylpropanoid esters and a flavonoid from Autonoë madeirensis using gas chromatographic/electron ionization, electrospray ionization and tandem mass spectrometric techniques. | 2003 | J Mass Spectrom | pmid:14696202 |
| Lai MY et al. | Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans. | 2003 | Biol. Pharm. Bull. | pmid:12520178 |
| Takano-Ishikawa Y et al. | Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha. | 2003 | Phytother Res | pmid:14669262 |
| Fang H et al. | Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. | 2003 | Chem. Res. Toxicol. | pmid:14565775 |
| Goutman JD et al. | Flavonoid modulation of ionic currents mediated by GABA(A) and GABA(C) receptors. | 2003 | Eur. J. Pharmacol. | pmid:12586201 |
| Caristi C et al. | Flavonoids detection by HPLC-DAD-MS-MS in lemon juices from Sicilian cultivars. | 2003 | J. Agric. Food Chem. | pmid:12769519 |
| Zhang P et al. | A maize QTL for silk maysin levels contains duplicated Myb-homologous genes which jointly regulate flavone biosynthesis. | 2003 | Plant Mol. Biol. | pmid:12825685 |
| Huen MS et al. | Naturally occurring 2'-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands. | 2003 | Biochem. Pharmacol. | pmid:14637197 |
| Kim SY et al. | Cis-2', 3'-dihydrodiol production on flavone B-ring by biphenyl dioxygenase from Pseudomonas pseudoalcaligenes KF707 expressed in Escherichia coli. | 2003 | Antonie Van Leeuwenhoek | pmid:14574103 |
| Jang SI et al. | Hepatoprotective effect of baicalin, a major flavone from Scutellaria radix, on acetaminophen-induced liver injury in mice. | 2003 | Immunopharmacol Immunotoxicol | pmid:14686800 |
| Ajay M et al. | Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. | 2003 | Life Sci. | pmid:14623031 |
| Almada-Ruiz E et al. | Fungicidal potential of methoxylated flavones from citrus for in vitro control of Colletotrichum gloeosporioides, causal agent of anthracnose disease in tropical fruits. | 2003 | Pest Manag. Sci. | pmid:14620052 |
| Haraguchi H et al. | A flavone from Manilkara indica as a specific inhibitor against aldose reductase in vitro. | 2003 | Planta Med. | pmid:14598214 |
| van der Logt EM et al. | Induction of rat hepatic and intestinal UDP-glucuronosyltransferases by naturally occurring dietary anticarcinogens. | 2003 | Carcinogenesis | pmid:12869420 |
| Chen JJ et al. | Furoquinoline alkaloids and cytotoxic constituents from the leaves of Melicope semecarpifolia. | 2003 | Planta Med. | pmid:12865974 |
| Maçanita AL et al. | Photochemistry of flavothione and hydroxyflavothiones: mechanisms and kinetics. | 2003 | Photochem. Photobiol. | pmid:12856878 |
| Vieira RF et al. | Chemical profiling of Ocimum americanum using external flavonoids. | 2003 | Phytochemistry | pmid:12809716 |
| Selloum L et al. | Anti-inflammatory effect of rutin on rat paw oedema, and on neutrophils chemotaxis and degranulation. | 2003 | Exp. Toxicol. Pathol. | pmid:12710715 |
| Pepper C et al. | Flavopiridol induces apoptosis in B-cell chronic lymphocytic leukaemia cells through a p38 and ERK MAP kinase-dependent mechanism. | 2003 | Leuk. Lymphoma | pmid:12688354 |
| Gabrieli C and Kokkalou E | A new acetylated glucoside of luteolin and two flavone glucosides from Lavandula stoechas ssp. stoechas. | 2003 | Pharmazie | pmid:12857010 |
| Reddy MK et al. | A flavone and an unusual 23-carbon terpenoid from Andrographis paniculata. | 2003 | Phytochemistry | pmid:12648550 |
| Hyup YH et al. | 2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12565941 |
| Nørbaek R et al. | Flavone C-glycoside, phenolic acid, and nitrogen contents in leaves of barley subject to organic fertilization treatments. | 2003 | J. Agric. Food Chem. | pmid:12537462 |
| Blonska M et al. | Effect of flavone derivatives on interleukin-1beta (IL-1beta) mRNA expression and IL-1beta protein synthesis in stimulated RAW 264.7 macrophages. | 2003 | Scand. J. Immunol. | pmid:12588662 |
| Toyo'oka T et al. | On-line screening methods for antioxidants scavenging superoxide anion radical and hydrogen peroxide by liquid chromatography with indirect chemiluminescence detection. | 2003 | Talanta | pmid:18969068 |
| Lee S et al. | Solubility enhancement of a hydrophobic flavonoid, luteolin by the complexation with cyclosophoraoses isolated from Rhizobium meliloti. | 2003 | Antonie Van Leeuwenhoek | pmid:14574115 |
| Ouyang P et al. | [Effects of flavone from leaves of Diospyros kaki on adventitial fibroblast proliferation induced by advanced glycation end-products in vitro]. | 2003 | Di Yi Jun Yi Da Xue Xue Bao | pmid:14678884 |
| Fukui Y et al. | A rationale for the shift in colour towards blue in transgenic carnation flowers expressing the flavonoid 3',5'-hydroxylase gene. | 2003 | Phytochemistry | pmid:12657292 |
| Schauber J et al. | Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways. | 2003 | Gut | pmid:12692061 |
| Topcu G et al. | Studies on di- and triterpenoids from Salvia staminea with cytotoxic activity. | 2003 | Planta Med. | pmid:12802732 |
| Martin HJ et al. | The inhibitory effects of flavonoids and antiestrogens on the Glut1 glucose transporter in human erythrocytes. | 2003 | Chem. Biol. Interact. | pmid:14642735 |
| Alexandrakis M et al. | Flavones inhibit proliferation and increase mediator content in human leukemic mast cells (HMC-1). | 2003 | Eur. J. Haematol. | pmid:14703695 |
| Wu SN et al. | Differential effects of quercetin, a natural polyphenolic flavonoid, on L-type calcium current in pituitary tumor (GH3) cells and neuronal NG108-15 cells. | 2003 | J. Cell. Physiol. | pmid:12652656 |