MeSH term | MeSH ID | Detail |
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Neoplasms, Experimental | D009374 | 10 associated lipids |
Lymphedema | D008209 | 4 associated lipids |
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Zhao L et al. | The antitumour activity of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF receptor-1 knockout mice. | 2002 | Br. J. Cancer | pmid:12177785 |
Hori K et al. | A novel combretastatin A-4 derivative, AC7700, strongly stanches tumour blood flow and inhibits growth of tumours developing in various tissues and organs. | 2002 | Br. J. Cancer | pmid:12085211 |
Ching LM et al. | Induction of endothelial cell apoptosis by the antivascular agent 5,6-Dimethylxanthenone-4-acetic acid. | 2002 | Br. J. Cancer | pmid:12085190 |
Jacobson KA et al. | Interactions of flavones and other phytochemicals with adenosine receptors. | 2002 | Adv. Exp. Med. Biol. | pmid:12083460 |
Kuffel MJ et al. | Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2. | 2002 | Mol. Pharmacol. | pmid:12065765 |
Hadjokas NE et al. | Arginine to lysine 108 substitution in recombinant CYP1A2 abolishes methoxyresorufin metabolism in lymphoblastoid cells. | 2002 | Br. J. Pharmacol. | pmid:12023936 |
Isobe T et al. | [Antibacterial constituents against Helicobacter pylori of Brazilian medicinal plant, Pariparoba]. | 2002 | Yakugaku Zasshi | pmid:11968842 |
Han DH et al. | Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12224631 |
Matsui T et al. | Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of alpha-glucosidase action. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12005074 |
Cai H et al. | A straightforward means of coupling preparative high-performance liquid chromatography and mass spectrometry. | 2002 | Rapid Commun. Mass Spectrom. | pmid:11870892 |
Kahnberg P et al. | Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. | 2002 | J. Med. Chem. | pmid:12213060 |
Vrielynck L et al. | Self-modelling analysis applied to nanosecond transient absorption spectroscopy of flavone: an aid to elucidate and characterise reaction intermediates. | 2002 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:12396046 |
Horsman MR and Murata R | Combination of vascular targeting agents with thermal or radiation therapy. | 2002 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:12459380 |
Franke K et al. | Flavone-coumarin hybrids from Gnidia socotrana. | 2002 | Phytochemistry | pmid:12453582 |
Thomas JP et al. | Phase I clinical and pharmacokinetic trial of the cyclin-dependent kinase inhibitor flavopiridol. | 2002 | Cancer Chemother. Pharmacol. | pmid:12451473 |
Sampson L et al. | Flavonol and flavone intakes in US health professionals. | 2002 | J Am Diet Assoc | pmid:12396158 |
Frangne N et al. | Flavone glucoside uptake into barley mesophyll and Arabidopsis cell culture vacuoles. Energization occurs by H(+)-antiport and ATP-binding cassette-type mechanisms. | 2002 | Plant Physiol. | pmid:11842175 |
López-Lázaro M | Flavonoids as anticancer agents: structure-activity relationship study. | 2002 | Curr Med Chem Anticancer Agents | pmid:12678721 |
Otake Y and Walle T | Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9. | 2002 | Drug Metab. Dispos. | pmid:11792676 |
Tanaka S et al. | Influence of natural and synthetic compounds on cell surface expression of cell adhesion molecules, ICAM-1 and VCAM-1. | 2001 | Planta Med. | pmid:11301853 |