MeSH term | MeSH ID | Detail |
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Neoplasms, Experimental | D009374 | 10 associated lipids |
Lymphedema | D008209 | 4 associated lipids |
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hirano T et al. | Effects of synthetic and naturally occurring flavonoids on Na+,K+-ATPase: aspects of the structure-activity relationship and action mechanism. | 1989 | Life Sci. | pmid:2552245 |
Cummings J and Smyth JF | Flavone 8-acetic acid: our current understanding of its mechanism of action in solid tumours. | 1989 | Cancer Chemother. Pharmacol. | pmid:2667786 |
Kerr DJ and Kaye SB | Flavone acetic acid--preclinical and clinical activity. | 1989 | Eur J Cancer Clin Oncol | pmid:2680512 |
Bonnay M et al. | [Flavone acetic acid and LY 186641 interfere in various ways in Jaffé's reaction]. | 1989 | Bull Cancer | pmid:2620109 |
Sun JR and Brown JM | Enhancement of the antitumor effect of flavone acetic acid by the bioreductive cytotoxic drug SR 4233 in a murine carcinoma. | 1989 | Cancer Res. | pmid:2790784 |
Cassidy J et al. | Could interspecies differences in the protein binding of flavone acetic acid contribute to the failure to predict lack of efficacy in patients? | 1989 | Cancer Chemother. Pharmacol. | pmid:2713962 |
Ertan R et al. | Synthesis of new annellated flavonoid derivatives possessing spasmolytic activity--VII. | 1989 | Arch. Pharm. (Weinheim) | pmid:2751412 |
Chabot GG et al. | Flavone acetic acid (LM-975; NSC-347512) activation to cytotoxic species in vivo and in vitro. | 1989 | Cancer Chemother. Pharmacol. | pmid:2758556 |
Cummings J et al. | Characterization of the major metabolites of flavone acetic acid and comparison of their disposition in humans and mice. | 1989 | Cancer Res. | pmid:2731178 |
Bibby MC et al. | Influence of site on the chemosensitivity of transplantable murine colon tumours to flavone acetic acid (LM975, NSC 347512). | 1989 | Cancer Chemother. Pharmacol. | pmid:2731316 |
Rabinovitz M | Flavone-8-acetic acid and the natural flavonoids. | 1989 | J. Natl. Cancer Inst. | pmid:2733041 |
Zwi LJ et al. | Blood flow failure as a major determinant in the antitumor action of flavone acetic acid. | 1989 | J. Natl. Cancer Inst. | pmid:2733044 |
Roy D and Liehr JG | Metabolic oxidation of diethylstilbestrol to diethylstilbestrol-4',4"-quinone in Syrian hamsters. | 1989 | Carcinogenesis | pmid:2736717 |
Ching LM and Baguley BC | Effect of flavone acetic acid (NSC 347,512) on splenic cytotoxic effector cells and their role in tumour necrosis. | 1989 | Eur J Cancer Clin Oncol | pmid:2737219 |
Atwell GJ et al. | Synthesis and anti-tumour activity of topologically-related analogues of flavoneacetic acid. | 1989 | Anticancer Drug Des. | pmid:2803464 |
Kerr DJ et al. | Phase II trials of flavone acetic acid in advanced malignant melanoma and colorectal carcinoma. | 1989 | Br. J. Cancer | pmid:2803908 |
Murray JC et al. | Flavone acetic acid induces a coagulopathy in mice. | 1989 | Br. J. Cancer | pmid:2803949 |
Relling MV et al. | Anticancer drugs as inhibitors of two polymorphic cytochrome P450 enzymes, debrisoquin and mephenytoin hydroxylase, in human liver microsomes. | 1989 | Cancer Res. | pmid:2908853 |
Wu ES et al. | Flavones. 2. Synthesis and structure-activity relationship of flavodilol and its analogues, a novel class of antihypertensive agents with catecholamine depleting properties. | 1989 | J. Med. Chem. | pmid:2909730 |
Ferrari F et al. | Structures of three new flavone derivatives, brosimones G, H, and I, from Brosimopsis oblongifolia. | 1989 | Planta Med. | pmid:17262259 |