MeSH term | MeSH ID | Detail |
---|---|---|
Stomach Ulcer | D013276 | 75 associated lipids |
Weight Loss | D015431 | 56 associated lipids |
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hausen BM et al. | 5,8-dihydroxyflavone (primetin) the contact sensitizer of Primula mistassinica Michaux. | 1983 | Arch. Dermatol. Res. | pmid:6660907 |
Rostom SA et al. | Synthesis and biological evaluation of some polymethoxylated fused pyridine ring systems as antitumor agents. | 2009 | Arch. Pharm. (Weinheim) | pmid:19714673 |
Ertan R et al. | Synthesis of new annellated flavonoid derivatives possessing spasmolytic activity--VII. | 1989 | Arch. Pharm. (Weinheim) | pmid:2751412 |
Aitken RA et al. | Synthesis and antitumour activity of new derivatives of flavone-8-acetic acid (FAA). Part 4: Variation of the basic structure. | 2000 | Arch. Pharm. (Weinheim) | pmid:10909190 |
Da Re P et al. | Beta-adrenergic blocking agents of the flavone group. [(author's transl)]. | 1975 | Arch. Pharm. (Weinheim) | pmid:236740 |
Yenjai C et al. | Structural modification of 5,7-dimethoxyflavone from Kaempferia parviflora and biological activities. | 2009 | Arch. Pharm. Res. | pmid:19784571 |
Liao Z et al. | Antidiabetic effect of flavones from Cirsium japonicum DC in diabetic rats. | 2010 | Arch. Pharm. Res. | pmid:20361298 |
Lee HJ et al. | Protection of prenylated flavonoids from Mori Cortex Radicis (Moraceae) against nitric oxide-induced cell death in neuroblastoma SH-SY5Y cells. | 2012 | Arch. Pharm. Res. | pmid:22297755 |
Kim SJ et al. | Inhibition of nitric oxide production from lipopolysaccharide-treated RAW 264.7 cells by synthetic flavones: structure-activity relationship and action mechanism. | 2004 | Arch. Pharm. Res. | pmid:15473664 |
Mitchell AE et al. | Isozyme- and gender-specific induction of glutathione S-transferases by flavonoids. | 2007 | Arch. Toxicol. | pmid:17503020 |