MeSH term | MeSH ID | Detail |
---|---|---|
Stomach Ulcer | D013276 | 75 associated lipids |
Weight Loss | D015431 | 56 associated lipids |
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hayeshi R et al. | The potential inhibitory effect of antiparasitic drugs and natural products on P-glycoprotein mediated efflux. | 2006 | Eur J Pharm Sci | pmid:16846720 |
Kim JH et al. | Characterization of flavonoid 7-O-glucosyltransferase from Arabidopsis thaliana. | 2006 | Biosci. Biotechnol. Biochem. | pmid:16794327 |
Sundararajan R et al. | Cytisus scoparius link--a natural antioxidant. | 2006 | BMC Complement Altern Med | pmid:16542432 |
Tsuji PA et al. | Accumulation and metabolism of the anticancer flavonoid 5,7-dimethoxyflavone compared to its unmethylated analog chrysin in the Atlantic killifish. | 2006 | Chem. Biol. Interact. | pmid:16999945 |
Bandyopadhyay S et al. | Attenuation of osteoclastogenesis and osteoclast function by apigenin. | 2006 | Biochem. Pharmacol. | pmid:16750176 |
Ferrer-Sueta G et al. | Reduction of manganese porphyrins by flavoenzymes and submitochondrial particles: a catalytic cycle for the reduction of peroxynitrite. | 2006 | Free Radic. Biol. Med. | pmid:16843831 |
Kim SK et al. | The mitogen-activated protein kinase kinase (mek) inhibitor PD98059 elevates primary cultured rat hepatocyte glutathione levels independent of inhibiting mek. | 2006 | Drug Metab. Dispos. | pmid:16443668 |
Lotito SB and Frei B | Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism. | 2006 | J. Biol. Chem. | pmid:16987811 |
He YM et al. | [Effects of Pollen Typhae total flavone on glucose and lipid metabolism in 3T3-L1 adipocytes]. | 2006 | Zhong Xi Yi Jie He Xue Bao | pmid:17090374 |
Hui RH et al. | [Simultaneous determination of total flavone and total saponin in Gynostemma pentaphyllum by signal multiplier spectrophotometry]. | 2006 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:17112063 |
Sato S et al. | Total synthesis of three naturally occurring 6,8-di-C-glycosylflavonoids: phloretin, naringenin, and apigenin bis-C-beta-D-glucosides. | 2006 | Carbohydr. Res. | pmid:16545348 |
Cheng XP et al. | Inhibitory effect of total flavone of Abelmoschus manihot L. Medic on NMDA receptor-mediated current in cultured rat hippocampal neurons. | 2006 | Neurosci. Res. | pmid:16616791 |
Lameira J et al. | Structure-activity relationship study of flavone compounds with anti-HIV-1 integrase activity: a density functional theory study. | 2006 | Bioorg. Med. Chem. | pmid:16890444 |
Wang D et al. | Immunologic synergism with IL-2 and effects of cCHMIs on mRNA expression of IL-2 and IFN-gamma in chicken peripheral T lymphocyte. | 2006 | Vaccine | pmid:16887240 |
Gobbi S et al. | Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme. | 2006 | J. Med. Chem. | pmid:16854084 |
Herath W et al. | Microbial metabolism. Part 6. Metabolites of 3- and 7-hydroxyflavones. | 2006 | Chem. Pharm. Bull. | pmid:16508185 |
da Fonseca R et al. | Molecular interactions between human cytochrome P450 1A2 and flavone derivatives. | 2006 | Med Chem | pmid:16848753 |
Liu S et al. | Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC. | 2006 | Int. Immunopharmacol. | pmid:16846832 |
Yang X et al. | Synthesis and immunosuppressive activity of L-rhamnopyranosyl flavonoids. | 2006 | Org. Biomol. Chem. | pmid:16763696 |
Stipcevic T et al. | Effect of different flavonoids on collagen synthesis in human fibroblasts. | 2006 | Plant Foods Hum Nutr | pmid:16642409 |
Qi S et al. | Simultaneous determination of bioactive flavone derivatives in Chinese herb extraction by capillary electrophoresis used different electrolyte systems--borate and ionic liquids. | 2006 | J Chromatogr A | pmid:16464459 |
Nguyen MT et al. | Xanthine oxidase inhibitors from the flowers of Chrysanthemum sinense. | 2006 | Planta Med. | pmid:16450295 |
Sandabe UK et al. | Phytochemical screening and effect of aqueous extract of Ficus sycomorus L. (Moraceae) stem bark on muscular activity in laboratory animals. | 2006 | J Ethnopharmacol | pmid:16448793 |
Sun JL et al. | Immunologic enhancement of compound Chinese herbal medicinal ingredients and their efficacy comparison with compound Chinese herbal medicines. | 2006 | Vaccine | pmid:16378665 |
Varga Z et al. | Structure prerequisite for antioxidant activity of silybin in different biochemical systems in vitro. | 2006 | Phytomedicine | pmid:16360937 |
Moon BH et al. | Complete assignment of (1)H and (13)C NMR data of dihydroxyflavone derivatives. | 2006 | Magn Reson Chem | pmid:16259053 |
Sandabe UK et al. | Phytochemical screening and effect of aqueous extract of Ficus sycomorus L. (Moraceae) stembark on muscular activity in laboratory animals. | 2006 | J Ethnopharmacol | pmid:16243463 |
Hamada M et al. | TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers. | 2006 | J. Agric. Food Chem. | pmid:17090139 |
González B et al. | Respiratory system of Gluconacetobacter diazotrophicus PAL5. Evidence for a cyanide-sensitive cytochrome bb and cyanide-resistant cytochrome ba quinol oxidases. | 2006 | Biochim. Biophys. Acta | pmid:16934215 |
Zhou JM et al. | Sequential O-methylation of tricetin by a single gene product in wheat. | 2006 | Biochim. Biophys. Acta | pmid:16730127 |
Kim BG et al. | Regioselectivity of 7-O-methyltransferase of poplar to flavones. | 2006 | J. Biotechnol. | pmid:16713650 |
Zgórka G | Retention behavior of silica-bonded and novel polymeric reversed-phase sorbents in studies on flavones as chemotaxonomic markers of Scutellaria L. genus. | 2006 | J Chromatogr A | pmid:16364344 |
Meyer H et al. | Bioavailability of apigenin from apiin-rich parsley in humans. | 2006 | Ann. Nutr. Metab. | pmid:16407641 |
Kite GC et al. | Data-directed scan sequence for the general assignment of C-glycosylflavone O-glycosides in plant extracts by liquid chromatography-ion trap mass spectrometry. | 2006 | J Chromatogr A | pmid:16360661 |
Schutte ME et al. | An in vitro and in silico study on the flavonoid-mediated modulation of the transport of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through Caco-2 monolayers. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16997339 |
Mavel S et al. | Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1). | 2006 | Bioorg. Med. Chem. | pmid:16263302 |
Lee MH et al. | Bioactive constituents of Spatholobus suberectus in regulating tyrosinase-related proteins and mRNA in HEMn cells. | 2006 | Phytochemistry | pmid:16782143 |
Chemler JA et al. | Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. | 2006 | Microb. Cell Fact. | pmid:16719921 |
Sagar SM et al. | Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 1. | 2006 | Curr Oncol | pmid:17576437 |
Sen N et al. | Leishmania donovani: intracellular ATP level regulates apoptosis-like death in luteolin induced dyskinetoplastid cells. | 2006 | Exp. Parasitol. | pmid:16707127 |
Rahman I | Antioxidant therapies in COPD. | 2006 | Int J Chron Obstruct Pulmon Dis | pmid:18046899 |
Kostova I et al. | Structure-Activity Relationships of Synthetic Coumarins as HIV-1 Inhibitors. | 2006 | Bioinorg Chem Appl | pmid:17497014 |
Zabala G et al. | Transcriptome changes in the phenylpropanoid pathway of Glycine max in response to Pseudomonas syringae infection. | 2006 | BMC Plant Biol. | pmid:17083738 |
Opassiri R et al. | Analysis of rice glycosyl hydrolase family 1 and expression of Os4bglu12 beta-glucosidase. | 2006 | BMC Plant Biol. | pmid:17196101 |
Park H et al. | Anti-inflammatory activity of the synthetic C-C biflavonoids. | 2006 | J. Pharm. Pharmacol. | pmid:17331331 |
Casadesus G et al. | Targeting gonadotropins: an alternative option for Alzheimer disease treatment. | 2006 | J. Biomed. Biotechnol. | pmid:17047306 |
Zhang J et al. | Transposition of reversed Ac element ends generates novel chimeric genes in maize. | 2006 | PLoS Genet. | pmid:17029561 |
Moorthy NS et al. | Synthesis, biological evaluation and in silico metabolic and toxicity prediction of some flavanone derivatives. | 2006 | Chem. Pharm. Bull. | pmid:17015974 |
Lévy V et al. | A phase I dose-finding and pharmacokinetic study of subcutaneous semisynthetic homoharringtonine (ssHHT) in patients with advanced acute myeloid leukaemia. | 2006 | Br. J. Cancer | pmid:16847470 |
Vargo MA et al. | Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. | 2006 | Biochem. Pharmacol. | pmid:16844095 |
Niho N et al. | Inhibition of intestinal carcinogenesis by a new flavone derivative, chafuroside, in oolong tea. | 2006 | Cancer Sci. | pmid:16630115 |
Bradshaw PC and Pfeiffer DR | Loss of NAD(H) from swollen yeast mitochondria. | 2006 | BMC Biochem. | pmid:16433924 |
Carrara M et al. | Mono- or di-fluorinated analogues of flavone-8-acetic acid: synthesis and in vitro biological activity. | 2005 Mar-Apr | Anticancer Res. | pmid:15868960 |
Kanho H et al. | Biotransformation of benzaldehyde-type and acetophenone-type derivatives by Pharbitis nil hairy roots. | 2005 | Chem. Pharm. Bull. | pmid:15802832 |
Zhang J et al. | Threshold dissociation and molecular modeling of transition metal complexes of flavonoids. | 2005 | J. Am. Soc. Mass Spectrom. | pmid:15694764 |
Madan V et al. | Requirement of the vesicular system for membrane permeabilization by Sindbis virus. | 2005 | Virology | pmid:15661162 |
Fernández SP et al. | Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. | 2005 | Eur. J. Pharmacol. | pmid:15840404 |
Jahaniani F et al. | Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent. | 2005 | Phytochemistry | pmid:15949825 |
Rayyan S et al. | Flavone C-glycosides from leaves of Oxalis triangularis. | 2005 | J. Agric. Food Chem. | pmid:16366694 |
Cai H et al. | Determination of the putative cancer chemopreventive flavone tricin in plasma and tissues of mice by HPLC with UV--visible detection. | 2005 | Biomed. Chromatogr. | pmid:15828058 |
Wenzel U et al. | Melatonin potentiates flavone-induced apoptosis in human colon cancer cells by increasing the level of glycolytic end products. | 2005 | Int. J. Cancer | pmid:15800915 |
Sasaki K et al. | Effect of flavones on rat brain and lung matrix metalloproteinase activity measured by film in-situ zymography. | 2005 | J. Pharm. Pharmacol. | pmid:15831206 |
Zheng W et al. | [Study on extraction of zhuyun 3# by supercritical CO2]. | 2005 | Zhong Yao Cai | pmid:16104514 |
Griffin RJ et al. | Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro. | 2005 | J. Med. Chem. | pmid:15658870 |
Ebert B et al. | Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3-carbinol enhance the formation and transport of benzo[a]pyrene sulfate conjugates in intestinal Caco-2 cells. | 2005 | Toxicol. Lett. | pmid:15890477 |
Park H et al. | Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives. | 2005 | Eur J Med Chem | pmid:15963606 |
Wang TC et al. | Synthesis, and cytotoxic and antiplatelet activities of oxime- and methyloxime-containing flavone, isoflavone, and xanthone derivatives. | 2005 | Chem. Biodivers. | pmid:17191978 |
Horvath CR et al. | Identification and quantification of eight flavones in root and shoot tissues of the medicinal plant huang-qin (Scutellaria baicalensis Georgi) using high-performance liquid chromatography with diode array and mass spectrometric detection. | 2005 | J Chromatogr A | pmid:15679157 |
Cappelli C et al. | Computational study of conformational and chiroptical properties of (2R,3S,4R)-(+)-3,3',4,4',7-flavanpentol. | 2005 | Chirality | pmid:16196026 |
Martens S and Mithöfer A | Flavones and flavone synthases. | 2005 | Phytochemistry | pmid:16137727 |
Wenzel U et al. | Increased mitochondrial palmitoylcarnitine/carnitine countertransport by flavone causes oxidative stress and apoptosis in colon cancer cells. | 2005 | Cell. Mol. Life Sci. | pmid:16314920 |
Yang Y et al. | Dietary rescue of fumble--a Drosophila model for pantothenate-kinase-associated neurodegeneration. | 2005 | J. Inherit. Metab. Dis. | pmid:16435199 |
Boyer J et al. | In vitro digestion and lactase treatment influence uptake of quercetin and quercetin glucoside by the Caco-2 cell monolayer. | 2005 | Nutr J | pmid:15644141 |
Li BH et al. | Structure-activity relationship of polyphenols that inhibit fatty acid synthase. | 2005 | J. Biochem. | pmid:16428296 |
Melidou M et al. | Protection against nuclear DNA damage offered by flavonoids in cells exposed to hydrogen peroxide: the role of iron chelation. | 2005 | Free Radic. Biol. Med. | pmid:16298684 |
Ono M et al. | Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain. | 2005 | J. Med. Chem. | pmid:16279784 |
Rothwell JA et al. | Experimental determination of octanol-water partition coefficients of quercetin and related flavonoids. | 2005 | J. Agric. Food Chem. | pmid:15913295 |
Shiono M et al. | Phytochemistry: structure of the blue cornflower pigment. | 2005 | Nature | pmid:16094358 |
Bankova V | Chemical diversity of propolis and the problem of standardization. | 2005 | J Ethnopharmacol | pmid:15993016 |
Machha A and Mustafa MR | Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta. | 2005 | J. Cardiovasc. Pharmacol. | pmid:15965352 |
Iori F et al. | Theoretical quantitative structure-activity relationships of flavone ligands interacting with cytochrome P450 1A1 and 1A2 isozymes. | 2005 | Bioorg. Med. Chem. | pmid:15914008 |
Han Y | Ginkgo terpene component has an anti-inflammatory effect on Candida albicans-caused arthritic inflammation. | 2005 | Int. Immunopharmacol. | pmid:15829420 |
Sawada Y and Ayabe S | Multiple mutagenesis of P450 isoflavonoid synthase reveals a key active-site residue. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15809082 |
Malolanarasimhan K et al. | Synthesis and biological study of a flavone acetic acid analogue containing an azido reporting group designed as a multifunctional binding site probe. | 2005 | Bioorg. Med. Chem. | pmid:15781383 |
Schütz K et al. | Characterization of phenolic acids and flavonoids in dandelion (Taraxacum officinale WEB. ex WIGG.) root and herb by high-performance liquid chromatography/electrospray ionization mass spectrometry. | 2005 | Rapid Commun. Mass Spectrom. | pmid:15593267 |
Ko WC et al. | Mechanisms of relaxant action of luteolin in isolated guinea pig trachea. | 2005 | Planta Med. | pmid:15931576 |
Nagai S et al. | Kinetic study of the quenching reaction of singlet oxygen by flavonoids in ethanol solution. | 2005 | J Phys Chem B | pmid:16851486 |
Kwon HM et al. | Anti-inflammatory inhibition of endothelial cell adhesion molecule expression by flavone derivatives. | 2005 | J. Agric. Food Chem. | pmid:15969490 |
Takeda K et al. | Components of protocyanin, a blue pigment from the blue flowers of Centaurea cyanus. | 2005 | Phytochemistry | pmid:16005311 |
Budzianowski J et al. | Lipophilic flavones of Primula veris L. from field cultivation and in vitro cultures. | 2005 | Phytochemistry | pmid:15896373 |
Xiao R et al. | Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis. | 2005 | Mol. Cancer | pmid:15644144 |
Wenzel U et al. | Activation of mitochondrial lactate uptake by flavone induces apoptosis in human colon cancer cells. | 2005 | J. Cell. Physiol. | pmid:15452831 |
Kachlicki P et al. | Profiling isoflavone conjugates in root extracts of lupine species with LC/ESI/MSn systems. | 2005 | J Mass Spectrom | pmid:15971291 |
Ahmed-Belkacem A et al. | Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2. | 2005 | Cancer Res. | pmid:15930306 |
Åania-Pietrzak B et al. | Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids. | 2005 | Life Sci. | pmid:15916776 |
Jeyabal PV et al. | Apigenin inhibits oxidative stress-induced macromolecular damage in N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinogenesis in Wistar albino rats. | 2005 | Mol. Carcinog. | pmid:15924350 |
Simons AL et al. | Human gut microbial degradation of flavonoids: structure-function relationships. | 2005 | J. Agric. Food Chem. | pmid:15884869 |
Chi YS and Kim HP | Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15589400 |
Watanabe J et al. | Coumarin and flavone derivatives from estragon and thyme as inhibitors of chemical mediator release from RBL-2H3 Cells. | 2005 | Biosci. Biotechnol. Biochem. | pmid:15665459 |
Xie F et al. | The osteoprotective effect of Herba epimedii (HEP) extract in vivo and in vitro. | 2005 | Evid Based Complement Alternat Med | pmid:16136213 |