MeSH term | MeSH ID | Detail |
---|---|---|
Adenoma | D000236 | 40 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Vandeputte OM et al. | The flavanone naringenin reduces the production of quorum sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1. | 2011 | Microbiology (Reading, Engl.) | pmid:21546585 |
Barrero RA et al. | De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes. | 2011 | BMC Genomics | pmid:22151917 |
Jeon JG et al. | Natural products in caries research: current (limited) knowledge, challenges and future perspective. | 2011 | Caries Res. | pmid:21576957 |
Liu LZ et al. | Acacetin inhibits VEGF expression, tumor angiogenesis and growth through AKT/HIF-1α pathway. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21893035 |
Singh S et al. | 2-(4-Chloro-phen-yl)chromen-4-one. | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:22199687 |
Zandi K et al. | Antiviral activity of four types of bioflavonoid against dengue virus type-2. | 2011 | Virol. J. | pmid:22201648 |
Walch SG et al. | Antioxidant Capacity and Polyphenolic Composition as Quality Indicators for Aqueous Infusions of Salvia officinalis L. (sage tea). | 2011 | Front Pharmacol | pmid:22194722 |
Silva RO et al. | Sulfated-polysaccharide fraction from red algae Gracilaria caudata protects mice gut against ethanol-induced damage. | 2011 | Mar Drugs | pmid:22163181 |
Manna P et al. | Phytomedicinal Role of Pithecellobium dulce against CCl(4)-mediated Hepatic Oxidative Impairments and Necrotic Cell Death. | 2011 | Evid Based Complement Alternat Med | pmid:21869899 |
Lee KN et al. | Prevention of NSAID-associated gastroduodenal injury in healthy volunteers-a randomized, double-blind, multicenter study comparing DA-9601 with misoprostol. | 2011 | J. Korean Med. Sci. | pmid:21860559 |
Klein T et al. | Structural basis for species specific inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1): computational study and biological validation. | 2011 | PLoS ONE | pmid:21857977 |
Park NI et al. | Enhancement of flavone levels through overexpression of chalcone isomerase in hairy root cultures of Scutellaria baicalensis. | 2011 | Funct. Integr. Genomics | pmid:21538138 |
Janovick JA et al. | Therapeutic rescue of misfolded mutants: validation of primary high throughput screens for identification of pharmacoperone drugs. | 2011 | PLoS ONE | pmid:21818389 |
Martin C et al. | How can research on plants contribute to promoting human health? | 2011 | Plant Cell | pmid:21586682 |
Ono M and Saji H | SPECT Imaging Agents for Detecting Cerebral β-Amyloid Plaques. | 2011 | Int J Mol Imaging | pmid:21603239 |
Yao N et al. | Novel flavonoids with antiproliferative activities against breast cancer cells. | 2011 | J. Med. Chem. | pmid:21599001 |
Wootten D et al. | Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids. | 2011 | J. Pharmacol. Exp. Ther. | pmid:21075839 |
Lin CC et al. | Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. | 2011 | Int. J. Oncol. | pmid:21573491 |
Yob NJ et al. | Zingiber zerumbet (L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses. | 2011 | Evid Based Complement Alternat Med | pmid:21584247 |
Vitalini S et al. | Primula spectabilis Tratt. aerial parts: morphology, volatile compounds and flavonoids. | 2011 | Phytochemistry | pmid:21612805 |
Yin Y et al. | Jaceosidin inhibits contact hypersensitivity in mice via down-regulating IFN-γ/STAT1/T-bet signaling in T cells. | 2011 | Eur. J. Pharmacol. | pmid:21093428 |
Enomoto R et al. | Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. | 2011 | Cancer Chemother. Pharmacol. | pmid:20658136 |
Varma A et al. | Andrographolide: a new plant-derived antineoplastic entity on horizon. | 2011 | Evid Based Complement Alternat Med | pmid:19752167 |
Phromnoi K et al. | Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1. | 2011 | Mol. Pharmacol. | pmid:21816954 |
Said SA | Two new special flavones from Uvaria accuminata. | 2011 | Nat. Prod. Res. | pmid:21644179 |
Seo J et al. | Flavonoids biotransformation by bacterial non-heme dioxygenases, biphenyl and naphthalene dioxygenase. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21626021 |
Chou ST et al. | Zanthoxylum ailanthoides Sieb and Zucc. extract inhibits growth and induces cell death through G2/M-phase arrest and activation of apoptotic signals in colo 205 human colon adenocarcinoma cells. | 2011 | Anticancer Res. | pmid:21617225 |
Baguley BC | Preclinical efficacy of vascular disrupting agents in non-small-cell lung cancer. | 2011 | Clin Lung Cancer | pmid:21550553 |
Suyenaga ES et al. | Appraisal of the antichemotactic activity of flavonoids on polymorphonuclear neutrophils. | 2011 | Planta Med. | pmid:21058242 |
Clark ST and Verwoerd WS | A systems approach to identifying correlated gene targets for the loss of colour pigmentation in plants. | 2011 | BMC Bioinformatics | pmid:21849042 |
Mafuvadze B et al. | Apigenin blocks induction of vascular endothelial growth factor mRNA and protein in progestin-treated human breast cancer cells. | 2010 Sep-Oct | Menopause | pmid:20551847 |
Marczak Å et al. | Fragmentation pathways of acylated flavonoid diglucuronides from leaves of Medicago truncatula. | 2010 May-Jun | Phytochem Anal | pmid:19950391 |
Acharya A et al. | Redox regulation in cancer: a double-edged sword with therapeutic potential. | 2010 Jan-Feb | Oxid Med Cell Longev | pmid:20716925 |
Carneiro CD et al. | Effect of flavonoids on 2'-deoxyguanosine and DNA oxidation caused by singlet molecular oxygen. | 2010 Aug-Sep | Food Chem. Toxicol. | pmid:20561949 |
Julião Lde S et al. | Flavones and phenylpropanoids from a sedative extract of Lantana trifolia L. | 2010 | Phytochemistry | pmid:19922967 |
Fekrazad HM et al. | A phase I study of flavopiridol in combination with gemcitabine and irinotecan in patients with metastatic cancer. | 2010 | Am. J. Clin. Oncol. | pmid:19884803 |
Seo J et al. | Time-dependent density functional theory-assisted absolute configuration determination of cis-dihydrodiol metabolite produced from isoflavone by biphenyl dioxygenase. | 2010 | Anal. Biochem. | pmid:19854147 |
Rayyan S et al. | Flavone C-glycosides from seeds of fenugreek, Trigonella foenum-graecum L. | 2010 | J. Agric. Food Chem. | pmid:20486688 |
Cabrera M et al. | Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. | 2010 | Bioorg. Med. Chem. | pmid:20639112 |
Zhao C et al. | [Study on extraction of anti-diabetes active constituents from Potentilla chinesis]. | 2010 | Zhong Yao Cai | pmid:20575426 |
Gülcemal D et al. | Phenolic Glycosides with antiproteasomal activity from Centaurea urvillei DC. subsp. urvillei. | 2010 | Carbohydr. Res. | pmid:20937505 |
Winkelmann I et al. | Flavone induces changes in intermediary metabolism that prevent microadenoma formation in colonic tissue of carcinogen-treated mice. | 2010 | Mol Nutr Food Res | pmid:20564477 |
Basile A et al. | Antibacterial and antifungal properties of acetonic extract of Feijoa sellowiana fruits and its effect on Helicobacter pylori growth. | 2010 | J Med Food | pmid:20136454 |
Seo J et al. | Location of flavone B-ring controls regioselectivity and stereoselectivity of naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816-4. | 2010 | Appl. Microbiol. Biotechnol. | pmid:20091026 |
Wang SQ et al. | Flavonoids from Dracocephalum tanguticum and their cardioprotective effects against doxorubicin-induced toxicity in H9c2 cells. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20932762 |
Morant M et al. | Metabolomic, transcriptional, hormonal, and signaling cross-talk in superroot2. | 2010 | Mol Plant | pmid:20008451 |
Kuete V and Efferth T | Cameroonian medicinal plants: pharmacology and derived natural products. | 2010 | Front Pharmacol | pmid:21833168 |
Halbwirth H | The creation and physiological relevance of divergent hydroxylation patterns in the flavonoid pathway. | 2010 | Int J Mol Sci | pmid:20386656 |
Chatuphonprasert W et al. | Potent modification of inducible CYP1A1 expression by flavonoids. | 2010 | Biol. Pharm. Bull. | pmid:20930378 |
Neveu V et al. | Phenol-Explorer: an online comprehensive database on polyphenol contents in foods. | 2010 | Database (Oxford) | pmid:20428313 |
Xia EQ et al. | Biological activities of polyphenols from grapes. | 2010 | Int J Mol Sci | pmid:20386657 |
Jayaraman P et al. | Activity and interactions of antibiotic and phytochemical combinations against Pseudomonas aeruginosa in vitro. | 2010 | Int. J. Biol. Sci. | pmid:20941374 |
Chirumbolo S | The role of quercetin, flavonols and flavones in modulating inflammatory cell function. | 2010 | Inflamm Allergy Drug Targets | pmid:20887269 |
Mukai R et al. | Suppression mechanisms of flavonoids on aryl hydrocarbon receptor-mediated signal transduction. | 2010 | Arch. Biochem. Biophys. | pmid:20450880 |
Jeng YJ et al. | Subchronic exposure to phytoestrogens alone and in combination with diethylstilbestrol - pituitary tumor induction in Fischer 344 rats. | 2010 | Nutr Metab (Lond) | pmid:20459739 |
Ci X et al. | Regulation of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 cells by 2''-hydroxy-3''-en-anhydroicaritin involves down-regulation of NF-kappaB and MAPK expression. | 2010 | Int. Immunopharmacol. | pmid:20462523 |
Qian LB et al. | Luteolin reduces high glucose-mediated impairment of endothelium-dependent relaxation in rat aorta by reducing oxidative stress. | 2010 | Pharmacol. Res. | pmid:19892019 |
Sasaki K et al. | Functional divergence within class B MADS-box genes TfGLO and TfDEF in Torenia fournieri Lind. | 2010 | Mol. Genet. Genomics | pmid:20872230 |
Zhang Y et al. | Dietary flavonol and flavone intakes and their major food sources in Chinese adults. | 2010 | Nutr Cancer | pmid:21058200 |
Treutter D | Managing phenol contents in crop plants by phytochemical farming and breeding-visions and constraints. | 2010 | Int J Mol Sci | pmid:20479987 |
Huang CH et al. | Natural flavone kaempferol suppresses chemokines expression in human monocyte THP-1 cells through MAPK pathways. | 2010 | J. Food Sci. | pmid:21535503 |
Lakhan SE and Vieira KF | Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. | 2010 | Nutr J | pmid:20929532 |
Fransen HP et al. | Assessment of health claims, content, and safety of herbal supplements containing Ginkgo biloba. | 2010 | Food Nutr Res | pmid:20927202 |
Wang XH et al. | Screen of micro-organisms for inducing the production of dragon's blood by leaf of Dracaena cochinchinensis. | 2010 | Lett. Appl. Microbiol. | pmid:20860774 |
Guo W et al. | Antagonistic effect of flavonoids on NSC-741909-mediated antitumor activity via scavenging of reactive oxygen species. | 2010 | Eur. J. Pharmacol. | pmid:20854805 |
Suttana W et al. | Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols. | 2010 | Mol. Cancer | pmid:20438634 |
Luo H et al. | Comparison of 454-ESTs from Huperzia serrata and Phlegmariurus carinatus reveals putative genes involved in lycopodium alkaloid biosynthesis and developmental regulation. | 2010 | BMC Plant Biol. | pmid:20854695 |
Chen CC et al. | Calcium- and phosphatidylinositol 3-kinase/Akt-dependent activation of endothelial nitric oxide synthase by apigenin. | 2010 | Life Sci. | pmid:21034748 |
Chen EP et al. | A mechanism-based mathematical model of aryl hydrocarbon receptor-mediated CYP1A induction in rats using beta-naphthoflavone as a tool compound. | 2010 | Drug Metab. Dispos. | pmid:20843940 |
Ragab FA et al. | Synthesis and anticonvulsant activity of certain substituted furochromone, benzofuran and flavone derivatives. | 2010 | Chem. Pharm. Bull. | pmid:20823592 |
Stark JL et al. | Solution structure and function of YndB, an AHSA1 protein from Bacillus subtilis. | 2010 | Proteins | pmid:20818668 |
Chung KS et al. | Eupafolin, a flavonoid isolated from Artemisia princeps, induced apoptosis in human cervical adenocarcinoma HeLa cells. | 2010 | Mol Nutr Food Res | pmid:20397191 |
Du Y et al. | Identification of flavone phytoalexins and a pathogen-inducible flavone synthase II gene (SbFNSII) in sorghum. | 2010 | J. Exp. Bot. | pmid:20007684 |
Gao LM and Meléndez E | Cytotoxic properties of titanocenyl amides on breast cancer cell line mcf-7. | 2010 | Met Based Drugs | pmid:20454639 |
Kyrgidis A et al. | Melanoma: Stem cells, sun exposure and hallmarks for carcinogenesis, molecular concepts and future clinical implications. | 2010 | J Carcinog | pmid:20442802 |
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Zhuang P et al. | Effect of flavone on the ocular blood flow and formation of choroidal neovascularization. | 2010 | Int J Ophthalmol | pmid:22553528 |
Semalty M et al. | Semecarpus anacardium Linn.: A review. | 2010 | Pharmacogn Rev | pmid:22228947 |
Wera M et al. | 2-(4-Fluoro-phen-yl)-3-hy-droxy-4H-chromen-4-one. | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21589426 |
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Baikar S and Malpathak N | Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs. | 2010 | Pharmacogn Rev | pmid:22228937 |
Ono M et al. | 99mTc/Re complexes based on flavone and aurone as SPECT probes for imaging cerebral β-amyloid plaques. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20797860 |
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Masoodi TA and Alhamdanz AH | Inhibitory effect of flavonoids on mutant H-Rasp protein. | 2010 | Bioinformation | pmid:21346872 |
Zhang C et al. | Functional characterization of cis-acting elements mediating flavone-inducible expression of CYP321A1. | 2010 | Insect Biochem. Mol. Biol. | pmid:20854909 |
Zhang Y et al. | Reproducibility and relative validity of a food frequency questionnaire to assess intake of dietary flavonol and flavone in Chinese university campus population. | 2010 | Nutr Res | pmid:20851305 |
Picon PD et al. | Randomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia for chronic constipation. | 2010 | BMC Complement Altern Med | pmid:20433751 |
Liu XH et al. | Synthesis and molecular docking studies of novel 2-chloro-pyridine derivatives containing flavone moieties as potential antitumor agents. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20538457 |
Tian Y et al. | Anti-HBV active flavone glucosides from Euphorbia humifusa Willd. | 2010 | Fitoterapia | pmid:20450964 |
Hori A and Naganuma K | Fully and partially fluorinated flavone derivatives. | 2010 | Acta Crystallogr C | pmid:20442510 |
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Knjazeva T and Kaljurand M | Capillary electrophoresis frontal analysis for the study of flavonoid interactions with human serum albumin. | 2010 | Anal Bioanal Chem | pmid:20422159 |
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