MeSH term | MeSH ID | Detail |
---|---|---|
Adenoma | D000236 | 40 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Tsuji PA and Walle T | Benzo[a]pyrene-induced cytochrome P450 1A and DNA binding in cultured trout hepatocytes - inhibition by plant polyphenols. | 2007 | Chem. Biol. Interact. | pmid:17583686 |
Brunskole M et al. | Trihydroxynaphthalene reductase of Curvularia lunata--a target for flavonoid action? | 2009 | Chem. Biol. Interact. | pmid:19010313 |
Khan MS et al. | Methylated chrysin induces co-ordinated attenuation of the canonical Wnt and NF-kB signaling pathway and upregulates apoptotic gene expression in the early hepatocarcinogenesis rat model. | 2011 | Chem. Biol. Interact. | pmid:21554863 |
Lanoë PH et al. | Cyclometallated platinum(II) complexes incorporating ethynyl-flavone ligands: switching between triplet and singlet emission induced by selective binding of Pb2+ ions. | 2008 | Chem. Commun. (Camb.) | pmid:18802561 |
Liu B et al. | A step toward simplified detection of serum albumin on SDS-PAGE using an environment-sensitive flavone sensor. | 2015 | Chem. Commun. (Camb.) | pmid:26068596 |
Asakawa T et al. | PET imaging of nobiletin based on a practical total synthesis. | 2011 | Chem. Commun. (Camb.) | pmid:21243163 |
Khoobi M et al. | A facile route to flavone and neoflavone backbones via a regioselective palladium catalyzed oxidative Heck reaction. | 2012 | Chem. Commun. (Camb.) | pmid:22318701 |
Kanho H et al. | Biotransformation of benzaldehyde-type and acetophenone-type derivatives by Pharbitis nil hairy roots. | 2005 | Chem. Pharm. Bull. | pmid:15802832 |
Kesava Reddy M et al. | A new chalcone and a flavone from Andrographis neesiana. | 2003 | Chem. Pharm. Bull. | pmid:12843595 |
Wu LZ et al. | Two new flavone C-glycosides from Trollius ledebourii. | 2011 | Chem. Pharm. Bull. | pmid:22041076 |
Phrutivorapongkul A et al. | Studies on the chemical constituents of stem bark of Millettia leucantha: isolation of new chalcones with cytotoxic, anti-herpes simplex virus and anti-inflammatory activities. | 2003 | Chem. Pharm. Bull. | pmid:12576653 |
Herath W et al. | Microbial metabolism. Part 6. Metabolites of 3- and 7-hydroxyflavones. | 2006 | Chem. Pharm. Bull. | pmid:16508185 |
Maheswara M et al. | Two new 5-deoxyflavonoids from Calliandra inermis. | 2004 | Chem. Pharm. Bull. | pmid:15304993 |
Waki T et al. | Key role of chemical hardness to compare 2,2-diphenyl-1-picrylhydrazyl radical scavenging power of flavone and flavonol O-glycoside and C-glycoside derivatives. | 2012 | Chem. Pharm. Bull. | pmid:22223373 |
Chokchaisiri R et al. | Bioactive flavonoids of the flowers of Butea monosperma. | 2009 | Chem. Pharm. Bull. | pmid:19336944 |
Murata T et al. | Hyaluronidase inhibitors from Keiskea japonica. | 2012 | Chem. Pharm. Bull. | pmid:22223383 |
Ragab FA et al. | Synthesis and anticonvulsant activity of certain substituted furochromone, benzofuran and flavone derivatives. | 2010 | Chem. Pharm. Bull. | pmid:20823592 |
Herath W et al. | Microbial metabolism part 9. Structure and antioxidant significance of the metabolites of 5,7-dihydroxyflavone (chrysin), and 5- and 6-hydroxyflavones. | 2008 | Chem. Pharm. Bull. | pmid:18379084 |
Alam MS and Lee DU | Facile synthesis and antibacterial activity of naturally occurring 5-methoxyfuroflavone. | 2010 | Chem. Pharm. Bull. | pmid:21139271 |
Fernandes DC et al. | Myeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitens. | 2008 | Chem. Pharm. Bull. | pmid:18451567 |
Hayashi T et al. | A cytotoxic flavone from Scoparia dulcis L. | 1988 | Chem. Pharm. Bull. | pmid:3246045 |
Wang XL et al. | Effects of eleven flavonoids from the osteoprotective fraction of Drynaria fortunei (KUNZE) J. SM. on osteoblastic proliferation using an osteoblast-like cell line. | 2008 | Chem. Pharm. Bull. | pmid:18175973 |
Moorthy NS et al. | Synthesis, biological evaluation and in silico metabolic and toxicity prediction of some flavanone derivatives. | 2006 | Chem. Pharm. Bull. | pmid:17015974 |
Goyal N et al. | Ethynylflavones, highly potent, and selective inhibitors of cytochrome P450 1A1. | 2014 | Chem. Res. Toxicol. | pmid:25033111 |
Fang H et al. | Structure-activity relationships for a large diverse set of natural, synthetic, and environmental estrogens. | 2001 | Chem. Res. Toxicol. | pmid:11258977 |
Fang H et al. | Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. | 2003 | Chem. Res. Toxicol. | pmid:14565775 |
Shimada T et al. | Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. | 2010 | Chem. Res. Toxicol. | pmid:21053930 |
Shimada T et al. | Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study. | 2009 | Chem. Res. Toxicol. | pmid:19563207 |
Tarling CA et al. | The search for novel human pancreatic alpha-amylase inhibitors: high-throughput screening of terrestrial and marine natural product extracts. | 2008 | Chembiochem | pmid:18214874 |
Goettert M et al. | Biological evaluation and structural determinants of p38α mitogen-activated-protein kinase and c-Jun-N-terminal kinase 3 inhibition by flavonoids. | 2010 | Chembiochem | pmid:21108268 |
Wang DJ et al. | Effect of Total Flavone of Haw Leaves on Nuclear Factor Erythroid-2 Related Factor and Other Related Factors in Nonalcoholic Steatohepatitis Rats. | 2018 | Chin J Integr Med | pmid:26919834 |
Guo AJ et al. | Kaempferol as a flavonoid induces osteoblastic differentiation via estrogen receptor signaling. | 2012 | Chin Med | pmid:22546174 |
Xu F et al. | Quasi-MSn identification of flavanone 7-glycoside isomers in Da Chengqi Tang by high performance liquid chromatography-tandem mass spectrometry. | 2009 | Chin Med | pmid:19630957 |
Tan W et al. | Anti-cancer natural products isolated from chinese medicinal herbs. | 2011 | Chin Med | pmid:21777476 |
Tang W et al. | Simultaneous determination of eight major bioactive compounds in Dachengqi Tang (DT) by high-performance liquid chromatography. | 2008 | Chin Med | pmid:18445276 |
Liu Z et al. | Protective effect of chrysoeriol against doxorubicin-induced cardiotoxicity in vitro. | 2009 | Chin. Med. J. | pmid:19951587 |
Cappelli C et al. | Computational study of conformational and chiroptical properties of (2R,3S,4R)-(+)-3,3',4,4',7-flavanpentol. | 2005 | Chirality | pmid:16196026 |
Goto S and Handa S | Antithrombotic effects of flavonoid. | 2001 | Circulation | pmid:11157735 |
Li GR et al. | Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs. | 2008 | Circulation | pmid:18458165 |
Mruk JS et al. | Flavone-8-acetic acid (Flavonoid) profoundly reduces platelet-dependent thrombosis and vasoconstriction after deep arterial injury In vivo. | 2000 | Circulation | pmid:10645930 |
Yan H et al. | Treating senile dementia with traditional Chinese medicine. | 2007 | Clin Interv Aging | pmid:18044136 |
Baguley BC | Preclinical efficacy of vascular disrupting agents in non-small-cell lung cancer. | 2011 | Clin Lung Cancer | pmid:21550553 |
Wurglics M and Schubert-Zsilavecz M | Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. | 2006 | Clin Pharmacokinet | pmid:16640452 |
Li Y et al. | Induction of apoptosis and inhibition of c-erbB-2 in breast cancer cells by flavopiridol. | 2000 | Clin. Cancer Res. | pmid:10656453 |
Motwani M et al. | Flavopiridol, a cyclin-dependent kinase inhibitor, prevents spindle inhibitor-induced endoreduplication in human cancer cells. | 2000 | Clin. Cancer Res. | pmid:10741717 |
Manna SK et al. | Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis. | 2007 | Clin. Cancer Res. | pmid:17404114 |
Kestell P et al. | Measurement of plasma 5-hydroxyindoleacetic acid as a possible clinical surrogate marker for the action of antivascular agents. | 2001 | Clin. Chim. Acta | pmid:11718691 |
Lefort EC and Blay J | The dietary flavonoid apigenin enhances the activities of the anti-metastatic protein CD26 on human colon carcinoma cells. | 2011 | Clin. Exp. Metastasis | pmid:21298326 |
Jeon SB et al. | Flavone inhibits vascular contraction by decreasing phosphorylation of the myosin phosphatase target subunit. | 2007 | Clin. Exp. Pharmacol. Physiol. | pmid:17880363 |
Buchanan CM et al. | DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular. | 2012 | Clin. Sci. | pmid:22142330 |