MeSH term | MeSH ID | Detail |
---|---|---|
Neoplasm Invasiveness | D009361 | 23 associated lipids |
Lymphedema | D008209 | 4 associated lipids |
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Cutroneo KR et al. | Induction of benzpyrene hydroxylase by flavone and its derivatives in fetal rat liver explants. | 1972 | Biochem. Pharmacol. | pmid:5064734 |
Okuda J et al. | Inhibition of aldose reductases from rat and bovine lenses by flavonoids. | 1982 | Biochem. Pharmacol. | pmid:6818971 |
Bandyopadhyay S et al. | Attenuation of osteoclastogenesis and osteoclast function by apigenin. | 2006 | Biochem. Pharmacol. | pmid:16750176 |
Lin HY et al. | Inhibition of lipopolysaccharide-induced nitric oxide production by flavonoids in RAW264.7 macrophages involves heme oxygenase-1. | 2003 | Biochem. Pharmacol. | pmid:14563492 |
Verbeek R et al. | The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells. | 2004 | Biochem. Pharmacol. | pmid:15276069 |
Huen MS et al. | Naturally occurring 2'-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands. | 2003 | Biochem. Pharmacol. | pmid:14637197 |
Kim MJ et al. | TNF-α induces expression of urokinase-type plasminogen activator and β-catenin activation through generation of ROS in human breast epithelial cells. | 2010 | Biochem. Pharmacol. | pmid:20804741 |
Furuya H et al. | Some flavonoids and DHEA-S prevent the cis-effect of expanded CTG repeats in a stable PC12 cell transformant. | 2005 | Biochem. Pharmacol. | pmid:15652241 |
Kundu R et al. | Carlinoside reduces hepatic bilirubin accumulation by stimulating bilirubin-UGT activity through Nrf2 gene expression. | 2011 | Biochem. Pharmacol. | pmid:21801714 |
Vargo MA et al. | Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. | 2006 | Biochem. Pharmacol. | pmid:16844095 |