MeSH term | MeSH ID | Detail |
---|---|---|
Neoplasm Invasiveness | D009361 | 23 associated lipids |
Lymphedema | D008209 | 4 associated lipids |
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Arya A et al. | Chloroform Fraction of Centratherum anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha and Exhibits Pleotropic Bioactivities: Inhibitory Role in Human Tumor Cells. | 2012 | Evid Based Complement Alternat Med | pmid:22474512 |
Chen WQ et al. | A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22901896 |
Ni F et al. | Flavonoid ampelopsin inhibits the growth and metastasis of prostate cancer in vitro and in mice. | 2012 | PLoS ONE | pmid:22693649 |
Chen CC et al. | Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury. | 2012 | PLoS ONE | pmid:22272328 |
Lee JM et al. | Acute Toxicity and General Pharmacological Action of QGC EXT. | 2012 | Korean J. Physiol. Pharmacol. | pmid:22416220 |
Wang BL et al. | Treating acute cystitis with biodegradable micelle-encapsulated quercetin. | 2012 | Int J Nanomedicine | pmid:22661886 |
Galindo P et al. | Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation. | 2012 | PLoS ONE | pmid:22427863 |
Chen HJ et al. | Inhibitory effects of adlay bran (Coix lachryma-jobi L. var. ma-yuen Stapf) on chemical mediator release and cytokine production in rat basophilic leukemia cells. | 2012 | J Ethnopharmacol | pmid:22353428 |
Lee DH et al. | Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells. | 2012 | Evid Based Complement Alternat Med | pmid:22194772 |
Lee H et al. | Angelicae Dahuricae Radix Inhibits Dust Mite Extract-Induced Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice. | 2012 | Evid Based Complement Alternat Med | pmid:22454682 |
Kim S et al. | Vascular disrupting agent drug classes differ in effects on the cytoskeleton. | 2012 | PLoS ONE | pmid:22848372 |
Xin HL et al. | Anti-inflammatory and analgesic activity of total flavone of Cunninghamia lanceolata. | 2012 | Molecules | pmid:22832885 |
Shih TL et al. | An alternative synthesis of 3',4'-diaminoflavones to evaluate their antioxidant ability and cell apoptosis of zebrafish larvae. | 2012 | Molecules | pmid:22777189 |
Thomas CM et al. | Anti-neoplastic activity of two flavone isomers derived from Gnaphalium elegans and Achyrocline bogotensis. | 2012 | PLoS ONE | pmid:22768128 |
Waki T et al. | Key role of chemical hardness to compare 2,2-diphenyl-1-picrylhydrazyl radical scavenging power of flavone and flavonol O-glycoside and C-glycoside derivatives. | 2012 | Chem. Pharm. Bull. | pmid:22223373 |
Wang YL et al. | Anxiolytic-like effects of compound zhi zhu xiang in rats. | 2012 | Evid Based Complement Alternat Med | pmid:22690249 |
Wang J et al. | Rapid Screening for Flavone C-Glycosides in the Leaves of Different Species of Bamboo and Simultaneous Quantitation of Four Marker Compounds by HPLC-UV/DAD. | 2012 | Int J Anal Chem | pmid:22654910 |
Bairwa R et al. | Trachyspermum ammi. | 2012 | Pharmacogn Rev | pmid:22654405 |
Huang Y et al. | Down-regulation of the PI3K/Akt signaling pathway and induction of apoptosis in CA46 Burkitt lymphoma cells by baicalin. | 2012 | J. Exp. Clin. Cancer Res. | pmid:22607709 |
Chantarudee A et al. | Chemical constituents and free radical scavenging activity of corn pollen collected from Apis mellifera hives compared to floral corn pollen at Nan, Thailand. | 2012 | BMC Complement Altern Med | pmid:22513008 |
Soumyanath A et al. | Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action. | 2012 | Int J Alzheimers Dis | pmid:22506133 |
Watts SD et al. | A sensitive membrane-targeted biosensor for monitoring changes in intracellular chloride in neuronal processes. | 2012 | PLoS ONE | pmid:22506078 |
Vermelho AB et al. | Microbial enzyme: applications in industry and in bioremediation. | 2012 | Enzyme Res | pmid:22496966 |
Walch SG et al. | Holistic Control of Herbal Teas and Tinctures Based on Sage (Salvia officinalis L.) for Compounds with Beneficial and Adverse Effects using NMR Spectroscopy. | 2012 | Anal Chem Insights | pmid:22493561 |
Sun S et al. | The evaluation of chinese therapeutic food for the treatment of moderate dyslipidemia. | 2012 | Evid Based Complement Alternat Med | pmid:22474507 |
Zandi K et al. | Flavone enhances dengue virus type-2 (NGC strain) infectivity and replication in vero cells. | 2012 | Molecules | pmid:22374315 |
Chen WC et al. | Baicalin induces apoptosis in SW620 human colorectal carcinoma cells in vitro and suppresses tumor growth in vivo. | 2012 | Molecules | pmid:22456615 |
Liu Y et al. | Chinese herb and formulas for promoting blood circulation and removing blood stasis and antiplatelet therapies. | 2012 | Evid Based Complement Alternat Med | pmid:22454656 |
Yong-Chun J et al. | A novel high-performance liquid chromatography fingerprint approach to discriminate Phyllostachys pubescens from China. | 2012 | Pharmacogn Mag | pmid:22438662 |
Zamboni A et al. | Genome-wide microarray analysis of tomato roots showed defined responses to iron deficiency. | 2012 | BMC Genomics | pmid:22433273 |
Khan R et al. | Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22155348 |
Ilboudo O et al. | Targeting structural motifs of flavonoid diglycosides using collision-induced dissociation experiments on flavonoid/Pb2+ complexes. | 2012 | Eur J Mass Spectrom (Chichester, Eng) | pmid:23221119 |
Qiao Y et al. | [Chemical constituents of n-BuOH extract of Comastoma pedunculatum]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23234130 |
Murata T et al. | Hyaluronidase inhibitors from Keiskea japonica. | 2012 | Chem. Pharm. Bull. | pmid:22223383 |
Chen YH et al. | Evaluation of the structure-activity relationship of flavonoids as antioxidants and toxicants of zebrafish larvae. | 2012 | Food Chem | pmid:23107683 |
Khan M et al. | Jaceosidin Induces Apoptosis in U87 Glioblastoma Cells through G2/M Phase Arrest. | 2012 | Evid Based Complement Alternat Med | pmid:22216058 |
Christensen KY et al. | The risk of lung cancer related to dietary intake of flavonoids. | 2012 | Nutr Cancer | pmid:23061904 |
Buszewski B and Noga S | Hydrophilic interaction liquid chromatography (HILIC)--a powerful separation technique. | 2012 | Anal Bioanal Chem | pmid:21879300 |
Wang D et al. | Study of the effects of total flavonoids of Astragalus on atherosclerosis formation and potential mechanisms. | 2012 | Oxid Med Cell Longev | pmid:22496932 |
Brito I et al. | 4',5-Dihy-droxy-7-meth-oxy-flavanone dihydrate. | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22259537 |
Gooda Sahib N et al. | Plants' metabolites as potential antiobesity agents. | 2012 | ScientificWorldJournal | pmid:22666121 |
Bandaruk Y et al. | Evaluation of the inhibitory effects of quercetin-related flavonoids and tea catechins on the monoamine oxidase-A reaction in mouse brain mitochondria. | 2012 | J. Agric. Food Chem. | pmid:23009399 |
Hatnapure GD et al. | Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22981334 |
Hamilton ML et al. | Elucidation of the biosynthesis of the di-C-glycosylflavone isoschaftoside, an allelopathic component from Desmodium spp. that inhibits Striga spp. development. | 2012 | Phytochemistry | pmid:22959223 |
Klier L et al. | Lewis acid-triggered selective zincation of chromones, quinolones, and thiochromones: application to the preparation of natural flavones and isoflavones. | 2012 | J. Am. Chem. Soc. | pmid:22860983 |
Kim D et al. | Synthetic approach to flavanones and flavones via ligand-free palladium(II)-catalyzed conjugate addition of arylboronic acids to chromones. | 2012 | Org. Biomol. Chem. | pmid:22850763 |
Jansakul C et al. | Relaxant mechanisms of 3, 5, 7, 3', 4'-pentamethoxyflavone on isolated human cavernosum. | 2012 | Eur. J. Pharmacol. | pmid:22800934 |
Kanda K et al. | Nobiletin suppresses adipocyte differentiation of 3T3-L1 cells by an insulin and IBMX mixture induction. | 2012 | Biochim. Biophys. Acta | pmid:22172985 |
Ho YC et al. | Re-examination of chromogenic quantitative assays for determining flavonoid content. | 2012 | J. Agric. Food Chem. | pmid:22352692 |
Barros L et al. | Characterization of phenolic compounds in flowers of wild medicinal plants from Northeastern Portugal. | 2012 | Food Chem. Toxicol. | pmid:22342808 |
Khoobi M et al. | A facile route to flavone and neoflavone backbones via a regioselective palladium catalyzed oxidative Heck reaction. | 2012 | Chem. Commun. (Camb.) | pmid:22318701 |
Lee HJ et al. | Protection of prenylated flavonoids from Mori Cortex Radicis (Moraceae) against nitric oxide-induced cell death in neuroblastoma SH-SY5Y cells. | 2012 | Arch. Pharm. Res. | pmid:22297755 |
Spatafora C and Tringali C | Natural-derived polyphenols as potential anticancer agents. | 2012 | Anticancer Agents Med Chem | pmid:22292766 |
de-Faria FM et al. | Antioxidant action of mangrove polyphenols against gastric damage induced by absolute ethanol and ischemia-reperfusion in the rat. | 2012 | ScientificWorldJournal | pmid:22654592 |
Li G et al. | Pharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC-MS method. | 2012 | Fitoterapia | pmid:22056665 |
Lewin G et al. | Influence of the skeleton on the cytotoxicity of flavonoids. | 2012 | Bioorg. Med. Chem. | pmid:22257529 |
Kongkum N et al. | DNA topoisomerase IIα inhibitory and anti-HIV-1 flavones from leaves and twigs of Gardenia carinata. | 2012 | Fitoterapia | pmid:22155186 |
Buchanan CM et al. | DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular. | 2012 | Clin. Sci. | pmid:22142330 |
Park NI et al. | Enhancement of rutin in Fagopyrum esculentum hairy root cultures by the Arabidopsis transcription factor AtMYB12. | 2012 | Biotechnol. Lett. | pmid:22113884 |
Qin S et al. | Gene expression profiling and pathway network analysis of hepatic metabolic enzymes targeted by baicalein. | 2012 | J Ethnopharmacol | pmid:22265932 |
Vauzour D | Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. | 2012 | Oxid Med Cell Longev | pmid:22701758 |
Rozza AL et al. | Morphologic and pharmacological investigations in the epicatechin gastroprotective effect. | 2012 | Evid Based Complement Alternat Med | pmid:22666296 |
Kim YW et al. | DA6034 promotes gastric epithelial cell migration and wound-healing through the mTOR pathway. | 2012 | J. Gastroenterol. Hepatol. | pmid:21793913 |
Gates PJ and Lopes NP | Characterisation of flavonoid aglycones by negative ion chip-based nanospray tandem mass spectrometry. | 2012 | Int J Anal Chem | pmid:22505914 |
Malherbe CJ et al. | Development of on-line high performance liquid chromatography (HPLC)-biochemical detection methods as tools in the identification of bioactives. | 2012 | Int J Mol Sci | pmid:22489144 |
Rahigude A et al. | Participation of antioxidant and cholinergic system in protective effect of naringenin against type-2 diabetes-induced memory dysfunction in rats. | 2012 | Neuroscience | pmid:22999973 |
Kostrzewa-Susłow E and Janeczko T | Microbial transformations of 7-hydroxyflavanone. | 2012 | ScientificWorldJournal | pmid:22654578 |
Zbidah M et al. | Apigenin-induced suicidal erythrocyte death. | 2012 | J. Agric. Food Chem. | pmid:22132906 |
Xie C et al. | The açaà flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-α and IL-6 production through inhibiting NF-κB activation and MAPK pathway. | 2012 | J. Nutr. Biochem. | pmid:22137267 |
Palmieri D et al. | Apigenin inhibits the TNFα-induced expression of eNOS and MMP-9 via modulating Akt signalling through oestrogen receptor engagement. | 2012 | Mol. Cell. Biochem. | pmid:22899172 |
El-Alfy TS et al. | A New Flavonoid C-Glycoside from Celtis australis L. and Celtis occidentalis L. Leaves and Potential Antioxidant and Cytotoxic Activities. | 2011 Oct-Dec | Sci Pharm | pmid:22145118 |
Zhao E and Mu Q | Phytoestrogen biological actions on Mammalian reproductive system and cancer growth. | 2011 Jan-Mar | Sci Pharm | pmid:21617769 |
Park SR et al. | Enhanced flavonoid production in Streptomyces venezuelae via metabolic engineering. | 2011 | J. Microbiol. Biotechnol. | pmid:22127124 |
Luo H et al. | Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers. | 2011 | BMC Genomics | pmid:22369100 |
Zhao J et al. | MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula. | 2011 | Plant Cell | pmid:21467581 |
Mladěnka P et al. | In vitro analysis of iron chelating activity of flavonoids. | 2011 | J. Inorg. Biochem. | pmid:21450273 |
Neves MP et al. | Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis. | 2011 | Eur J Med Chem | pmid:21496973 |
Yang C et al. | Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. | 2011 | PLoS ONE | pmid:21779360 |
Han S et al. | Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet. | 2011 | Nutr Res Pract | pmid:21779522 |
Villela A et al. | Fast chromatographic separation for the quantitation of the main flavone dyes in Reseda luteola (weld). | 2011 | J Chromatogr A | pmid:21999916 |
Wera M et al. | 3-Hy-droxy-2-(4-meth-oxy-phen-yl)-4H-chromen-4-one. | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:21523104 |
Zolkipli Z et al. | Vulnerability to oxidative stress in vitro in pathophysiology of mitochondrial short-chain acyl-CoA dehydrogenase deficiency: response to antioxidants. | 2011 | PLoS ONE | pmid:21483766 |
Zhang J et al. | Studies on the active components and antioxidant activities of the extracts of Mimosa pudica Linn. from southern China. | 2011 | Pharmacogn Mag | pmid:21472077 |
Pham MH et al. | Identification and induction of cytochrome P450s involved in the metabolism of flavone-8-acetic acid in mice. | 2011 | Drug Metab Lett | pmid:21457135 |
Theoharides TC and Zhang B | Neuro-inflammation, blood-brain barrier, seizures and autism. | 2011 | J Neuroinflammation | pmid:22129087 |
Novy P et al. | In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus. | 2011 | J. Antimicrob. Chemother. | pmid:21421582 |
Ren L et al. | Effects of flavone 6-substitutions on GABAA receptors efficacy. | 2011 | Eur. J. Pharmacol. | pmid:21914441 |
Kochevenko A and Fernie AR | The genetic architecture of branched-chain amino acid accumulation in tomato fruits. | 2011 | J. Exp. Bot. | pmid:21436187 |
Phromnoi K et al. | A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents. | 2011 | Mol. Pharmacol. | pmid:20930110 |
Ortet R et al. | Furfuran lignans and a flavone from Artemisia gorgonum Webb and their in vitro activity against Plasmodium falciparum. | 2011 | J Ethnopharmacol | pmid:21982788 |
Yamagata K et al. | Apigenin inhibits tumor necrosis factor alpha plus high glucose-induced LOX-1 expression in human endothelial cells. | 2011 | Microvasc. Res. | pmid:21040737 |
Etinski M et al. | Time-dependent approaches for the calculation of intersystem crossing rates. | 2011 | J Chem Phys | pmid:21513373 |
Li LJ et al. | Flavans from the leaf of Ilex centrochinensis. | 2011 | J Asian Nat Prod Res | pmid:21462042 |
Kim JY et al. | Isolation of cholinesterase-inhibiting flavonoids from Morus lhou. | 2011 | J. Agric. Food Chem. | pmid:21434689 |
Mehla R et al. | A flavonoid, luteolin, cripples HIV-1 by abrogation of tat function. | 2011 | PLoS ONE | pmid:22140483 |
Cai RL et al. | Antihypertensive effect of total flavone extracts from Puerariae Radix. | 2011 | J Ethnopharmacol | pmid:20933075 |
Pan SY et al. | New perspectives on chinese herbal medicine (zhong-yao) research and development. | 2011 | Evid Based Complement Alternat Med | pmid:21785622 |
Wang YJ et al. | Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment of menopausal symptoms. | 2011 | Regul. Toxicol. Pharmacol. | pmid:20920542 |
Samarghandian S et al. | Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. | 2011 | Clinics (Sao Paulo) | pmid:21808878 |
Xiao J et al. | Non-covalent interaction of dietary polyphenols with total plasma proteins of type II diabetes: molecular structure/property-affinity relationships. | 2011 | Integr Biol (Camb) | pmid:21947088 |