MeSH term | MeSH ID | Detail |
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Neoplasm Invasiveness | D009361 | 23 associated lipids |
Lymphedema | D008209 | 4 associated lipids |
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Tanaka S et al. | Influence of natural and synthetic compounds on cell surface expression of cell adhesion molecules, ICAM-1 and VCAM-1. | 2001 | Planta Med. | pmid:11301853 |
Chi YS et al. | Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells. | 2001 | Biochem. Pharmacol. | pmid:11322923 |
Velázquez I and Pardo JP | Kinetic characterization of the rotenone-insensitive internal NADH: ubiquinone oxidoreductase of mitochondria from Saccharomyces cerevisiae. | 2001 | Arch. Biochem. Biophys. | pmid:11370674 |
Lim SS et al. | Synthesis of flavonoids and their effects on aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues. | 2001 | J. Pharm. Pharmacol. | pmid:11370705 |
Huang X et al. | 3D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors. | 2001 | J. Med. Chem. | pmid:11384234 |
D'arc Felicio J et al. | Biflavonoids from Ouratea multiflora. | 2001 | Fitoterapia | pmid:11395278 |
Fabre N et al. | Determination of flavone, flavonol, and flavanone aglycones by negative ion liquid chromatography electrospray ion trap mass spectrometry. | 2001 | J. Am. Soc. Mass Spectrom. | pmid:11401161 |
Schrag ML and Wienkers LC | Covalent alteration of the CYP3A4 active site: evidence for multiple substrate binding domains. | 2001 | Arch. Biochem. Biophys. | pmid:11414684 |
Krakauer T et al. | The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines. | 2001 | FEBS Lett. | pmid:11434925 |
Tabak C et al. | Chronic obstructive pulmonary disease and intake of catechins, flavonols, and flavones: the MORGEN Study. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11435239 |
Kim SJ | Effect of biflavones of Ginkgo biloba against UVB-induced cytotoxicity in vitro. | 2001 | J. Dermatol. | pmid:11449670 |
MarÃn FR and Del RÃo JA | Selection of hybrids and edible citrus species with a high content in the diosmin functional compound. Modulating effect of plant growth regulators on contents. | 2001 | J. Agric. Food Chem. | pmid:11453775 |
Stochmal A et al. | Acylated apigenin glycosides from alfalfa (Medicago sativa L.) var. Artal. | 2001 | Phytochemistry | pmid:11454348 |
Pepper C et al. | Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukaemia. | 2001 | Br. J. Haematol. | pmid:11472347 |
Park BK et al. | Inhibition of TPA-induced cyclooxygenase-2 expression and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix. | 2001 | Eur. J. Pharmacol. | pmid:11502282 |
Kumazawa T et al. | Synthesis of 8-C-glucosylflavones. | 2001 | Carbohydr. Res. | pmid:11513825 |
Collins-Burow BM et al. | Estrogenic and antiestrogenic activities of flavonoid phytochemicals through estrogen receptor binding-dependent and -independent mechanisms. | 2000 | Nutr Cancer | pmid:11525602 |
Mcmullen MD et al. | The biological basis of epistasis between quantitative trait loci for flavone and 3-deoxyanthocyanin synthesis in maize (Zea mays L.). | 2001 | Genome | pmid:11550903 |
Seo HJ and Surh YJ | Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human promyelocytic leukemia cells. | 2001 | Mutat. Res. | pmid:11551495 |
Philpott M et al. | The antitumour agent 5,6-dimethylxanthenone-4-acetic acid acts in vitro on human mononuclear cells as a co-stimulator with other inducers of tumour necrosis factor. | 2001 | Eur. J. Cancer | pmid:11576850 |
Saarinen N et al. | No evidence for the in vivo activity of aromatase-inhibiting flavonoids. | 2001 | J. Steroid Biochem. Mol. Biol. | pmid:11595503 |
Andrade-Cetto A and Wiedenfeld H | Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats. | 2001 | J Ethnopharmacol | pmid:11694359 |
Hirvonen T et al. | Flavonol and flavone intake and the risk of cancer in male smokers (Finland). | 2001 | Cancer Causes Control | pmid:11714106 |
Lee SE et al. | Inhibitory effects of naturally occurring compounds on aflatoxin B(1) biotransformation. | 2001 | J. Agric. Food Chem. | pmid:11714299 |
Kestell P et al. | Measurement of plasma 5-hydroxyindoleacetic acid as a possible clinical surrogate marker for the action of antivascular agents. | 2001 | Clin. Chim. Acta | pmid:11718691 |
Duportail G et al. | Neutral fluorescence probe with strong ratiometric response to surface charge of phospholipid membranes. | 2001 | FEBS Lett. | pmid:11718715 |
Otake Y and Walle T | Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9. | 2002 | Drug Metab. Dispos. | pmid:11792676 |
Chung MI et al. | Synthesis, antiplatelet and vasorelaxing effects of monooxygenated flavones and flavonoxypropanolamines. | 2001 | J. Pharm. Pharmacol. | pmid:11804390 |
Cook SA and Shiemke AK | Evidence that a type-2 NADH:quinone oxidoreductase mediates electron transfer to particulate methane monooxygenase in methylococcus capsulatus. | 2002 | Arch. Biochem. Biophys. | pmid:11811946 |
Tunçbilek M et al. | Synthesis and antioxidant properties of some new flavone derivatives on lipid peroxidation in the rat liver. | 2000 | Pharmazie | pmid:11828615 |
Kulevanova S et al. | HPLC identification and determination of flavone aglycones in Helichrysum plicatum DC. (Asteraceae). | 2000 | Pharmazie | pmid:11828624 |
Frangne N et al. | Flavone glucoside uptake into barley mesophyll and Arabidopsis cell culture vacuoles. Energization occurs by H(+)-antiport and ATP-binding cassette-type mechanisms. | 2002 | Plant Physiol. | pmid:11842175 |
Fang J and Beattie DS | Novel FMN-containing rotenone-insensitive NADH dehydrogenase from Trypanosoma brucei mitochondria: isolation and characterization. | 2002 | Biochemistry | pmid:11863445 |
Cai H et al. | A straightforward means of coupling preparative high-performance liquid chromatography and mass spectrometry. | 2002 | Rapid Commun. Mass Spectrom. | pmid:11870892 |
Rajendran NN et al. | Modulation by insulin rather than blood glucose of the pain threshold in acute physiological and flavone induced antinociception in mice. | 2001 | Indian J. Exp. Biol. | pmid:11883508 |
Isobe T et al. | [Antibacterial constituents against Helicobacter pylori of Brazilian medicinal plant, Pariparoba]. | 2002 | Yakugaku Zasshi | pmid:11968842 |
Kragh M et al. | Acute effects of vascular modifying agents in solid tumors assessed by noninvasive laser Doppler flowmetry and near infrared spectroscopy. | 2002 May-Jun | Neoplasia | pmid:11988846 |
Matsui T et al. | Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of alpha-glucosidase action. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12005074 |
Hadjokas NE et al. | Arginine to lysine 108 substitution in recombinant CYP1A2 abolishes methoxyresorufin metabolism in lymphoblastoid cells. | 2002 | Br. J. Pharmacol. | pmid:12023936 |
Lin YM et al. | Chalcones and flavonoids as anti-tuberculosis agents. | 2002 | Bioorg. Med. Chem. | pmid:12057669 |
Rawel HM et al. | Interactions of different phenolic acids and flavonoids with soy proteins. | 2002 | Int. J. Biol. Macromol. | pmid:12063116 |
Kuffel MJ et al. | Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2. | 2002 | Mol. Pharmacol. | pmid:12065765 |
Jacobson KA et al. | Interactions of flavones and other phytochemicals with adenosine receptors. | 2002 | Adv. Exp. Med. Biol. | pmid:12083460 |
Ching LM et al. | Induction of endothelial cell apoptosis by the antivascular agent 5,6-Dimethylxanthenone-4-acetic acid. | 2002 | Br. J. Cancer | pmid:12085190 |
Hori K et al. | A novel combretastatin A-4 derivative, AC7700, strongly stanches tumour blood flow and inhibits growth of tumours developing in various tissues and organs. | 2002 | Br. J. Cancer | pmid:12085211 |
Choi J et al. | Flavones from Scutellaria baicalensis Georgi attenuate apoptosis and protein oxidation in neuronal cell lines. | 2002 | Biochim. Biophys. Acta | pmid:12090934 |
Shimizu E and Ogata Y | Activation of bone sialoprotein gene transcription by flavonoids is mediated through an inverted CCAAT box in ROS 17/2.8 cells. | 2002 | J. Cell. Biochem. | pmid:12112014 |
Blatt CT et al. | Cytotoxic flavonoids from the stem bark of Lonchocarpus aff. fluvialis. | 2002 | Phytother Res | pmid:12112286 |
Voskresensky ON and Levitsky AP | QSAR aspects of flavonoids as a plentiful source of new drugs. | 2002 | Curr. Med. Chem. | pmid:12132993 |
Marder M and Paladini AC | GABA(A)-receptor ligands of flavonoid structure. | 2002 | Curr Top Med Chem | pmid:12171576 |