MeSH term | MeSH ID | Detail |
---|---|---|
Neoplasm Invasiveness | D009361 | 23 associated lipids |
Lymphedema | D008209 | 4 associated lipids |
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Yuqing Z et al. | Flavone ingredients can synergistically inhibit NDV infecting cell and improve ND vaccine's protective rate. | 2012 | Int. J. Biol. Macromol. | pmid:22575392 |
Fan Y et al. | Liposome and epimedium polysaccharide-propolis flavone can synergistically enhance immune effect of vaccine. | 2012 | Int. J. Biol. Macromol. | pmid:22020157 |
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Chen WC et al. | Baicalin induces apoptosis in SW620 human colorectal carcinoma cells in vitro and suppresses tumor growth in vivo. | 2012 | Molecules | pmid:22456615 |
Liu Y et al. | Chinese herb and formulas for promoting blood circulation and removing blood stasis and antiplatelet therapies. | 2012 | Evid Based Complement Alternat Med | pmid:22454656 |
Yong-Chun J et al. | A novel high-performance liquid chromatography fingerprint approach to discriminate Phyllostachys pubescens from China. | 2012 | Pharmacogn Mag | pmid:22438662 |
Zamboni A et al. | Genome-wide microarray analysis of tomato roots showed defined responses to iron deficiency. | 2012 | BMC Genomics | pmid:22433273 |
Furukawa Y et al. | Isolation and characterization of activators of ERK/MAPK from citrus plants. | 2012 | Int J Mol Sci | pmid:22408427 |
Khan R et al. | Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22155348 |
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Zhang H and Zhang C | Vasoprotection by dietary supplements and exercise: role of TNFα signaling. | 2012 | Exp Diabetes Res | pmid:22110483 |
Shi L et al. | Gossypin induces G2/M arrest in human malignant glioma U251 cells by the activation of Chk1/Cdc25C pathway. | 2012 | Cell. Mol. Neurobiol. | pmid:21984341 |
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Chen YH et al. | Evaluation of the structure-activity relationship of flavonoids as antioxidants and toxicants of zebrafish larvae. | 2012 | Food Chem | pmid:23107683 |
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Hatnapure GD et al. | Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22981334 |
Hamilton ML et al. | Elucidation of the biosynthesis of the di-C-glycosylflavone isoschaftoside, an allelopathic component from Desmodium spp. that inhibits Striga spp. development. | 2012 | Phytochemistry | pmid:22959223 |
Klier L et al. | Lewis acid-triggered selective zincation of chromones, quinolones, and thiochromones: application to the preparation of natural flavones and isoflavones. | 2012 | J. Am. Chem. Soc. | pmid:22860983 |
Kim D et al. | Synthetic approach to flavanones and flavones via ligand-free palladium(II)-catalyzed conjugate addition of arylboronic acids to chromones. | 2012 | Org. Biomol. Chem. | pmid:22850763 |
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Ulrich-Merzenich G et al. | Novel neurological and immunological targets for salicylate-based phytopharmaceuticals and for the anti-depressant imipramine. | 2012 | Phytomedicine | pmid:22743246 |
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Surichan S et al. | Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells. | 2012 | Food Chem. Toxicol. | pmid:22743247 |
Guo F et al. | Effect of the citrus lycopene β-cyclase transgene on carotenoid metabolism in transgenic tomato fruits. | 2012 | PLoS ONE | pmid:22384184 |
de-Faria FM et al. | Antioxidant action of mangrove polyphenols against gastric damage induced by absolute ethanol and ischemia-reperfusion in the rat. | 2012 | ScientificWorldJournal | pmid:22654592 |
Li G et al. | Pharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC-MS method. | 2012 | Fitoterapia | pmid:22056665 |
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Kongkum N et al. | DNA topoisomerase IIα inhibitory and anti-HIV-1 flavones from leaves and twigs of Gardenia carinata. | 2012 | Fitoterapia | pmid:22155186 |
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Park NI et al. | Enhancement of rutin in Fagopyrum esculentum hairy root cultures by the Arabidopsis transcription factor AtMYB12. | 2012 | Biotechnol. Lett. | pmid:22113884 |
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Lolli G et al. | Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight. | 2012 | Biochemistry | pmid:22794353 |
Zhang T et al. | Inhibitory effects and underlying mechanism of 7-hydroxyflavone phosphate ester in HeLa cells. | 2012 | PLoS ONE | pmid:22574207 |
Lin TY et al. | Hispidulin inhibits the release of glutamate in rat cerebrocortical nerve terminals. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22759588 |
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