MeSH term | MeSH ID | Detail |
---|---|---|
Neoplasm Invasiveness | D009361 | 23 associated lipids |
Lymphedema | D008209 | 4 associated lipids |
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Cao H et al. | Binding Citrus flavanones to human serum albumin: effect of structure on affinity. | 2011 | Mol. Biol. Rep. | pmid:20878474 |
Vitcheva V et al. | Hepatoprotective effects of saponarin, isolated from Gypsophila trichotoma Wend. on cocaine-induced oxidative stress in rats. | 2011 | Redox Rep. | pmid:21722413 |
Park SR et al. | Enhanced flavonoid production in Streptomyces venezuelae via metabolic engineering. | 2011 | J. Microbiol. Biotechnol. | pmid:22127124 |
Luo H et al. | Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers. | 2011 | BMC Genomics | pmid:22369100 |
Barrero RA et al. | De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes. | 2011 | BMC Genomics | pmid:22151917 |
Kloska A et al. | Effects of flavonoids on glycosaminoglycan synthesis: implications for substrate reduction therapy in Sanfilippo disease and other mucopolysaccharidoses. | 2011 | Metab Brain Dis | pmid:21305347 |
Bojić M et al. | Evaluation of antiaggregatory activity of flavonoid aglycone series. | 2011 | Nutr J | pmid:21745360 |
Shiromwar SS and Chidrawar VR | Combined effects of p-coumaric acid and naringenin against doxorubicin-induced cardiotoxicity in rats. | 2011 | Pharmacognosy Res | pmid:22022172 |
Zuk M et al. | Flavonoid engineering of flax potentiate its biotechnological application. | 2011 | BMC Biotechnol. | pmid:21276227 |
Wang Y et al. | Screening Antitumor Compounds Psoralen and Isopsoralen from Psoralea corylifolia L. Seeds. | 2011 | Evid Based Complement Alternat Med | pmid:19131395 |
Duan K et al. | LC-MS/MS determination and pharmacokinetic study of five flavone components after solvent extraction/acid hydrolysis in rat plasma after oral administration of Verbena officinalis L. extract. | 2011 | J Ethnopharmacol | pmid:21220003 |
Mladěnka P et al. | In vitro analysis of iron chelating activity of flavonoids. | 2011 | J. Inorg. Biochem. | pmid:21450273 |
Singh S et al. | 2-(4-Chloro-phen-yl)chromen-4-one. | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:22199687 |
Lee SJ et al. | Hypolipidemic and hypoglycemic effects of Orostachys japonicus A. Berger extracts in streptozotocin-induced diabetic rats. | 2011 | Nutr Res Pract | pmid:21994524 |
Asakawa T et al. | PET imaging of nobiletin based on a practical total synthesis. | 2011 | Chem. Commun. (Camb.) | pmid:21243163 |
Xiao J et al. | Noncovalent interaction of dietary polyphenols with common human plasma proteins. | 2011 | J. Agric. Food Chem. | pmid:21863815 |
Lima de Medeiros BJ et al. | Liver protective activity of a hydroethanolic extract of Arrabidaea chica (Humb. and Bonpl.) B. Verl. (pariri). | 2011 | Pharmacognosy Res | pmid:21772750 |
Raza SS et al. | Silymarin protects neurons from oxidative stress associated damages in focal cerebral ischemia: a behavioral, biochemical and immunohistological study in Wistar rats. | 2011 | J. Neurol. Sci. | pmid:21840019 |
Walch SG et al. | Antioxidant Capacity and Polyphenolic Composition as Quality Indicators for Aqueous Infusions of Salvia officinalis L. (sage tea). | 2011 | Front Pharmacol | pmid:22194722 |
Nigam A | Senescence (ageing) @ 2011. | 2011 | Indian J Dermatol | pmid:22345758 |
Kyselova Z | Toxicological aspects of the use of phenolic compounds in disease prevention. | 2011 | Interdiscip Toxicol | pmid:22319251 |
Mohammadi-Motlagh HR et al. | Anticancer and anti-inflammatory activities of shallot (Allium ascalonicum) extract. | 2011 | Arch Med Sci | pmid:22291731 |
Silva RO et al. | Sulfated-polysaccharide fraction from red algae Gracilaria caudata protects mice gut against ethanol-induced damage. | 2011 | Mar Drugs | pmid:22163181 |
Kothandan G et al. | Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of p-glycoprotein targeting the nucleotide binding domain. | 2011 | Eur J Med Chem | pmid:21723648 |
Thirupathy KP et al. | Neuropharmacological activity of Lippia nodiflora Linn. | 2011 | Pharmacognosy Res | pmid:22022169 |
Elmann A et al. | Anti-neuroinflammatory effects of the extract of Achillea fragrantissima. | 2011 | BMC Complement Altern Med | pmid:22018032 |
Himi E et al. | Differential expression of three flavanone 3-hydroxylase genes in grains and coleoptiles of wheat. | 2011 | Int J Plant Genomics | pmid:21977025 |
Niazmand S et al. | Cardiovascular effects of Teucrium polium L. extract in rabbit. | 2011 | Pharmacogn Mag | pmid:21969799 |
Mazzio EA et al. | The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. | 2011 | Int J Mol Sci | pmid:21340000 |
Lee KN et al. | Prevention of NSAID-associated gastroduodenal injury in healthy volunteers-a randomized, double-blind, multicenter study comparing DA-9601 with misoprostol. | 2011 | J. Korean Med. Sci. | pmid:21860559 |
Neves MP et al. | Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis. | 2011 | Eur J Med Chem | pmid:21496973 |
Klein T et al. | Structural basis for species specific inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1): computational study and biological validation. | 2011 | PLoS ONE | pmid:21857977 |
Yang C et al. | Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. | 2011 | PLoS ONE | pmid:21779360 |
Janovick JA et al. | Therapeutic rescue of misfolded mutants: validation of primary high throughput screens for identification of pharmacoperone drugs. | 2011 | PLoS ONE | pmid:21818389 |
Han S et al. | Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet. | 2011 | Nutr Res Pract | pmid:21779522 |
Martin C et al. | How can research on plants contribute to promoting human health? | 2011 | Plant Cell | pmid:21586682 |
Tan W et al. | Anti-cancer natural products isolated from chinese medicinal herbs. | 2011 | Chin Med | pmid:21777476 |
Gohain M et al. | Racemic tricarbon-yl[7-meth-oxy-2-(η-phen-yl)chromane]-chromium(0). | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:21753961 |
Li D et al. | Transcriptional profiling of Medicago truncatula under salt stress identified a novel CBF transcription factor MtCBF4 that plays an important role in abiotic stress responses. | 2011 | BMC Plant Biol. | pmid:21718548 |
Gasiorowski K et al. | Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? | 2011 | CNS Neurol Disord Drug Targets | pmid:21222632 |
Saeidnia S et al. | A review on phytochemistry and medicinal properties of the genus Achillea. | 2011 | Daru | pmid:22615655 |
Ono M and Saji H | SPECT Imaging Agents for Detecting Cerebral β-Amyloid Plaques. | 2011 | Int J Mol Imaging | pmid:21603239 |
Yao N et al. | Novel flavonoids with antiproliferative activities against breast cancer cells. | 2011 | J. Med. Chem. | pmid:21599001 |
Perry CN et al. | Xenotransplantation of mitochondrial electron transfer enzyme, Ndi1, in myocardial reperfusion injury. | 2011 | PLoS ONE | pmid:21339825 |
Marinova MD and Tchorbanov BP | Preparation of antioxidant enzymatic hydrolysates from honeybee-collected pollen using plant enzymes. | 2011 | Enzyme Res | pmid:21318132 |
Gauci AJ et al. | Identification of polyphenolic compounds and black tea extract as potent inhibitors of lipid membrane destabilization by Aβ₄₂ aggregates. | 2011 | J. Alzheimers Dis. | pmid:21891862 |
Garateix A et al. | Antinociception produced by Thalassia testudinum extract BM-21 is mediated by the inhibition of acid sensing ionic channels by the phenolic compound thalassiolin B. | 2011 | Mol Pain | pmid:21261973 |
Casati P et al. | Rapid Maize Leaf and Immature Ear Responses to UV-B Radiation. | 2011 | Front Plant Sci | pmid:22666224 |
Seo S et al. | Cyanide, a coproduct of plant hormone ethylene biosynthesis, contributes to the resistance of rice to blast fungus. | 2011 | Plant Physiol. | pmid:21075959 |
Wootten D et al. | Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids. | 2011 | J. Pharmacol. Exp. Ther. | pmid:21075839 |
Cai H et al. | Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone). | 2011 | Cancer Chemother. Pharmacol. | pmid:20364427 |
Theoharides TC and Zhang B | Neuro-inflammation, blood-brain barrier, seizures and autism. | 2011 | J Neuroinflammation | pmid:22129087 |
Lewin G et al. | Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk. | 2011 | Bioorg. Med. Chem. | pmid:21146994 |
Szliszka E et al. | Ethanolic Extract of Propolis Augments TRAIL-Induced Apoptotic Death in Prostate Cancer Cells. | 2011 | Evid Based Complement Alternat Med | pmid:19892808 |
Pick A et al. | Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP). | 2011 | Bioorg. Med. Chem. | pmid:21354800 |
Novy P et al. | In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus. | 2011 | J. Antimicrob. Chemother. | pmid:21421582 |
Seo YJ et al. | Apoptotic effects of genistein, biochanin-A and apigenin on LNCaP and PC-3 cells by p21 through transcriptional inhibition of polo-like kinase-1. | 2011 | J. Korean Med. Sci. | pmid:22065906 |
Ren L et al. | Effects of flavone 6-substitutions on GABAA receptors efficacy. | 2011 | Eur. J. Pharmacol. | pmid:21914441 |
Yob NJ et al. | Zingiber zerumbet (L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses. | 2011 | Evid Based Complement Alternat Med | pmid:21584247 |
Shin SY et al. | Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21907578 |
Hämäläinen M et al. | Effects of flavonoids on prostaglandin E2 production and on COX-2 and mPGES-1 expressions in activated macrophages. | 2011 | Planta Med. | pmid:21341175 |
Varma A et al. | Andrographolide: a new plant-derived antineoplastic entity on horizon. | 2011 | Evid Based Complement Alternat Med | pmid:19752167 |
Fletcher JN et al. | In vitro evaluation of flavonoids from Eriodictyon californicum for antagonist activity against the bitterness receptor hTAS2R31. | 2011 | J. Agric. Food Chem. | pmid:22059530 |
Ortet R et al. | Furfuran lignans and a flavone from Artemisia gorgonum Webb and their in vitro activity against Plasmodium falciparum. | 2011 | J Ethnopharmacol | pmid:21982788 |
Yamagata K et al. | Apigenin inhibits tumor necrosis factor alpha plus high glucose-induced LOX-1 expression in human endothelial cells. | 2011 | Microvasc. Res. | pmid:21040737 |
Gao L et al. | 3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21843936 |
Phromnoi K et al. | Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1. | 2011 | Mol. Pharmacol. | pmid:21816954 |
Kundu R et al. | Carlinoside reduces hepatic bilirubin accumulation by stimulating bilirubin-UGT activity through Nrf2 gene expression. | 2011 | Biochem. Pharmacol. | pmid:21801714 |
Wei H et al. | Neuropective constituents from the rhizomes of Abacopteris penangiana. | 2011 | J Asian Nat Prod Res | pmid:21751838 |
Xue L et al. | Pd-carbene catalyzed carbonylation reactions of aryl iodides. | 2011 | Dalton Trans | pmid:21677940 |
Schumacher M et al. | Potential role of P-gp for flavone-induced diminished apoptosis and increased adenoma size in the small intestine of APC(min/+) mice. | 2011 | Cancer Invest. | pmid:21649465 |
Polier G et al. | Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. | 2011 | Cell Death Dis | pmid:21776020 |
Li LJ et al. | Flavans from the leaf of Ilex centrochinensis. | 2011 | J Asian Nat Prod Res | pmid:21462042 |
Kim JY et al. | Isolation of cholinesterase-inhibiting flavonoids from Morus lhou. | 2011 | J. Agric. Food Chem. | pmid:21434689 |
Uchi H et al. | A clinical trial of kampo formulae for the treatment of symptoms of yusho, a poisoning caused by dioxins and related organochlorine compounds. | 2011 | Evid Based Complement Alternat Med | pmid:19996156 |
Manhita A et al. | Extracting natural dyes from wool--an evaluation of extraction methods. | 2011 | Anal Bioanal Chem | pmid:21416400 |
Zhang JW et al. | Structural elucidation of a new flavone from Sarcopyramis nepalensis. | 2011 | J Asian Nat Prod Res | pmid:21409688 |
Kumagai A et al. | A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells. | 2011 | PLoS ONE | pmid:22022544 |
Semwal RB et al. | Chemical constituents from the stem bark of Symplocos paniculata Thunb. with antimicrobial, analgesic and anti-inflammatory activities. | 2011 | J Ethnopharmacol | pmid:21354288 |
Khan MS et al. | Methylated chrysin induces co-ordinated attenuation of the canonical Wnt and NF-kB signaling pathway and upregulates apoptotic gene expression in the early hepatocarcinogenesis rat model. | 2011 | Chem. Biol. Interact. | pmid:21554863 |
Larroque-Lombard AL et al. | Synthesis and studies on three-compartment flavone-containing combi-molecules designed to target EGFR, DNA, and MEK. | 2011 | Chem Biol Drug Des | pmid:21294849 |
Fan Y et al. | Epimedium polysaccharide and propolis flavone can synergistically inhibit the cellular infectivity of NDV and improve the curative effect of ND in chicken. | 2011 | Int. J. Biol. Macromol. | pmid:21238483 |
Mehla R et al. | A flavonoid, luteolin, cripples HIV-1 by abrogation of tat function. | 2011 | PLoS ONE | pmid:22140483 |
Boyle SP et al. | Evaluation of quality control strategies in Scutellaria herbal medicines. | 2011 | J Pharm Biomed Anal | pmid:21163602 |
Kang KP et al. | Luteolin ameliorates cisplatin-induced acute kidney injury in mice by regulation of p53-dependent renal tubular apoptosis. | 2011 | Nephrol. Dial. Transplant. | pmid:20817674 |
Lefort EC and Blay J | The dietary flavonoid apigenin enhances the activities of the anti-metastatic protein CD26 on human colon carcinoma cells. | 2011 | Clin. Exp. Metastasis | pmid:21298326 |
Wang XX et al. | Simultaneous structural identification of natural products in fractions of crude extract of the rare endangered plant Anoectochilus roxburghii using H NMR/RRLC-MS parallel dynamic spectroscopy. | 2011 | Int J Mol Sci | pmid:21731458 |
Cai RL et al. | Antihypertensive effect of total flavone extracts from Puerariae Radix. | 2011 | J Ethnopharmacol | pmid:20933075 |
Pan SY et al. | New perspectives on chinese herbal medicine (zhong-yao) research and development. | 2011 | Evid Based Complement Alternat Med | pmid:21785622 |
Wang YJ et al. | Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment of menopausal symptoms. | 2011 | Regul. Toxicol. Pharmacol. | pmid:20920542 |
Chahar MK et al. | Flavonoids: A versatile source of anticancer drugs. | 2011 | Pharmacogn Rev | pmid:22096313 |
Kozics K et al. | Structure of flavonoids influences the degree inhibition of Benzo(a)pyrene - induced DNA damage and micronuclei in HepG2 cells. | 2011 | Neoplasma | pmid:21895405 |
Patra JC and Chua BH | Artificial neural network-based drug design for diabetes mellitus using flavonoids. | 2011 | J Comput Chem | pmid:20806262 |
Clark ST and Verwoerd WS | A systems approach to identifying correlated gene targets for the loss of colour pigmentation in plants. | 2011 | BMC Bioinformatics | pmid:21849042 |
Bensasson RV et al. | Potency of inhibition of human DNA topoisomerase I by flavones assessed through physicochemical parameters. | 2011 | Free Radic. Biol. Med. | pmid:21745563 |
Ohno S et al. | A bHLH transcription factor, DvIVS, is involved in regulation of anthocyanin synthesis in dahlia (Dahlia variabilis). | 2011 | J. Exp. Bot. | pmid:21765172 |
Maher P et al. | Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. | 2011 | PLoS ONE | pmid:21738623 |
Samarghandian S et al. | Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. | 2011 | Clinics (Sao Paulo) | pmid:21808878 |
Xiao J et al. | Non-covalent interaction of dietary polyphenols with total plasma proteins of type II diabetes: molecular structure/property-affinity relationships. | 2011 | Integr Biol (Camb) | pmid:21947088 |
Fang W et al. | Flavonoids from the aerial parts of Macrothelypteris torresiana. | 2011 | Nat. Prod. Res. | pmid:21240759 |