FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Neoplasm Invasiveness D009361 23 associated lipids
Lymphedema D008209 4 associated lipids
Per page 10 20 50 | Total 32

PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

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Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Cao H et al. Binding Citrus flavanones to human serum albumin: effect of structure on affinity. 2011 Mol. Biol. Rep. pmid:20878474
Vitcheva V et al. Hepatoprotective effects of saponarin, isolated from Gypsophila trichotoma Wend. on cocaine-induced oxidative stress in rats. 2011 Redox Rep. pmid:21722413
Park SR et al. Enhanced flavonoid production in Streptomyces venezuelae via metabolic engineering. 2011 J. Microbiol. Biotechnol. pmid:22127124
Luo H et al. Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers. 2011 BMC Genomics pmid:22369100
Barrero RA et al. De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes. 2011 BMC Genomics pmid:22151917
Kloska A et al. Effects of flavonoids on glycosaminoglycan synthesis: implications for substrate reduction therapy in Sanfilippo disease and other mucopolysaccharidoses. 2011 Metab Brain Dis pmid:21305347
Bojić M et al. Evaluation of antiaggregatory activity of flavonoid aglycone series. 2011 Nutr J pmid:21745360
Shiromwar SS and Chidrawar VR Combined effects of p-coumaric acid and naringenin against doxorubicin-induced cardiotoxicity in rats. 2011 Pharmacognosy Res pmid:22022172
Zuk M et al. Flavonoid engineering of flax potentiate its biotechnological application. 2011 BMC Biotechnol. pmid:21276227
Wang Y et al. Screening Antitumor Compounds Psoralen and Isopsoralen from Psoralea corylifolia L. Seeds. 2011 Evid Based Complement Alternat Med pmid:19131395
Duan K et al. LC-MS/MS determination and pharmacokinetic study of five flavone components after solvent extraction/acid hydrolysis in rat plasma after oral administration of Verbena officinalis L. extract. 2011 J Ethnopharmacol pmid:21220003
Mladěnka P et al. In vitro analysis of iron chelating activity of flavonoids. 2011 J. Inorg. Biochem. pmid:21450273
Singh S et al. 2-(4-Chloro-phen-yl)chromen-4-one. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:22199687
Lee SJ et al. Hypolipidemic and hypoglycemic effects of Orostachys japonicus A. Berger extracts in streptozotocin-induced diabetic rats. 2011 Nutr Res Pract pmid:21994524
Asakawa T et al. PET imaging of nobiletin based on a practical total synthesis. 2011 Chem. Commun. (Camb.) pmid:21243163
Xiao J et al. Noncovalent interaction of dietary polyphenols with common human plasma proteins. 2011 J. Agric. Food Chem. pmid:21863815
Lima de Medeiros BJ et al. Liver protective activity of a hydroethanolic extract of Arrabidaea chica (Humb. and Bonpl.) B. Verl. (pariri). 2011 Pharmacognosy Res pmid:21772750
Raza SS et al. Silymarin protects neurons from oxidative stress associated damages in focal cerebral ischemia: a behavioral, biochemical and immunohistological study in Wistar rats. 2011 J. Neurol. Sci. pmid:21840019
Walch SG et al. Antioxidant Capacity and Polyphenolic Composition as Quality Indicators for Aqueous Infusions of Salvia officinalis L. (sage tea). 2011 Front Pharmacol pmid:22194722
Nigam A Senescence (ageing) @ 2011. 2011 Indian J Dermatol pmid:22345758
Kyselova Z Toxicological aspects of the use of phenolic compounds in disease prevention. 2011 Interdiscip Toxicol pmid:22319251
Mohammadi-Motlagh HR et al. Anticancer and anti-inflammatory activities of shallot (Allium ascalonicum) extract. 2011 Arch Med Sci pmid:22291731
Silva RO et al. Sulfated-polysaccharide fraction from red algae Gracilaria caudata protects mice gut against ethanol-induced damage. 2011 Mar Drugs pmid:22163181
Kothandan G et al. Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of p-glycoprotein targeting the nucleotide binding domain. 2011 Eur J Med Chem pmid:21723648
Thirupathy KP et al. Neuropharmacological activity of Lippia nodiflora Linn. 2011 Pharmacognosy Res pmid:22022169
Elmann A et al. Anti-neuroinflammatory effects of the extract of Achillea fragrantissima. 2011 BMC Complement Altern Med pmid:22018032
Himi E et al. Differential expression of three flavanone 3-hydroxylase genes in grains and coleoptiles of wheat. 2011 Int J Plant Genomics pmid:21977025
Niazmand S et al. Cardiovascular effects of Teucrium polium L. extract in rabbit. 2011 Pharmacogn Mag pmid:21969799
Mazzio EA et al. The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. 2011 Int J Mol Sci pmid:21340000
Lee KN et al. Prevention of NSAID-associated gastroduodenal injury in healthy volunteers-a randomized, double-blind, multicenter study comparing DA-9601 with misoprostol. 2011 J. Korean Med. Sci. pmid:21860559
Neves MP et al. Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis. 2011 Eur J Med Chem pmid:21496973
Klein T et al. Structural basis for species specific inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1): computational study and biological validation. 2011 PLoS ONE pmid:21857977
Yang C et al. Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. 2011 PLoS ONE pmid:21779360
Janovick JA et al. Therapeutic rescue of misfolded mutants: validation of primary high throughput screens for identification of pharmacoperone drugs. 2011 PLoS ONE pmid:21818389
Han S et al. Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet. 2011 Nutr Res Pract pmid:21779522
Martin C et al. How can research on plants contribute to promoting human health? 2011 Plant Cell pmid:21586682
Tan W et al. Anti-cancer natural products isolated from chinese medicinal herbs. 2011 Chin Med pmid:21777476
Gohain M et al. Racemic tricarbon-yl[7-meth-oxy-2-(η-phen-yl)chromane]-chromium(0). 2011 Acta Crystallogr Sect E Struct Rep Online pmid:21753961
Li D et al. Transcriptional profiling of Medicago truncatula under salt stress identified a novel CBF transcription factor MtCBF4 that plays an important role in abiotic stress responses. 2011 BMC Plant Biol. pmid:21718548
Gasiorowski K et al. Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? 2011 CNS Neurol Disord Drug Targets pmid:21222632
Saeidnia S et al. A review on phytochemistry and medicinal properties of the genus Achillea. 2011 Daru pmid:22615655
Ono M and Saji H SPECT Imaging Agents for Detecting Cerebral β-Amyloid Plaques. 2011 Int J Mol Imaging pmid:21603239
Yao N et al. Novel flavonoids with antiproliferative activities against breast cancer cells. 2011 J. Med. Chem. pmid:21599001
Perry CN et al. Xenotransplantation of mitochondrial electron transfer enzyme, Ndi1, in myocardial reperfusion injury. 2011 PLoS ONE pmid:21339825
Marinova MD and Tchorbanov BP Preparation of antioxidant enzymatic hydrolysates from honeybee-collected pollen using plant enzymes. 2011 Enzyme Res pmid:21318132
Gauci AJ et al. Identification of polyphenolic compounds and black tea extract as potent inhibitors of lipid membrane destabilization by Aβ₄₂ aggregates. 2011 J. Alzheimers Dis. pmid:21891862
Garateix A et al. Antinociception produced by Thalassia testudinum extract BM-21 is mediated by the inhibition of acid sensing ionic channels by the phenolic compound thalassiolin B. 2011 Mol Pain pmid:21261973
Casati P et al. Rapid Maize Leaf and Immature Ear Responses to UV-B Radiation. 2011 Front Plant Sci pmid:22666224
Seo S et al. Cyanide, a coproduct of plant hormone ethylene biosynthesis, contributes to the resistance of rice to blast fungus. 2011 Plant Physiol. pmid:21075959
Wootten D et al. Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids. 2011 J. Pharmacol. Exp. Ther. pmid:21075839
Cai H et al. Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone). 2011 Cancer Chemother. Pharmacol. pmid:20364427
Theoharides TC and Zhang B Neuro-inflammation, blood-brain barrier, seizures and autism. 2011 J Neuroinflammation pmid:22129087
Lewin G et al. Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk. 2011 Bioorg. Med. Chem. pmid:21146994
Szliszka E et al. Ethanolic Extract of Propolis Augments TRAIL-Induced Apoptotic Death in Prostate Cancer Cells. 2011 Evid Based Complement Alternat Med pmid:19892808
Pick A et al. Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP). 2011 Bioorg. Med. Chem. pmid:21354800
Novy P et al. In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus. 2011 J. Antimicrob. Chemother. pmid:21421582
Seo YJ et al. Apoptotic effects of genistein, biochanin-A and apigenin on LNCaP and PC-3 cells by p21 through transcriptional inhibition of polo-like kinase-1. 2011 J. Korean Med. Sci. pmid:22065906
Ren L et al. Effects of flavone 6-substitutions on GABAA receptors efficacy. 2011 Eur. J. Pharmacol. pmid:21914441
Yob NJ et al. Zingiber zerumbet (L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses. 2011 Evid Based Complement Alternat Med pmid:21584247
Shin SY et al. Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities. 2011 Bioorg. Med. Chem. Lett. pmid:21907578
Hämäläinen M et al. Effects of flavonoids on prostaglandin E2 production and on COX-2 and mPGES-1 expressions in activated macrophages. 2011 Planta Med. pmid:21341175
Varma A et al. Andrographolide: a new plant-derived antineoplastic entity on horizon. 2011 Evid Based Complement Alternat Med pmid:19752167
Fletcher JN et al. In vitro evaluation of flavonoids from Eriodictyon californicum for antagonist activity against the bitterness receptor hTAS2R31. 2011 J. Agric. Food Chem. pmid:22059530
Ortet R et al. Furfuran lignans and a flavone from Artemisia gorgonum Webb and their in vitro activity against Plasmodium falciparum. 2011 J Ethnopharmacol pmid:21982788
Yamagata K et al. Apigenin inhibits tumor necrosis factor alpha plus high glucose-induced LOX-1 expression in human endothelial cells. 2011 Microvasc. Res. pmid:21040737
Gao L et al. 3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase. 2011 Bioorg. Med. Chem. Lett. pmid:21843936
Phromnoi K et al. Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1. 2011 Mol. Pharmacol. pmid:21816954
Kundu R et al. Carlinoside reduces hepatic bilirubin accumulation by stimulating bilirubin-UGT activity through Nrf2 gene expression. 2011 Biochem. Pharmacol. pmid:21801714
Wei H et al. Neuropective constituents from the rhizomes of Abacopteris penangiana. 2011 J Asian Nat Prod Res pmid:21751838
Xue L et al. Pd-carbene catalyzed carbonylation reactions of aryl iodides. 2011 Dalton Trans pmid:21677940
Schumacher M et al. Potential role of P-gp for flavone-induced diminished apoptosis and increased adenoma size in the small intestine of APC(min/+) mice. 2011 Cancer Invest. pmid:21649465
Polier G et al. Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. 2011 Cell Death Dis pmid:21776020
Li LJ et al. Flavans from the leaf of Ilex centrochinensis. 2011 J Asian Nat Prod Res pmid:21462042
Kim JY et al. Isolation of cholinesterase-inhibiting flavonoids from Morus lhou. 2011 J. Agric. Food Chem. pmid:21434689
Uchi H et al. A clinical trial of kampo formulae for the treatment of symptoms of yusho, a poisoning caused by dioxins and related organochlorine compounds. 2011 Evid Based Complement Alternat Med pmid:19996156
Manhita A et al. Extracting natural dyes from wool--an evaluation of extraction methods. 2011 Anal Bioanal Chem pmid:21416400
Zhang JW et al. Structural elucidation of a new flavone from Sarcopyramis nepalensis. 2011 J Asian Nat Prod Res pmid:21409688
Kumagai A et al. A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells. 2011 PLoS ONE pmid:22022544
Semwal RB et al. Chemical constituents from the stem bark of Symplocos paniculata Thunb. with antimicrobial, analgesic and anti-inflammatory activities. 2011 J Ethnopharmacol pmid:21354288
Khan MS et al. Methylated chrysin induces co-ordinated attenuation of the canonical Wnt and NF-kB signaling pathway and upregulates apoptotic gene expression in the early hepatocarcinogenesis rat model. 2011 Chem. Biol. Interact. pmid:21554863
Larroque-Lombard AL et al. Synthesis and studies on three-compartment flavone-containing combi-molecules designed to target EGFR, DNA, and MEK. 2011 Chem Biol Drug Des pmid:21294849
Fan Y et al. Epimedium polysaccharide and propolis flavone can synergistically inhibit the cellular infectivity of NDV and improve the curative effect of ND in chicken. 2011 Int. J. Biol. Macromol. pmid:21238483
Mehla R et al. A flavonoid, luteolin, cripples HIV-1 by abrogation of tat function. 2011 PLoS ONE pmid:22140483
Boyle SP et al. Evaluation of quality control strategies in Scutellaria herbal medicines. 2011 J Pharm Biomed Anal pmid:21163602
Kang KP et al. Luteolin ameliorates cisplatin-induced acute kidney injury in mice by regulation of p53-dependent renal tubular apoptosis. 2011 Nephrol. Dial. Transplant. pmid:20817674
Lefort EC and Blay J The dietary flavonoid apigenin enhances the activities of the anti-metastatic protein CD26 on human colon carcinoma cells. 2011 Clin. Exp. Metastasis pmid:21298326
Wang XX et al. Simultaneous structural identification of natural products in fractions of crude extract of the rare endangered plant Anoectochilus roxburghii using H NMR/RRLC-MS parallel dynamic spectroscopy. 2011 Int J Mol Sci pmid:21731458
Cai RL et al. Antihypertensive effect of total flavone extracts from Puerariae Radix. 2011 J Ethnopharmacol pmid:20933075
Pan SY et al. New perspectives on chinese herbal medicine (zhong-yao) research and development. 2011 Evid Based Complement Alternat Med pmid:21785622
Wang YJ et al. Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment of menopausal symptoms. 2011 Regul. Toxicol. Pharmacol. pmid:20920542
Chahar MK et al. Flavonoids: A versatile source of anticancer drugs. 2011 Pharmacogn Rev pmid:22096313
Kozics K et al. Structure of flavonoids influences the degree inhibition of Benzo(a)pyrene - induced DNA damage and micronuclei in HepG2 cells. 2011 Neoplasma pmid:21895405
Patra JC and Chua BH Artificial neural network-based drug design for diabetes mellitus using flavonoids. 2011 J Comput Chem pmid:20806262
Clark ST and Verwoerd WS A systems approach to identifying correlated gene targets for the loss of colour pigmentation in plants. 2011 BMC Bioinformatics pmid:21849042
Bensasson RV et al. Potency of inhibition of human DNA topoisomerase I by flavones assessed through physicochemical parameters. 2011 Free Radic. Biol. Med. pmid:21745563
Ohno S et al. A bHLH transcription factor, DvIVS, is involved in regulation of anthocyanin synthesis in dahlia (Dahlia variabilis). 2011 J. Exp. Bot. pmid:21765172
Maher P et al. Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. 2011 PLoS ONE pmid:21738623
Samarghandian S et al. Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. 2011 Clinics (Sao Paulo) pmid:21808878
Xiao J et al. Non-covalent interaction of dietary polyphenols with total plasma proteins of type II diabetes: molecular structure/property-affinity relationships. 2011 Integr Biol (Camb) pmid:21947088
Fang W et al. Flavonoids from the aerial parts of Macrothelypteris torresiana. 2011 Nat. Prod. Res. pmid:21240759