MeSH term | MeSH ID | Detail |
---|---|---|
Neoplasm Invasiveness | D009361 | 23 associated lipids |
Lymphedema | D008209 | 4 associated lipids |
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Alworth WL et al. | Stimulation of mammalian epoxide hydrase activity by flavones. | 1980 | Xenobiotica | pmid:7415221 |
Kagawa H et al. | Oxidation and rearrangements of flavanones by mammalian cytochrome P450. | 2004 | Xenobiotica | pmid:15742975 |
Ibrahim AR and Abul-Hajj YJ | Microbiological transformation of flavone and isoflavone. | 1990 | Xenobiotica | pmid:2346033 |
Lee HS et al. | In vitro metabolism of eupatilin by multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes. | 2007 | Xenobiotica | pmid:17701830 |
Chang CW et al. | Daphne Genkwa sieb. Et zucc. Water-soluble extracts act on enterovirus 71 by inhibiting viral entry. | 2012 | Viruses | pmid:22590685 |
Madan V et al. | Requirement of the vesicular system for membrane permeabilization by Sindbis virus. | 2005 | Virology | pmid:15661162 |
Zandi K et al. | Antiviral activity of four types of bioflavonoid against dengue virus type-2. | 2011 | Virol. J. | pmid:22201648 |
UydeÅŸ-DoÄŸan BS et al. | The comparison of the relaxant effects of two methoxylated flavones in rat aortic rings. | 2005 | Vascul. Pharmacol. | pmid:16169284 |
Yang L et al. | Compound Chinese herbal medicinal ingredients can enhance immune response and efficacy of RHD vaccine in rabbit. | 2008 | Vaccine | pmid:18602959 |
Sun JL et al. | Immunologic enhancement of compound Chinese herbal medicinal ingredients and their efficacy comparison with compound Chinese herbal medicines. | 2006 | Vaccine | pmid:16378665 |