MeSH term | MeSH ID | Detail |
---|---|---|
Neoplasm Invasiveness | D009361 | 23 associated lipids |
Lymphedema | D008209 | 4 associated lipids |
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Wenzel U et al. | Nitric oxide levels in human preneoplastic colonocytes determine their susceptibility toward antineoplastic agents. | 2003 | Mol. Pharmacol. | pmid:14645680 |
Shibata H et al. | Flavone markedly affects phenotypic expression of beta-lactam resistance in methicillin-resistant Staphylococcus aureus strains isolated clinically. | 2003 | Biol. Pharm. Bull. | pmid:14519958 |
Govindarajan R et al. | Studies on the antioxidant activities of Desmodium gangeticum. | 2003 | Biol. Pharm. Bull. | pmid:14519948 |
Springsteel MF et al. | Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. | 2003 | Bioorg. Med. Chem. | pmid:12927873 |
Gafner S et al. | Inhibition of [3H]-LSD binding to 5-HT7 receptors by flavonoids from Scutellaria lateriflora. | 2003 | J. Nat. Prod. | pmid:12713409 |
Suzuki R et al. | Two flavone C-glycosides from the style of Zea mays with glycation inhibitory activity. | 2003 | J. Nat. Prod. | pmid:12713418 |
Tunçbilek M et al. | Synthesis and hypoglycemic activity of some substituted flavonyl thiazolidinedione derivatives--fifth communication: flavonyl benzyl substituted 2,4-thiazolidinediones. | 2003 | Farmaco | pmid:12595040 |
Alonso M et al. | Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway. | 2003 | Mol. Cancer Ther. | pmid:12589031 |
Artali R et al. | Synthesis, X-ray crystal structure and biological properties of acetylenic flavone derivatives. | 2003 | Farmaco | pmid:13679182 |
Moreno JA et al. | [Effect of phenolic compounds of virgin olive oil on LDL oxidation resistance]. | 2003 | Med Clin (Barc) | pmid:12605836 |
Peterson J et al. | Flavonoid intake and breast cancer risk: a case--control study in Greece. | 2003 | Br. J. Cancer | pmid:14520456 |
Bozdağ-Dündar O et al. | Synthesis and antimicrobial activity of flavone-3'-carboxaldehyde oxime ether derivatives. | 2003 | Arzneimittelforschung | pmid:12918219 |
Gobbi S et al. | Synthesis and biological evaluation of 3-alkoxy analogues of flavone-8-acetic acid. | 2003 | J. Med. Chem. | pmid:12904070 |
Bauvois B et al. | Synthesis and biological evaluation of novel flavone-8-acetic acid derivatives as reversible inhibitors of aminopeptidase N/CD13. | 2003 | J. Med. Chem. | pmid:12930151 |
Chi YS et al. | Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. | 2003 | Biochem. Pharmacol. | pmid:14505806 |
Mihara M et al. | Flavopiridol, a cyclin dependent kinase (CDK) inhibitor, induces apoptosis by regulating Bcl-x in oral cancer cells. | 2003 | Oral Oncol. | pmid:12457721 |
Albach DC et al. | Acylated flavone glycosides from Veronica. | 2003 | Phytochemistry | pmid:14599528 |
Mackenzie CA et al. | Gonadal differentiation in frogs exposed to estrogenic and antiestrogenic compounds. | 2003 | Environ. Toxicol. Chem. | pmid:14552012 |
Newell DR et al. | Professor Tom Connors and the development of novel cancer therapies by the Phase I/II Clinical Trials Committee of Cancer Research UK. | 2003 | Br. J. Cancer | pmid:12888809 |
Suetsugi M et al. | Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. | 2003 | Mol. Cancer Res. | pmid:14638870 |