FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Neoplasm Invasiveness D009361 23 associated lipids
Lymphedema D008209 4 associated lipids
Per page 10 20 50 | Total 32

PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

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Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Vaher M and Koel M Separation of polyphenolic compounds extracted from plant matrices using capillary electrophoresis. 2003 J Chromatogr A pmid:12685601
Boué SM et al. Identification of flavone aglycones and glycosides in soybean pods by liquid chromatography-tandem mass spectrometry. 2003 J Chromatogr A pmid:12703901
Lai MY et al. Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats. 2003 J. Pharm. Pharmacol. pmid:12631413
Cai H et al. Determination of the flavone tricin in human plasma by high-performance liquid chromatography. 2003 Biomed. Chromatogr. pmid:14598326
Goutman JD et al. Flavonoid modulation of ionic currents mediated by GABA(A) and GABA(C) receptors. 2003 Eur. J. Pharmacol. pmid:12586201
Gleye C et al. Acaricidal activity of tonka bean extracts. Synthesis and structure-activity relationships of bioactive derivatives. 2003 J. Nat. Prod. pmid:12762809
Khan KK et al. Homotropic versus heterotopic cooperativity of cytochrome P450eryF: a substrate oxidation and spectral titration study. 2003 Drug Metab. Dispos. pmid:12642459
Huen MS et al. Naturally occurring 2'-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands. 2003 Biochem. Pharmacol. pmid:14637197
Kim SY et al. Cis-2', 3'-dihydrodiol production on flavone B-ring by biphenyl dioxygenase from Pseudomonas pseudoalcaligenes KF707 expressed in Escherichia coli. 2003 Antonie Van Leeuwenhoek pmid:14574103
Ajay M et al. Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. 2003 Life Sci. pmid:14623031
Almada-Ruiz E et al. Fungicidal potential of methoxylated flavones from citrus for in vitro control of Colletotrichum gloeosporioides, causal agent of anthracnose disease in tropical fruits. 2003 Pest Manag. Sci. pmid:14620052
Haraguchi H et al. A flavone from Manilkara indica as a specific inhibitor against aldose reductase in vitro. 2003 Planta Med. pmid:14598214
Selloum L et al. Anti-inflammatory effect of rutin on rat paw oedema, and on neutrophils chemotaxis and degranulation. 2003 Exp. Toxicol. Pathol. pmid:12710715
Pepper C et al. Flavopiridol induces apoptosis in B-cell chronic lymphocytic leukaemia cells through a p38 and ERK MAP kinase-dependent mechanism. 2003 Leuk. Lymphoma pmid:12688354
Reddy MK et al. A flavone and an unusual 23-carbon terpenoid from Andrographis paniculata. 2003 Phytochemistry pmid:12648550
Hyup YH et al. 2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors. 2003 Bioorg. Med. Chem. Lett. pmid:12565941
Toyo'oka T et al. On-line screening methods for antioxidants scavenging superoxide anion radical and hydrogen peroxide by liquid chromatography with indirect chemiluminescence detection. 2003 Talanta pmid:18969068
Lee S et al. Solubility enhancement of a hydrophobic flavonoid, luteolin by the complexation with cyclosophoraoses isolated from Rhizobium meliloti. 2003 Antonie Van Leeuwenhoek pmid:14574115
Fukui Y et al. A rationale for the shift in colour towards blue in transgenic carnation flowers expressing the flavonoid 3',5'-hydroxylase gene. 2003 Phytochemistry pmid:12657292
Wu SN et al. Differential effects of quercetin, a natural polyphenolic flavonoid, on L-type calcium current in pituitary tumor (GH3) cells and neuronal NG108-15 cells. 2003 J. Cell. Physiol. pmid:12652656