MeSH term | MeSH ID | Detail |
---|---|---|
Neoplasm Invasiveness | D009361 | 23 associated lipids |
Lymphedema | D008209 | 4 associated lipids |
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Julião Lde S et al. | Flavones and phenylpropanoids from a sedative extract of Lantana trifolia L. | 2010 | Phytochemistry | pmid:19922967 |
Fekrazad HM et al. | A phase I study of flavopiridol in combination with gemcitabine and irinotecan in patients with metastatic cancer. | 2010 | Am. J. Clin. Oncol. | pmid:19884803 |
Seo J et al. | Time-dependent density functional theory-assisted absolute configuration determination of cis-dihydrodiol metabolite produced from isoflavone by biphenyl dioxygenase. | 2010 | Anal. Biochem. | pmid:19854147 |
Rayyan S et al. | Flavone C-glycosides from seeds of fenugreek, Trigonella foenum-graecum L. | 2010 | J. Agric. Food Chem. | pmid:20486688 |
Cabrera M et al. | Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. | 2010 | Bioorg. Med. Chem. | pmid:20639112 |
Zhao C et al. | [Study on extraction of anti-diabetes active constituents from Potentilla chinesis]. | 2010 | Zhong Yao Cai | pmid:20575426 |
Gülcemal D et al. | Phenolic Glycosides with antiproteasomal activity from Centaurea urvillei DC. subsp. urvillei. | 2010 | Carbohydr. Res. | pmid:20937505 |
Winkelmann I et al. | Flavone induces changes in intermediary metabolism that prevent microadenoma formation in colonic tissue of carcinogen-treated mice. | 2010 | Mol Nutr Food Res | pmid:20564477 |
Basile A et al. | Antibacterial and antifungal properties of acetonic extract of Feijoa sellowiana fruits and its effect on Helicobacter pylori growth. | 2010 | J Med Food | pmid:20136454 |
Seo J et al. | Location of flavone B-ring controls regioselectivity and stereoselectivity of naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816-4. | 2010 | Appl. Microbiol. Biotechnol. | pmid:20091026 |
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D'Archivio M et al. | Bioavailability of the polyphenols: status and controversies. | 2010 | Int J Mol Sci | pmid:20480022 |
Wang SQ et al. | Flavonoids from Dracocephalum tanguticum and their cardioprotective effects against doxorubicin-induced toxicity in H9c2 cells. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20932762 |
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Chirumbolo S | The role of quercetin, flavonols and flavones in modulating inflammatory cell function. | 2010 | Inflamm Allergy Drug Targets | pmid:20887269 |
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Meng X et al. | Effects of Various Flavonoids on the α-Synuclein Fibrillation Process. | 2010 | Parkinsons Dis | pmid:20976092 |
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Madeira PJ et al. | Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometric and semi-empirical calculations study of five isoflavone aglycones. | 2010 | Rapid Commun. Mass Spectrom. | pmid:21072799 |
Qian LB et al. | Luteolin reduces high glucose-mediated impairment of endothelium-dependent relaxation in rat aorta by reducing oxidative stress. | 2010 | Pharmacol. Res. | pmid:19892019 |
Shimada T et al. | Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. | 2010 | Chem. Res. Toxicol. | pmid:21053930 |
Sasaki K et al. | Functional divergence within class B MADS-box genes TfGLO and TfDEF in Torenia fournieri Lind. | 2010 | Mol. Genet. Genomics | pmid:20872230 |
Zhang Y et al. | Dietary flavonol and flavone intakes and their major food sources in Chinese adults. | 2010 | Nutr Cancer | pmid:21058200 |
Kumar GS et al. | Synthesis and biological evaluation of novel benzyl-substituted flavones as free radical (DPPH) scavengers and α-glucosidase inhibitors. | 2010 | J Asian Nat Prod Res | pmid:21061220 |
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Treutter D | Managing phenol contents in crop plants by phytochemical farming and breeding-visions and constraints. | 2010 | Int J Mol Sci | pmid:20479987 |
Huang CH et al. | Natural flavone kaempferol suppresses chemokines expression in human monocyte THP-1 cells through MAPK pathways. | 2010 | J. Food Sci. | pmid:21535503 |
Xu B and Chang SK | Phenolic substance characterization and chemical and cell-based antioxidant activities of 11 lentils grown in the northern United States. | 2010 | J. Agric. Food Chem. | pmid:20058926 |
Attimarad M | Liquid Chromatographic Determination of Flavoxate HCl in Pharmaceutical Formulation. | 2010 | J Young Pharm | pmid:21042486 |
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Lakhan SE and Vieira KF | Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. | 2010 | Nutr J | pmid:20929532 |
Demiroglu-Zergeroglu A et al. | The investigation of effects of quercetin and its combination with Cisplatin on malignant mesothelioma cells in vitro. | 2010 | J. Biomed. Biotechnol. | pmid:20508819 |
Fransen HP et al. | Assessment of health claims, content, and safety of herbal supplements containing Ginkgo biloba. | 2010 | Food Nutr Res | pmid:20927202 |
Wang XH et al. | Screen of micro-organisms for inducing the production of dragon's blood by leaf of Dracaena cochinchinensis. | 2010 | Lett. Appl. Microbiol. | pmid:20860774 |
Guo W et al. | Antagonistic effect of flavonoids on NSC-741909-mediated antitumor activity via scavenging of reactive oxygen species. | 2010 | Eur. J. Pharmacol. | pmid:20854805 |
Suttana W et al. | Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols. | 2010 | Mol. Cancer | pmid:20438634 |
Luo H et al. | Comparison of 454-ESTs from Huperzia serrata and Phlegmariurus carinatus reveals putative genes involved in lycopodium alkaloid biosynthesis and developmental regulation. | 2010 | BMC Plant Biol. | pmid:20854695 |
Chen CC et al. | Calcium- and phosphatidylinositol 3-kinase/Akt-dependent activation of endothelial nitric oxide synthase by apigenin. | 2010 | Life Sci. | pmid:21034748 |
Chen EP et al. | A mechanism-based mathematical model of aryl hydrocarbon receptor-mediated CYP1A induction in rats using beta-naphthoflavone as a tool compound. | 2010 | Drug Metab. Dispos. | pmid:20843940 |
Ragab FA et al. | Synthesis and anticonvulsant activity of certain substituted furochromone, benzofuran and flavone derivatives. | 2010 | Chem. Pharm. Bull. | pmid:20823592 |
Stark JL et al. | Solution structure and function of YndB, an AHSA1 protein from Bacillus subtilis. | 2010 | Proteins | pmid:20818668 |
Chung KS et al. | Eupafolin, a flavonoid isolated from Artemisia princeps, induced apoptosis in human cervical adenocarcinoma HeLa cells. | 2010 | Mol Nutr Food Res | pmid:20397191 |
Du Y et al. | Identification of flavone phytoalexins and a pathogen-inducible flavone synthase II gene (SbFNSII) in sorghum. | 2010 | J. Exp. Bot. | pmid:20007684 |
Gao LM and Meléndez E | Cytotoxic properties of titanocenyl amides on breast cancer cell line mcf-7. | 2010 | Met Based Drugs | pmid:20454639 |
Kyrgidis A et al. | Melanoma: Stem cells, sun exposure and hallmarks for carcinogenesis, molecular concepts and future clinical implications. | 2010 | J Carcinog | pmid:20442802 |
Filak LK et al. | Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy. | 2010 | J. Biol. Inorg. Chem. | pmid:20369265 |
Zhuang P et al. | Effects of flavone on the oxidation-induced injury of retinal pigment epithelium cells. | 2010 | Int J Ophthalmol | pmid:22553529 |
Zhuang P et al. | Effect of flavone on the ocular blood flow and formation of choroidal neovascularization. | 2010 | Int J Ophthalmol | pmid:22553528 |
Semalty M et al. | Semecarpus anacardium Linn.: A review. | 2010 | Pharmacogn Rev | pmid:22228947 |
Wera M et al. | 2-(4-Fluoro-phen-yl)-3-hy-droxy-4H-chromen-4-one. | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21589426 |
van Tonder JH et al. | Racemic tricarbonyl[(4a,5,6,7,8,8a-η)-2-phenyl-3,4-dihydro-2H-1-benzopyran]chromium(0). | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21588503 |
Janeczko T et al. | 2-(4-Bromo-phen-yl)-6-methyl-4H-1-benzopyran-4-one (4'-bromo-6-methyl-flavone). | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21580767 |
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Dirscherl K et al. | Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype. | 2010 | J Neuroinflammation | pmid:20074346 |
Ono M et al. | 99mTc/Re complexes based on flavone and aurone as SPECT probes for imaging cerebral β-amyloid plaques. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20797860 |
Xu H et al. | Molecular cloning and characterization of phenylalanine ammonia-lyase, cinnamate 4-hydroxylase and genes involved in flavone biosynthesis in Scutellaria baicalensis. | 2010 | Bioresour. Technol. | pmid:20708926 |
Sabarinathan D et al. | Naringenin promote apoptosis in cerebrally implanted C6 glioma cells. | 2010 | Mol. Cell. Biochem. | pmid:20717707 |
Valdameri G et al. | Importance of the core structure of flavones in promoting inhibition of the mitochondrial respiratory chain. | 2010 | Chem. Biol. Interact. | pmid:20654598 |
Hanhineva K et al. | Impact of dietary polyphenols on carbohydrate metabolism. | 2010 | Int J Mol Sci | pmid:20480025 |
Alam MS and Lee DU | Facile synthesis and antibacterial activity of naturally occurring 5-methoxyfuroflavone. | 2010 | Chem. Pharm. Bull. | pmid:21139271 |
Dobritsa AA et al. | LAP5 and LAP6 encode anther-specific proteins with similarity to chalcone synthase essential for pollen exine development in Arabidopsis. | 2010 | Plant Physiol. | pmid:20442277 |
Hong TB et al. | Potential effects of chrysin on MDA-MB-231 cells. | 2010 | Int J Mol Sci | pmid:20479999 |
Perumal Samy R and Gopalakrishnakone P | Therapeutic Potential of Plants as Anti-microbials for Drug Discovery. | 2010 | Evid Based Complement Alternat Med | pmid:18955349 |
Alvarez G et al. | Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity. | 2010 | Eur J Med Chem | pmid:20889239 |
Masoodi TA and Alhamdanz AH | Inhibitory effect of flavonoids on mutant H-Rasp protein. | 2010 | Bioinformation | pmid:21346872 |
Lakshmi V et al. | Antifilarial activity in vitro and in vivo of some flavonoids tested against Brugia malayi. | 2010 | Acta Trop. | pmid:20609356 |
Yang Y et al. | Binding research on flavones as ligands of β-amyloid aggregates by fluorescence and their 3D-QSAR, docking studies. | 2010 | J. Mol. Graph. Model. | pmid:21094069 |
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Zhang C et al. | Functional characterization of cis-acting elements mediating flavone-inducible expression of CYP321A1. | 2010 | Insect Biochem. Mol. Biol. | pmid:20854909 |
Zhang Y et al. | Reproducibility and relative validity of a food frequency questionnaire to assess intake of dietary flavonol and flavone in Chinese university campus population. | 2010 | Nutr Res | pmid:20851305 |
Shaker E et al. | Anti-inflammatory and anti-ulcer activity of the extract from Alhagi maurorum (camelthorn). | 2010 | Food Chem. Toxicol. | pmid:20633591 |
Gautam N et al. | In-situ absorption, protein binding and pharmacokinetic studies of S002-853, a novel antidiabetic and antidyslipidaemic flavone derivative in rats. | 2010 | J. Pharm. Pharmacol. | pmid:20609062 |
Cesla P et al. | Separation of phenolic acids and flavone natural antioxidants by two-dimensional method combining liquid chromatography and micellar electrokinetic capillary chromatography. | 2010 | Electrophoresis | pmid:20593394 |
Fan Y et al. | Epimedium polysaccharide and propolis flavone can synergistically stimulate lymphocyte proliferation in vitro and enhance the immune responses to ND vaccine in chickens. | 2010 | Int. J. Biol. Macromol. | pmid:20562020 |
Picon PD et al. | Randomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia for chronic constipation. | 2010 | BMC Complement Altern Med | pmid:20433751 |
Liu XH et al. | Synthesis and molecular docking studies of novel 2-chloro-pyridine derivatives containing flavone moieties as potential antitumor agents. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20538457 |
Tian Y et al. | Anti-HBV active flavone glucosides from Euphorbia humifusa Willd. | 2010 | Fitoterapia | pmid:20450964 |
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Wang H et al. | Xeno-oestrogens and phyto-oestrogens are alternative ligands for the androgen receptor. | 2010 | Asian J. Androl. | pmid:20436506 |
Kosmider B et al. | Structure-activity relationship and apoptosis induction in A549 cells by the potential anticancer compound cis-bis(3-aminoflavone)dichloroplatinum(II). | 2010 | Arzneimittelforschung | pmid:20422947 |
Knjazeva T and Kaljurand M | Capillary electrophoresis frontal analysis for the study of flavonoid interactions with human serum albumin. | 2010 | Anal Bioanal Chem | pmid:20422159 |
Guendel I et al. | Inhibition of human immunodeficiency virus type-1 by cdk inhibitors. | 2010 | AIDS Res Ther | pmid:20334651 |
Yashiroda Y et al. | A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20214890 |
Ramful D et al. | Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: potential prophylactic ingredients for functional foods application. | 2010 | Toxicology | pmid:20100535 |
Echeverry C et al. | Pretreatment with natural flavones and neuronal cell survival after oxidative stress: a structure-activity relationship study. | 2010 | J. Agric. Food Chem. | pmid:20095615 |
Bacher M et al. | Complete 1H and 13C NMR data assignment of new constituents from Severinia buxifolia. | 2010 | Magn Reson Chem | pmid:19937908 |
Jandera P et al. | Dual hydrophilic interaction-RP retention mechanism on polar columns: structural correlations and implementation for 2-D separations on a single column. | 2010 | J Sep Sci | pmid:20087874 |
Kasai N et al. | Atypical kinetics of cytochromes P450 catalysing 3'-hydroxylation of flavone from the white-rot fungus Phanerochaete chrysosporium. | 2010 | J. Biochem. | pmid:19819902 |
Rajesh G et al. | Effect of hydroxyl substitution of flavone on angiogenesis and free radical scavenging activities: a structure-activity relationship studies using computational tools. | 2010 | Eur J Pharm Sci | pmid:19874890 |
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