MeSH term | MeSH ID | Detail |
---|---|---|
Neoplasm Invasiveness | D009361 | 23 associated lipids |
Lymphedema | D008209 | 4 associated lipids |
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kim DH et al. | Molecular characterization of flavonoid malonyltransferase from Oryza sativa. | 2009 Nov-Dec | Plant Physiol. Biochem. | pmid:19733090 |
Duchowicz PR et al. | QSAR analysis on Spodoptera litura antifeedant activities for flavone derivatives. | 2009 | Sci. Total Environ. | pmid:19846206 |
Jandera P and Hájek T | Utilization of dual retention mechanism on columns with bonded PEG and diol stationary phases for adjusting the separation selectivity of phenolic and flavone natural antioxidants. | 2009 | J Sep Sci | pmid:19839014 |
Geng X et al. | High selective purification of flavonoids from natural plants based on polymeric adsorbent with hydrogen-bonding interaction. | 2009 | J Chromatogr A | pmid:19837412 |
Zhang HM et al. | [Analysis of Belamcanda chinensis with space flight mutagenesis by FTIR]. | 2009 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:19798954 |
Rostom SA et al. | Synthesis and biological evaluation of some polymethoxylated fused pyridine ring systems as antitumor agents. | 2009 | Arch. Pharm. (Weinheim) | pmid:19714673 |
Cao H et al. | Arsenic accumulation in Scutellaria baicalensis Georgi and its effects on plant growth and pharmaceutical components. | 2009 | J. Hazard. Mater. | pmid:19577841 |
Kwak HS et al. | Marked individual variation in isoflavone metabolism after a soy challenge can modulate the skeletal effect of isoflavones in premenopausal women. | 2009 | J. Korean Med. Sci. | pmid:19794985 |
Xia C et al. | Differential effect of Shenmai injection, a herbal preparation, on the cytochrome P450 3A-mediated 1'-hydroxylation and 4-hydroxylation of midazolam. | 2009 | Chem. Biol. Interact. | pmid:19557931 |
Fiorentino A et al. | Identification and assessment of antioxidant capacity of phytochemicals from kiwi fruits. | 2009 | J. Agric. Food Chem. | pmid:19358604 |
Marian CM | Spin-forbidden transitions in flavone. | 2009 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:19264543 |
Jeong SH et al. | Tyrosinase inhibitory polyphenols from roots of Morus lhou. | 2009 | J. Agric. Food Chem. | pmid:19166303 |
Shukla S and Gupta S | Apigenin suppresses insulin-like growth factor I receptor signaling in human prostate cancer: an in vitro and in vivo study. | 2009 | Mol. Carcinog. | pmid:18726972 |
Lee EA et al. | Robustness of QTLs across germplasm pools using a model quantitative trait. | 2009 | Genome | pmid:19132070 |
Guo SS et al. | [The cytology mechanism of anti-parainfluenza virus infection of total flavone of Scutellaria barbata]. | 2009 | Yao Xue Xue Bao | pmid:21351467 |
Justino GC et al. | Electrospray ionization tandem mass spectrometry fragmentation of protonated flavone and flavonol aglycones: a re-examination. | 2009 | Rapid Commun. Mass Spectrom. | pmid:19089862 |
Alipieva KI et al. | An iridoid and a flavonoid from Sideritis lanata L. | 2009 | Fitoterapia | pmid:18938229 |
Yenjai C et al. | Structural modification of 5,7-dimethoxyflavone from Kaempferia parviflora and biological activities. | 2009 | Arch. Pharm. Res. | pmid:19784571 |
Cesla P et al. | Optimization of two-dimensional gradient liquid chromatography separations. | 2009 | J Chromatogr A | pmid:18804770 |
Tan WJ et al. | Bioactive compounds of inhibiting xanthine oxidase from Selaginella labordei. | 2009 | Nat. Prod. Res. | pmid:19296380 |
Bjorøy O et al. | C-glycosylanthocyanidins synthesized from C-glycosylflavones. | 2009 | Phytochemistry | pmid:19185884 |
Choi EJ and Kim GH | Apigenin Induces Apoptosis through a Mitochondria/Caspase-Pathway in Human Breast Cancer MDA-MB-453 Cells. | 2009 | J Clin Biochem Nutr | pmid:19430615 |
Froyen EB et al. | Regulation of phase II enzymes by genistein and daidzein in male and female Swiss Webster mice. | 2009 | J Med Food | pmid:20041775 |
Otaki N et al. | Distribution and major sources of flavonoid intakes in the middle-aged Japanese women. | 2009 | J Clin Biochem Nutr | pmid:19430611 |
Li Z et al. | Up-regulation of Toll-like receptor 4 was suppressed by emodin and baicalin in the setting of acute pancreatitis. | 2009 | Biomed. Pharmacother. | pmid:18343629 |
Furuta T et al. | Concise synthesis of chafurosides A and B. | 2009 | Org. Lett. | pmid:19473042 |
Zhou X et al. | Flavone and isoflavone derivatives of terrestrial plants as larval settlement inhibitors of the barnacle Balanus amphitrite. | 2009 | Biofouling | pmid:18855151 |
Jeon YM et al. | Biological synthesis of 7-O-methyl Apigenin from naringenin using escherichia coli expressing two genes. | 2009 | J. Microbiol. Biotechnol. | pmid:19494697 |
Zhu JT et al. | Estrogenic and neuroprotective properties of scutellarin from Erigeron breviscapus: a drug against postmenopausal symptoms and Alzheimer's disease. | 2009 | Planta Med. | pmid:19533578 |
López-Lázaro M | Distribution and biological activities of the flavonoid luteolin. | 2009 | Mini Rev Med Chem | pmid:19149659 |
Smit N et al. | The hunt for natural skin whitening agents. | 2009 | Int J Mol Sci | pmid:20054473 |
Cai H et al. | Flavones as colorectal cancer chemopreventive agents--phenol-o-methylation enhances efficacy. | 2009 | Cancer Prev Res (Phila) | pmid:19638489 |
Jin M et al. | Suppressive effects of T-412, a flavone on interleukin-4 production in T cells. | 2009 | Biol. Pharm. Bull. | pmid:19881301 |
Walle T | Methylation of dietary flavones increases their metabolic stability and chemopreventive effects. | 2009 | Int J Mol Sci | pmid:20087474 |
Ryu YB et al. | Structural characteristics of flavanones and flavones from Cudrania tricuspidata for neuraminidase inhibition. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19660948 |
Gunnarsson D et al. | Effects of dietary phytoestrogens on plasma testosterone and triiodothyronine (T3) levels in male goat kids. | 2009 | Acta Vet. Scand. | pmid:20003293 |
Chokchaisiri R et al. | Bioactive flavonoids of the flowers of Butea monosperma. | 2009 | Chem. Pharm. Bull. | pmid:19336944 |
Kang HK et al. | Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells. | 2009 | Arthritis Res. Ther. | pmid:19405952 |
Appeldoorn MM et al. | Some phenolic compounds increase the nitric oxide level in endothelial cells in vitro. | 2009 | J. Agric. Food Chem. | pmid:19722703 |
Androutsopoulos VP et al. | Anticancer effects of the flavonoid diosmetin on cell cycle progression and proliferation of MDA-MB 468 breast cancer cells due to CYP1 activation. | 2009 | Oncol. Rep. | pmid:19424633 |
Medić-Sarić M et al. | From functional food to medicinal product: systematic approach in analysis of polyphenolics from propolis and wine. | 2009 | Nutr J | pmid:19624827 |
Simons CC et al. | Dietary flavonol, flavone and catechin intake and risk of colorectal cancer in the Netherlands Cohort Study. | 2009 | Int. J. Cancer | pmid:19530252 |
Zhang ZF et al. | Separation and purification of two flavone glucuronides from Erigeron multiradiatus (Lindl.) Benth with macroporous resins. | 2009 | J. Biomed. Biotechnol. | pmid:19918373 |
Xu F et al. | Quasi-MSn identification of flavanone 7-glycoside isomers in Da Chengqi Tang by high performance liquid chromatography-tandem mass spectrometry. | 2009 | Chin Med | pmid:19630957 |
Liu Q et al. | Metabolism profile of scutellarin in urine following oral administration to rats by ultra performance liquid chromatography coupled to time-of-flight mass spectrometry. | 2009 | Talanta | pmid:19782195 |
Najmus-Saqib Q et al. | Antimicrobial and cytotoxicity activities of the medicinal plant Primula macrophylla. | 2009 | J Enzyme Inhib Med Chem | pmid:18686139 |
Göpfert JC et al. | Identification, functional characterization and developmental regulation of sesquiterpene synthases from sunflower capitate glandular trichomes. | 2009 | BMC Plant Biol. | pmid:19580670 |
Oyama T et al. | Dietary tricin suppresses inflammation-related colon carcinogenesis in male Crj: CD-1 mice. | 2009 | Cancer Prev Res (Phila) | pmid:19934339 |
Tanaka Y et al. | Recent progress of flower colour modification by biotechnology. | 2009 | Int J Mol Sci | pmid:20054474 |
Mohammed MM et al. | New acylated flavone and cyanogenic glycosides from Linum grandiflorum. | 2009 | Nat. Prod. Res. | pmid:19296395 |
Chang TL | Inhibitory effect of flavonoids on 26S proteasome activity. | 2009 | J. Agric. Food Chem. | pmid:19795881 |
Li ZF et al. | Emodin and baicalein inhibit pancreatic stromal derived factor-1 expression in rats with acute pancreatitis. | 2009 | HBPD INT | pmid:19357036 |
Yamada T et al. | New azaphilones, seco-chaetomugilins A and D, produced by a marine-fish-derived Chaetomium globosum. | 2009 | Mar Drugs | pmid:19597583 |
Lee E et al. | Inhibition of P-glycoprotein by wogonin is involved with the potentiation of etoposide-induced apoptosis in cancer cells. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723047 |
Tan M et al. | Synthesis, cytotoxic activity, and DNA binding properties of copper (II) complexes with hesperetin, naringenin, and apigenin. | 2009 | Bioinorg Chem Appl | pmid:19830248 |
Shin EK et al. | Chrysin, a natural flavone, improves murine inflammatory bowel diseases. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19233127 |
Bregestovski P et al. | Genetically encoded optical sensors for monitoring of intracellular chloride and chloride-selective channel activity. | 2009 | Front Mol Neurosci | pmid:20057911 |
Putz MV et al. | Quantum-SAR extension of the spectral-SAR algorithm: application to polyphenolic anticancer bioactivity. | 2009 | Int J Mol Sci | pmid:19399244 |
Baek I et al. | Flavone Attenuates Vascular Contractions by Inhibiting RhoA/Rho Kinase Pathway. | 2009 | Korean J. Physiol. Pharmacol. | pmid:19885038 |
Galla G et al. | Computational annotation of genes differentially expressed along olive fruit development. | 2009 | BMC Plant Biol. | pmid:19852839 |
Li N et al. | Proteomic analysis of differentially expressed proteins in hepatitis B virus-related hepatocellular carcinoma tissues. | 2009 | J. Exp. Clin. Cancer Res. | pmid:19715608 |
Masada S et al. | Functional and structural characterization of a flavonoid glucoside 1,6-glucosyltransferase from Catharanthus roseus. | 2009 | Plant Cell Physiol. | pmid:19561332 |
Yokohira M et al. | Lack of Modifying Effects of Intratracheal Instillation of Quartz or Dextran Sulfate Sodium (DSS) in Drinking Water on Lung Tumor Development Initiated with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Female A/J Mice. | 2009 | J Toxicol Pathol | pmid:22271992 |
Li HQ et al. | Synthesis of C(7) modified chrysin derivatives designing to inhibit beta-ketoacyl-acyl carrier protein synthase III (FabH) as antibiotics. | 2009 | Bioorg. Med. Chem. | pmid:19664929 |
Studholme DJ et al. | A draft genome sequence and functional screen reveals the repertoire of type III secreted proteins of Pseudomonas syringae pathovar tabaci 11528. | 2009 | BMC Genomics | pmid:19703286 |
Yoshimura S et al. | Inhibitory effect of flavonoids on the efflux of N-acetyl 5-aminosalicylic acid intracellularly formed in Caco-2 cells. | 2009 | J. Biomed. Biotechnol. | pmid:19688110 |
Maddocks KJ and Lin TS | Update in the management of chronic lymphocytic leukemia. | 2009 | J Hematol Oncol | pmid:19619273 |
Goettel W and Messing J | Change of gene structure and function by non-homologous end-joining, homologous recombination, and transposition of DNA. | 2009 | PLoS Genet. | pmid:19521498 |
Peng H et al. | A novel two mode-acting inhibitor of ABCG2-mediated multidrug transport and resistance in cancer chemotherapy. | 2009 | PLoS ONE | pmid:19479068 |
Bastos ML et al. | Studies on the antimicrobial activity and brine shrimp toxicity of Zeyheria tuberculosa (Vell.) Bur. (Bignoniaceae) extracts and their main constituents. | 2009 | Ann. Clin. Microbiol. Antimicrob. | pmid:19450272 |
Kim KS et al. | Inhibition of overexpressed CDC-25.1 phosphatase activity by flavone in Caenorhabditis elegans. | 2009 | Mol. Cells | pmid:19326082 |
Wang Y et al. | Inactivation of GSK-3beta by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling. | 2009 | Diabetes | pmid:19324938 |
Parekh HS et al. | A new dawn for the use of traditional Chinese medicine in cancer therapy. | 2009 | Mol. Cancer | pmid:19298677 |
Xiong HP et al. | 5,7-Dihydr-oxy-3,6,8-trimethoxy-flavone. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578970 |
Aree T and Sawasdee P | 3,5,7-Trimeth-oxy-2-(4-methoxy-phen-yl)-4H-1-benzopyran-4-one. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578306 |
Brunskole M et al. | Trihydroxynaphthalene reductase of Curvularia lunata--a target for flavonoid action? | 2009 | Chem. Biol. Interact. | pmid:19010313 |
Si D et al. | Mechanism of CYP2C9 inhibition by flavones and flavonols. | 2009 | Drug Metab. Dispos. | pmid:19074529 |
Aree T et al. | 5,7-Dimeth-oxy-2-(4-methoxy-phen-yl)-4H-1-benzopyran-4-one methanol solvate monohydrate. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578297 |
van Tonder JH et al. | Tricarbon-yl(η-flavone)chromium(0). | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578102 |
Chang TS | An updated review of tyrosinase inhibitors. | 2009 | Int J Mol Sci | pmid:19582213 |
Geraets L et al. | Inhibition of LPS-induced pulmonary inflammation by specific flavonoids. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19292976 |
Herath W et al. | Microbial metabolism. Part 10: Metabolites of 7,8-dimethoxyflavone and 5-methoxyflavone. | 2009 | Nat. Prod. Res. | pmid:19731142 |
Gong T et al. | Novel benzil and isoflavone derivatives from Millettia dielsiana. | 2009 | Planta Med. | pmid:19140097 |
Shimada T et al. | Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study. | 2009 | Chem. Res. Toxicol. | pmid:19563207 |
Karvela E et al. | Deployment of response surface methodology to optimise recovery of grape (Vitis vinifera) stem polyphenols. | 2009 | Talanta | pmid:19635365 |
Liu G et al. | On-line strategies for the identification of unknown flavone glycosides in Dracocephalum tanguticum Maxim. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19615954 |
Wang C et al. | [Advances in chemical components and pharmacology of genus Gentiana]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:20222408 |
Petroianu G et al. | Monitoring by HPLC of chamomile flavonoids exposed to rat liver microsomal metabolism. | 2009 | Open Med Chem J | pmid:19707521 |
Liu Z et al. | Protective effect of chrysoeriol against doxorubicin-induced cardiotoxicity in vitro. | 2009 | Chin. Med. J. | pmid:19951587 |
Ibanez S et al. | Plant chemical defence: a partner control mechanism stabilising plant--seed-eating pollinator mutualisms. | 2009 | BMC Evol. Biol. | pmid:19887006 |
Bao K et al. | Selective demethylation and debenzylation of aryl ethers by magnesium iodide under solvent-free conditions and its application to the total synthesis of natural products. | 2009 | Org. Biomol. Chem. | pmid:20024102 |
Lin Z et al. | Enhanced electrochemiluminescence of Ru(bpy)3(2+) by flavone compounds. | 2008 Nov-Dec | Luminescence | pmid:18506909 |
Nilsson J et al. | Azaflavones compared to flavones as ligands to the benzodiazepine binding site of brain GABA(A) receptors. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18851913 |
Li WW and Zhang ZT | Hexaquacobalt(II) bis(5-hydroxy-7-methoxy-4-oxo-2-phenyl-4H-chromene-6-sulfonate) tetrahydrate. | 2008 | Acta Crystallogr C | pmid:18391382 |
Mursu J et al. | Flavonoid intake and the risk of ischaemic stroke and CVD mortality in middle-aged Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study. | 2008 | Br. J. Nutr. | pmid:18377681 |
Seelinger G et al. | Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin. | 2008 | Planta Med. | pmid:18937165 |
He XZ et al. | Regioselective synthesis of plant (iso)flavone glycosides in Escherichia coli. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18568307 |
March RE et al. | Empirically predicted 13C NMR chemical shifts for 8-hydroxyflavone starting from 7,8,4'-trihydroxyflavone and from 7,8-dihydroxyflavone. | 2008 | Magn Reson Chem | pmid:18389493 |
Agbottah E et al. | Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways. | 2008 | AIDS Res Ther | pmid:18544167 |
Li GM et al. | [Effects of elevated carbon dioxide and ozone on the growth and secondary metabolism of spring wheat]. | 2008 | Ying Yong Sheng Tai Xue Bao | pmid:18808021 |