| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Lymphedema | D008209 | 4 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kanwar JR et al. | Vascular attack by 5,6-dimethylxanthenone-4-acetic acid combined with B7.1 (CD80)-mediated immunotherapy overcomes immune resistance and leads to the eradication of large tumors and multiple tumor foci. | 2001 | Cancer Res. | pmid:11280751 |
| Ching LM et al. | Induction of tumor necrosis factor-alpha messenger RNA in human and murine cells by the flavone acetic acid analogue 5,6-dimethylxanthenone-4-acetic acid (NSC 640488). | 1994 | Cancer Res. | pmid:8313372 |
| Shukla S et al. | Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice. | 2007 | Cancer Res. | pmid:17638904 |
| Sun JR and Brown JM | Enhancement of the antitumor effect of flavone acetic acid by the bioreductive cytotoxic drug SR 4233 in a murine carcinoma. | 1989 | Cancer Res. | pmid:2790784 |
| Cummings J et al. | Characterization of the major metabolites of flavone acetic acid and comparison of their disposition in humans and mice. | 1989 | Cancer Res. | pmid:2731178 |
| Wenzel U et al. | Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells. | 2000 | Cancer Res. | pmid:10919656 |
| Weiss RB et al. | Phase I and clinical pharmacology study of intravenous flavone acetic acid (NSC 347512). | 1988 | Cancer Res. | pmid:3167843 |
| Kerr DJ et al. | Phase I and pharmacokinetic study of LM985 (flavone acetic acid ester). | 1986 | Cancer Res. | pmid:3698028 |
| Evelhoch JL et al. | Flavone acetic acid (NSC 347512)-induced modulation of murine tumor physiology monitored by in vivo nuclear magnetic resonance spectroscopy. | 1988 | Cancer Res. | pmid:3409216 |
| Bissery MC et al. | Flavone acetic acid (NSC 347512)-induced DNA damage in Glasgow osteogenic sarcoma in vivo. | 1988 | Cancer Res. | pmid:3422592 |
| Ahmed-Belkacem A et al. | Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2. | 2005 | Cancer Res. | pmid:15930306 |
| Niho N et al. | Inhibition of intestinal carcinogenesis by a new flavone derivative, chafuroside, in oolong tea. | 2006 | Cancer Sci. | pmid:16630115 |
| Zaharko DS et al. | Therapeutic and pharmacokinetic relationships of flavone acetic acid: an agent with activity against solid tumors. | 1986 | Cancer Treat Rep | pmid:3791254 |
| Plowman J et al. | Flavone acetic acid: a novel agent with preclinical antitumor activity against colon adenocarcinoma 38 in mice. | 1986 | Cancer Treat Rep | pmid:3708611 |
| Fan Y et al. | The activation of Epimedium polysaccharide-propolis flavone liposome on Kupffer cells. | 2015 | Carbohydr Polym | pmid:26344320 |
| Gülcemal D et al. | Phenolic Glycosides with antiproteasomal activity from Centaurea urvillei DC. subsp. urvillei. | 2010 | Carbohydr. Res. | pmid:20937505 |
| do Nascimento AM and de Oliveira DC | A new 5-deoxyflavone glycoside from the aerial parts of Calea clausseniana. | 2007 | Carbohydr. Res. | pmid:17420009 |
| Sato S et al. | Total synthesis of three naturally occurring 6,8-di-C-glycosylflavonoids: phloretin, naringenin, and apigenin bis-C-beta-D-glucosides. | 2006 | Carbohydr. Res. | pmid:16545348 |
| Kumazawa T et al. | Synthesis of 8-C-glucosylflavones. | 2001 | Carbohydr. Res. | pmid:11513825 |
| Nijhoff WA et al. | Enhancement of rat hepatic and gastrointestinal glutathione and glutathione S-transferases by alpha-angelicalactone and flavone. | 1995 | Carcinogenesis | pmid:7697820 |
| Winkelmann I et al. | The suppression of aberrant crypt multiplicity in colonic tissue of 1,2-dimethylhydrazine-treated C57BL/6J mice by dietary flavone is associated with an increased expression of Krebs cycle enzymes. | 2007 | Carcinogenesis | pmid:17347140 |
| Singh RP et al. | Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate. | 2005 | Carcinogenesis | pmid:15637089 |
| Reiners JJ et al. | Suppression of cell cycle progression by flavonoids: dependence on the aryl hydrocarbon receptor. | 1999 | Carcinogenesis | pmid:10426807 |
| Kaur P et al. | Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study. | 2008 | Carcinogenesis | pmid:18725386 |
| Kang KW et al. | Activation of CCAAT/enhancer-binding protein beta by 2'-amino-3'-methoxyflavone (PD98059) leads to the induction of glutathione S-transferase A2. | 2003 | Carcinogenesis | pmid:12663507 |
| van der Logt EM et al. | Induction of rat hepatic and intestinal UDP-glucuronosyltransferases by naturally occurring dietary anticarcinogens. | 2003 | Carcinogenesis | pmid:12869420 |
| Roy D and Liehr JG | Metabolic oxidation of diethylstilbestrol to diethylstilbestrol-4',4"-quinone in Syrian hamsters. | 1989 | Carcinogenesis | pmid:2736717 |
| Dertinger SD et al. | Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo. | 2001 | Carcinogenesis | pmid:11159756 |
| Yamazoe Y et al. | Metabolic activation of a protein pyrolysate promutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by rat liver microsomes and purified cytochrome P-450. | 1988 | Carcinogenesis | pmid:3121205 |
| Wenzel U et al. | Ascorbic acid suppresses drug-induced apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions. | 2004 | Carcinogenesis | pmid:14754875 |
| Alworth WL and Slaga TJ | Effects of ellipticine, flavone, and 7,8-benzoflavone upon 7,12-dimethylbenz[a]anthracene, 7,14-dimethyldibenzo[a,h]anthracene and dibenzo[a,h]anthracene initiated skin tumors in mice. | 1985 | Carcinogenesis | pmid:3921269 |
| Jeon JG et al. | Natural products in caries research: current (limited) knowledge, challenges and future perspective. | 2011 | Caries Res. | pmid:21576957 |
| Polier G et al. | Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. | 2011 | Cell Death Dis | pmid:21776020 |
| Wenzel U et al. | Increased mitochondrial palmitoylcarnitine/carnitine countertransport by flavone causes oxidative stress and apoptosis in colon cancer cells. | 2005 | Cell. Mol. Life Sci. | pmid:16314920 |
| Shi L et al. | Gossypin induces G2/M arrest in human malignant glioma U251 cells by the activation of Chk1/Cdc25C pathway. | 2012 | Cell. Mol. Neurobiol. | pmid:21984341 |
| Wenzel U and Daniel H | Early and late apoptosis events in human transformed and non-transformed colonocytes are independent on intracellular acidification. | 2004 | Cell. Physiol. Biochem. | pmid:14976408 |
| Jung Y et al. | Plant-derived flavones as inhibitors of aurora B kinase and their quantitative structure-activity relationships. | 2015 | Chem Biol Drug Des | pmid:25298094 |
| Larroque-Lombard AL et al. | Synthesis and studies on three-compartment flavone-containing combi-molecules designed to target EGFR, DNA, and MEK. | 2011 | Chem Biol Drug Des | pmid:21294849 |
| Trusheva B et al. | Different extraction methods of biologically active components from propolis: a preliminary study. | 2007 | Chem Cent J | pmid:17880743 |
| Feng Y et al. | Iridoid glucosides and flavones from the aerial parts of Avicennia marina. | 2006 | Chem. Biodivers. | pmid:17193312 |
| Wu B and Wang J | Phenolic compounds from Selaginella moellendorfii. | 2011 | Chem. Biodivers. | pmid:21922662 |
| Iida N et al. | A new flavone xyloside and two new flavan-3-ol glucosides from Juniperus communis var. depressa. | 2007 | Chem. Biodivers. | pmid:17256732 |
| Wang TC et al. | Synthesis, and cytotoxic and antiplatelet activities of oxime- and methyloxime-containing flavone, isoflavone, and xanthone derivatives. | 2005 | Chem. Biodivers. | pmid:17191978 |
| Živković JČ et al. | Chemical Profiling and Assessment of Antineurodegenerative and Antioxidant Properties of Veronica teucrium L. and Veronica jacquinii Baumg. | 2017 | Chem. Biodivers. | pmid:28488389 |
| Xia C et al. | Differential effect of Shenmai injection, a herbal preparation, on the cytochrome P450 3A-mediated 1'-hydroxylation and 4-hydroxylation of midazolam. | 2009 | Chem. Biol. Interact. | pmid:19557931 |
| Tsuji PA and Walle T | Benzo[a]pyrene-induced cytochrome P450 1A and DNA binding in cultured trout hepatocytes - inhibition by plant polyphenols. | 2007 | Chem. Biol. Interact. | pmid:17583686 |
| Djeridane A et al. | Inhibition of porcine liver carboxylesterase by a new flavone glucoside isolated from Deverra scoparia. | 2008 | Chem. Biol. Interact. | pmid:18163984 |
| Valdameri G et al. | Importance of the core structure of flavones in promoting inhibition of the mitochondrial respiratory chain. | 2010 | Chem. Biol. Interact. | pmid:20654598 |
| Khan MS et al. | Methylated chrysin induces co-ordinated attenuation of the canonical Wnt and NF-kB signaling pathway and upregulates apoptotic gene expression in the early hepatocarcinogenesis rat model. | 2011 | Chem. Biol. Interact. | pmid:21554863 |
| Le Bon AM et al. | Inhibition of microsome-mediated binding of benzo[a]pyrene to DNA by flavonoids either in vitro or after dietary administration to rats. | 1992 | Chem. Biol. Interact. | pmid:1643669 |