MeSH term | MeSH ID | Detail |
---|---|---|
Neoplasm Invasiveness | D009361 | 23 associated lipids |
Lymphedema | D008209 | 4 associated lipids |
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Cao H et al. | Binding Citrus flavanones to human serum albumin: effect of structure on affinity. | 2011 | Mol. Biol. Rep. | pmid:20878474 |
Schmidt A et al. | Polymethylated myricetin in trichomes of the wild tomato species Solanum habrochaites and characterization of trichome-specific 3'/5'- and 7/4'-myricetin O-methyltransferases. | 2011 | Plant Physiol. | pmid:21343428 |
Bredebach M et al. | Three 2-oxoglutarate-dependent dioxygenase activities of Equisetum arvense L. forming flavone and flavonol from (2S)-naringenin. | 2011 | Phytochemistry | pmid:21353683 |
Wu LZ et al. | Two new flavone C-glycosides from Trollius ledebourii. | 2011 | Chem. Pharm. Bull. | pmid:22041076 |
Wu B and Wang J | Phenolic compounds from Selaginella moellendorfii. | 2011 | Chem. Biodivers. | pmid:21922662 |
Hamman C et al. | The use of ammonium hydroxide as an additive in supercritical fluid chromatography for achiral and chiral separations and purifications of small, basic medicinal molecules. | 2011 | J Chromatogr A | pmid:21939976 |
Bojić M et al. | Evaluation of antiaggregatory activity of flavonoid aglycone series. | 2011 | Nutr J | pmid:21745360 |
Shiromwar SS and Chidrawar VR | Combined effects of p-coumaric acid and naringenin against doxorubicin-induced cardiotoxicity in rats. | 2011 | Pharmacognosy Res | pmid:22022172 |
Nagib DA and MacMillan DW | Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis. | 2011 | Nature | pmid:22158245 |
Nigam A | Senescence (ageing) @ 2011. | 2011 | Indian J Dermatol | pmid:22345758 |
Kyselova Z | Toxicological aspects of the use of phenolic compounds in disease prevention. | 2011 | Interdiscip Toxicol | pmid:22319251 |
Thirupathy KP et al. | Neuropharmacological activity of Lippia nodiflora Linn. | 2011 | Pharmacognosy Res | pmid:22022169 |
Mazzio EA et al. | The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. | 2011 | Int J Mol Sci | pmid:21340000 |
Gohain M et al. | Racemic tricarbon-yl[7-meth-oxy-2-(η-phen-yl)chromane]-chromium(0). | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:21753961 |
Perry CN et al. | Xenotransplantation of mitochondrial electron transfer enzyme, Ndi1, in myocardial reperfusion injury. | 2011 | PLoS ONE | pmid:21339825 |
Marinova MD and Tchorbanov BP | Preparation of antioxidant enzymatic hydrolysates from honeybee-collected pollen using plant enzymes. | 2011 | Enzyme Res | pmid:21318132 |
Gauci AJ et al. | Identification of polyphenolic compounds and black tea extract as potent inhibitors of lipid membrane destabilization by Aβ₄₂ aggregates. | 2011 | J. Alzheimers Dis. | pmid:21891862 |
Pick A et al. | Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP). | 2011 | Bioorg. Med. Chem. | pmid:21354800 |
Novy P et al. | In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus. | 2011 | J. Antimicrob. Chemother. | pmid:21421582 |
An L et al. | Total flavonoids extracted from xiaobuxin-tang on the hyperactivity of hypothalamic-pituitary-adrenal axis in chronically stressed rats. | 2011 | Evid Based Complement Alternat Med | pmid:20028718 |
Fletcher JN et al. | In vitro evaluation of flavonoids from Eriodictyon californicum for antagonist activity against the bitterness receptor hTAS2R31. | 2011 | J. Agric. Food Chem. | pmid:22059530 |
Shi G et al. | Molecular characteristics and antitumor capacity of Glycan extracted from Cynomorium songaricum. | 2011 | Int. J. Biol. Macromol. | pmid:21396396 |
Jin J et al. | Design, synthesis and biological evaluation of new arylpiperazine derivatives bearing a flavone moiety as α1-adrenoceptor antagonists. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21236664 |
Baxter A et al. | Non-covalent inhibitors of rhinovirus 3C protease. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21183345 |
Manhita A et al. | Extracting natural dyes from wool--an evaluation of extraction methods. | 2011 | Anal Bioanal Chem | pmid:21416400 |
Zhang JW et al. | Structural elucidation of a new flavone from Sarcopyramis nepalensis. | 2011 | J Asian Nat Prod Res | pmid:21409688 |
Kumagai A et al. | A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells. | 2011 | PLoS ONE | pmid:22022544 |
Semwal RB et al. | Chemical constituents from the stem bark of Symplocos paniculata Thunb. with antimicrobial, analgesic and anti-inflammatory activities. | 2011 | J Ethnopharmacol | pmid:21354288 |
Kozics K et al. | Structure of flavonoids influences the degree inhibition of Benzo(a)pyrene - induced DNA damage and micronuclei in HepG2 cells. | 2011 | Neoplasma | pmid:21895405 |
Ohno S et al. | A bHLH transcription factor, DvIVS, is involved in regulation of anthocyanin synthesis in dahlia (Dahlia variabilis). | 2011 | J. Exp. Bot. | pmid:21765172 |
Mafuvadze B et al. | Apigenin blocks induction of vascular endothelial growth factor mRNA and protein in progestin-treated human breast cancer cells. | 2010 Sep-Oct | Menopause | pmid:20551847 |
Marczak Å et al. | Fragmentation pathways of acylated flavonoid diglucuronides from leaves of Medicago truncatula. | 2010 May-Jun | Phytochem Anal | pmid:19950391 |
Acharya A et al. | Redox regulation in cancer: a double-edged sword with therapeutic potential. | 2010 Jan-Feb | Oxid Med Cell Longev | pmid:20716925 |
Carneiro CD et al. | Effect of flavonoids on 2'-deoxyguanosine and DNA oxidation caused by singlet molecular oxygen. | 2010 Aug-Sep | Food Chem. Toxicol. | pmid:20561949 |
Yamada K et al. | A lipase inhibitor monoterpene and monoterpene glycosides from Monarda punctata. | 2010 | Phytochemistry | pmid:20832830 |
Han Y et al. | Ectopic expression of apple F3'H genes contributes to anthocyanin accumulation in the Arabidopsis tt7 mutant grown under nitrogen stress. | 2010 | Plant Physiol. | pmid:20357139 |
Xiang H et al. | Synthesis and biological evaluation of isoflavone fatty acid esters with potential weight loss and hypolipidemic activities. | 2010 | Bioorg. Med. Chem. | pmid:20392645 |
Wang P et al. | Structural basis for certain naturally occurring bioflavonoids to function as reducing co-substrates of cyclooxygenase I and II. | 2010 | PLoS ONE | pmid:20808785 |
Prajapati RP et al. | Phytochemical and pharmacological review of Lagenaria sicereria. | 2010 | J Ayurveda Integr Med | pmid:21731373 |
Kurian G et al. | A Novel Approach for Oral Delivery of Insulin via Desmodium gangeticum Aqueous Root Extract. | 2010 | J Young Pharm | pmid:21264119 |
Zou GA et al. | Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook. | 2010 | Molecules | pmid:20335965 |
Goodger JQ et al. | Isolation of intact sub-dermal secretory cavities from Eucalyptus. | 2010 | Plant Methods | pmid:20807444 |
Zhang A et al. | Augmented inhibition of angiogenesis by combination of HER2 antibody chA21 and trastuzumab in human ovarian carcinoma xenograft. | 2010 | J Ovarian Res | pmid:20723224 |
Lei W et al. | Molecular cloning and expression profiling of a chalcone synthase gene from hairy root cultures of Scutellaria viscidula Bunge. | 2010 | Genet. Mol. Biol. | pmid:21637484 |
Perez-Vizcaino F and Duarte J | Flavonols and cardiovascular disease. | 2010 | Mol. Aspects Med. | pmid:20837053 |
Büchner FL et al. | Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). | 2010 | Cancer Causes Control | pmid:19924549 |
Mays JR et al. | The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derrubone. | 2010 | Bioorg. Med. Chem. | pmid:19932969 |
Kanth BK et al. | Homology modeling, binding site identification and docking in flavone hydroxylase CYP105P2 in Streptomyces peucetius ATCC 27952. | 2010 | Comput Biol Chem | pmid:20889382 |
Zeng YW et al. | [The zonal characteristics and cultivated types difference of functional components in brown rice for core collection of Yunnan rice]. | 2010 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:21322246 |
Valant-Vetschera KM et al. | Chemodiversity of exudate flavonoids in Dionysia (Primulaceae): a comparative study. | 2010 | Phytochemistry | pmid:20378133 |