| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lymphedema | D008209 | 4 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Asthma | D001249 | 52 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lin Z et al. | Enhanced electrochemiluminescence of Ru(bpy)3(2+) by flavone compounds. | 2008 Nov-Dec | Luminescence | pmid:18506909 |
| Duchowicz PR et al. | QSAR analysis on Spodoptera litura antifeedant activities for flavone derivatives. | 2009 | Sci. Total Environ. | pmid:19846206 |
| Jandera P and Hájek T | Utilization of dual retention mechanism on columns with bonded PEG and diol stationary phases for adjusting the separation selectivity of phenolic and flavone natural antioxidants. | 2009 | J Sep Sci | pmid:19839014 |
| Geng X et al. | High selective purification of flavonoids from natural plants based on polymeric adsorbent with hydrogen-bonding interaction. | 2009 | J Chromatogr A | pmid:19837412 |
| Zhang HM et al. | [Analysis of Belamcanda chinensis with space flight mutagenesis by FTIR]. | 2009 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:19798954 |
| Rostom SA et al. | Synthesis and biological evaluation of some polymethoxylated fused pyridine ring systems as antitumor agents. | 2009 | Arch. Pharm. (Weinheim) | pmid:19714673 |
| Jeong SH et al. | Tyrosinase inhibitory polyphenols from roots of Morus lhou. | 2009 | J. Agric. Food Chem. | pmid:19166303 |
| Shukla S and Gupta S | Apigenin suppresses insulin-like growth factor I receptor signaling in human prostate cancer: an in vitro and in vivo study. | 2009 | Mol. Carcinog. | pmid:18726972 |
| Lee EA et al. | Robustness of QTLs across germplasm pools using a model quantitative trait. | 2009 | Genome | pmid:19132070 |
| Guo SS et al. | [The cytology mechanism of anti-parainfluenza virus infection of total flavone of Scutellaria barbata]. | 2009 | Yao Xue Xue Bao | pmid:21351467 |
| Justino GC et al. | Electrospray ionization tandem mass spectrometry fragmentation of protonated flavone and flavonol aglycones: a re-examination. | 2009 | Rapid Commun. Mass Spectrom. | pmid:19089862 |
| Alipieva KI et al. | An iridoid and a flavonoid from Sideritis lanata L. | 2009 | Fitoterapia | pmid:18938229 |
| Yenjai C et al. | Structural modification of 5,7-dimethoxyflavone from Kaempferia parviflora and biological activities. | 2009 | Arch. Pharm. Res. | pmid:19784571 |
| Cesla P et al. | Optimization of two-dimensional gradient liquid chromatography separations. | 2009 | J Chromatogr A | pmid:18804770 |
| Choi EJ and Kim GH | Apigenin Induces Apoptosis through a Mitochondria/Caspase-Pathway in Human Breast Cancer MDA-MB-453 Cells. | 2009 | J Clin Biochem Nutr | pmid:19430615 |
| Otaki N et al. | Distribution and major sources of flavonoid intakes in the middle-aged Japanese women. | 2009 | J Clin Biochem Nutr | pmid:19430611 |
| Li Z et al. | Up-regulation of Toll-like receptor 4 was suppressed by emodin and baicalin in the setting of acute pancreatitis. | 2009 | Biomed. Pharmacother. | pmid:18343629 |
| Zhou X et al. | Flavone and isoflavone derivatives of terrestrial plants as larval settlement inhibitors of the barnacle Balanus amphitrite. | 2009 | Biofouling | pmid:18855151 |
| Jeon YM et al. | Biological synthesis of 7-O-methyl Apigenin from naringenin using escherichia coli expressing two genes. | 2009 | J. Microbiol. Biotechnol. | pmid:19494697 |
| López-Lázaro M | Distribution and biological activities of the flavonoid luteolin. | 2009 | Mini Rev Med Chem | pmid:19149659 |
| Jin M et al. | Suppressive effects of T-412, a flavone on interleukin-4 production in T cells. | 2009 | Biol. Pharm. Bull. | pmid:19881301 |
| Ryu YB et al. | Structural characteristics of flavanones and flavones from Cudrania tricuspidata for neuraminidase inhibition. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19660948 |
| Gunnarsson D et al. | Effects of dietary phytoestrogens on plasma testosterone and triiodothyronine (T3) levels in male goat kids. | 2009 | Acta Vet. Scand. | pmid:20003293 |
| Chokchaisiri R et al. | Bioactive flavonoids of the flowers of Butea monosperma. | 2009 | Chem. Pharm. Bull. | pmid:19336944 |
| Kang HK et al. | Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells. | 2009 | Arthritis Res. Ther. | pmid:19405952 |
| Appeldoorn MM et al. | Some phenolic compounds increase the nitric oxide level in endothelial cells in vitro. | 2009 | J. Agric. Food Chem. | pmid:19722703 |
| Simons CC et al. | Dietary flavonol, flavone and catechin intake and risk of colorectal cancer in the Netherlands Cohort Study. | 2009 | Int. J. Cancer | pmid:19530252 |
| Zhang ZF et al. | Separation and purification of two flavone glucuronides from Erigeron multiradiatus (Lindl.) Benth with macroporous resins. | 2009 | J. Biomed. Biotechnol. | pmid:19918373 |
| Liu Q et al. | Metabolism profile of scutellarin in urine following oral administration to rats by ultra performance liquid chromatography coupled to time-of-flight mass spectrometry. | 2009 | Talanta | pmid:19782195 |
| Göpfert JC et al. | Identification, functional characterization and developmental regulation of sesquiterpene synthases from sunflower capitate glandular trichomes. | 2009 | BMC Plant Biol. | pmid:19580670 |
| Oyama T et al. | Dietary tricin suppresses inflammation-related colon carcinogenesis in male Crj: CD-1 mice. | 2009 | Cancer Prev Res (Phila) | pmid:19934339 |
| Chang TL | Inhibitory effect of flavonoids on 26S proteasome activity. | 2009 | J. Agric. Food Chem. | pmid:19795881 |
| Li ZF et al. | Emodin and baicalein inhibit pancreatic stromal derived factor-1 expression in rats with acute pancreatitis. | 2009 | HBPD INT | pmid:19357036 |
| Yamada T et al. | New azaphilones, seco-chaetomugilins A and D, produced by a marine-fish-derived Chaetomium globosum. | 2009 | Mar Drugs | pmid:19597583 |
| Lee E et al. | Inhibition of P-glycoprotein by wogonin is involved with the potentiation of etoposide-induced apoptosis in cancer cells. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723047 |
| Putz MV et al. | Quantum-SAR extension of the spectral-SAR algorithm: application to polyphenolic anticancer bioactivity. | 2009 | Int J Mol Sci | pmid:19399244 |
| Baek I et al. | Flavone Attenuates Vascular Contractions by Inhibiting RhoA/Rho Kinase Pathway. | 2009 | Korean J. Physiol. Pharmacol. | pmid:19885038 |
| Li HQ et al. | Synthesis of C(7) modified chrysin derivatives designing to inhibit beta-ketoacyl-acyl carrier protein synthase III (FabH) as antibiotics. | 2009 | Bioorg. Med. Chem. | pmid:19664929 |
| Goettel W and Messing J | Change of gene structure and function by non-homologous end-joining, homologous recombination, and transposition of DNA. | 2009 | PLoS Genet. | pmid:19521498 |
| Peng H et al. | A novel two mode-acting inhibitor of ABCG2-mediated multidrug transport and resistance in cancer chemotherapy. | 2009 | PLoS ONE | pmid:19479068 |
| Bastos ML et al. | Studies on the antimicrobial activity and brine shrimp toxicity of Zeyheria tuberculosa (Vell.) Bur. (Bignoniaceae) extracts and their main constituents. | 2009 | Ann. Clin. Microbiol. Antimicrob. | pmid:19450272 |
| Kim KS et al. | Inhibition of overexpressed CDC-25.1 phosphatase activity by flavone in Caenorhabditis elegans. | 2009 | Mol. Cells | pmid:19326082 |
| Wang Y et al. | Inactivation of GSK-3beta by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling. | 2009 | Diabetes | pmid:19324938 |
| Parekh HS et al. | A new dawn for the use of traditional Chinese medicine in cancer therapy. | 2009 | Mol. Cancer | pmid:19298677 |
| Brunskole M et al. | Trihydroxynaphthalene reductase of Curvularia lunata--a target for flavonoid action? | 2009 | Chem. Biol. Interact. | pmid:19010313 |
| Chang TS | An updated review of tyrosinase inhibitors. | 2009 | Int J Mol Sci | pmid:19582213 |
| Geraets L et al. | Inhibition of LPS-induced pulmonary inflammation by specific flavonoids. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19292976 |
| Herath W et al. | Microbial metabolism. Part 10: Metabolites of 7,8-dimethoxyflavone and 5-methoxyflavone. | 2009 | Nat. Prod. Res. | pmid:19731142 |
| Gong T et al. | Novel benzil and isoflavone derivatives from Millettia dielsiana. | 2009 | Planta Med. | pmid:19140097 |
| Liu Z et al. | Protective effect of chrysoeriol against doxorubicin-induced cardiotoxicity in vitro. | 2009 | Chin. Med. J. | pmid:19951587 |