FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypertension D006973 115 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

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Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Wang SQ et al. Flavonoids from Dracocephalum tanguticum and their cardioprotective effects against doxorubicin-induced toxicity in H9c2 cells. 2010 Bioorg. Med. Chem. Lett. pmid:20932762
Nilsson J et al. Azaflavones compared to flavones as ligands to the benzodiazepine binding site of brain GABA(A) receptors. 2008 Bioorg. Med. Chem. Lett. pmid:18851913
An JY et al. Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE2 in LPS-induced RAW 264.7 cells. 2017 Bioorg. Med. Chem. Lett. pmid:28408221
Nakagawa-Goto K et al. Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs. 2005 Bioorg. Med. Chem. Lett. pmid:15913998
Lebeau J et al. Beneficial effects of different flavonoids, on functional recovery after ischemia and reperfusion in isolated rat heart. 2001 Bioorg. Med. Chem. Lett. pmid:11140725
Balboni G et al. Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. 2012 Bioorg. Med. Chem. Lett. pmid:22487176
Hyup YH et al. 2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors. 2003 Bioorg. Med. Chem. Lett. pmid:12565941
Kang Y et al. Inhibitory potential of flavonoids on PtdIns(3,4,5)P3 binding with the phosphoinositide-dependent kinase 1 pleckstrin homology domain. 2017 Bioorg. Med. Chem. Lett. pmid:28049590
Ahmed N et al. Synthesis, characterization, and estrogen receptor binding affinity of flavone-, indole-, and furan-estradiol conjugates. 2007 Bioorg. Med. Chem. Lett. pmid:17379515
Shin SY et al. Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities. 2011 Bioorg. Med. Chem. Lett. pmid:21907578
Ono M et al. 99mTc/Re complexes based on flavone and aurone as SPECT probes for imaging cerebral β-amyloid plaques. 2010 Bioorg. Med. Chem. Lett. pmid:20797860
Gao L et al. 3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase. 2011 Bioorg. Med. Chem. Lett. pmid:21843936
Jin J et al. Design, synthesis and biological evaluation of new arylpiperazine derivatives bearing a flavone moiety as α1-adrenoceptor antagonists. 2011 Bioorg. Med. Chem. Lett. pmid:21236664
Baxter A et al. Non-covalent inhibitors of rhinovirus 3C protease. 2011 Bioorg. Med. Chem. Lett. pmid:21183345
Cabrera M et al. Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. 2007 Bioorg. Med. Chem. pmid:17383189
Kuemmerle J et al. Synthesis of caged 2,3,3a,7a-tetrahydro-3,6-methanobenzofuran-7(6H)-ones: Evaluating the minimum structure for apoptosis induction by gambogic acid. 2008 Bioorg. Med. Chem. pmid:18337106
Dei S et al. Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR). 2018 Bioorg. Med. Chem. pmid:29162309
Göker H et al. Synthesis and potent antimicrobial activity of some novel 2-phenyl or methyl-4H-1-benzopyran-4-ones carrying amidinobenzimidazoles. 2005 Bioorg. Med. Chem. pmid:15698788
Lewin G et al. Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk. 2011 Bioorg. Med. Chem. pmid:21146994
Li HQ et al. Synthesis of C(7) modified chrysin derivatives designing to inhibit beta-ketoacyl-acyl carrier protein synthase III (FabH) as antibiotics. 2009 Bioorg. Med. Chem. pmid:19664929