| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Julião Lde S et al. | Flavones and phenylpropanoids from a sedative extract of Lantana trifolia L. | 2010 | Phytochemistry | pmid:19922967 |
| Jahaniani F et al. | Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent. | 2005 | Phytochemistry | pmid:15949825 |
| Bjorøy O et al. | C-glycosylanthocyanidins synthesized from C-glycosylflavones. | 2009 | Phytochemistry | pmid:19185884 |
| Fossen T et al. | Covalent anthocyanin-flavone dimer from leaves of Oxalis triangularis. | 2007 | Phytochemistry | pmid:17182069 |
| Martens S and Mithöfer A | Flavones and flavone synthases. | 2005 | Phytochemistry | pmid:16137727 |
| Meng Y et al. | Flavones and flavone glycosides from Halophila johnsonii. | 2008 | Phytochemistry | pmid:18771781 |
| Tomazela DM et al. | Pyrano chalcones and a flavone from Neoraputia magnifica and their Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase-inhibitory activities. | 2000 | Phytochemistry | pmid:11130676 |
| Kong C et al. | Two compounds from allelopathic rice accession and their inhibitory activity on weeds and fungal pathogens. | 2004 | Phytochemistry | pmid:15110693 |
| Vieira RF et al. | Chemical profiling of Ocimum americanum using external flavonoids. | 2003 | Phytochemistry | pmid:12809716 |
| Wang HB et al. | Flavone glucosides with immunomodulatory activity from the leaves of Pleioblastus amarus. | 2004 | Phytochemistry | pmid:15081303 |
| Klein M et al. | The ABC-like vacuolar transporter for rye mesophyll flavone glucuronides is not species-specific. | 2001 | Phytochemistry | pmid:11219807 |
| DomÃnguez M et al. | Pensteminoside, an unusual catalpol-type iridoid from Penstemon gentianoides HBK (Plantaginaceae). | 2007 | Phytochemistry | pmid:17507063 |
| Albach DC et al. | Acylated flavone glycosides from Veronica. | 2003 | Phytochemistry | pmid:14599528 |
| Takeda K et al. | Components of protocyanin, a blue pigment from the blue flowers of Centaurea cyanus. | 2005 | Phytochemistry | pmid:16005311 |
| Budzianowski J et al. | Lipophilic flavones of Primula veris L. from field cultivation and in vitro cultures. | 2005 | Phytochemistry | pmid:15896373 |
| Hamilton ML et al. | Elucidation of the biosynthesis of the di-C-glycosylflavone isoschaftoside, an allelopathic component from Desmodium spp. that inhibits Striga spp. development. | 2012 | Phytochemistry | pmid:22959223 |
| Vitalini S et al. | Primula spectabilis Tratt. aerial parts: morphology, volatile compounds and flavonoids. | 2011 | Phytochemistry | pmid:21612805 |
| Saracoglu I et al. | Acylated flavonoids and phenol glycosides from Veronica thymoides subsp. pseudocinerea. | 2004 | Phytochemistry | pmid:15381011 |
| Veitch NC et al. | Flavonoid glycosides of the black locust tree, Robinia pseudoacacia (Leguminosae). | 2010 | Phytochemistry | pmid:19948349 |
| Matsuda H et al. | Inhibitory effects of thunberginols A and B isolated from Hydrangeae Dulcis Folium on mRNA expression of cytokines and on activation of activator protein-1 in RBL-2H3 cells. | 2008 | Phytomedicine | pmid:17950587 |
| Borges-Argáez R et al. | Cytotoxic and antiprotozoal activity of flavonoids from Lonchocarpus spp. | 2007 | Phytomedicine | pmid:17291734 |
| Varga Z et al. | Structure prerequisite for antioxidant activity of silybin in different biochemical systems in vitro. | 2006 | Phytomedicine | pmid:16360937 |
| Perez RM et al. | Isolation and hypoglycemic activity of 5, 7,3'-trihydroxy-3,6,4'-trimethoxyflavone from Brickellia veronicaefolia. | 2000 | Phytomedicine | pmid:10782487 |
| Flemmig J et al. | Olea europaea leaf (Ph.Eur.) extract as well as several of its isolated phenolics inhibit the gout-related enzyme xanthine oxidase. | 2011 | Phytomedicine | pmid:21144719 |
| Ulrich-Merzenich G et al. | Novel neurological and immunological targets for salicylate-based phytopharmaceuticals and for the anti-depressant imipramine. | 2012 | Phytomedicine | pmid:22743246 |
| Garritano S et al. | Assessment of estrogenic activity of flavonoids from Mediterranean plants using an in vitro short-term test. | 2005 | Phytomedicine | pmid:15693722 |
| Innocenti G et al. | In vitro estrogenic activity of Achillea millefolium L. | 2007 | Phytomedicine | pmid:16860978 |
| Soriano IR et al. | Inducible Flavone in Oats (Avena sativa) Is a Novel Defense Against Plant-Parasitic Nematodes. | 2004 | Phytopathology | pmid:18944456 |
| Nitoda T et al. | Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells. | 2008 | Phytother Res | pmid:18567053 |
| Mishra KP et al. | Effect of Seabuckthorn (Hippophae rhamnoides) flavone on immune system: an in-vitro approach. | 2008 | Phytother Res | pmid:18570236 |
| Takano-Ishikawa Y et al. | Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha. | 2003 | Phytother Res | pmid:14669262 |
| Blatt CT et al. | Cytotoxic flavonoids from the stem bark of Lonchocarpus aff. fluvialis. | 2002 | Phytother Res | pmid:12112286 |
| Shi Y et al. | Analgesic and uterine relaxant effects of isoliquiritigenin, a flavone from Glycyrrhiza glabra. | 2012 | Phytother Res | pmid:22389128 |
| Almeida JR et al. | 3,6-Dimethoxy-6″,6″-Dimethyl-(7,8,2″,3″)-Chromeneflavone, a Flavonoid Isolated from Lonchocarpus Araripensis Benth. (Fabaceae), Reduces Nociceptive Behaviour in Mice. | 2015 | Phytother Res | pmid:26172339 |
| Zhao J et al. | MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula. | 2011 | Plant Cell | pmid:21467581 |
| Martin C et al. | How can research on plants contribute to promoting human health? | 2011 | Plant Cell | pmid:21586682 |
| Akhtar TA et al. | Photosynthetic redox imbalance influences flavonoid biosynthesis in Lemna gibba. | 2010 | Plant Cell Environ. | pmid:20199616 |
| Yan J et al. | GmFNSII-controlled soybean flavone metabolism responds to abiotic stresses and regulates plant salt tolerance. | 2014 | Plant Cell Physiol. | pmid:24192294 |
| Masada S et al. | Functional and structural characterization of a flavonoid glucoside 1,6-glucosyltransferase from Catharanthus roseus. | 2009 | Plant Cell Physiol. | pmid:19561332 |
| Berim A et al. | Identification of a unique 2-oxoglutarate-dependent flavone 7-O-demethylase completes the elucidation of the lipophilic flavone network in basil. | 2015 | Plant Cell Physiol. | pmid:25378691 |
| Stipcevic T et al. | Effect of different flavonoids on collagen synthesis in human fibroblasts. | 2006 | Plant Foods Hum Nutr | pmid:16642409 |
| Stracke R et al. | Differential regulation of closely related R2R3-MYB transcription factors controls flavonol accumulation in different parts of the Arabidopsis thaliana seedling. | 2007 | Plant J. | pmid:17419845 |
| Berim A et al. | Unexpected roles for ancient proteins: flavone 8-hydroxylase in sweet basil trichomes is a Rieske-type, PAO-family oxygenase. | 2014 | Plant J. | pmid:25139498 |
| Goodger JQ et al. | Isolation of intact sub-dermal secretory cavities from Eucalyptus. | 2010 | Plant Methods | pmid:20807444 |
| Zhang P et al. | A maize QTL for silk maysin levels contains duplicated Myb-homologous genes which jointly regulate flavone biosynthesis. | 2003 | Plant Mol. Biol. | pmid:12825685 |
| Yan J et al. | The soybean R2R3 MYB transcription factor GmMYB100 negatively regulates plant flavonoid biosynthesis. | 2015 | Plant Mol. Biol. | pmid:26231207 |
| Schmidt A et al. | Polymethylated myricetin in trichomes of the wild tomato species Solanum habrochaites and characterization of trichome-specific 3'/5'- and 7/4'-myricetin O-methyltransferases. | 2011 | Plant Physiol. | pmid:21343428 |
| Han Y et al. | Ectopic expression of apple F3'H genes contributes to anthocyanin accumulation in the Arabidopsis tt7 mutant grown under nitrogen stress. | 2010 | Plant Physiol. | pmid:20357139 |
| Berim A et al. | A set of regioselective O-methyltransferases gives rise to the complex pattern of methoxylated flavones in sweet basil. | 2012 | Plant Physiol. | pmid:22923679 |
| Frangne N et al. | Flavone glucoside uptake into barley mesophyll and Arabidopsis cell culture vacuoles. Energization occurs by H(+)-antiport and ATP-binding cassette-type mechanisms. | 2002 | Plant Physiol. | pmid:11842175 |