| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Aslan E and Adem S | In vitro effects of some flavones on human pyruvate kinase isoenzyme M2. | 2015 | J. Biochem. Mol. Toxicol. | pmid:25388478 |
| Yan J et al. | The soybean R2R3 MYB transcription factor GmMYB100 negatively regulates plant flavonoid biosynthesis. | 2015 | Plant Mol. Biol. | pmid:26231207 |
| Almeida JR et al. | 3,6-Dimethoxy-6″,6″-Dimethyl-(7,8,2″,3″)-Chromeneflavone, a Flavonoid Isolated from Lonchocarpus Araripensis Benth. (Fabaceae), Reduces Nociceptive Behaviour in Mice. | 2015 | Phytother Res | pmid:26172339 |
| Hong H et al. | Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. | 2015 | Toxicol. Sci. | pmid:25349334 |
| Liu B et al. | Biocompatible flavone-based fluorogenic probes for quick wash-free mitochondrial imaging in living cells. | 2014 | ACS Appl Mater Interfaces | pmid:25382851 |
| Cassidy A et al. | Intake of dietary flavonoids and risk of epithelial ovarian cancer. | 2014 | Am. J. Clin. Nutr. | pmid:25332332 |
| Rossi M and La Vecchia C | Flavonoids and the risk of ovarian cancer. | 2014 | Am. J. Clin. Nutr. | pmid:25332318 |
| Zhang C et al. | Common and unique cis-acting elements mediate xanthotoxin and flavone induction of the generalist P450 CYP321A1. | 2014 | Sci Rep | pmid:25262756 |
| Zhang M et al. | Comparison of flavonoid compounds in the flavedo and juice of two pummelo cultivars (Citrus grandis L. Osbeck) from different cultivation regions in China. | 2014 | Molecules | pmid:25353383 |
| Barreca D et al. | First evidence of C- and O-glycosyl flavone in blood orange (Citrus sinensis (L.) Osbeck) juice and their influence on antioxidant properties. | 2014 | Food Chem | pmid:24295703 |
| Zhang H et al. | Stimulatory effect of nobiletin, a citrus polymethoxy flavone, on catecholamine synthesis through Ser19 and Ser40 phosphorylation of tyrosine hydroxylase in cultured bovine adrenal medullary cells. | 2014 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:24043291 |
| Chen LX et al. | A new flavonoid from the aerial parts of Andrographis paniculata. | 2014 | Nat. Prod. Res. | pmid:24236635 |
| Zhao HN et al. | [A new flavone C-glycoside from leaves of Lophatherum gracile]. | 2014 | Zhongguo Zhong Yao Za Zhi | pmid:24761639 |
| Chen X et al. | Effects of epimedium polysaccharide-propolis flavone oral liquid on mucosal immunity in chickens. | 2014 | Int. J. Biol. Macromol. | pmid:24296407 |
| He R et al. | [Chemical constituents of leaves of Panax japonicus var. major]. | 2014 | Zhongguo Zhong Yao Za Zhi | pmid:25095375 |
| Liu B et al. | Flavone-based ESIPT ratiometric chemodosimeter for detection of cysteine in living cells. | 2014 | ACS Appl Mater Interfaces | pmid:24571859 |
| Amato E et al. | Investigation of fluorinated and bifunctionalized 3-phenylchroman-4-one (isoflavanone) aromatase inhibitors. | 2014 | Bioorg. Med. Chem. | pmid:24345481 |
| Kim M et al. | Metabolism of Kaempferia parviflora polymethoxyflavones by human intestinal bacterium Bautia sp. MRG-PMF1. | 2014 | J. Agric. Food Chem. | pmid:25437273 |
| Król-Kogus B et al. | Application of one- and two-dimensional high-performance liquid chromatography methodologies for the analysis of C-glycosylflavones from fenugreek seeds. | 2014 | J Chromatogr A | pmid:25282311 |
| Feng XT et al. | Pollen Typhae total flavone improves insulin resistance in high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats. | 2014 | Biosci. Biotechnol. Biochem. | pmid:25273139 |