| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cabrera M et al. | Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. | 2010 | Bioorg. Med. Chem. | pmid:20639112 |
| Chen IL et al. | Synthesis and antiproliferative evaluation of amide-containing flavone and isoflavone derivatives. | 2008 | Bioorg. Med. Chem. | pmid:18662883 |
| Lin YM et al. | Chalcones and flavonoids as anti-tuberculosis agents. | 2002 | Bioorg. Med. Chem. | pmid:12057669 |
| Springsteel MF et al. | Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. | 2003 | Bioorg. Med. Chem. | pmid:12927873 |
| Betti L et al. | Design, synthesis, and alpha(1)-adrenoceptor binding properties of new arylpiperazine derivatives bearing a flavone nucleus as the terminal heterocyclic molecular portion. | 2004 | Bioorg. Med. Chem. | pmid:15018926 |
| Ono M et al. | Synthesis and characterization of styrylchromone derivatives as beta-amyloid imaging agents. | 2007 | Bioorg. Med. Chem. | pmid:17035032 |
| Lameira J et al. | Structure-activity relationship study of flavone compounds with anti-HIV-1 integrase activity: a density functional theory study. | 2006 | Bioorg. Med. Chem. | pmid:16890444 |
| Kubo I et al. | Flavonols from Heterotheca inuloides: tyrosinase inhibitory activity and structural criteria. | 2000 | Bioorg. Med. Chem. | pmid:10976523 |
| Dong X et al. | Identification of SVM-based classification model, synthesis and evaluation of prenylated flavonoids as vasorelaxant agents. | 2008 | Bioorg. Med. Chem. | pmid:18678502 |
| Greeff J et al. | Antioxidant properties of 4-quinolones and structurally related flavones. | 2012 | Bioorg. Med. Chem. | pmid:22197671 |
| Iori F et al. | Theoretical quantitative structure-activity relationships of flavone ligands interacting with cytochrome P450 1A1 and 1A2 isozymes. | 2005 | Bioorg. Med. Chem. | pmid:15914008 |
| Malolanarasimhan K et al. | Synthesis and biological study of a flavone acetic acid analogue containing an azido reporting group designed as a multifunctional binding site probe. | 2005 | Bioorg. Med. Chem. | pmid:15781383 |
| Amato E et al. | Investigation of fluorinated and bifunctionalized 3-phenylchroman-4-one (isoflavanone) aromatase inhibitors. | 2014 | Bioorg. Med. Chem. | pmid:24345481 |
| Valenti P et al. | Synthesis and biological activity of some rigid analogues of flavone-8-acetic acid. | 2000 | Bioorg. Med. Chem. | pmid:10968283 |
| Marder M et al. | Molecular modeling and QSAR analysis of the interaction of flavone derivatives with the benzodiazepine binding site of the GABA(A) receptor complex. | 2001 | Bioorg. Med. Chem. | pmid:11249125 |
| Pick A et al. | Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP). | 2011 | Bioorg. Med. Chem. | pmid:21354800 |
| Lewin G et al. | Influence of the skeleton on the cytotoxicity of flavonoids. | 2012 | Bioorg. Med. Chem. | pmid:22257529 |
| Liu H et al. | New synthetic flavone derivatives induce apoptosis of hepatocarcinoma cells. | 2010 | Bioorg. Med. Chem. | pmid:20674374 |
| Wang SQ et al. | Flavonoids from Dracocephalum tanguticum and their cardioprotective effects against doxorubicin-induced toxicity in H9c2 cells. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20932762 |
| Nilsson J et al. | Azaflavones compared to flavones as ligands to the benzodiazepine binding site of brain GABA(A) receptors. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18851913 |
| Chen WQ et al. | A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22901896 |
| An JY et al. | Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE2 in LPS-induced RAW 264.7 cells. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28408221 |
| Nakagawa-Goto K et al. | Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15913998 |
| Auffret G et al. | Synthesis and antimalarial evaluation of a series of piperazinyl flavones. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17166718 |
| Ryu YB et al. | Structural characteristics of flavanones and flavones from Cudrania tricuspidata for neuraminidase inhibition. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19660948 |
| Lebeau J et al. | Beneficial effects of different flavonoids, on functional recovery after ischemia and reperfusion in isolated rat heart. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11140725 |
| Balboni G et al. | Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22487176 |
| Choe H et al. | Structure-based design of flavone-based inhibitors of wild-type and T315I mutant of ABL. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23790540 |
| Hyup YH et al. | 2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12565941 |
| Tamura S et al. | New inhibitors for expression of IgE receptor on human mast cell. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20202836 |
| Kang Y et al. | Inhibitory potential of flavonoids on PtdIns(3,4,5)P3 binding with the phosphoinositide-dependent kinase 1 pleckstrin homology domain. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28049590 |
| Hatnapure GD et al. | Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22981334 |
| Ahmed N et al. | Synthesis, characterization, and estrogen receptor binding affinity of flavone-, indole-, and furan-estradiol conjugates. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17379515 |
| Shin SY et al. | Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21907578 |
| Ono M et al. | 99mTc/Re complexes based on flavone and aurone as SPECT probes for imaging cerebral β-amyloid plaques. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20797860 |
| Gao L et al. | 3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21843936 |
| Jin J et al. | Design, synthesis and biological evaluation of new arylpiperazine derivatives bearing a flavone moiety as α1-adrenoceptor antagonists. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21236664 |
| Baxter A et al. | Non-covalent inhibitors of rhinovirus 3C protease. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21183345 |
| Liu XH et al. | Synthesis and molecular docking studies of novel 2-chloro-pyridine derivatives containing flavone moieties as potential antitumor agents. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20538457 |
| Aboul-Enein HY et al. | Scavenging effects of phenolic compounds on reactive oxygen species. | 2007 | Biopolymers | pmid:17373654 |
| Xu H et al. | Molecular cloning and characterization of phenylalanine ammonia-lyase, cinnamate 4-hydroxylase and genes involved in flavone biosynthesis in Scutellaria baicalensis. | 2010 | Bioresour. Technol. | pmid:20708926 |
| Kim JH et al. | Characterization of flavonoid 7-O-glucosyltransferase from Arabidopsis thaliana. | 2006 | Biosci. Biotechnol. Biochem. | pmid:16794327 |
| Kanho H et al. | Glucosylation of phenolic compounds by Pharbitis nil hairy roots: I. Glucosylation of coumarin and flavone derivatives. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15502347 |
| Ueda H et al. | A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-alpha production. | 2004 | Biosci. Biotechnol. Biochem. | pmid:14745173 |
| Han DH et al. | Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12224631 |
| Matsui T et al. | Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of alpha-glucosidase action. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12005074 |
| Gao H et al. | Structure-activity relationships for alpha-glucosidase inhibition of baicalein, 5,6,7-trihydroxyflavone: the effect of A-ring substitution. | 2004 | Biosci. Biotechnol. Biochem. | pmid:14981300 |
| Yun CS et al. | Expression of parsley flavone synthase I establishes the flavone biosynthetic pathway in Arabidopsis thaliana. | 2008 | Biosci. Biotechnol. Biochem. | pmid:18391443 |
| Feng XT et al. | Pollen Typhae total flavone improves insulin resistance in high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats. | 2014 | Biosci. Biotechnol. Biochem. | pmid:25273139 |
| Watanabe J et al. | Coumarin and flavone derivatives from estragon and thyme as inhibitors of chemical mediator release from RBL-2H3 Cells. | 2005 | Biosci. Biotechnol. Biochem. | pmid:15665459 |