| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yushchenko DA et al. | Sensing of adenosine-5'-triphosphate anion in aqueous solutions and mitochondria by a fluorescent 3-hydroxyflavone dye. | 2007 | Anal. Biochem. | pmid:17568555 |
| Huang GC et al. | Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophages. | 2007 | Int. Immunopharmacol. | pmid:17570322 |
| Sagar SM et al. | Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 1. | 2006 | Curr Oncol | pmid:17576437 |
| Tsuji PA and Walle T | Benzo[a]pyrene-induced cytochrome P450 1A and DNA binding in cultured trout hepatocytes - inhibition by plant polyphenols. | 2007 | Chem. Biol. Interact. | pmid:17583686 |
| Bontempo P et al. | Feijoa sellowiana derived natural Flavone exerts anti-cancer action displaying HDAC inhibitory activities. | 2007 | Int. J. Biochem. Cell Biol. | pmid:17604209 |
| Jung SM et al. | Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels. | 2007 | Arthritis Res. Ther. | pmid:17612394 |
| Shukla S et al. | Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice. | 2007 | Cancer Res. | pmid:17638904 |
| Geraets L et al. | Flavone as PARP-1 inhibitor: its effect on lipopolysaccharide induced gene-expression. | 2007 | Eur. J. Pharmacol. | pmid:17643414 |
| Zeng Y et al. | Baicalin reduces the severity of experimental autoimmune encephalomyelitis. | 2007 | Braz. J. Med. Biol. Res. | pmid:17653455 |
| Pham MH et al. | Identification of new flavone-8-acetic acid metabolites using mouse microsomes and comparison with human microsomes. | 2007 | Drug Metab. Dispos. | pmid:17664249 |
| Jung SH et al. | Aldose reductase and advanced glycation endproducts inhibitory effect of Phyllostachys nigra. | 2007 | Biol. Pharm. Bull. | pmid:17666823 |
| Liu S et al. | Anticancer activity and quantitative analysis of flavone of Cirsium japonicum DC. | 2007 | Nat. Prod. Res. | pmid:17680503 |
| Enomoto R et al. | Wogonin prevents glucocorticoid-induced thymocyte apoptosis without diminishing its anti-inflammatory action. | 2007 | J. Pharmacol. Sci. | pmid:17690528 |
| Lee HS et al. | In vitro metabolism of eupatilin by multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes. | 2007 | Xenobiotica | pmid:17701830 |
| Walle UK and Walle T | Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones. | 2007 | Drug Metab. Dispos. | pmid:17709371 |
| Wu Y et al. | [Effects of the total flavone of radix puerariae on apoptotic cell and apoptotic related-gene in atherosclerotic plaques of apoE gene deficiency mice]. | 2007 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:17711723 |
| Burns DC et al. | A predictive tool for assessing (13)C NMR chemical shifts of flavonoids. | 2007 | Magn Reson Chem | pmid:17729229 |
| Yadava RN and Tiwari L | New antifungal flavone glycoside from Butea monosperma O. Kuntze. | 2007 | J Enzyme Inhib Med Chem | pmid:17847718 |
| Jeon SB et al. | Flavone inhibits vascular contraction by decreasing phosphorylation of the myosin phosphatase target subunit. | 2007 | Clin. Exp. Pharmacol. Physiol. | pmid:17880363 |
| Trusheva B et al. | Different extraction methods of biologically active components from propolis: a preliminary study. | 2007 | Chem Cent J | pmid:17880743 |
| Pham MH et al. | Characterization of monohydroxylated derivatives of the anticancer agent flavone-8-acetic acid by liquid chromatography with on-line UV and mass spectrometry. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17891752 |
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| Matsuda H et al. | Inhibitory effects of thunberginols A and B isolated from Hydrangeae Dulcis Folium on mRNA expression of cytokines and on activation of activator protein-1 in RBL-2H3 cells. | 2008 | Phytomedicine | pmid:17950587 |
| Jung J et al. | Inhibition of estrogen action by 2-phenylchromone as AhR agonist in MCF-7 cells. | 2007 | Life Sci. | pmid:17950758 |
| Billard C et al. | Flavopiridol-induced iNOS downregulation during apoptosis of chronic lymphocytic leukemia cells is caspase-dependent. | 2008 | Leuk. Res. | pmid:17981326 |
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| Young J et al. | Antimicrobial effects of flavone analogues and their structure-activity relationships. | 2007 | J. Microbiol. Biotechnol. | pmid:18050960 |
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| Liao SY et al. | QSAR, action mechanism and molecular design of flavone and isoflavone derivatives with cytotoxicity against HeLa. | 2008 | Eur J Med Chem | pmid:18082913 |
| Barbera M et al. | The ability of coumarin-, flavanon- and flavonol-analogues of flavone acetic acid to stimulate human monocytes. | 2008 | Oncol. Rep. | pmid:18097594 |
| Djeridane A et al. | Inhibition of porcine liver carboxylesterase by a new flavone glucoside isolated from Deverra scoparia. | 2008 | Chem. Biol. Interact. | pmid:18163984 |
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| Wang XL et al. | Effects of eleven flavonoids from the osteoprotective fraction of Drynaria fortunei (KUNZE) J. SM. on osteoblastic proliferation using an osteoblast-like cell line. | 2008 | Chem. Pharm. Bull. | pmid:18175973 |
| Yamada P et al. | Inhibitory effect of various Tunisian olive oils on chemical mediator release and cytokine production by basophilic cells. | 2008 | J Ethnopharmacol | pmid:18178046 |
| Shanmugam K et al. | Plant-derived polyphenols attenuate lipopolysaccharide-induced nitric oxide and tumour necrosis factor production in murine microglia and macrophages. | 2008 | Mol Nutr Food Res | pmid:18186104 |
| Bovee TF et al. | Screening of synthetic and plant-derived compounds for (anti)estrogenic and (anti)androgenic activities. | 2008 | Anal Bioanal Chem | pmid:18188547 |
| Quintieri L et al. | Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes. | 2008 | Biochem. Pharmacol. | pmid:18191104 |
| Winkelmann I et al. | Proteome response in HT-29 human colorectal cancer cells to two apoptosis-inducing compounds with different mode of action. | 2008 | Int. J. Cancer | pmid:18214853 |
| Tarling CA et al. | The search for novel human pancreatic alpha-amylase inhibitors: high-throughput screening of terrestrial and marine natural product extracts. | 2008 | Chembiochem | pmid:18214874 |
| Ramajayam R et al. | Synthesis and antiproliferative activity of some diaryldiazepines and diarylpyrimidines. | 2007 | J Enzyme Inhib Med Chem | pmid:18237024 |
| Gobbo-Neto L and Lopes NP | Online identification of chlorogenic acids, sesquiterpene lactones, and flavonoids in the Brazilian arnica Lychnophora ericoides Mart. (Asteraceae) leaves by HPLC-DAD-MS and HPLC-DAD-MS/MS and a validated HPLC-DAD method for their simultaneous analysis. | 2008 | J. Agric. Food Chem. | pmid:18237124 |
| Takahashi-Ando N et al. | A screening system for inhibitors of trichothecene biosynthesis: hydroxylation of trichodiene as a target. | 2008 | Biotechnol. Lett. | pmid:18239857 |
| Mirzoeva S et al. | Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells. | 2008 | Mol. Carcinog. | pmid:18240292 |
| Hämäläinen M et al. | Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. | 2007 | Mediators Inflamm. | pmid:18274639 |
| Campos DA et al. | Gastroprotective effect of a flavone from Lonchocarpus araripensis Benth. (Leguminosae) and the possible mechanism. | 2008 | J. Pharm. Pharmacol. | pmid:18284821 |
| Takada Y et al. | Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells. | 2008 | Mol. Pharmacol. | pmid:18287248 |
| Henry EC and Gasiewicz TA | Molecular determinants of species-specific agonist and antagonist activity of a substituted flavone towards the aryl hydrocarbon receptor. | 2008 | Arch. Biochem. Biophys. | pmid:18294953 |
| Heller G et al. | Transcriptional analysis of Pinus sylvestris roots challenged with the ectomycorrhizal fungus Laccaria bicolor. | 2008 | BMC Plant Biol. | pmid:18298811 |
| Lee YJ et al. | Characterization of flavone synthase I from rice. | 2008 | BMB Rep | pmid:18304453 |
| Cerqueira F et al. | The natural prenylated flavone artelastin is an inhibitor of ROS and NO production. | 2008 | Int. Immunopharmacol. | pmid:18328452 |
| Kuemmerle J et al. | Synthesis of caged 2,3,3a,7a-tetrahydro-3,6-methanobenzofuran-7(6H)-ones: Evaluating the minimum structure for apoptosis induction by gambogic acid. | 2008 | Bioorg. Med. Chem. | pmid:18337106 |
| Sarkar M et al. | Polarity dependence of the radiative and nonradiative rates of flavone derivatives comprising structurally similar amino moieties: change in the nature of the emitting state. | 2008 | J Phys Chem A | pmid:18338875 |
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| Cui XQ et al. | A new Diels-Alder type adduct and two new flavones from the stem bark of Morus yunanensis Koidz. | J Asian Nat Prod Res | pmid:18348061 | |
| Lagiou P et al. | Flavonoid intake and liver cancer: a case-control study in Greece. | 2008 | Cancer Causes Control | pmid:18350370 |
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| Herath W et al. | Microbial metabolism part 9. Structure and antioxidant significance of the metabolites of 5,7-dihydroxyflavone (chrysin), and 5- and 6-hydroxyflavones. | 2008 | Chem. Pharm. Bull. | pmid:18379084 |
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| Diniz A et al. | Characterization of interactions between polyphenolic compounds and human serum proteins by capillary electrophoresis. | 2008 | Anal Bioanal Chem | pmid:18418586 |
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| Nirmal J et al. | Evaluation of behavioural and antioxidant activity of Cytisus scoparius Link in rats exposed to chronic unpredictable mild stress. | 2008 | BMC Complement Altern Med | pmid:18435835 |
| Anbazhagan V et al. | Investigations on the fluorescence quenching of 2,3-diazabicyclo[2.2.2]oct-2-ene by certain flavonoids. | 2008 | J. Photochem. Photobiol. B, Biol. | pmid:18440819 |
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| Li GR et al. | Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs. | 2008 | Circulation | pmid:18458165 |
| Mori M et al. | Cyanosalvianin, a supramolecular blue metalloanthocyanin, from petals of Salvia uliginosa. | 2008 | Phytochemistry | pmid:18466933 |
| Rudolf JL et al. | The influence of diet composition on phase I and II biotransformation enzyme induction. | 2008 | Arch. Toxicol. | pmid:18488195 |
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| Lin Z et al. | Enhanced electrochemiluminescence of Ru(bpy)3(2+) by flavone compounds. | 2008 Nov-Dec | Luminescence | pmid:18506909 |
| Ulanovskaya OA et al. | Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide. | 2008 | Nat. Chem. Biol. | pmid:18516048 |
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| Agbottah E et al. | Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways. | 2008 | AIDS Res Ther | pmid:18544167 |
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| Ryu YB et al. | Inhibitory effects on mushroom tyrosinase by flavones from the stem barks of Morus lhou (S.) Koidz. | 2008 | J Enzyme Inhib Med Chem | pmid:18608767 |
| Zhai K et al. | Chrysin induces hyperalgesia via the GABAA receptor in mice. | 2008 | Planta Med. | pmid:18612941 |
| Wu B et al. | Metabonomic study on ageing: NMR-based investigation into rat urinary metabolites and the effect of the total flavone of Epimedium. | 2008 | Mol Biosyst | pmid:18633487 |
| Furtmueller R et al. | 6,3'-Dinitroflavone is a low efficacy modulator of GABA(A) receptors. | 2008 | Eur. J. Pharmacol. | pmid:18639544 |
| Hara T et al. | Flavopiridol potentiates the cytotoxic effects of radiation in radioresistant tumor cells in which p53 is mutated or Bcl-2 is overexpressed. | 2008 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:18640498 |
| Zhao Z et al. | Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats. | 2008 | Behav. Brain Res. | pmid:18655806 |