| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lymphedema | D008209 | 4 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Vaher M and Koel M | Separation of polyphenolic compounds extracted from plant matrices using capillary electrophoresis. | 2003 | J Chromatogr A | pmid:12685601 |
| Wenzel U et al. | Nitric oxide levels in human preneoplastic colonocytes determine their susceptibility toward antineoplastic agents. | 2003 | Mol. Pharmacol. | pmid:14645680 |
| Jasso-Chávez R and Moreno-Sánchez R | Cytosol-mitochondria transfer of reducing equivalents by a lactate shuttle in heterotrophic Euglena. | 2003 | Eur. J. Biochem. | pmid:14653820 |
| Boué SM et al. | Identification of flavone aglycones and glycosides in soybean pods by liquid chromatography-tandem mass spectrometry. | 2003 | J Chromatogr A | pmid:12703901 |
| Lai MY et al. | Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats. | 2003 | J. Pharm. Pharmacol. | pmid:12631413 |
| MartÃnez-Richa A and Joseph-Nathan P | Carbon-13 CP-MAS nuclear magnetic resonance studies of teas. | 2003 | Solid State Nucl Magn Reson | pmid:12763559 |
| Morimoto M et al. | Insect antifeedant activity of flavones and chromones against Spodoptera litura. | 2003 | J. Agric. Food Chem. | pmid:12517100 |
| Cai H et al. | Determination of the flavone tricin in human plasma by high-performance liquid chromatography. | 2003 | Biomed. Chromatogr. | pmid:14598326 |
| Lai MY et al. | Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans. | 2003 | Biol. Pharm. Bull. | pmid:12520178 |
| Fang H et al. | Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. | 2003 | Chem. Res. Toxicol. | pmid:14565775 |
| Lin HY et al. | Inhibition of lipopolysaccharide-induced nitric oxide production by flavonoids in RAW264.7 macrophages involves heme oxygenase-1. | 2003 | Biochem. Pharmacol. | pmid:14563492 |
| Goutman JD et al. | Flavonoid modulation of ionic currents mediated by GABA(A) and GABA(C) receptors. | 2003 | Eur. J. Pharmacol. | pmid:12586201 |
| Gleye C et al. | Acaricidal activity of tonka bean extracts. Synthesis and structure-activity relationships of bioactive derivatives. | 2003 | J. Nat. Prod. | pmid:12762809 |
| Khan KK et al. | Homotropic versus heterotopic cooperativity of cytochrome P450eryF: a substrate oxidation and spectral titration study. | 2003 | Drug Metab. Dispos. | pmid:12642459 |
| Zhang P et al. | A maize QTL for silk maysin levels contains duplicated Myb-homologous genes which jointly regulate flavone biosynthesis. | 2003 | Plant Mol. Biol. | pmid:12825685 |
| Huen MS et al. | Naturally occurring 2'-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands. | 2003 | Biochem. Pharmacol. | pmid:14637197 |
| Xiao Z et al. | [The inhibitory effect of total flavonoids of hippophae on the activation of NF-kappa B by stretching cultured cardiac myocytes]. | 2003 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:12947714 |
| Ahlemeyer B and Krieglstein J | Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. | 2003 | Pharmacopsychiatry | pmid:13130383 |
| Kang KW et al. | Activation of CCAAT/enhancer-binding protein beta by 2'-amino-3'-methoxyflavone (PD98059) leads to the induction of glutathione S-transferase A2. | 2003 | Carcinogenesis | pmid:12663507 |
| Kim SY et al. | Cis-2', 3'-dihydrodiol production on flavone B-ring by biphenyl dioxygenase from Pseudomonas pseudoalcaligenes KF707 expressed in Escherichia coli. | 2003 | Antonie Van Leeuwenhoek | pmid:14574103 |
| Gafner S et al. | Inhibition of [3H]-LSD binding to 5-HT7 receptors by flavonoids from Scutellaria lateriflora. | 2003 | J. Nat. Prod. | pmid:12713409 |
| Suzuki R et al. | Two flavone C-glycosides from the style of Zea mays with glycation inhibitory activity. | 2003 | J. Nat. Prod. | pmid:12713418 |
| Ajay M et al. | Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. | 2003 | Life Sci. | pmid:14623031 |
| Almada-Ruiz E et al. | Fungicidal potential of methoxylated flavones from citrus for in vitro control of Colletotrichum gloeosporioides, causal agent of anthracnose disease in tropical fruits. | 2003 | Pest Manag. Sci. | pmid:14620052 |
| Haraguchi H et al. | A flavone from Manilkara indica as a specific inhibitor against aldose reductase in vitro. | 2003 | Planta Med. | pmid:14598214 |
| Rudek MA et al. | Clinical pharmacology of flavopiridol following a 72-hour continuous infusion. | 2003 | Ann Pharmacother | pmid:14519054 |
| Selloum L et al. | Anti-inflammatory effect of rutin on rat paw oedema, and on neutrophils chemotaxis and degranulation. | 2003 | Exp. Toxicol. Pathol. | pmid:12710715 |
| Pepper C et al. | Flavopiridol induces apoptosis in B-cell chronic lymphocytic leukaemia cells through a p38 and ERK MAP kinase-dependent mechanism. | 2003 | Leuk. Lymphoma | pmid:12688354 |
| Reddy MK et al. | A flavone and an unusual 23-carbon terpenoid from Andrographis paniculata. | 2003 | Phytochemistry | pmid:12648550 |
| Chi YS et al. | Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. | 2003 | Biochem. Pharmacol. | pmid:14505806 |
| Hyup YH et al. | 2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12565941 |
| Nørbaek R et al. | Flavone C-glycoside, phenolic acid, and nitrogen contents in leaves of barley subject to organic fertilization treatments. | 2003 | J. Agric. Food Chem. | pmid:12537462 |
| Zuo L et al. | 2D-IR correlation analysis of deteriorative process of traditional Chinese medicine 'Qing Kai Ling' injection. | 2003 | J Pharm Biomed Anal | pmid:12467920 |
| Schwalm K et al. | Flavonoid-related regulation of auxin accumulation in Agrobacterium tumefaciens-induced plant tumors. | 2003 | Planta | pmid:14523649 |
| Mihara M et al. | Flavopiridol, a cyclin dependent kinase (CDK) inhibitor, induces apoptosis by regulating Bcl-x in oral cancer cells. | 2003 | Oral Oncol. | pmid:12457721 |
| Toyo'oka T et al. | On-line screening methods for antioxidants scavenging superoxide anion radical and hydrogen peroxide by liquid chromatography with indirect chemiluminescence detection. | 2003 | Talanta | pmid:18969068 |
| Lee S et al. | Solubility enhancement of a hydrophobic flavonoid, luteolin by the complexation with cyclosophoraoses isolated from Rhizobium meliloti. | 2003 | Antonie Van Leeuwenhoek | pmid:14574115 |
| Fukui Y et al. | A rationale for the shift in colour towards blue in transgenic carnation flowers expressing the flavonoid 3',5'-hydroxylase gene. | 2003 | Phytochemistry | pmid:12657292 |
| Carcache-Blanco EJ et al. | Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase. | 2003 | J. Nat. Prod. | pmid:14510596 |
| Suetsugi M et al. | Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. | 2003 | Mol. Cancer Res. | pmid:14638870 |
| Wu SN et al. | Differential effects of quercetin, a natural polyphenolic flavonoid, on L-type calcium current in pituitary tumor (GH3) cells and neuronal NG108-15 cells. | 2003 | J. Cell. Physiol. | pmid:12652656 |
| Takada Y and Aggarwal BB | Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. | 2004 | J. Biol. Chem. | pmid:14630924 |
| Uyemura SA et al. | Oxidative phosphorylation and rotenone-insensitive malate- and NADH-quinone oxidoreductases in Plasmodium yoelii yoelii mitochondria in situ. | 2004 | J. Biol. Chem. | pmid:14561763 |
| Goppel M and Franz G | Stability control of senna leaves and senna extracts. | 2004 | Planta Med. | pmid:15124088 |
| Kong C et al. | Two compounds from allelopathic rice accession and their inhibitory activity on weeds and fungal pathogens. | 2004 | Phytochemistry | pmid:15110693 |
| Tao SH and Wu FE | A new flavone from Hypericum wightianum. | 2004 | J Asian Nat Prod Res | pmid:15621592 |
| Wang HB et al. | Flavone glucosides with immunomodulatory activity from the leaves of Pleioblastus amarus. | 2004 | Phytochemistry | pmid:15081303 |
| Ohno S et al. | Flavonoid inhibition of overexpressed human 3beta-hydroxysteroid dehydrogenase type II. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15084349 |
| Badria FA and Zidan OA | Natural products for dental caries prevention. | 2004 | J Med Food | pmid:15383236 |
| Tammela P et al. | Permeability characteristics and membrane affinity of flavonoids and alkyl gallates in Caco-2 cells and in phospholipid vesicles. | 2004 | Arch. Biochem. Biophys. | pmid:15111127 |