FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adenoma D000236 40 associated lipids
Asthma D001249 52 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cystitis D003556 23 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Edema D004487 152 associated lipids
Encephalitis D004660 15 associated lipids
Glioma D005910 112 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hypertension D006973 115 associated lipids
Leukemia P388 D007941 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

Download all related citations
Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Arya A et al. Chloroform Fraction of Centratherum anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha and Exhibits Pleotropic Bioactivities: Inhibitory Role in Human Tumor Cells. 2012 Evid Based Complement Alternat Med pmid:22474512
Wang Y et al. Screening Antitumor Compounds Psoralen and Isopsoralen from Psoralea corylifolia L. Seeds. 2011 Evid Based Complement Alternat Med pmid:19131395
Lee DH et al. Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells. 2012 Evid Based Complement Alternat Med pmid:22194772
Lee H et al. Angelicae Dahuricae Radix Inhibits Dust Mite Extract-Induced Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice. 2012 Evid Based Complement Alternat Med pmid:22454682
Wang YL et al. Anxiolytic-like effects of compound zhi zhu xiang in rats. 2012 Evid Based Complement Alternat Med pmid:22690249
Sun S et al. The evaluation of chinese therapeutic food for the treatment of moderate dyslipidemia. 2012 Evid Based Complement Alternat Med pmid:22474507
Liu Y et al. Chinese herb and formulas for promoting blood circulation and removing blood stasis and antiplatelet therapies. 2012 Evid Based Complement Alternat Med pmid:22454656
Khan M et al. Jaceosidin Induces Apoptosis in U87 Glioblastoma Cells through G2/M Phase Arrest. 2012 Evid Based Complement Alternat Med pmid:22216058
Manna P et al. Phytomedicinal Role of Pithecellobium dulce against CCl(4)-mediated Hepatic Oxidative Impairments and Necrotic Cell Death. 2011 Evid Based Complement Alternat Med pmid:21869899
Quintão NL et al. Aleurites moluccana (L.) Willd. Leaves: Mechanical Antinociceptive Properties of a Standardized Dried Extract and Its Chemical Markers. 2011 Evid Based Complement Alternat Med pmid:21660087
Szliszka E et al. Ethanolic Extract of Propolis Augments TRAIL-Induced Apoptotic Death in Prostate Cancer Cells. 2011 Evid Based Complement Alternat Med pmid:19892808
Yob NJ et al. Zingiber zerumbet (L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses. 2011 Evid Based Complement Alternat Med pmid:21584247
Varma A et al. Andrographolide: a new plant-derived antineoplastic entity on horizon. 2011 Evid Based Complement Alternat Med pmid:19752167
Rozza AL et al. Morphologic and pharmacological investigations in the epicatechin gastroprotective effect. 2012 Evid Based Complement Alternat Med pmid:22666296
Uchi H et al. A clinical trial of kampo formulae for the treatment of symptoms of yusho, a poisoning caused by dioxins and related organochlorine compounds. 2011 Evid Based Complement Alternat Med pmid:19996156
Pan SY et al. New perspectives on chinese herbal medicine (zhong-yao) research and development. 2011 Evid Based Complement Alternat Med pmid:21785622
Capodice JL et al. Complementary and alternative medicine for chronic prostatitis/chronic pelvic pain syndrome. 2005 Evid Based Complement Alternat Med pmid:16322807
Xie F et al. The osteoprotective effect of Herba epimedii (HEP) extract in vivo and in vitro. 2005 Evid Based Complement Alternat Med pmid:16136213
Zhang H and Zhang C Vasoprotection by dietary supplements and exercise: role of TNFα signaling. 2012 Exp Diabetes Res pmid:22110483
Sen N et al. Leishmania donovani: intracellular ATP level regulates apoptosis-like death in luteolin induced dyskinetoplastid cells. 2006 Exp. Parasitol. pmid:16707127
Selloum L et al. Anti-inflammatory effect of rutin on rat paw oedema, and on neutrophils chemotaxis and degranulation. 2003 Exp. Toxicol. Pathol. pmid:12710715
Tunçbilek M et al. Synthesis and hypoglycemic activity of some substituted flavonyl thiazolidinedione derivatives--fifth communication: flavonyl benzyl substituted 2,4-thiazolidinediones. 2003 Farmaco pmid:12595040
Artali R et al. Synthesis, X-ray crystal structure and biological properties of acetylenic flavone derivatives. 2003 Farmaco pmid:13679182
Ficarra P et al. Analysis of 2-phenyl-chromon derivatives and chlorogenic acid. II. High-performance thin layer chromatography and high-performance liquid chromatography in flowers, leaves and buds extractives of Crataegus oxyacantha L. 1984 Farmaco Prat pmid:6542533
Kitajima-Ihara T and Yagi T Rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria: the enzyme expressed in Escherichia coli acts as a member of the respiratory chain in the host cells. 1998 FEBS Lett. pmid:9462835
Tombola F et al. Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogen Helicobacter pylori. 2003 FEBS Lett. pmid:12753930
Duportail G et al. Neutral fluorescence probe with strong ratiometric response to surface charge of phospholipid membranes. 2001 FEBS Lett. pmid:11718715
Krakauer T et al. The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines. 2001 FEBS Lett. pmid:11434925
Bai F et al. Promoter activation and following induction of the p21/WAF1 gene by flavone is involved in G1 phase arrest in A549 lung adenocarcinoma cells. 1998 FEBS Lett. pmid:9804172
Minagawa N et al. Possible involvement of superoxide anion in the induction of cyanide-resistant respiration in Hansenula anomala. 1992 FEBS Lett. pmid:1318225
Alipieva KI et al. An iridoid and a flavonoid from Sideritis lanata L. 2009 Fitoterapia pmid:18938229
Yarmolinsky L et al. Potent antiviral flavone glycosides from Ficus benjamina leaves. 2012 Fitoterapia pmid:22155188
David JP et al. A new sesquiterpene from the fruits of Allophylus laevigatus. 2004 Fitoterapia pmid:15567269
D'arc Felicio J et al. Biflavonoids from Ouratea multiflora. 2001 Fitoterapia pmid:11395278
Huang QH et al. Isoprenylated phenolic compounds with PTP1B inhibition from Morus alba. 2017 Fitoterapia pmid:28916258
Arriaga AM et al. Constituents of Bowdichia virgilioides. 2000 Fitoterapia pmid:10727826
Li G et al. Pharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC-MS method. 2012 Fitoterapia pmid:22056665
Kongkum N et al. DNA topoisomerase IIα inhibitory and anti-HIV-1 flavones from leaves and twigs of Gardenia carinata. 2012 Fitoterapia pmid:22155186
Venditti A et al. A C-methylated resacetophenone from Cistus monspeliensis L. 2014 Fitoterapia pmid:24685506
Tian Y et al. Anti-HBV active flavone glucosides from Euphorbia humifusa Willd. 2010 Fitoterapia pmid:20450964
Kalisz S et al. Stabilization of anthocyanin and skullcap flavone complexes--investigations with computer simulation and experimental methods. 2013 Food Chem pmid:23265516
Chen YH et al. Evaluation of the structure-activity relationship of flavonoids as antioxidants and toxicants of zebrafish larvae. 2012 Food Chem pmid:23107683
Sun Y et al. Enrichment and antioxidant properties of flavone C-glycosides from trollflowers using macroporous resin. 2013 Food Chem pmid:23768390
Barreca D et al. First evidence of C- and O-glycosyl flavone in blood orange (Citrus sinensis (L.) Osbeck) juice and their influence on antioxidant properties. 2014 Food Chem pmid:24295703
Yi Lau GT and Leung LK The dietary flavonoid apigenin blocks phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in breast cell lines. 2010 Food Chem. Toxicol. pmid:20691240
Nielsen SE et al. Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus. 2000 Food Chem. Toxicol. pmid:10930694
Surichan S et al. Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells. 2012 Food Chem. Toxicol. pmid:22743247
Barros L et al. Characterization of phenolic compounds in flowers of wild medicinal plants from Northeastern Portugal. 2012 Food Chem. Toxicol. pmid:22342808
Vernet A and Siess MH Comparison of the effects of various flavonoids on ethoxycoumarin deethylase activity of rat intestinal and hepatic microsomes. 1986 Food Chem. Toxicol. pmid:3491024
Shaker E et al. Anti-inflammatory and anti-ulcer activity of the extract from Alhagi maurorum (camelthorn). 2010 Food Chem. Toxicol. pmid:20633591