| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ramful D et al. | Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: potential prophylactic ingredients for functional foods application. | 2010 | Toxicology | pmid:20100535 |
| Kaneko T et al. | Inhibition of prostaglandin E2 production by flavone and its related compounds. | In Vivo | pmid:20133976 | |
| Saleem A et al. | A RP-HPLC-DAD-APCI/MSD method for the characterisation of medicinal Ericaceae used by the Eeyou Istchee Cree First Nations. | Phytochem Anal | pmid:20135709 | |
| Basile A et al. | Antibacterial and antifungal properties of acetonic extract of Feijoa sellowiana fruits and its effect on Helicobacter pylori growth. | 2010 | J Med Food | pmid:20136454 |
| Ansó E et al. | Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism. | 2010 | Biochem. Pharmacol. | pmid:20153296 |
| Mbouangouere RN et al. | Piptaderol from Piptadenia africana. | 2007 | Afr J Tradit Complement Altern Med | pmid:20161892 |
| Cheung FW et al. | Geoditin A induces oxidative stress and apoptosis on human colon HT29 cells. | 2010 | Mar Drugs | pmid:20161972 |
| McKeage MJ and Baguley BC | Disrupting established tumor blood vessels: an emerging therapeutic strategy for cancer. | 2010 | Cancer | pmid:20166210 |
| Kim JM et al. | Morin modulates the oxidative stress-induced NF-kappaB pathway through its anti-oxidant activity. | 2010 | Free Radic. Res. | pmid:20187708 |
| Chang TL et al. | 5,6,3',4'-Tetrahydroxy-7-methoxyflavone as a novel potential proteasome inhibitor. | 2010 | Planta Med. | pmid:20195959 |
| Song WY et al. | Effect of ethanol extracts from red pepper seeds on antioxidative defense system and oxidative stress in rats fed high-fat . high-cholesterol diet. | 2010 | Nutr Res Pract | pmid:20198203 |
| Akhtar TA et al. | Photosynthetic redox imbalance influences flavonoid biosynthesis in Lemna gibba. | 2010 | Plant Cell Environ. | pmid:20199616 |
| Galabov AS | Virucidal agents in the eve of manorapid synergy. | 2007 | GMS Krankenhhyg Interdiszip | pmid:20200679 |
| Tamura S et al. | New inhibitors for expression of IgE receptor on human mast cell. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20202836 |
| Zhang A et al. | Anti-HER-2 engineering antibody ChA21 inhibits growth and induces apoptosis of SK-OV-3 cells. | 2010 | J. Exp. Clin. Cancer Res. | pmid:20214830 |
| Yashiroda Y et al. | A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20214890 |
| Wang J et al. | Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation. | 2010 | PLoS ONE | pmid:20221395 |
| Wang C et al. | [Advances in chemical components and pharmacology of genus Gentiana]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:20222408 |
| Ono E et al. | Co-pigmentation and flavonoid glycosyltransferases in blue Veronica persica flowers. | 2010 | Phytochemistry | pmid:20223486 |
| Parravicini C et al. | Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach. | 2010 | BMC Struct. Biol. | pmid:20233425 |
| Shukla S and Gupta S | Apigenin: a promising molecule for cancer prevention. | 2010 | Pharm. Res. | pmid:20306120 |
| Xiao J et al. | Structure-affinity relationship of flavones on binding to serum albumins: effect of hydroxyl groups on ring A. | 2010 | Mol Nutr Food Res | pmid:20306480 |
| Guendel I et al. | Inhibition of human immunodeficiency virus type-1 by cdk inhibitors. | 2010 | AIDS Res Ther | pmid:20334651 |
| Zou GA et al. | Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook. | 2010 | Molecules | pmid:20335965 |
| Chen Q et al. | Measurement of total flavone content in snow lotus (Saussurea involucrate) using near infrared spectroscopy combined with interval PLS and genetic algorithm. | 2010 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:20338806 |
| Vidyalakshmi K et al. | Antinociceptive effect of certain dihydroxy flavones in mice. | 2010 | Pharmacol. Biochem. Behav. | pmid:20346369 |
| Torres-Piedra M et al. | A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition. | 2010 | Eur J Med Chem | pmid:20346546 |
| Lewin G et al. | Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin. | 2010 | J. Nat. Prod. | pmid:20356063 |
| Han Y et al. | Ectopic expression of apple F3'H genes contributes to anthocyanin accumulation in the Arabidopsis tt7 mutant grown under nitrogen stress. | 2010 | Plant Physiol. | pmid:20357139 |
| Liao Z et al. | Antidiabetic effect of flavones from Cirsium japonicum DC in diabetic rats. | 2010 | Arch. Pharm. Res. | pmid:20361298 |
| Cai H et al. | Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone). | 2011 | Cancer Chemother. Pharmacol. | pmid:20364427 |
| Filak LK et al. | Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy. | 2010 | J. Biol. Inorg. Chem. | pmid:20369265 |
| Valant-Vetschera KM et al. | Chemodiversity of exudate flavonoids in Dionysia (Primulaceae): a comparative study. | 2010 | Phytochemistry | pmid:20378133 |
| Halbwirth H | The creation and physiological relevance of divergent hydroxylation patterns in the flavonoid pathway. | 2010 | Int J Mol Sci | pmid:20386656 |
| Xia EQ et al. | Biological activities of polyphenols from grapes. | 2010 | Int J Mol Sci | pmid:20386657 |
| Xiang H et al. | Synthesis and biological evaluation of isoflavone fatty acid esters with potential weight loss and hypolipidemic activities. | 2010 | Bioorg. Med. Chem. | pmid:20392645 |
| Chung KS et al. | Eupafolin, a flavonoid isolated from Artemisia princeps, induced apoptosis in human cervical adenocarcinoma HeLa cells. | 2010 | Mol Nutr Food Res | pmid:20397191 |
| Knjazeva T and Kaljurand M | Capillary electrophoresis frontal analysis for the study of flavonoid interactions with human serum albumin. | 2010 | Anal Bioanal Chem | pmid:20422159 |
| Kosmider B et al. | Structure-activity relationship and apoptosis induction in A549 cells by the potential anticancer compound cis-bis(3-aminoflavone)dichloroplatinum(II). | 2010 | Arzneimittelforschung | pmid:20422947 |
| Neveu V et al. | Phenol-Explorer: an online comprehensive database on polyphenol contents in foods. | 2010 | Database (Oxford) | pmid:20428313 |
| Picon PD et al. | Randomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia for chronic constipation. | 2010 | BMC Complement Altern Med | pmid:20433751 |
| Wang H et al. | Xeno-oestrogens and phyto-oestrogens are alternative ligands for the androgen receptor. | 2010 | Asian J. Androl. | pmid:20436506 |
| Suttana W et al. | Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols. | 2010 | Mol. Cancer | pmid:20438634 |
| Dobritsa AA et al. | LAP5 and LAP6 encode anther-specific proteins with similarity to chalcone synthase essential for pollen exine development in Arabidopsis. | 2010 | Plant Physiol. | pmid:20442277 |
| Hori A and Naganuma K | Fully and partially fluorinated flavone derivatives. | 2010 | Acta Crystallogr C | pmid:20442510 |
| Kyrgidis A et al. | Melanoma: Stem cells, sun exposure and hallmarks for carcinogenesis, molecular concepts and future clinical implications. | 2010 | J Carcinog | pmid:20442802 |
| Mukai R et al. | Suppression mechanisms of flavonoids on aryl hydrocarbon receptor-mediated signal transduction. | 2010 | Arch. Biochem. Biophys. | pmid:20450880 |
| Tian Y et al. | Anti-HBV active flavone glucosides from Euphorbia humifusa Willd. | 2010 | Fitoterapia | pmid:20450964 |
| Gao LM and Meléndez E | Cytotoxic properties of titanocenyl amides on breast cancer cell line mcf-7. | 2010 | Met Based Drugs | pmid:20454639 |
| Jeng YJ et al. | Subchronic exposure to phytoestrogens alone and in combination with diethylstilbestrol - pituitary tumor induction in Fischer 344 rats. | 2010 | Nutr Metab (Lond) | pmid:20459739 |