| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Berthier A et al. | Effect of 7-O-beta-D-glucopyranosylchrysin and its aglycone chrysin isolated from Podocytisus caramanicus on estrogen receptor alpha transcriptional activity. | 2007 | Planta Med. | pmid:17948189 |
| Yan H et al. | Treating senile dementia with traditional Chinese medicine. | 2007 | Clin Interv Aging | pmid:18044136 |
| Ebert B et al. | Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. | 2007 | Toxicol. Sci. | pmid:17077187 |
| Han X et al. | Isolation of high-purity casticin from Artemisia annua L. by high-speed counter-current chromatography. | 2007 | J Chromatogr A | pmid:17374377 |
| Lohner K et al. | Flavonoids alter P-gp expression in intestinal epithelial cells in vitro and in vivo. | 2007 | Mol Nutr Food Res | pmid:17295420 |
| Walle UK and Walle T | Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones. | 2007 | Drug Metab. Dispos. | pmid:17709371 |
| Patanasethanont D et al. | Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function. | 2007 | J Pharm Sci | pmid:17031860 |
| Walle T et al. | Cancer chemopreventive properties of orally bioavailable flavonoids--methylated versus unmethylated flavones. | 2007 | Biochem. Pharmacol. | pmid:17250812 |
| Bovicelli P et al. | Efficient synthesis of polyoxygenated flavones from naturally occurring flavanones. | 2007 | J. Pharm. Pharmacol. | pmid:18053332 |
| Jung J et al. | Inhibition of estrogen action by 2-phenylchromone as AhR agonist in MCF-7 cells. | 2007 | Life Sci. | pmid:17950758 |
| Allouche Y et al. | How heating affects extra virgin olive oil quality indexes and chemical composition. | 2007 | J. Agric. Food Chem. | pmid:17935291 |
| Diniz A et al. | Permeability profile estimation of flavonoids and other phenolic compounds by biopartitioning micellar capillary chromatography. | 2007 | J. Agric. Food Chem. | pmid:17927146 |
| Pham MH et al. | Characterization of monohydroxylated derivatives of the anticancer agent flavone-8-acetic acid by liquid chromatography with on-line UV and mass spectrometry. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17891752 |
| Guo M et al. | Iron-binding properties of plant phenolics and cranberry's bio-effects. | 2007 | Dalton Trans | pmid:17992280 |
| Wu Y et al. | [Effects of the total flavone of radix puerariae on apoptotic cell and apoptotic related-gene in atherosclerotic plaques of apoE gene deficiency mice]. | 2007 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:17711723 |
| Aboul-Enein HY et al. | Scavenging effects of phenolic compounds on reactive oxygen species. | 2007 | Biopolymers | pmid:17373654 |
| Ono M | [Molecular imaging of beta-amyloid plaques in the brain]. | 2007 | Brain Nerve | pmid:17370649 |
| Duarte-Almeida JM et al. | Antiproliferative and antioxidant activities of a tricin acylated glycoside from sugarcane (Saccharum officinarum) juice. | 2007 | Phytochemistry | pmid:17350657 |
| Winkelmann I et al. | The suppression of aberrant crypt multiplicity in colonic tissue of 1,2-dimethylhydrazine-treated C57BL/6J mice by dietary flavone is associated with an increased expression of Krebs cycle enzymes. | 2007 | Carcinogenesis | pmid:17347140 |
| Cacciola F et al. | Comprehensive two-dimensional liquid chromatography with parallel gradients for separation of phenolic and flavone antioxidants. | 2007 | J Chromatogr A | pmid:17331519 |
| Boumendjel A et al. | Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2. | 2007 | Bioorg. Med. Chem. | pmid:17317193 |
| Ono M et al. | Synthesis and characterization of styrylchromone derivatives as beta-amyloid imaging agents. | 2007 | Bioorg. Med. Chem. | pmid:17035032 |
| Lin J et al. | Dietary intakes of flavonols and flavones and coronary heart disease in US women. | 2007 | Am. J. Epidemiol. | pmid:17379619 |
| Kim MJ et al. | Jaceosidin induces apoptosis in ras-transformed human breast epithelial cells through generation of reactive oxygen species. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17404061 |
| Lee HS et al. | In vitro metabolism of eupatilin by multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes. | 2007 | Xenobiotica | pmid:17701830 |
| Galabov AS | Virucidal agents in the eve of manorapid synergy. | 2007 | GMS Krankenhhyg Interdiszip | pmid:20200679 |
| Ahmed N et al. | Synthesis, characterization, and estrogen receptor binding affinity of flavone-, indole-, and furan-estradiol conjugates. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17379515 |
| Jeong MA et al. | Jaceosidin, a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbol-ester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17404058 |
| Enomoto R et al. | Wogonin prevents immunosuppressive action but not anti-inflammatory effect induced by glucocorticoid. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17404053 |
| Zhao JH et al. | Chemical chaperone and inhibitor discovery: potential treatments for protein conformational diseases. | 2007 | Perspect Medicin Chem | pmid:19812735 |
| Young J et al. | Antimicrobial effects of flavone analogues and their structure-activity relationships. | 2007 | J. Microbiol. Biotechnol. | pmid:18050960 |
| Gao D et al. | Hypoglycemic effects and mechanisms of action of Cortex Lycii Radicis on alloxan-induced diabetic mice. | 2007 | Yakugaku Zasshi | pmid:17917429 |
| Trusheva B et al. | Different extraction methods of biologically active components from propolis: a preliminary study. | 2007 | Chem Cent J | pmid:17880743 |
| Enomoto R et al. | Wogonin prevents glucocorticoid-induced thymocyte apoptosis without diminishing its anti-inflammatory action. | 2007 | J. Pharmacol. Sci. | pmid:17690528 |
| Burns DC et al. | A predictive tool for assessing (13)C NMR chemical shifts of flavonoids. | 2007 | Magn Reson Chem | pmid:17729229 |
| Perry JD et al. | Evaluation of novel chromogenic substrates for the detection of bacterial beta-glucosidase. | 2007 | J. Appl. Microbiol. | pmid:17241346 |
| Innocenti G et al. | In vitro estrogenic activity of Achillea millefolium L. | 2007 | Phytomedicine | pmid:16860978 |
| Pikulski M et al. | Tunable transition metal-ligand complexation for enhanced elucidation of flavonoid diglycosides by electrospray ionization mass spectrometry. | 2007 | J. Am. Soc. Mass Spectrom. | pmid:17112735 |
| Mbouangouere RN et al. | Piptaderol from Piptadenia africana. | 2007 | Afr J Tradit Complement Altern Med | pmid:20161892 |
| Sundararajan R et al. | Cytisus scoparius link--a natural antioxidant. | 2006 | BMC Complement Altern Med | pmid:16542432 |
| Ferrer-Sueta G et al. | Reduction of manganese porphyrins by flavoenzymes and submitochondrial particles: a catalytic cycle for the reduction of peroxynitrite. | 2006 | Free Radic. Biol. Med. | pmid:16843831 |
| Kim SK et al. | The mitogen-activated protein kinase kinase (mek) inhibitor PD98059 elevates primary cultured rat hepatocyte glutathione levels independent of inhibiting mek. | 2006 | Drug Metab. Dispos. | pmid:16443668 |
| Lotito SB and Frei B | Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism. | 2006 | J. Biol. Chem. | pmid:16987811 |
| Herath W et al. | Microbial metabolism. Part 6. Metabolites of 3- and 7-hydroxyflavones. | 2006 | Chem. Pharm. Bull. | pmid:16508185 |
| Yang X et al. | Synthesis and immunosuppressive activity of L-rhamnopyranosyl flavonoids. | 2006 | Org. Biomol. Chem. | pmid:16763696 |
| Moon BH et al. | Complete assignment of (1)H and (13)C NMR data of dihydroxyflavone derivatives. | 2006 | Magn Reson Chem | pmid:16259053 |
| Sandabe UK et al. | Phytochemical screening and effect of aqueous extract of Ficus sycomorus L. (Moraceae) stembark on muscular activity in laboratory animals. | 2006 | J Ethnopharmacol | pmid:16243463 |
| Lee MH et al. | Bioactive constituents of Spatholobus suberectus in regulating tyrosinase-related proteins and mRNA in HEMn cells. | 2006 | Phytochemistry | pmid:16782143 |
| Vargo MA et al. | Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. | 2006 | Biochem. Pharmacol. | pmid:16844095 |
| Niho N et al. | Inhibition of intestinal carcinogenesis by a new flavone derivative, chafuroside, in oolong tea. | 2006 | Cancer Sci. | pmid:16630115 |