FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Osteosarcoma D012516 50 associated lipids
Melanoma D008545 69 associated lipids
Asthma D001249 52 associated lipids
Glioma D005910 112 associated lipids
Per page 10 20 50 | Total 32

PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with FLAVONE

Download all related citations
Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Yang L et al. Compound Chinese herbal medicinal ingredients can enhance immune response and efficacy of RHD vaccine in rabbit. 2008 Vaccine pmid:18602959
Schrader KK Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus). 2010 Toxins (Basel) pmid:22069655
Canivenc-Lavier MC et al. Comparative effects of flavonoids and model inducers on drug-metabolizing enzymes in rat liver. 1996 Toxicology pmid:8931757
Ramful D et al. Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: potential prophylactic ingredients for functional foods application. 2010 Toxicology pmid:20100535
Ebert B et al. Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. 2007 Toxicol. Sci. pmid:17077187
Sanderson JT et al. Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. 2004 Toxicol. Sci. pmid:15319488
Bugel SM et al. Comparative Developmental Toxicity of Flavonoids Using an Integrative Zebrafish System. 2016 Toxicol. Sci. pmid:27492224
van Duursen MB et al. Phytochemicals inhibit catechol-O-methyltransferase activity in cytosolic fractions from healthy human mammary tissues: implications for catechol estrogen-induced DNA damage. 2004 Toxicol. Sci. pmid:15254334
Hong H et al. Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. 2015 Toxicol. Sci. pmid:25349334
Ebert B et al. Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3-carbinol enhance the formation and transport of benzo[a]pyrene sulfate conjugates in intestinal Caco-2 cells. 2005 Toxicol. Lett. pmid:15890477
Lim H et al. Flavonoids interfere with NLRP3 inflammasome activation. 2018 Toxicol. Appl. Pharmacol. pmid:29960001
Khan R et al. Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53. 2012 Toxicol. Appl. Pharmacol. pmid:22155348
Schutte ME et al. An in vitro and in silico study on the flavonoid-mediated modulation of the transport of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through Caco-2 monolayers. 2006 Toxicol. Appl. Pharmacol. pmid:16997339
Lin TY et al. Hispidulin inhibits the release of glutamate in rat cerebrocortical nerve terminals. 2012 Toxicol. Appl. Pharmacol. pmid:22759588
Kamata R et al. Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay. 2018 Toxicol In Vitro pmid:28927721
Russo EB Cannabinoids in the management of difficult to treat pain. 2008 Ther Clin Risk Manag pmid:18728714
Meyer JD et al. Quantitative trait loci for maysin synthesis in maize (Zea mays L.) lines selected for high silk maysin content. 2007 Theor. Appl. Genet. pmid:17486311
Baranowska I and Raróg D Application of derivative spectrophotometry to determination of flavonoid mixtures. 2001 Talanta pmid:18968363
Liu Q et al. Metabolism profile of scutellarin in urine following oral administration to rats by ultra performance liquid chromatography coupled to time-of-flight mass spectrometry. 2009 Talanta pmid:19782195
Toyo'oka T et al. On-line screening methods for antioxidants scavenging superoxide anion radical and hydrogen peroxide by liquid chromatography with indirect chemiluminescence detection. 2003 Talanta pmid:18969068
Zhang J et al. A flavone-based turn-on fluorescent probe for intracellular cysteine/homocysteine sensing with high selectivity. 2016 Talanta pmid:26695232
Karvela E et al. Deployment of response surface methodology to optimise recovery of grape (Vitis vinifera) stem polyphenols. 2009 Talanta pmid:19635365
Collins BM et al. The estrogenic and antiestrogenic activities of phytochemicals with the human estrogen receptor expressed in yeast. 1997 Steroids pmid:9090797
Marian CM Spin-forbidden transitions in flavone. 2009 Spectrochim Acta A Mol Biomol Spectrosc pmid:19264543
Mitra A et al. Studies on the interaction of a synthetic nitro-flavone derivative with DNA: A multi-spectroscopic and molecular docking approach. 2018 Spectrochim Acta A Mol Biomol Spectrosc pmid:29885634
Vrielynck L et al. Self-modelling analysis applied to nanosecond transient absorption spectroscopy of flavone: an aid to elucidate and characterise reaction intermediates. 2002 Spectrochim Acta A Mol Biomol Spectrosc pmid:12396046
Xu S et al. A novel flavone-based fluorescent probe for relay recognition of HSO3(-) and Al(3+). 2015 Spectrochim Acta A Mol Biomol Spectrosc pmid:25965168
Chen Q et al. Measurement of total flavone content in snow lotus (Saussurea involucrate) using near infrared spectroscopy combined with interval PLS and genetic algorithm. 2010 Spectrochim Acta A Mol Biomol Spectrosc pmid:20338806
Martínez-Richa A and Joseph-Nathan P Carbon-13 CP-MAS nuclear magnetic resonance studies of teas. 2003 Solid State Nucl Magn Reson pmid:12763559
Xiao Z et al. [The inhibitory effect of total flavonoids of hippophae on the activation of NF-kappa B by stretching cultured cardiac myocytes]. 2003 Sichuan Da Xue Xue Bao Yi Xue Ban pmid:12947714
Gooda Sahib N et al. Plants' metabolites as potential antiobesity agents. 2012 ScientificWorldJournal pmid:22666121
de-Faria FM et al. Antioxidant action of mangrove polyphenols against gastric damage induced by absolute ethanol and ischemia-reperfusion in the rat. 2012 ScientificWorldJournal pmid:22654592
Kostrzewa-Susłow E and Janeczko T Microbial transformations of 7-hydroxyflavanone. 2012 ScientificWorldJournal pmid:22654578
Lasker JM et al. In vivo activation of zoxazolamine metabolism by flavone. 1982 Science pmid:7089530
Duchowicz PR et al. QSAR analysis on Spodoptera litura antifeedant activities for flavone derivatives. 2009 Sci. Total Environ. pmid:19846206
Zhang C et al. Common and unique cis-acting elements mediate xanthotoxin and flavone induction of the generalist P450 CYP321A1. 2014 Sci Rep pmid:25262756
Yan X et al. 58-F, a flavanone from Ophiopogon japonicus, prevents hepatocyte death by decreasing lysosomal membrane permeability. 2016 Sci Rep pmid:27306715
Zhao E and Mu Q Phytoestrogen biological actions on Mammalian reproductive system and cancer growth. 2011 Jan-Mar Sci Pharm pmid:21617769
El-Alfy TS et al. A New Flavonoid C-Glycoside from Celtis australis L. and Celtis occidentalis L. Leaves and Potential Antioxidant and Cytotoxic Activities. 2011 Oct-Dec Sci Pharm pmid:22145118
Zhao Q et al. A specialized flavone biosynthetic pathway has evolved in the medicinal plant, Scutellaria baicalensis. 2016 Sci Adv pmid:27152350
Blonska M et al. Effect of flavone derivatives on interleukin-1beta (IL-1beta) mRNA expression and IL-1beta protein synthesis in stimulated RAW 264.7 macrophages. 2003 Scand. J. Immunol. pmid:12588662
Barrellier MT [Lymphedema: is there a treatment?]. 1992 Jan-Feb Rev Med Interne pmid:1410875
Dorneanu V et al. [Determination of flavone derivatives. I. Quantitative determination of condensation products of rutin with epsiolon-aminocaproic acid]. 1974 Oct-Dec Rev Med Chir Soc Med Nat Iasi pmid:4453725
Khan SI et al. Potential utility of natural products as regulators of breast cancer-associated aromatase promoters. 2011 Reprod. Biol. Endocrinol. pmid:21693041
Wang YJ et al. Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment of menopausal symptoms. 2011 Regul. Toxicol. Pharmacol. pmid:20920542
Vitcheva V et al. Hepatoprotective effects of saponarin, isolated from Gypsophila trichotoma Wend. on cocaine-induced oxidative stress in rats. 2011 Redox Rep. pmid:21722413
Justino GC et al. Electrospray ionization tandem mass spectrometry fragmentation of protonated flavone and flavonol aglycones: a re-examination. 2009 Rapid Commun. Mass Spectrom. pmid:19089862
Pham MH et al. Characterization of monohydroxylated derivatives of the anticancer agent flavone-8-acetic acid by liquid chromatography with on-line UV and mass spectrometry. 2007 Rapid Commun. Mass Spectrom. pmid:17891752
Burns DC et al. A combined nuclear magnetic resonance and computational study of monohydroxyflavones applied to product ion mass spectra. 2007 Rapid Commun. Mass Spectrom. pmid:17216597
Cai H et al. A straightforward means of coupling preparative high-performance liquid chromatography and mass spectrometry. 2002 Rapid Commun. Mass Spectrom. pmid:11870892