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Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme. |
2006 |
J. Med. Chem. |
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Moorthy NS et al. |
Synthesis, biological evaluation and in silico metabolic and toxicity prediction of some flavanone derivatives. |
2006 |
Chem. Pharm. Bull. |
pmid:17015974
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Carrara M et al. |
Mono- or di-fluorinated analogues of flavone-8-acetic acid: synthesis and in vitro biological activity. |
2005 Mar-Apr |
Anticancer Res. |
pmid:15868960
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Kanho H et al. |
Biotransformation of benzaldehyde-type and acetophenone-type derivatives by Pharbitis nil hairy roots. |
2005 |
Chem. Pharm. Bull. |
pmid:15802832
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Zhang J et al. |
Threshold dissociation and molecular modeling of transition metal complexes of flavonoids. |
2005 |
J. Am. Soc. Mass Spectrom. |
pmid:15694764
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Madan V et al. |
Requirement of the vesicular system for membrane permeabilization by Sindbis virus. |
2005 |
Virology |
pmid:15661162
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Yoon JH and Baek SJ |
Molecular targets of dietary polyphenols with anti-inflammatory properties. |
2005 |
Yonsei Med. J. |
pmid:16259055
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Ebert B et al. |
Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3-carbinol enhance the formation and transport of benzo[a]pyrene sulfate conjugates in intestinal Caco-2 cells. |
2005 |
Toxicol. Lett. |
pmid:15890477
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Erhart LM et al. |
Flavone initiates a hierarchical activation of the caspase-cascade in colon cancer cells. |
2005 |
Apoptosis |
pmid:15909122
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Nakagawa-Goto K et al. |
Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs. |
2005 |
Bioorg. Med. Chem. Lett. |
pmid:15913998
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Wang TC et al. |
Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime-containing flavone and isoflavone derivatives. |
2005 |
Bioorg. Med. Chem. |
pmid:15990314
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Wang TC et al. |
Synthesis, and cytotoxic and antiplatelet activities of oxime- and methyloxime-containing flavone, isoflavone, and xanthone derivatives. |
2005 |
Chem. Biodivers. |
pmid:17191978
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Cappelli C et al. |
Computational study of conformational and chiroptical properties of (2R,3S,4R)-(+)-3,3',4,4',7-flavanpentol. |
2005 |
Chirality |
pmid:16196026
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Martens S and Mithöfer A |
Flavones and flavone synthases. |
2005 |
Phytochemistry |
pmid:16137727
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Cong Y et al. |
A new flavonoside from Leonurus heterophyllus. |
2005 |
J Asian Nat Prod Res |
pmid:15621638
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Singh RP et al. |
Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate. |
2005 |
Carcinogenesis |
pmid:15637089
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Melidou M et al. |
Protection against nuclear DNA damage offered by flavonoids in cells exposed to hydrogen peroxide: the role of iron chelation. |
2005 |
Free Radic. Biol. Med. |
pmid:16298684
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Ono M et al. |
Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain. |
2005 |
J. Med. Chem. |
pmid:16279784
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Wang F et al. |
Neuroactive flavonoids interacting with GABAA receptor complex. |
2005 |
Curr Drug Targets CNS Neurol Disord |
pmid:16266290
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Kim H et al. |
Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid. |
2005 |
J. Agric. Food Chem. |
pmid:16248550
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Kovacic P |
Fundamental, electron transfer mechanism by pyrylium-type ions for the anticancer drugs 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA). |
2005 |
Curr Med Chem Anticancer Agents |
pmid:16178775
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Ozbey S et al. |
Antibacterial 4-amino-N-(5-methylisoxazol-3-yl)-N-[(4-oxo-2-phenyl-4H-1-benzopyran-6-yl)methyl]benzenesulfonamide. |
2005 |
Acta Crystallogr C |
pmid:16143780
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Huong DT et al. |
A new flavone and cytotoxic activity of flavonoid constituents isolated from Miliusa balansae (Annonaceae). |
2005 |
Pharmazie |
pmid:16124409
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Woodman OL et al. |
Vasorelaxant and antioxidant activity of flavonols and flavones: structure-activity relationships. |
2005 |
J. Cardiovasc. Pharmacol. |
pmid:16116335
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Shiono M et al. |
Phytochemistry: structure of the blue cornflower pigment. |
2005 |
Nature |
pmid:16094358
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Bankova V |
Chemical diversity of propolis and the problem of standardization. |
2005 |
J Ethnopharmacol |
pmid:15993016
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Machha A and Mustafa MR |
Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta. |
2005 |
J. Cardiovasc. Pharmacol. |
pmid:15965352
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Malolanarasimhan K et al. |
Synthesis and biological study of a flavone acetic acid analogue containing an azido reporting group designed as a multifunctional binding site probe. |
2005 |
Bioorg. Med. Chem. |
pmid:15781383
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Ngadjui BT et al. |
Prenylated chalcones, flavone and other constituents of the twigs of Dorstenia angusticornis and Dorstenia barteri var. subtriangularis. |
2005 |
Phytochemistry |
pmid:15771891
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Zhang J and Brodbelt JS |
Silver complexation and tandem mass spectrometry for differentiation of isomeric flavonoid diglycosides. |
2005 |
Anal. Chem. |
pmid:15762583
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Göker H et al. |
Synthesis and potent antimicrobial activity of some novel 2-phenyl or methyl-4H-1-benzopyran-4-ones carrying amidinobenzimidazoles. |
2005 |
Bioorg. Med. Chem. |
pmid:15698788
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Schütz K et al. |
Characterization of phenolic acids and flavonoids in dandelion (Taraxacum officinale WEB. ex WIGG.) root and herb by high-performance liquid chromatography/electrospray ionization mass spectrometry. |
2005 |
Rapid Commun. Mass Spectrom. |
pmid:15593267
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Nagai S et al. |
Kinetic study of the quenching reaction of singlet oxygen by flavonoids in ethanol solution. |
2005 |
J Phys Chem B |
pmid:16851486
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Likhitwitayawuid K et al. |
Phenolics with antiviral activity from Millettia erythrocalyx and Artocarpus lakoocha. |
2005 |
Nat. Prod. Res. |
pmid:15715263
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Furuya H et al. |
Some flavonoids and DHEA-S prevent the cis-effect of expanded CTG repeats in a stable PC12 cell transformant. |
2005 |
Biochem. Pharmacol. |
pmid:15652241
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Wenzig E et al. |
Flavonolignans from Avena sativa. |
2005 |
J. Nat. Prod. |
pmid:15730266
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Cai H et al. |
The rice bran constituent tricin potently inhibits cyclooxygenase enzymes and interferes with intestinal carcinogenesis in ApcMin mice. |
2005 |
Mol. Cancer Ther. |
pmid:16170019
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Kwon HM et al. |
Anti-inflammatory inhibition of endothelial cell adhesion molecule expression by flavone derivatives. |
2005 |
J. Agric. Food Chem. |
pmid:15969490
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Takeda K et al. |
Components of protocyanin, a blue pigment from the blue flowers of Centaurea cyanus. |
2005 |
Phytochemistry |
pmid:16005311
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Xiao R et al. |
Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis. |
2005 |
Mol. Cancer |
pmid:15644144
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Garritano S et al. |
Assessment of estrogenic activity of flavonoids from Mediterranean plants using an in vitro short-term test. |
2005 |
Phytomedicine |
pmid:15693722
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Kachlicki P et al. |
Profiling isoflavone conjugates in root extracts of lupine species with LC/ESI/MSn systems. |
2005 |
J Mass Spectrom |
pmid:15971291
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Girish KS and Kemparaju K |
Inhibition of Naja naja venom hyaluronidase by plant-derived bioactive components and polysaccharides. |
2005 |
Biochemistry Mosc. |
pmid:16212553
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Ahmed-Belkacem A et al. |
Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2. |
2005 |
Cancer Res. |
pmid:15930306
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UydeÅŸ-DoÄŸan BS et al. |
The comparison of the relaxant effects of two methoxylated flavones in rat aortic rings. |
2005 |
Vascul. Pharmacol. |
pmid:16169284
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Chi YS and Kim HP |
Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix. |
2005 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:15589400
|
Lu H et al. |
Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. |
2005 |
J. Med. Chem. |
pmid:15689157
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Capodice JL et al. |
Complementary and alternative medicine for chronic prostatitis/chronic pelvic pain syndrome. |
2005 |
Evid Based Complement Alternat Med |
pmid:16322807
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Watanabe J et al. |
Coumarin and flavone derivatives from estragon and thyme as inhibitors of chemical mediator release from RBL-2H3 Cells. |
2005 |
Biosci. Biotechnol. Biochem. |
pmid:15665459
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Xie F et al. |
The osteoprotective effect of Herba epimedii (HEP) extract in vivo and in vitro. |
2005 |
Evid Based Complement Alternat Med |
pmid:16136213
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