| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Carvalho JC et al. | Anti-inflammatory activity of flavone and some of its derivates from Virola michelli Heckel. | 1999 | J Ethnopharmacol | pmid:10197753 |
| Reiners JJ et al. | Suppression of cell cycle progression by flavonoids: dependence on the aryl hydrocarbon receptor. | 1999 | Carcinogenesis | pmid:10426807 |
| Houghten RA et al. | Mixture-based synthetic combinatorial libraries. | 1999 | J. Med. Chem. | pmid:10508425 |
| Mruk JS et al. | Flavone-8-acetic acid (Flavonoid) profoundly reduces platelet-dependent thrombosis and vasoconstriction after deep arterial injury In vivo. | 2000 | Circulation | pmid:10645930 |
| Li Y et al. | Induction of apoptosis and inhibition of c-erbB-2 in breast cancer cells by flavopiridol. | 2000 | Clin. Cancer Res. | pmid:10656453 |
| Ramelet AA | Pharmacologic aspects of a phlebotropic drug in CVI-associated edema. | 2000 | Angiology | pmid:10667639 |
| Viola H et al. | 6-Chloro-3'-nitroflavone is a potent ligand for the benzodiazepine binding site of the GABA(A) receptor devoid of intrinsic activity. | 2000 | Pharmacol. Biochem. Behav. | pmid:10672984 |
| Ma YL et al. | Internal glucose residue loss in protonated O-diglycosyl flavonoids upon low-energy collision-induced dissociation. | 2000 | J. Am. Soc. Mass Spectrom. | pmid:10689666 |
| Arriaga AM et al. | Constituents of Bowdichia virgilioides. | 2000 | Fitoterapia | pmid:10727826 |
| Wollenweber E et al. | Epicuticular flavonoids of some Scrophulariaceae. | 2000 Jan-Feb | Z. Naturforsch., C, J. Biosci. | pmid:10739092 |
| Motwani M et al. | Flavopiridol, a cyclin-dependent kinase inhibitor, prevents spindle inhibitor-induced endoreduplication in human cancer cells. | 2000 | Clin. Cancer Res. | pmid:10741717 |
| Sue M et al. | Purification and characterization of a hydroxamic acid glucoside beta-glucosidase from wheat (Triticum aestivum L.) seedlings. | 2000 | Planta | pmid:10750901 |
| Liu IX et al. | Baicalin synergy with beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus and other beta-lactam-resistant strains of S. aureus. | 2000 | J. Pharm. Pharmacol. | pmid:10757427 |
| Perez RM et al. | Isolation and hypoglycemic activity of 5, 7,3'-trihydroxy-3,6,4'-trimethoxyflavone from Brickellia veronicaefolia. | 2000 | Phytomedicine | pmid:10782487 |
| Maulik SK et al. | Effect of flavone in a canine model of myocardial stunning. | 1999 | Indian J. Exp. Biol. | pmid:10783754 |
| Schwinger RH et al. | Crataegus special extract WS 1442 increases force of contraction in human myocardium cAMP-independently. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10813370 |
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| Valenti P et al. | Synthesis and biological activity of some rigid analogues of flavone-8-acetic acid. | 2000 | Bioorg. Med. Chem. | pmid:10968283 |
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| da Silva EL et al. | Inhibitory effect of flavonoids on low-density lipoprotein peroxidation catalyzed by mammalian 15-lipoxygenase. | 2000 | IUBMB Life | pmid:10995031 |
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| Dertinger SD et al. | Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo. | 2001 | Carcinogenesis | pmid:11159756 |
| Guz NR et al. | Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump: structure-activity relationships. | 2001 | J. Med. Chem. | pmid:11170636 |
| Rossi M et al. | Molecular structure and activity toward DNA of baicalein, a flavone constituent of the Asian herbal medicine "Sho-saiko-to". | 2001 | J. Nat. Prod. | pmid:11170661 |
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| Akao T et al. | Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form. | 2000 | J. Pharm. Pharmacol. | pmid:11197087 |
| Siess MH et al. | Mechanisms involved in the chemoprevention of flavonoids. | 2000 | Biofactors | pmid:11216486 |
| Rajendran NN et al. | Antinociceptive pattern of flavone and its mechanism as tested by formalin assay. | 2000 | Indian J. Exp. Biol. | pmid:11218837 |
| Klein M et al. | The ABC-like vacuolar transporter for rye mesophyll flavone glucuronides is not species-specific. | 2001 | Phytochemistry | pmid:11219807 |
| Summanen J et al. | Effects of simple aromatic compounds and flavonoids on Ca2+ fluxes in rat pituitary GH(4)C(1) cells. | 2001 | Eur. J. Pharmacol. | pmid:11239912 |
| Marder M et al. | Molecular modeling and QSAR analysis of the interaction of flavone derivatives with the benzodiazepine binding site of the GABA(A) receptor complex. | 2001 | Bioorg. Med. Chem. | pmid:11249125 |
| Fang H et al. | Structure-activity relationships for a large diverse set of natural, synthetic, and environmental estrogens. | 2001 | Chem. Res. Toxicol. | pmid:11258977 |
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| Galietta LJ et al. | Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds. | 2001 | J. Biol. Chem. | pmid:11262417 |
| Kanwar JR et al. | Vascular attack by 5,6-dimethylxanthenone-4-acetic acid combined with B7.1 (CD80)-mediated immunotherapy overcomes immune resistance and leads to the eradication of large tumors and multiple tumor foci. | 2001 | Cancer Res. | pmid:11280751 |
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| Chi YS et al. | Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells. | 2001 | Biochem. Pharmacol. | pmid:11322923 |
| Velázquez I and Pardo JP | Kinetic characterization of the rotenone-insensitive internal NADH: ubiquinone oxidoreductase of mitochondria from Saccharomyces cerevisiae. | 2001 | Arch. Biochem. Biophys. | pmid:11370674 |
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| Krakauer T et al. | The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines. | 2001 | FEBS Lett. | pmid:11434925 |
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| Ching LM et al. | Induction of endothelial cell apoptosis by the antivascular agent 5,6-Dimethylxanthenone-4-acetic acid. | 2002 | Br. J. Cancer | pmid:12085190 |
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| Choi J et al. | Flavones from Scutellaria baicalensis Georgi attenuate apoptosis and protein oxidation in neuronal cell lines. | 2002 | Biochim. Biophys. Acta | pmid:12090934 |
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