| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Brauch D et al. | Changes in isovitexin-O-glycosylation during the development of young barley plants. | 2018 | Phytochemistry | pmid:29421507 |
| Kamata R et al. | Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay. | 2018 | Toxicol In Vitro | pmid:28927721 |
| Lim H et al. | Flavonoids interfere with NLRP3 inflammasome activation. | 2018 | Toxicol. Appl. Pharmacol. | pmid:29960001 |
| Liu L et al. | Rational Design for Multicolor Flavone-Based Fluorophores with Aggregation-Induced Emission Enhancement Characteristics and Applications in Mitochondria-Imaging. | 2018 | Molecules | pmid:30205485 |
| Ngabaza T et al. | Anti-acidogenic and anti-biofilm activity of 5,6,8-trihydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one. | 2018 | Microb. Pathog. | pmid:30008421 |
| Nakabo D et al. | Convenient Synthesis and Physiological Activities of Flavonoids in Coreopsis lanceolata L. Petals and Their Related Compounds. | 2018 | Molecules | pmid:29987259 |
| Mitra A et al. | Studies on the interaction of a synthetic nitro-flavone derivative with DNA: A multi-spectroscopic and molecular docking approach. | 2018 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:29885634 |
| Dei S et al. | Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR). | 2018 | Bioorg. Med. Chem. | pmid:29162309 |
| Kim J et al. | In vitro characterization of CYP102G4 from Streptomyces cattleya: A self-sufficient P450 naturally producing indigo. | 2018 | Biochim Biophys Acta Proteins Proteom | pmid:28821467 |
| Rahmouni N et al. | L. Phenolic Content Clarifies Its Antioxidant Activity. | 2018 | Molecules | pmid:29861483 |
| Bevara GB et al. | C-glycosyl flavone from inhibits proliferation & angiogenesis & induces apoptosis via cyclin-dependent kinase 6 in human breast, hepatic & colon cancer cell lines. | 2018 | Indian J. Med. Res. | pmid:29806604 |
| Oh JM et al. | Characterization of two extracellular β-glucosidases produced from the cellulolytic fungus Aspergillus sp. YDJ216 and their potential applications for the hydrolysis of flavone glycosides. | 2018 | Int. J. Biol. Macromol. | pmid:29339289 |
| Huang L et al. | Autophagy induction by hispidulin provides protection against sevoflurane-induced neuronal apoptosis in aged rats. | 2018 | Biomed. Pharmacother. | pmid:29287193 |
| Vetrani C et al. | Association between different dietary polyphenol subclasses and the improvement in cardiometabolic risk factors: evidence from a randomized controlled clinical trial. | 2018 | Acta Diabetol | pmid:29151225 |
| Xie H et al. | Total flavone of Desmodium styracifolium relieved apoptosis and autophagy of COM-induced HK-2 cells by regulating KIM-1 via p38/MAPK pathway. | 2018 | Mol. Cell. Biochem. | pmid:29071538 |
| Wang DJ et al. | Effect of Total Flavone of Haw Leaves on Nuclear Factor Erythroid-2 Related Factor and Other Related Factors in Nonalcoholic Steatohepatitis Rats. | 2018 | Chin J Integr Med | pmid:26919834 |
| An JY et al. | Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE2 in LPS-induced RAW 264.7 cells. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28408221 |
| Ismail NA and Jusoh SA | Molecular Docking and Molecular Dynamics Simulation Studies to Predict Flavonoid Binding on the Surface of DENV2 E Protein. | 2017 | Interdiscip Sci | pmid:26969331 |
| Miyata Y et al. | In vitro studies on nobiletin isolated from citrus plants and the bioactive metabolites, inhibitory action against gelatinase enzymatic activity and the molecular mechanisms in human retinal Müller cell line. | 2017 | Biomed. Pharmacother. | pmid:28623785 |
| Montenegro CA et al. | In Silico Study and Bioprospection of the Antibacterial and Antioxidant Effects of Flavone and Its Hydroxylated Derivatives. | 2017 | Molecules | pmid:28538688 |
| Qu Y et al. | Expression of Root Genes in Arabidopsis Seedlings Grown by Standard and Improved Growing Methods. | 2017 | Int J Mol Sci | pmid:28467358 |
| Corradi E et al. | Metabolite Profile and Antiproliferative Effects in HaCaT Cells of a Salix reticulata Extract. | 2017 | Planta Med. | pmid:28449181 |
| Thangaraj K and Vaiyapuri M | Orientin, a C-glycosyl dietary flavone, suppresses colonic cell proliferation and mitigates NF-κB mediated inflammatory response in 1,2-dimethylhydrazine induced colorectal carcinogenesis. | 2017 | Biomed. Pharmacother. | pmid:29198745 |
| Yu FL et al. | NIR Rapid Assessments of Blumea balsamifera (Ai-na-xiang) in China. | 2017 | Molecules | pmid:29035305 |
| Chung YC et al. | Pratol, an O-Methylated Flavone, Induces Melanogenesis in B16F10 Melanoma Cells via p-p38 and p-JNK Upregulation. | 2017 | Molecules | pmid:29019920 |
| Das S et al. | Antioxidant flavone analog functionalized fluorescent silica nanoparticles: Synthesis and exploration of their possible use as biomolecule sensor. | 2017 | Colloids Surf B Biointerfaces | pmid:28601757 |
| Berczyński P et al. | Synthesis and in vitro antioxidant activity study of some new piperazinyl flavone compounds. | 2017 | Luminescence | pmid:28569387 |
| Al-Rimawi F et al. | ANALYSIS OF PHENOLIC AND FLAVONOIDS OF WILD EPHEDRA ALATA PLANT EXTRACTS BY LC/PDA AND LC/MS AND THEIR ANTIOXIDANT ACTIVITY. | 2017 | Afr J Tradit Complement Altern Med | pmid:28573229 |
| Huang QH et al. | Isoprenylated phenolic compounds with PTP1B inhibition from Morus alba. | 2017 | Fitoterapia | pmid:28916258 |
| Živković JČ et al. | Chemical Profiling and Assessment of Antineurodegenerative and Antioxidant Properties of Veronica teucrium L. and Veronica jacquinii Baumg. | 2017 | Chem. Biodivers. | pmid:28488389 |
| Kim S et al. | Promotion of Glucose Uptake in C2C12 Myotubes by Cereal Flavone Tricin and Its Underlying Molecular Mechanism. | 2017 | J. Agric. Food Chem. | pmid:28474889 |
| Tsai YF et al. | 6-Hydroxy-5,7-dimethoxy-flavone suppresses the neutrophil respiratory burst via selective PDE4 inhibition to ameliorate acute lung injury. | 2017 | Free Radic. Biol. Med. | pmid:28263828 |
| Li S et al. | Chemical profiling of Fufang-Xialian-Capsule by UHPLC-Q-TOF-MS and its antioxidant activity evaluated by in vitro method. | 2017 | J Pharm Biomed Anal | pmid:28235732 |
| Yang Y et al. | Encapsulation of Polymethoxyflavones in Citrus Oil Emulsion-Based Delivery Systems. | 2017 | J. Agric. Food Chem. | pmid:28182421 |
| Li YP et al. | Three new C-alkylated flavonoids from Desmodium oblongum. | 2017 | J Asian Nat Prod Res | pmid:28145124 |
| Kang Y et al. | Inhibitory potential of flavonoids on PtdIns(3,4,5)P3 binding with the phosphoinositide-dependent kinase 1 pleckstrin homology domain. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28049590 |
| Kamto EL et al. | Alternating isocratic and step gradient elution high-speed counter-current chromatography for the isolation of minor phenolics from Ormocarpum kirkii bark. | 2017 | J Chromatogr A | pmid:27988077 |
| Feng XT et al. | Protective role of Pollen Typhae total flavone against the palmitic acid-induced impairment of glucose-stimulated insulin secretion involving GPR40 signaling in INS-1 cells. | 2017 | Int. J. Mol. Med. | pmid:28731171 |
| Lan W et al. | Maize Tricin-Oligolignol Metabolites and Their Implications for Monocot Lignification. | 2016 | Plant Physiol. | pmid:27208246 |
| Zhao Q et al. | A specialized flavone biosynthetic pathway has evolved in the medicinal plant, Scutellaria baicalensis. | 2016 | Sci Adv | pmid:27152350 |
| Li YR et al. | Tangeretin derivative, 5-acetyloxy-6,7,8,4'-tetramethoxyflavone induces G2/M arrest, apoptosis and autophagy in human non-small cell lung cancer cells in vitro and in vivo. | 2016 | Cancer Biol. Ther. | pmid:26569090 |
| Bugel SM et al. | Comparative Developmental Toxicity of Flavonoids Using an Integrative Zebrafish System. | 2016 | Toxicol. Sci. | pmid:27492224 |
| Yan X et al. | 58-F, a flavanone from Ophiopogon japonicus, prevents hepatocyte death by decreasing lysosomal membrane permeability. | 2016 | Sci Rep | pmid:27306715 |
| Lameiras P and Nuzillard JM | Highly Viscous Binary Solvents: DMSO-d6/Glycerol and DMSO-d6/Glycerol-d8 for Polar and Apolar Mixture Analysis by NMR. | 2016 | Anal. Chem. | pmid:27008506 |
| Zhu W et al. | Flavone inhibits migration through DLC1/RhoA pathway by decreasing ROS generation in breast cancer cells. | 2016 | In Vitro Cell. Dev. Biol. Anim. | pmid:26935193 |
| Kasala ER et al. | Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. | 2016 | Pharmacol Rep | pmid:26922533 |
| Kant R et al. | Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities. | 2016 | Eur J Med Chem | pmid:26922227 |
| Zhang J et al. | A flavone-based turn-on fluorescent probe for intracellular cysteine/homocysteine sensing with high selectivity. | 2016 | Talanta | pmid:26695232 |
| Malkhasian AY and Howlin BJ | Docking and DFT studies on ligand binding to Quercetin 2,3-dioxygenase. | 2016 | J. Biomol. Struct. Dyn. | pmid:26599260 |
| Berim A et al. | Identification of a unique 2-oxoglutarate-dependent flavone 7-O-demethylase completes the elucidation of the lipophilic flavone network in basil. | 2015 | Plant Cell Physiol. | pmid:25378691 |