FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Per page 10 20 50 | Total 32

PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

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Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Pan SY et al. New perspectives on chinese herbal medicine (zhong-yao) research and development. 2011 Evid Based Complement Alternat Med pmid:21785622
Kassem ME et al. A sulphated flavone glycoside from Livistona australis and its antioxidant and cytotoxic activity. 2012 Nat. Prod. Res. pmid:21793764
Kim YW et al. DA6034 promotes gastric epithelial cell migration and wound-healing through the mTOR pathway. 2012 J. Gastroenterol. Hepatol. pmid:21793913
Kundu R et al. Carlinoside reduces hepatic bilirubin accumulation by stimulating bilirubin-UGT activity through Nrf2 gene expression. 2011 Biochem. Pharmacol. pmid:21801714
Khalafalah AK et al. Chemical constituents of Tephrosia purpurea. 2010 Pharmacognosy Res pmid:21808544
Samarghandian S et al. Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. 2011 Clinics (Sao Paulo) pmid:21808878
Hammoud L et al. A new flavonoid and other constituents from Centaurea nicaeensis All. var. walliana M. 2012 Nat. Prod. Res. pmid:21815723
Phromnoi K et al. Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1. 2011 Mol. Pharmacol. pmid:21816954
Janovick JA et al. Therapeutic rescue of misfolded mutants: validation of primary high throughput screens for identification of pharmacoperone drugs. 2011 PLoS ONE pmid:21818389
Kuete V and Efferth T Cameroonian medicinal plants: pharmacology and derived natural products. 2010 Front Pharmacol pmid:21833168
Raza SS et al. Silymarin protects neurons from oxidative stress associated damages in focal cerebral ischemia: a behavioral, biochemical and immunohistological study in Wistar rats. 2011 J. Neurol. Sci. pmid:21840019
Gao L et al. 3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase. 2011 Bioorg. Med. Chem. Lett. pmid:21843936
Clark ST and Verwoerd WS A systems approach to identifying correlated gene targets for the loss of colour pigmentation in plants. 2011 BMC Bioinformatics pmid:21849042
Klein T et al. Structural basis for species specific inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1): computational study and biological validation. 2011 PLoS ONE pmid:21857977
Lee KN et al. Prevention of NSAID-associated gastroduodenal injury in healthy volunteers-a randomized, double-blind, multicenter study comparing DA-9601 with misoprostol. 2011 J. Korean Med. Sci. pmid:21860559
Xiao J et al. Noncovalent interaction of dietary polyphenols with common human plasma proteins. 2011 J. Agric. Food Chem. pmid:21863815
Manna P et al. Phytomedicinal Role of Pithecellobium dulce against CCl(4)-mediated Hepatic Oxidative Impairments and Necrotic Cell Death. 2011 Evid Based Complement Alternat Med pmid:21869899
Wang Y et al. Flavone C-glycosides from the leaves of Lophatherum gracile and their in vitro antiviral activity. 2012 Planta Med. pmid:21870321
Buszewski B and Noga S Hydrophilic interaction liquid chromatography (HILIC)--a powerful separation technique. 2012 Anal Bioanal Chem pmid:21879300
Gauci AJ et al. Identification of polyphenolic compounds and black tea extract as potent inhibitors of lipid membrane destabilization by Aβ₄₂ aggregates. 2011 J. Alzheimers Dis. pmid:21891862
Liu LZ et al. Acacetin inhibits VEGF expression, tumor angiogenesis and growth through AKT/HIF-1α pathway. 2011 Biochem. Biophys. Res. Commun. pmid:21893035
Kozics K et al. Structure of flavonoids influences the degree inhibition of Benzo(a)pyrene - induced DNA damage and micronuclei in HepG2 cells. 2011 Neoplasma pmid:21895405
Bhavsar AS et al. A review on recent advances in dry eye: Pathogenesis and management. 2011 Oman J Ophthalmol pmid:21897618
Fong YK et al. In vitro and in situ evaluation of herb-drug interactions during intestinal metabolism and absorption of baicalein. 2012 J Ethnopharmacol pmid:21906668
Shin SY et al. Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities. 2011 Bioorg. Med. Chem. Lett. pmid:21907578
Hunyadi A et al. Direct semi-synthesis of the anticancer lead-drug protoapigenone from apigenin, and synthesis of further new cytotoxic protoflavone derivatives. 2011 PLoS ONE pmid:21912610
Ren L et al. Effects of flavone 6-substitutions on GABAA receptors efficacy. 2011 Eur. J. Pharmacol. pmid:21914441
Wu B and Wang J Phenolic compounds from Selaginella moellendorfii. 2011 Chem. Biodivers. pmid:21922662
Hamman C et al. The use of ammonium hydroxide as an additive in supercritical fluid chromatography for achiral and chiral separations and purifications of small, basic medicinal molecules. 2011 J Chromatogr A pmid:21939976
Vila-Real H et al. Enzymatic Synthesis of the Flavone Glucosides, Prunin and Isoquercetin, and the Aglycones, Naringenin and Quercetin, with Selective α-L-Rhamnosidase and β-D-Glucosidase Activities of Naringinase. 2011 Enzyme Res pmid:21941631
Xiao J et al. Non-covalent interaction of dietary polyphenols with total plasma proteins of type II diabetes: molecular structure/property-affinity relationships. 2011 Integr Biol (Camb) pmid:21947088
Derdemezis CS et al. Effect of Plant Polyphenols on Adipokine Secretion from Human SGBS Adipocytes. 2011 Biochem Res Int pmid:21949907
Ibrahim MH et al. Effects of nitrogen fertilization on synthesis of primary and secondary metabolites in three varieties of Kacip Fatimah (Labisia pumila Blume). 2011 Int J Mol Sci pmid:21954355
Xia EQ et al. Microwave-assisted extraction of oleanolic acid and ursolic acid from Ligustrum lucidum Ait. 2011 Int J Mol Sci pmid:21954361
Sumbul S et al. Role of phenolic compounds in peptic ulcer: An overview. 2011 J Pharm Bioallied Sci pmid:21966156
Kurian GA and Paddikkala J Role of Mitochondrial Enzymes and Sarcoplasmic ATPase in Cardioprotection Mediated by Aqueous Extract of Desmodium gangeticum (L) DC Root on Ischemic Reperfusion Injury. 2010 Indian J Pharm Sci pmid:21969747
Niazmand S et al. Cardiovascular effects of Teucrium polium L. extract in rabbit. 2011 Pharmacogn Mag pmid:21969799
Himi E et al. Differential expression of three flavanone 3-hydroxylase genes in grains and coleoptiles of wheat. 2011 Int J Plant Genomics pmid:21977025
Ortet R et al. Furfuran lignans and a flavone from Artemisia gorgonum Webb and their in vitro activity against Plasmodium falciparum. 2011 J Ethnopharmacol pmid:21982788
Shi L et al. Gossypin induces G2/M arrest in human malignant glioma U251 cells by the activation of Chk1/Cdc25C pathway. 2012 Cell. Mol. Neurobiol. pmid:21984341
Lee SJ et al. Hypolipidemic and hypoglycemic effects of Orostachys japonicus A. Berger extracts in streptozotocin-induced diabetic rats. 2011 Nutr Res Pract pmid:21994524
Villela A et al. Fast chromatographic separation for the quantitation of the main flavone dyes in Reseda luteola (weld). 2011 J Chromatogr A pmid:21999916
Elmann A et al. Anti-neuroinflammatory effects of the extract of Achillea fragrantissima. 2011 BMC Complement Altern Med pmid:22018032
Fan Y et al. Liposome and epimedium polysaccharide-propolis flavone can synergistically enhance immune effect of vaccine. 2012 Int. J. Biol. Macromol. pmid:22020157
Thirupathy KP et al. Neuropharmacological activity of Lippia nodiflora Linn. 2011 Pharmacognosy Res pmid:22022169
Shiromwar SS and Chidrawar VR Combined effects of p-coumaric acid and naringenin against doxorubicin-induced cardiotoxicity in rats. 2011 Pharmacognosy Res pmid:22022172
Kumagai A et al. A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells. 2011 PLoS ONE pmid:22022544
Wu LZ et al. Two new flavone C-glycosides from Trollius ledebourii. 2011 Chem. Pharm. Bull. pmid:22041076
Li G et al. Pharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC-MS method. 2012 Fitoterapia pmid:22056665
Fletcher JN et al. In vitro evaluation of flavonoids from Eriodictyon californicum for antagonist activity against the bitterness receptor hTAS2R31. 2011 J. Agric. Food Chem. pmid:22059530
Seo YJ et al. Apoptotic effects of genistein, biochanin-A and apigenin on LNCaP and PC-3 cells by p21 through transcriptional inhibition of polo-like kinase-1. 2011 J. Korean Med. Sci. pmid:22065906
Schrader KK Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus). 2010 Toxins (Basel) pmid:22069655
Chahar MK et al. Flavonoids: A versatile source of anticancer drugs. 2011 Pharmacogn Rev pmid:22096313
Zhang H and Zhang C Vasoprotection by dietary supplements and exercise: role of TNFα signaling. 2012 Exp Diabetes Res pmid:22110483
Park NI et al. Enhancement of rutin in Fagopyrum esculentum hairy root cultures by the Arabidopsis transcription factor AtMYB12. 2012 Biotechnol. Lett. pmid:22113884
Park SR et al. Enhanced flavonoid production in Streptomyces venezuelae via metabolic engineering. 2011 J. Microbiol. Biotechnol. pmid:22127124
Skizim NJ et al. Metabolic pathways for photobiological hydrogen production by nitrogenase- and hydrogenase-containing unicellular cyanobacteria Cyanothece. 2012 J. Biol. Chem. pmid:22128188
Theoharides TC and Zhang B Neuro-inflammation, blood-brain barrier, seizures and autism. 2011 J Neuroinflammation pmid:22129087
Zbidah M et al. Apigenin-induced suicidal erythrocyte death. 2012 J. Agric. Food Chem. pmid:22132906
Xie C et al. The açaí flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-α and IL-6 production through inhibiting NF-κB activation and MAPK pathway. 2012 J. Nutr. Biochem. pmid:22137267
Shukla S et al. Apigenin attenuates insulin-like growth factor-I signaling in an autochthonous mouse prostate cancer model. 2012 Pharm. Res. pmid:22139534
Mehla R et al. A flavonoid, luteolin, cripples HIV-1 by abrogation of tat function. 2011 PLoS ONE pmid:22140483
Buchanan CM et al. DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular. 2012 Clin. Sci. pmid:22142330
El-Alfy TS et al. A New Flavonoid C-Glycoside from Celtis australis L. and Celtis occidentalis L. Leaves and Potential Antioxidant and Cytotoxic Activities. 2011 Oct-Dec Sci Pharm pmid:22145118
Barrero RA et al. De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes. 2011 BMC Genomics pmid:22151917
Kongkum N et al. DNA topoisomerase IIα inhibitory and anti-HIV-1 flavones from leaves and twigs of Gardenia carinata. 2012 Fitoterapia pmid:22155186
Yarmolinsky L et al. Potent antiviral flavone glycosides from Ficus benjamina leaves. 2012 Fitoterapia pmid:22155188
Khan R et al. Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53. 2012 Toxicol. Appl. Pharmacol. pmid:22155348
Nagib DA and MacMillan DW Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis. 2011 Nature pmid:22158245
Silva RO et al. Sulfated-polysaccharide fraction from red algae Gracilaria caudata protects mice gut against ethanol-induced damage. 2011 Mar Drugs pmid:22163181
Kanda K et al. Nobiletin suppresses adipocyte differentiation of 3T3-L1 cells by an insulin and IBMX mixture induction. 2012 Biochim. Biophys. Acta pmid:22172985
Walch SG et al. Antioxidant Capacity and Polyphenolic Composition as Quality Indicators for Aqueous Infusions of Salvia officinalis L. (sage tea). 2011 Front Pharmacol pmid:22194722
Lee DH et al. Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells. 2012 Evid Based Complement Alternat Med pmid:22194772
Greeff J et al. Antioxidant properties of 4-quinolones and structurally related flavones. 2012 Bioorg. Med. Chem. pmid:22197671
Singh S et al. 2-(4-Chloro-phen-yl)chromen-4-one. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:22199687
Zandi K et al. Antiviral activity of four types of bioflavonoid against dengue virus type-2. 2011 Virol. J. pmid:22201648
Khan M et al. Jaceosidin Induces Apoptosis in U87 Glioblastoma Cells through G2/M Phase Arrest. 2012 Evid Based Complement Alternat Med pmid:22216058
Cai WJ et al. Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. 2011 PLoS ONE pmid:22216122
Waki T et al. Key role of chemical hardness to compare 2,2-diphenyl-1-picrylhydrazyl radical scavenging power of flavone and flavonol O-glycoside and C-glycoside derivatives. 2012 Chem. Pharm. Bull. pmid:22223373
Murata T et al. Hyaluronidase inhibitors from Keiskea japonica. 2012 Chem. Pharm. Bull. pmid:22223383
Hostetler GL et al. Endogenous enzymes, heat, and pH affect flavone profiles in parsley (Petroselinum crispum var. neapolitanum) and celery (Apium graveolens) during juice processing. 2012 J. Agric. Food Chem. pmid:22224550
Baikar S and Malpathak N Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs. 2010 Pharmacogn Rev pmid:22228937
Semalty M et al. Semecarpus anacardium Linn.: A review. 2010 Pharmacogn Rev pmid:22228947
Medjakovic S et al. Potential health-modulating effects of isoflavones and metabolites via activation of PPAR and AhR. 2010 Nutrients pmid:22254019
Meydani M and Hasan ST Dietary polyphenols and obesity. 2010 Nutrients pmid:22254051
Lewin G et al. Influence of the skeleton on the cytotoxicity of flavonoids. 2012 Bioorg. Med. Chem. pmid:22257529
Brito I et al. 4',5-Dihy-droxy-7-meth-oxy-flavanone dihydrate. 2012 Acta Crystallogr Sect E Struct Rep Online pmid:22259537
Qin S et al. Gene expression profiling and pathway network analysis of hepatic metabolic enzymes targeted by baicalein. 2012 J Ethnopharmacol pmid:22265932
Yokohira M et al. Lack of Modifying Effects of Intratracheal Instillation of Quartz or Dextran Sulfate Sodium (DSS) in Drinking Water on Lung Tumor Development Initiated with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Female A/J Mice. 2009 J Toxicol Pathol pmid:22271992
Sancho MI et al. Spectroscopic study of solvent effects on the electronic absorption spectra of flavone and 7-hydroxyflavone in neat and binary solvent mixtures. 2011 Int J Mol Sci pmid:22272110
Chen CC et al. Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury. 2012 PLoS ONE pmid:22272328
Beg S et al. Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives. 2011 Pharmacogn Rev pmid:22279370
Sati SC et al. Bioactive constituents and medicinal importance of genus Alnus. 2011 Pharmacogn Rev pmid:22279375
Tsai IT et al. Flavone is efficient to protect zebrafish fins from UV-induced damage. 2012 Drug Chem Toxicol pmid:22289409
Mohammadi-Motlagh HR et al. Anticancer and anti-inflammatory activities of shallot (Allium ascalonicum) extract. 2011 Arch Med Sci pmid:22291731
Spatafora C and Tringali C Natural-derived polyphenols as potential anticancer agents. 2012 Anticancer Agents Med Chem pmid:22292766
Lee HJ et al. Protection of prenylated flavonoids from Mori Cortex Radicis (Moraceae) against nitric oxide-induced cell death in neuroblastoma SH-SY5Y cells. 2012 Arch. Pharm. Res. pmid:22297755
Huang WY et al. Survey of antioxidant capacity and phenolic composition of blueberry, blackberry, and strawberry in Nanjing. 2012 J Zhejiang Univ Sci B pmid:22302422
Chen HJ et al. Determination of phenolic acids and flavonoids in Taraxacum formosanum Kitam by liquid chromatography-tandem mass spectrometry coupled with a post-column derivatization technique. 2012 Int J Mol Sci pmid:22312251
Chen LY et al. Structural elucidation and bioactivity of biflavonoids from the stems of Wikstroemia taiwanensis. 2012 Int J Mol Sci pmid:22312302